Property, Plant, and Equipment (Details) (USD $)	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 526,094,000	$ 478,757,000
Less, accumulated depreciation and amortization	(158,139,000)	(131,307,000)
Property, plant and equipment, net	367,955,000	347,450,000
Depreciation and amortization expense	31,100,000	19,700,000	14,200,000
Capitalized interest costs		6,400,000
Change in Accounting Estimate [Line Items]
Change in accounting estimate, decrease in depreciation expense		4,000,000
Change in accounting estimate, decrease in net loss per share (in dollars per share)		$ 0.05
Land [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	2,117,000	2,117,000
Building and Improvements [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	322,753,000	242,035,000
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	4,479,000	4,063,000
Construction-in-Progress [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	10,880,000	70,356,000
Laboratory and Other Equipment [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	156,397,000	137,951,000
Furniture, Computer and Office Equipment, and Other [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	29,468,000	22,235,000
Leased Equipment Under Capital Leases [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	3,600,000	2,800,000
Less, accumulated depreciation and amortization	(500,000)	(100,000)
New Laboratory and Office Facilities [Member]
Property, Plant and Equipment [Line Items]
Costs incurred by the landlord to construct new laboratory and office facilities	$ 86,200,000	$ 86,200,000