0001206774-12-000709.txt : 20120221 0001206774-12-000709.hdr.sgml : 20120220 20120221073108 ACCESSION NUMBER: 0001206774-12-000709 CONFORMED SUBMISSION TYPE: 10-K PUBLIC DOCUMENT COUNT: 14 CONFORMED PERIOD OF REPORT: 20111231 FILED AS OF DATE: 20120221 DATE AS OF CHANGE: 20120221 FILER: COMPANY DATA: COMPANY CONFORMED NAME: REGENERON PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000872589 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 133444607 STATE OF INCORPORATION: NY FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-K SEC ACT: 1934 Act SEC FILE NUMBER: 000-19034 FILM NUMBER: 12624899 BUSINESS ADDRESS: STREET 1: 777 OLD SAW MILL RIVER RD CITY: TARRYTOWN STATE: NY ZIP: 10591-6707 BUSINESS PHONE: 9143477000 10-K 1 regeneron_10k.htm ANNUAL REPORT

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 10-K

(Mark One)  
    (X)          ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the fiscal year ended December 31, 2011
OR
(   ) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from _____ to _____

Commission File Number 0-19034

REGENERON PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)

New York 13-3444607
(State or other jurisdiction of (I.R.S. Employer Identification No)
incorporation or organization)
 
777 Old Saw Mill River Road, Tarrytown, New York 10591-6707
(Address of principal executive offices) (Zip code)

(914) 847-7000
(Registrant's telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class Name of each exchange on which registered
Common Stock - par value $.001 per share NASDAQ Global Select Market

Securities registered pursuant to section 12(g) of the Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes   ü   No ____

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes ____ No   ü   

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes   ü   No ____

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes   ü   No ____

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not contained herein, and will not be contained, to the best of registrant's knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. ___

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer”, “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated file   ü  

Accelerated filer __

Non-accelerated filer ___

Smaller reporting company ___

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ____ No   ü   

The aggregate market value of the common stock held by non-affiliates of the registrant was approximately $4,913,223,000, computed by reference to the closing sales price of the stock on NASDAQ on June 30, 2011, the last trading day of the registrant’s most recently completed second fiscal quarter.

The number of shares outstanding of each of the registrant's classes of common stock as of February 10, 2012:

Class of Common Stock   Number of Shares
  Class A Stock, $.001 par value 2,109,512
     Common Stock, $.001 par value 91,779,465

DOCUMENTS INCORPORATED BY REFERENCE:
     Specified portions of the Registrant's definitive proxy statement to be filed in connection with solicitation of proxies for its 2012 Annual Meeting of Shareholders are incorporated by reference into Part III of this Form 10-K. Exhibit index is located on pages 79 to 82 of this filing.


PART I

ITEM 1. BUSINESS

This Annual Report on Form 10-K contains forward-looking statements that involve risks and uncertainties relating to future events and the future financial performance of Regeneron Pharmaceuticals, Inc., and actual events or results may differ materially from these forward-looking statements. These statements concern, and these risks and uncertainties include, among other things, the success of our commercialization of EYLEA®, the nature, timing, and possible success of and therapeutic applications for our product candidates and research programs now underway or planned, the likelihood and timing of possible regulatory approval and commercial launch of our late-stage product candidates, determinations by regulatory and administrative governmental authorities which may delay or restrict our ability to continue to develop or commercialize our product and drug candidates, competing drugs that may be superior to our product and drug candidates, uncertainty of market acceptance of our product and drug candidates, unanticipated expenses, the availability and cost of capital, the costs of developing, producing, and selling products, the potential for any collaboration agreement, including our agreements with Sanofi and Bayer HealthCare LLC, to be canceled or terminated without any product success, and risks associated with third-party intellectual property and pending or future litigation relating thereto. These statements are made by us based on management's current beliefs and judgment. In evaluating such statements, shareholders and potential investors should specifically consider the various factors identified under the caption “Risk Factors” which could cause actual events and results to differ materially from those indicated by such forward-looking statements. We do not undertake any obligation to update publicly any forward-looking statement, whether as a result of new information, future events, or otherwise, except as required by law.

General

     Regeneron Pharmaceuticals, Inc. is a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. We currently have two marketed products:

  • EYLEA® (aflibercept) Injection, known in the scientific literature as VEGF Trap-Eye, which is available in the United States for the treatment of neovascular age-related macular degeneration (wet AMD). Wet AMD is the leading cause of acquired blindness for people over the age of 65 in the United States and Europe; and
  • ARCALYST® (rilonacept) Injection for Subcutaneous Use, which is available by prescription in the United States for the treatment of Cryopyrin-Associated Periodic Syndromes (CAPS), including Familial Cold Auto-inflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS) in adults and children 12 and older.

     We have 13 product candidates in clinical development, all of which were discovered in our research laboratories. Our Trap-based, late-stage programs are:

  • EYLEA®, which is being developed for the treatment of additional serious eye diseases;
  • ZALTRAP® (aflibercept), known in the scientific literature as VEGF Trap, which is being developed in oncology in collaboration with Sanofi; and
  • ARCALYST®, which is being developed for the prevention of gout flares in patients initiating uric acid-lowering treatment.

     Our antibody-based clinical programs include the following fully human monoclonal antibodies:

  • Sarilumab (REGN88), an antibody to the interleukin-6 receptor (IL-6R), which is being developed in rheumatoid arthritis;
  • REGN727, an antibody to Proprotein Convertase Substilisin/Kexin type 9 (PCSK9), which is being developed for low-density lipoprotein (LDL) cholesterol reduction;
  • REGN668, an antibody to the interleukin-4 receptor (IL-4R), which is being developed in atopic dermatitis and eosinophilic asthma;
  • REGN421, an antibody to Delta-like ligand-4 (Dll4), a novel angiogenesis target, which is being developed in oncology;
  • REGN910, an antibody to Angiopoietin-2 (ANG2), another novel angiogenesis target, which is being developed in oncology;
  • REGN475, an antibody to Nerve Growth Factor (NGF), which is being developed for the treatment of pain (currently on clinical hold);
  • REGN728, an antibody in clinical development against an undisclosed target;
  • REGN1033, an antibody in clinical development against an undisclosed target;
  • REGN846, an antibody in clinical development against an undisclosed target, which is being developed in atopic dermatitis; and
  • REGN1154, an antibody in clinical development against an undisclosed target.

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     With the exception of REGN475, REGN846, and REGN1154, which we are developing independently, all of these antibodies are being developed in collaboration with Sanofi.

     Our core business strategy is to maintain a strong foundation in basic scientific research and discovery-enabling technologies, to combine that foundation with our clinical development and manufacturing capabilities, and to continue to expand our commercialization capabilities in anticipation of possible regulatory approval and launch of one or more of our late-stage product candidates. Our long-term objective is to build a successful, integrated, multi-product biopharmaceutical company that provides patients and medical professionals with innovative options for preventing and treating human diseases.

     We believe that our ability to develop product candidates is enhanced by the application of our VelociSuite™ technology platforms. Our discovery platforms are designed to identify specific proteins of therapeutic interest for a particular disease or cell type and validate these targets through high-throughput production of genetically modified mice using our VelociGene® technology to understand the role of these proteins in normal physiology, as well as in models of disease. Our human monoclonal antibody technology (VelocImmune®) and cell line expression technologies (VelociMab®) may then be utilized to discover and produce new product candidates directed against the disease target. Our antibody product candidates currently in clinical trials were developed using VelocImmune®. Under the terms of our antibody collaboration with Sanofi, which was expanded during 2009, we plan to advance a total of 20 to 30 candidates into clinical development over the life of the agreement. We continue to invest in the development of enabling technologies to assist in our efforts to identify, develop, manufacture, and commercialize new product candidates.

Commercial Products:

EYLEA®(aflibercept) Injection – wet AMD

     In November 2011, we received U.S. marketing approval from the U.S. Food and Drug Administration (FDA) for EYLEA® Injection for the treatment of patients with wet AMD. The approval of EYLEA® was granted by the FDA under a Priority Review, a designation that is given to drugs that offer major advances in treatment, or provide a treatment where no adequate therapy exists. Net product sales of EYLEA® in 2011 were $24.8 million.

     EYLEA®, known in the scientific literature as VEGF Trap-Eye, is a fusion protein locally administered in the eye that is designed to bind Vascular Endothelial Growth Factor-A (VEGF-A) and Placental Growth Factor (PlGF) proteins that are involved in the abnormal growth of new blood vessels. The abnormal growth of new blood vessels could leak blood and fluid, which causes disruption and dysfunction of the retina creating distortion and/or blind spots in central vision.

     We are collaborating with Bayer HealthCare on the global development of EYLEA®. Bayer HealthCare has submitted applications for marketing authorization in the European Union, Japan, and other countries for wet AMD. Bayer HealthCare will market EYLEA® outside the United States, where the companies will share equally the profits from any future sales of EYLEA®. We maintain exclusive rights to EYLEA® in the United States and are entitled to all profits from any such sales.

ARCALYST® – CAPS

     Net product sales of ARCALYST® (rilonacept) in 2011 were $19.9 million. Net product sales of ARCALYST® in 2010 were $25.3 million, which included $20.5 million of ARCALYST® net product sales made in 2010 and $4.8 million of previously deferred net product sales, as described below under Item 7. “Management’s Discussion and Analysis of Financial Condition and Results of Operations - Results of Operations.”

     ARCALYST® is a protein-based product designed to bind the interleukin-1 (called IL-1) cytokine and prevent its interaction with cell surface receptors. ARCALYST® is available by prescription in the United States for the treatment of CAPS, including FCAS and MWS in adults and children 12 and older. CAPS are a group of rare, inherited, auto-inflammatory conditions characterized by life-long, recurrent symptoms of rash, fever/chills, joint pain, eye redness/pain, and fatigue. Intermittent, disruptive exacerbations or flares can be triggered at any time by exposure to cooling temperatures, stress, exercise, or other unknown stimuli.

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Clinical Programs:

1. EYLEA® – Ophthalmologic Diseases

     We, together with our ex-U.S. collaborator Bayer HealthCare, are evaluating EYLEA® in Phase 3 programs in patients with central retinal vein occlusion (CRVO), diabetic macular edema (DME), and choroidal neovascularisation (CNV) of the retina as a result of pathologic myopia. We plan on initiating a Phase 3 study in branch retinal vein occlusion (BRVO) in the first quarter of 2012. Wet AMD, diabetic retinopathy (which includes DME), and retinal vein occlusion are three of the leading causes of adult blindness in the developed world. In these conditions, severe visual loss is caused by a combination of retinal edema and neovascular proliferation.

     The Phase 3 trials in wet AMD, known as VIEW 1 and VIEW 2 (VEGF Trap: Investigation of Efficacy and Safety in Wet age-related macular degeneration), compared EYLEA® and Lucentis® (ranibizumab injection), a registered trademark of Genentech, Inc. Lucentis® is an anti-VEGF agent approved for use and the current standard of care in wet AMD. VIEW 1 was conducted in North America and VIEW 2 was conducted in Europe, Asia Pacific, Japan, and Latin America. The VIEW 1 and VIEW 2 trials both evaluated EYLEA® doses of 0.5 milligrams (mg) and 2.0 mg at dosing intervals of four weeks and 2.0 mg at a dosing interval of eight weeks (following three initial monthly doses), compared with Lucentis® dosed according to its U.S. label, which specifies doses of 0.5 mg administered every four weeks over the first year. The primary endpoint of these non-inferiority studies was the proportion of patients treated with EYLEA® who maintain visual acuity at the end of one year compared to patients dosed monthly with Lucentis®. Visual acuity is defined as the total number of letters read correctly on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart, a standard research tool for measuring visual acuity. Maintenance of vision is defined as losing fewer than three lines (equivalent to 15 letters) on the ETDRS chart. Secondary endpoints included the mean change from baseline in visual acuity as measured by ETDRS, the proportion of patients who gained at least 15 letters of vision at week 52, and the amount of fluid under the retina.

     We and Bayer HealthCare announced week 52 results from the VIEW 1 and VIEW 2 studies in November 2010. In these studies, all regimens of EYLEA®, including EYLEA® dosed every two months, successfully met the primary endpoint of statistical non-inferiority compared to Lucentis® dosed every month. A generally favorable safety profile was observed for both EYLEA® and Lucentis®. The incidence of ocular treatment emergent adverse events was balanced across all four treatment groups in both studies, with the most frequent events associated with the injection procedure, the underlying disease, and/or the aging process. The most frequent ocular adverse events were conjunctival hemorrhage, macular degeneration, eye pain, retinal hemorrhage, and vitreous floaters. The most frequent serious non-ocular adverse events were typical of those reported in this elderly population who receive intravitreal treatment for wet AMD; the most frequently reported events were falls, pneumonia, myocardial infarction, atrial fibrillation, breast cancer, and acute coronary syndrome. There were no notable differences among the study arms.

     Based on these positive results, we submitted a Biologics License Application (BLA) to the FDA in February 2011 for marketing approval of EYLEA® in wet AMD in the United States. In April 2011, the FDA accepted the BLA for filing and granted our request for Priority Review. In June 2011, the Dermatologic and Ophthalmic Drugs Advisory Committee of the FDA unanimously recommended that the FDA approve our BLA. In 2011, Bayer HealthCare submitted regulatory applications for marketing approval of EYLEA® in wet AMD in the European Union, Japan, and other countries. In November 2011, we received U.S. marketing approval from the FDA for EYLEA® Injection for the treatment of patients with wet AMD.

     In December 2011, we and Bayer HealthCare announced Year 2 results from the VIEW 1 and VIEW 2 studies. In the second year of the studies, patients were treated with the same dose per injection as in the first year and were evaluated monthly to determine need for retreatment. Patients were treated at least every 12 weeks. All Year 2 analyses were considered exploratory. In an integrated analysis of the VIEW 1 and VIEW 2 studies, the visual acuity gain from baseline in the EYLEA® 2.0 mg every eight week group at week 96 was 7.6 letters compared to 8.4 letters at week 52, with an average of 11.2 injections over two years and 4.2 injections during the second year. The visual acuity gain from baseline in the monthly Lucentis® group at week 96 was 7.9 letters compared to 8.7 letters at week 52, with an average of 16.5 injections over two years and 4.7 injections during the second year. The results of each of the VIEW 1 and VIEW 2 studies were consistent with the integrated analysis.

     The overall fewer average number of injections in the second year in the EYLEA® 2.0 mg every eight week group compared to the Lucentis® group (4.2 versus 4.7; nominal p<0.0001) was driven by the fact that fewer patients needed more intense therapy in the EYLEA® group and those patients required fewer injections.

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     The proportion of patients who required frequent injections (six or more) during Year 2 was lower in the EYLEA® 2.0 mg every eight week group compared to the Lucentis® group (15.9% versus 26.5%). In the 25% of patients who required the most intense therapy (the greatest number of injections), patients in the EYLEA® 2.0 mg every eight week group required an average of 1.4 fewer injections in Year 2 compared to the Lucentis® group (6.6 versus 8.0). In the 25% of patients in each group who had the fewest number of injections in Year 2, the average number of injections was similar (approximately 3 for both groups, corresponding to the protocol-mandated minimum number of injections).

     A generally favorable safety profile was observed for both EYLEA® and Lucentis®. The incidence of ocular treatment emergent adverse events was balanced across all four treatment groups in both studies. The most frequent ocular adverse events (greater than 10% of patients for the overall study population) were conjunctival hemorrhage, eye pain, retinal hemorrhage, and visual acuity reduced. The most frequent serious non-ocular adverse events were typical of those reported in this elderly population who receive intravitreal treatment for wet AMD; the most frequently reported events (greater than 1% of patients for the overall study population) were falls, pneumonia, myocardial infarction and atrial fibrillation. There were no notable differences among the study arms. The incidence of arterial thrombotic events as defined by the "Anti-Platelet Trialists" group criteria was 3.2% of patients for Lucentis® and 3.3% of patients in the combined EYLEA® groups.

     In the fourth quarter of 2011, we and Bayer HealthCare initiated a Phase 3 trial, known as SIGHT, evaluating the efficacy and safety of EYLEA® in the neovascular form of wet AMD in China. EYLEA® will be evaluated for its effect on improving and maintaining vision when dosed as an intravitreal injection on a schedule of 2.0 mg every two months (following three initial monthly doses), as compared with Photodynamic Therapy (PDT) with verteporfin. After assessment of the primary endpoint at week 28, all patients, including those on PDT, will receive EYLEA® treatment until the end of the study at week 52. The trial will include approximately 300 patients and will be the largest retinal trial conducted in China. The SIGHT trial is being led by Bayer HealthCare.

     EYLEA® was also in Phase 3 clinical studies for the treatment of CRVO, another cause of visual impairment. We led the COPERNICUS (COntrolled Phase 3 Evaluation of Repeated iNtravitreal administration of VEGF Trap-Eye In Central retinal vein occlusion: Utility and Safety) study, and Bayer HealthCare led the GALILEO (General Assessment Limiting InfiLtration of Exudates in central retinal vein Occlusion with VEGF Trap-Eye) study. Patients in both studies received six monthly intravitreal injections of either EYLEA® at a dose of 2.0 mg or sham control injections. The primary endpoint of both studies was improvement in visual acuity versus baseline after six months of treatment as measured by the ETDRS eye chart. At the end of the initial six months, patients were dosed on an as-needed (PRN) basis for another six months. All patients were eligible for rescue laser treatment. In the COPERNICUS study, patients who were randomized to sham injections in the first six months were eligible to cross over to EYLEA® PRN dosing in the second six months.

     In December 2010, we and Bayer HealthCare announced that in the COPERNICUS study, EYLEA® demonstrated a statistically significant improvement in visual acuity at six months compared to sham injections, the primary endpoint of the study. In this study, 56.1% of patients receiving EYLEA® gained at least 15 letters of vision from baseline, compared to 12.3% of patients receiving sham injections (p<0.0001). In the study, EYLEA® was generally well tolerated. The most common adverse events were those typically associated with intravitreal injections or the underlying disease. Serious ocular adverse events in the EYLEA® group were uncommon (3.5%), consisting of individual reports of corneal abrasion, endophalmitis, retinal vein occlusion, and reduced visual acuity, and were more frequent in the control group (13.5%). The incidence of non-ocular serious adverse events was generally well-balanced between the treatment arms. There were no deaths among the 114 patients treated with EYLEA® and two (2.7%) in the 73 patients treated with sham injections.

     The one-year COPERNICUS results showed that 55.3% of patients receiving EYLEA® dosed monthly for 24 weeks, then on a PRN basis (guided by anatomic and visual acuity monitoring) over the next 28 weeks, gained at least 15 letters from baseline on an ETDRS eye chart compared to 30.1% of patients who received sham injections for the first 24 weeks followed by EYLEA® PRN from week 24 to week 52 (p=0.0006).  In terms of gain in visual acuity from baseline to week 52, patients receiving EYLEA® monthly for 24 weeks followed by EYLEA® PRN gained, on average, 16.2 letters of vision compared to a mean gain of 3.8 letters for patients who switched at week 24 from sham to EYLEA® PRN (p<0.0001).   These results demonstrate that the benefits achieved with monthly EYLEA® treatment through week 24 were maintained out to week 52.  At week 24, patients receiving EYLEA® had a mean gain of 17.3 letters, while patients receiving sham had a mean loss of 4.0 letters (p<0.0001).  Patients who received EYLEA® monthly followed by EYLEA® PRN, were administered a mean of 2.7 EYLEA® injections from week 24 to 52, while patients who switched from sham to EYLEA® PRN received a mean of 3.9 EYLEA® injections.  EYLEA® was generally well tolerated in the study.  At week 52, the most frequently reported adverse events in patients who went from monthly EYLEA® to EYLEA® PRN were reduction of visual acuity, conjunctival hemorrhage, eye pain, and intraocular pressure increased.  The most frequently reported adverse events in patients who switched from sham to EYLEA® PRN were reduction of visual acuity, conjunctival hemorrhage, intraocular pressure increased, and retinal hemorrhage.  At week 52, 5.3% of patients receiving EYLEA® who switched to EYLEA® PRN and 16.2% of patients who switched from sham to EYLEA® PRN reported at least one ocular serious adverse event.

     In April 2011, we and Bayer HealthCare announced that in the GALILEO study, EYLEA® also demonstrated a statistically significant improvement in visual acuity at six months compared to sham injections, the primary endpoint of the study. In this trial, 60.2% of patients receiving 2.0 mg of EYLEA® monthly gained at least 15 letters of vision from baseline, compared to 22.1% of patients receiving sham injections (p<0.0001). Patients receiving 2.0 mg of EYLEA® monthly gained, on average, 18 letters of vision compared to a mean gain of 3.3 letters with sham injections (p<0.0001), a secondary endpoint.

     As in the COPERNICUS trial, EYLEA® was generally well tolerated in the GALILEO study and the most common adverse events were those typically associated with intravitreal injections or the underlying disease. Serious ocular adverse events in the EYLEA® group were 2.9% and were more frequent in the control group (8.8%). The most frequently reported adverse events overall in the EYLEA® arm were eye pain, conjunctival hemorrhage, and elevated intraocular pressure. The most frequently reported adverse events in the control group were macular edema, eye irritation, and reduced visual acuity. The incidence of non-ocular serious adverse events was generally well-balanced between the treatment arms. The most frequent non-ocular adverse events were headache and nasopharyngitis. There were no deaths in the study.

     The one-year GALILEO results showed that 60.2% of patients receiving EYLEA® dosed monthly for 24 weeks, then on a PRN basis (guided by anatomic and visual acuity monitoring) over the next 28 weeks, gained at least 15 letters from baseline on an ETDRS eye chart compared to 32.4% of patients receiving sham injections (p=0.0004).  In terms of gain in visual acuity from baseline to week 52, patients receiving EYLEA® gained, on average, 16.9 letters of vision compared to a mean gain of 3.8 letters for patients receiving sham injections (p<0.0001).  These results demonstrate that the benefits achieved with monthly EYLEA® treatment through week 24 were maintained out to week 52.  At week 24, patients receiving EYLEA® had a mean gain of 18 letters compared to a mean gain of 3.3 letters for patients with sham injections (p<0.0001). Patients treated with EYLEA® received an average of 2.5 EYLEA® injections from week 24 to week 52.  EYLEA® was generally well tolerated in the study.  At week 52, the most frequently reported adverse events overall in the EYLEA® arm were macular edema, elevated intraocular pressure, eye pain, conjunctival hemorrhage, and retinal hemorrhage.  The most frequently reported adverse events in the sham group were macular edema, retinal hemorrhage, retinal vascular disorder, reduction of visual acuity and eye irritation.  At week 52, 9.6% of patients in the EYLEA® arm and 8.8% of patients in the sham arm presented with at least one ocular serious adverse event.

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     Based on the positive six-month results in the COPERNICUS and GALILEO studies, we submitted a supplemental BLA for U.S. regulatory approval of EYLEA® in CRVO in November 2011. Under the Prescription Drug User Fee Act (PDUFA), we were granted a target date for an FDA decision on our EYLEA® supplemental BLA of September 23, 2012. Bayer HealthCare plans to submit regulatory applications in this indication in Europe in late 2012 or early 2013.

     In the second quarter of 2011, we and Bayer HealthCare initiated Phase 3 studies to evaluate the safety and efficacy of EYLEA® in DME. These clinical trials have three study arms. In the first arm, patients will be treated every month with 2.0 mg of EYLEA®. In the second arm, patients will be treated with 2.0 mg of EYLEA® every two months after an initial phase of monthly injections. In the third arm, the comparator arm, patients will be treated with macular laser photocoagulation. The primary endpoint of the study is mean change in visual acuity from baseline as measured by the ETDRS eye chart. All patients will be followed for three years. We are conducting one of these studies, called VISTA-DME (VEGF Trap-Eye: Investigation of Safety, Treatment effect, and Anatomic outcomes in DME), with study centers in the United States. Bayer HealthCare is conducting the second study, named VIVID-DME (VEGF Trap-Eye In Vision Impairment Due to DME), with study centers in Europe, Japan, and Australia. The VISTA-DME trial was fully enrolled in early 2012.

     In the first quarter of 2011, we and Bayer HealthCare initiated a Phase 3 trial in Asia in collaboration with the Singapore Eye Research Institute (SERI) investigating the efficacy and safety of EYLEA® in patients with CNV of the retina as a result of pathologic myopia. The study, which will enroll approximately 110 patients, has started in Japan and is scheduled to run until June 2013.

     In the first quarter of 2012, we plan to initiate a multinational study of EYLEA® in patients with BRVO (VIBRANT).

Collaboration with Bayer HealthCare

     In October 2006, we entered into a license and collaboration agreement with Bayer HealthCare for the global development and commercialization outside the United States of EYLEA®. Under the agreement, we and Bayer HealthCare collaborate on, and share the costs of, the development of EYLEA® through an integrated global plan. Bayer HealthCare will market EYLEA® outside the United States, where the companies will share equally in profits from any future sales of EYLEA®. Commencing on the first commercial sale of EYLEA® in a major market country outside the United States, we will be obligated to reimburse Bayer HealthCare for 50% of the development costs that it has incurred under the agreement from our share of the collaboration profits. The reimbursement payment in any quarter will equal 5% of the then outstanding repayment obligation, but never more than our share of the collaboration profits in the quarter unless we elect to reimburse Bayer HealthCare at a faster rate. Within the United States, we retain exclusive commercialization rights to EYLEA® and are entitled to all profits from any such sales. We have received $60 million in development milestone payments and can earn up to $50 million in future milestone payments related to marketing approvals of EYLEA® in major market countries outside the United States. We can also earn up to $135 million in sales milestone payments if total annual sales of EYLEA® outside the United States achieve certain specified levels starting at $200 million.

2. ZALTRAP® (aflibercept) also known as VEGF Trap – Oncology

     ZALTRAP® (aflibercept) is a fusion protein that is designed to bind all forms of VEGF-A, VEGF-B, and PlGF, and prevent their interaction with cell surface receptors. VEGF-A (and to a lesser degree, PlGF) is required for the growth of new blood vessels (a process known as angiogenesis) that are needed for tumors to grow.

     ZALTRAP® is being developed globally in cancer indications in collaboration with Sanofi. In April 2011, we and Sanofi announced that the Phase 3 VELOUR trial evaluating ZALTRAP® in combination with the FOLFIRI chemotherapy regimen [folinic acid (leucovorin), 5-fluorouracil, and irinotecan] versus a regimen of FOLFIRI plus placebo met its primary endpoint of improving overall survival (OS) in previously treated metastatic colorectal cancer (mCRC) patients. The VELOUR data were presented in June 2011 at the European Society of Medical Oncology World Congress on Gastrointestinal Cancer. In this study, the addition of ZALTRAP® to the FOLFIRI chemotherapy regimen significantly improved both overall survival (HR=0.817; p=0.0032) and progression-free survival (HR=0.758; p=0.00007) compared to FOLFIRI plus placebo. A similar effect was seen with ZALTRAP® therapy whether or not patients had received prior bevacizumab therapy.

     In the VELOUR study, grade 3 or 4 adverse events that occurred with a more than two percent greater incidence in the ZALTRAP® arm than in the placebo arm included diarrhea, asthenia/fatigue, stomatitis/ulceration, infections, hypertension, GI/abdominal pains, neutropenia, neutropenic complications and proteinuria. Deaths on study treatment due to adverse events occurred in 2.4 percent of patients in the ZALTRAP® arm and in 1.0 percent of patients in the placebo arm.

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     Based upon these positive findings, Sanofi submitted regulatory applications for marketing approval of ZALTRAP® for the treatment of previously-treated mCRC patients to the European Medicines Agency (EMA) in December 2011, and to the FDA in early February 2012.

     Another randomized, double-blind Phase 3 trial (VENICE), which is fully enrolled, is evaluating ZALTRAP® as a first-line treatment for hormone-refractory metastatic prostate cancer in combination with docetaxel/prednisone. The VENICE trial is being monitored by an Independent Data Monitoring Committee (IDMC), a body of independent clinical and statistical experts. The IDMCs meet periodically to evaluate data from the trial and may recommend changes in study design or study discontinuation. In July 2011, the study’s IDMC met for a scheduled interim analysis and recommended that the trial continue to completion. A final analysis will be conducted when a pre-specified number of events have occurred in this trial, which is anticipated in the second quarter of 2012.

     In December 2011, we announced initial data from the Phase 2 AFFIRM study in the first-line mCRC setting of ZALTRAP® in combination with the modified FOLFOX6 [folinic acid (leucovorin), 5-fluorouracil, and oxaliplatin] chemotherapy regimen. The primary endpoint of the study was the Progression Free Survival (PFS) rate at one year. The results showed that in patients who received ZALTRAP®, the PFS rate at one year was similar to that seen in the standard therapy arm for patients who received modified FOLFOX6 alone. The study was not designed for a direct statistical comparison between arms. The control arm was used as an internal benchmark only. The side effect profile of ZALTRAP® was similar to what has been seen in prior trials with ZALTRAP®.

ZALTRAP® Collaboration with Sanofi

     We and Sanofi globally collaborate on the development and commercialization of ZALTRAP®. Under the terms of our September 2003 collaboration agreement, as amended, we and Sanofi will share co-promotion rights and profits on sales, if any, of ZALTRAP® outside of Japan for disease indications included in our collaboration. In Japan, we are entitled to a royalty of approximately 35% on annual sales of ZALTRAP®, subject to certain potential adjustments. We may also receive up to $400 million in milestone payments upon receipt of specified marketing approvals, including up to $360 million related to the receipt of marketing approvals for up to eight ZALTRAP® oncology and other indications in the United States or the European Union and up to $40 million related to the receipt of marketing approvals for up to five oncology indications in Japan.

     Under the ZALTRAP® collaboration agreement, as amended, agreed upon worldwide development expenses incurred by both companies during the term of the agreement will be funded by Sanofi. If the collaboration becomes profitable, we will be obligated to reimburse Sanofi out of our share of ZALTRAP® profits for 50% of the development expenses that they funded. The reimbursement payment in any quarter will equal 5% of the then outstanding repayment obligation, but never more than our share of the ZALTRAP® profits in the quarter unless we elect to reimburse Sanofi at a faster rate.

3. ARCALYST® (rilonacept) – Inflammatory Diseases

     ARCALYST® is being developed for the prevention of gout flares in patients initiating uric acid-lowering therapy. Gout, a disease in which IL-1 may play an important role in pain and inflammation, is a very painful and common form of arthritis that results from high levels of uric acid, a bodily waste product normally excreted by the kidneys. The elevated uric acid can lead to formation of urate crystals in the joints of the toes, ankles, knees, wrists, fingers, and elbows. Uric acid-lowering therapy, most commonly allopurinol, is prescribed to eliminate the urate crystals and prevent them from reforming. Paradoxically, the initiation of uric acid-lowering therapy often triggers an increase in the frequency of gout attacks in the first several months of treatment, which may lead to discontinuation of therapy. The break-up of urate crystals can result in stimulation of inflammatory mediators, including IL-1, resulting in acute flares of joint pain and inflammation. These painful flares generally persist for at least five days.

     We conducted a Phase 3 clinical development program with ARCALYST® in gout patients initiating uric acid-lowering therapy. The program consisted of three studies: PRE-SURGE 1 (PREvention Study against URate-lowering drug-induced Gout Exacerbations), PRE-SURGE 2, and RE-SURGE (REview of Safety Utilizing Rilonacept in Gout Exacerbations).

     In June 2010, we announced that results from PRE-SURGE 1, a North America-based double-blind, placebo-controlled study, showed that ARCALYST® prevented gout attacks, as measured by the primary study endpoint of the number of gout flares per patient over the 16 week treatment period. In addition, all secondary endpoints of the study were positive (p<0.001 vs. placebo). Among these endpoints, treatment with ARCALYST® reduced the proportion of patients who experienced two or more flares during the study period by up to 88%. Treatment with ARCALYST® also reduced the proportion of patients who experienced at least one gout flare during the study period by up to 65%.

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     In February 2011, we reported the results of PRE-SURGE 2 and RE-SURGE. In the PRE-SURGE 2 efficacy study in gout patients initiating allopurinol therapy, which was identical to PRE-SURGE 1 in design and analysis, 248 patients were randomized. ARCALYST® met the primary and all secondary study endpoints. The primary endpoint was the number of gout flares per patient over the 16-week treatment period. Patients who received ARCALYST® at a weekly, self-administered, subcutaneous dose of either 160 mg or 80 mg had a 72% decrease in mean number of gout flares compared to the placebo group (p<0.0001). Among secondary endpoints, treatment with ARCALYST® reduced the proportion of patients who experienced two or more flares during the study period by up to 82%. In addition, treatment with ARCALYST® reduced the proportion of patients who experienced at least one gout flare during the study period by up to 63%.

     We also announced that in the RE-SURGE study, which evaluated the safety of ARCALYST® versus placebo over 16 weeks, ARCALYST® was generally well tolerated, and the safety profile was consistent with that reported in the PRE-SURGE 1 and PRE-SURGE 2 studies. In the overall gout program, the most frequently reported adverse events were injection site reaction and headache.

     In the RE-SURGE study, ARCALYST® also met all secondary endpoints, which evaluated efficacy, over the 16 week treatment period (p<0.0001). These included the number of gout flares per patient, the proportion of patients who experienced two or more flares, and the proportion of patients who experienced at least one gout flare during the study period.

     Based on the results of the three Phase 3 studies, we submitted a supplemental BLA for U.S. regulatory approval of ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering therapy. In November 2011, the FDA accepted for review our supplemental BLA. Under PDUFA, we were granted a target date for an FDA decision on the ARCALYST® supplemental BLA of July 30, 2012.

     We also initiated a long-term safety study in this setting, known as UPSURGE (Understanding long-term safety in a Preventative Study against URate-lowering drug-induced Gout Exacerbations), during the fourth quarter of 2011.

     We own worldwide rights to ARCALYST®.

4. Sarilumab (REGN88; IL-6R Antibody) for inflammatory diseases

     IL-6 is a key cytokine involved in the pathogenesis of rheumatoid arthritis, causing inflammation and joint destruction. A therapeutic antibody to IL-6R, Actemra® (tocilizumab), a registered trademark of Chugai Seiyaku Kabushiki Kaisha, has been approved for the treatment of rheumatoid arthritis.

     Sarilumab is a fully human monoclonal antibody to IL-6R generated using our VelocImmune® technology. In July 2011, we and Sanofi announced that in the Phase 2b stage of the MOBILITY trial in rheumatoid arthritis, patients treated with sarilumab in combination with a standard RA treatment, methotrexate (MTX), achieved a significant and clinically meaningful improvement in signs and symptoms of moderate-to-severe RA compared to patients treated with MTX alone. The Phase 2b stage of the MOBILITY study was a 306-patient, dose-ranging, multi-national, randomized, multi-arm, double-blind, placebo-controlled study, that compared five different dose regimens of sarilumab in combination with MTX to placebo plus MTX. The primary endpoint of the study was the proportion of patients achieving at least a 20% improvement in RA symptoms (ACR20) after 12 weeks.

     In the Phase 2b stage of the MOBILITY trial, there was a dose response observed in patients receiving sarilumab in combination with MTX. An ACR20 response after 12 weeks was seen in 49.0% of patients receiving the lowest sarilumab dose regimen and 72.0% of patients receiving the highest dose regimen compared to 46.2% of patients receiving placebo and MTX (p=0.02, corrected for multiplicity, for the highest sarilumab dose regimen). The most common adverse events (>5%) reported more frequently in active treatment arms included infections (non-serious), neutropenia, and liver function test abnormalities. The types and frequencies of adverse events were consistent with those previously reported with IL-6 inhibition. The incidence of serious adverse events among the five sarilumab treatment groups and the placebo group was comparable.

     Sarilumab also demonstrated significant benefit compared to placebo in secondary endpoints, including ACR 50, ACR 70, and Disease Activity Score (DAS) 28 scores, additional measures of clinical activity used in RA trials.

     In July 2011, we and Sanofi announced that in the phase 2b ALIGN trial in ankylosing spondylitis (AS), sarilumab did not demonstrate significant improvements in the signs and symptoms of active AS compared to placebo in patients who had inadequate response to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Sarilumab was generally well tolerated. The most common adverse events reported more frequently in active treatment arms included infections and neutropenia.

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     During the third quarter of 2011, we and Sanofi initiated the Phase 3 stage of the Phase 2/3 MOBILITY study.

5. REGN727 (PCSK9 Antibody) for LDL cholesterol reduction

     Elevated LDL cholesterol (“bad cholesterol”) level is a validated risk factor leading to cardiovascular disease. Statins are a class of drugs that lower LDL cholesterol by upregulating the expression of the LDL receptor (LDLR), which removes LDL from circulation. PCSK9 is a naturally occurring secreted protein that also modulates LDL cholesterol levels through its interaction with the LDL receptor. In a landmark study published in the New England Journal of Medicine in March 2006, patients with lower than normal PCSK9 levels due to a genetic abnormality not only had significantly lower levels of LDL cholesterol, but also a significant reduction in the risk of coronary heart disease. We used our VelocImmune® technology to generate a fully human monoclonal antibody inhibitor of PCSK9, called REGN727, that is intended to lower LDL cholesterol.

     In May 2010, we announced that in an interim efficacy analysis of a dose-escalating, randomized, double-blind, placebo-controlled, Phase 1 trial in healthy volunteers, REGN727 achieved substantial, dose dependent decreases of LDL cholesterol. Each dosing cohort consisted of six treated and two placebo patients. In July 2010, we presented additional data from this Phase 1 program. At the highest intravenous dose tested, a single dose of REGN727 achieved a greater than 60% maximum mean reduction of LDL cholesterol from baseline that lasted for more than one month. At the highest subcutaneous dose tested, a single dose of REGN727 achieved a greater than 60% maximum mean reduction of LDL cholesterol from baseline that lasted for more than two weeks. In these early trials, REGN727 was generally safe and well tolerated with no trend in drug-related adverse events and no evidence of hepato- or myo-toxicity. Injection site reactions were minimal.

     In July 2010, we also presented the results of an interim efficacy analysis of a dose escalating, randomized, double-blind, placebo-controlled Phase 1 trial of subcutaneously delivered REGN727 in hyperlipidemic patients (familial hypercholesterolemia and non-familial hypercholesterolemia) on stable doses of statins whose LDL levels were greater than 100 milligrams per deciliter (mg/dL). At the highest dose tested at that time, in eleven patients, a single dose of REGN727 achieved an approximately 40% maximum mean additional reduction of LDL cholesterol from baseline. No serious adverse events and no dose limiting toxicities were reported.

     During 2011, three Phase 2 studies with subcutaneous regimens of REGN727 were initiated: (1) a randomized, double-blind, multi-dose, placebo controlled, 75-patient trial in patients with heterozygous familial hypercholesterolemia (heFH), (2) a randomized, double-blind, multi-dose, placebo controlled, 90-patient trial in combination with atorvastatin in patients with primary hypercholesterolemia, and (3) a randomized, double-blind, multi-dose, placebo controlled, 180-patient trial in combination with atorvastatin in patients with primary hypercholesterolemia and on stable doses of atorvastatin. The primary endpoint of each Phase 2 study is the change in LDL cholesterol from baseline compared to placebo over the study period.

     In November 2011, we announced preliminary results from the Phase 2 heFH trial. The objective of the study was to compare the effect of adding REGN727 to the existing lipid lowering therapy in heFH patients. In the primary efficacy analysis of the study, after 12 weeks of treatment, patients who received different dosing regimens of REGN727 achieved mean LDL cholesterol reductions from baseline ranging from approximately 30% to greater than 65%, depending on the dosing regimen of REGN727, compared to a mean reduction of 10% with placebo (p<0.05 for all dose groups). Patients in the study are being followed for a total of 20 weeks for safety. In this trial, REGN727 was generally well tolerated over 12 weeks. There were no elevations in liver function tests greater than three times the upper limit of normal (ULN) and no cases of elevated creatine phosphokinase reported. The most common adverse event was injection site reaction and there were no serious adverse events on active treatment. Full safety data from the 8-week post-treatment monitoring period will be presented at a future medical congress upon final analysis.

     In November 2011, we also announced preliminary results from the Phase 2 trial studying patients with primary hypercholesterolemia who were on stable doses of atorvastatin. The primary objective of the study was to compare the effect of switching to a high dose of atorvastatin alone (80mg) versus a high dose of atorvastatin combined with REGN727. In the primary endpoint of the study, after eight weeks of treatment, patients who received REGN727 plus atorvastatin 80mg achieved a greater than 65% reduction in mean LDL cholesterol compared to a mean reduction of 17% for atorvastatin 80mg alone (p<0.001). The study also included a third arm in which REGN727 was added to the stable low dose of atorvastatin and the patients achieved a greater than 65% reduction in mean LDL cholesterol. Patients in the study were followed for a total of 16 weeks for safety. In this trial, REGN727 was generally well tolerated over 16 weeks. There was one serious adverse event of dehydration in the REGN727 plus atorvastatin 80mg group that was deemed not treatment related. One patient in the REGN727 plus atorvastatin 80mg group with mildly elevated aspartate aminotransferase (AST) prior to randomization (>ULN and </= 3ULN) experienced an elevation of AST>3ULN and </=5ULN and one patient discontinued therapy due to a hypersensitivity reaction (rash).

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     Initial data from the third Phase 2 trial, studying subcutaneous regimens of REGN727 in combination with atorvastatin in patients with primary hypercholesterolemia, are expected to be available in the first half of 2012.

     REGN727 is being developed in collaboration with Sanofi.

6. REGN668 (IL-4R Antibody) for allergic and immune conditions

     IL-4R is required for signaling by the cytokines IL-4 and IL-13. Both of these cytokines are critical mediators of immune response, which, in turn, drives the formation of Immunoglobulin E (IgE) antibodies and the development of allergic responses, as well as the atopic state that underlies asthma and atopic dermatitis.

     REGN668 is a fully human monoclonal antibody generated using our VelocImmune® technology that is designed to bind to IL-4R. REGN668 is in a Phase 1b study in patients with atopic dermatitis and a Phase 2 study in eosinophilic asthma. REGN668 is being developed in collaboration with Sanofi.

7. REGN421 (Dll4 Antibody) for advanced malignancies

     In many clinical settings, positively or negatively regulating blood vessel growth could have important therapeutic benefits, as could the repair of damaged and leaky vessels. VEGF was the first growth factor shown to be specific for blood vessels, by virtue of having its receptor primarily expressed on blood vessel cells. In the December 21, 2006 issue of the journal Nature, we reported data from a preclinical study demonstrating that blocking an important cell signaling molecule, known as Dll4, inhibited the growth of experimental tumors by interfering with their ability to produce a functional blood supply. The inhibition of tumor growth was seen in a variety of tumor types, including those that were resistant to blockade of VEGF, suggesting a novel anti-angiogenesis therapeutic approach. Moreover, inhibition of tumor growth is enhanced by the combination of Dll4 and VEGF blockade in many preclinical tumor models.

     REGN421 is a fully human monoclonal antibody to Dll4 generated using our VelocImmune® technology, and is in Phase 1 clinical development. REGN421 is being developed in collaboration with Sanofi.

8. REGN910 (ANG2 Antibody) for oncology

     In the fourth quarter of 2010, we initiated a Phase 1 study in an oncology setting of REGN910, an antibody that specifically blocks ANG2. The angiopoietins, which were discovered at Regeneron, are ligands for the endothelial cell receptor Tie2 and are essential for vascular development and angiogenesis. Unlike other family members, ANG2 is strongly upregulated by endothelial cells at sites of angiogenesis and vascular remodeling, including tumors.

     REGN910 is a fully human monoclonal antibody generated using our VelocImmune® technology, which is being developed for cancer indications. REGN910 is being developed in collaboration with Sanofi.

9. REGN475 (NGF Antibody) for pain

     REGN475 is a fully human monoclonal antibody to NGF, generated using our VelocImmune® technology, which is designed to block pain sensitization in neurons. Preclinical experiments indicate that REGN475 specifically binds to and blocks NGF activity and does not bind to or block cell signaling for closely related neurotrophins such as NT-3, NT-4, or BDNF.

     In May 2010, we announced positive results from an interim analysis of a randomized, double-blind, four-arm, placebo-controlled Phase 2 trial in 217 patients with osteoarthritis of the knee. In July 2010, we presented additional results from this trial through 16 weeks.

     In December 2010, we were informed by the FDA that a case confirmed as avascular necrosis of a joint was seen in another company’s anti-NGF program. The FDA believes this case, which follows previously-reported cases of joint replacements in patients on an anti-NGF drug candidate being developed by another pharmaceutical company, provides evidence to suggest a class-effect and has placed REGN475, along with the two other anti-NGF antibodies in development by competitors, on clinical hold. An FDA Arthritis Advisory Committee meeting is scheduled for March 12, 2012 to discuss possible safety issues related to anti-NGF compounds. There are currently no ongoing trials with REGN475.

     In February 2012, Sanofi elected not to continue co-development of REGN475, and Regeneron now has sole global rights to REGN475. Under the terms of our agreement, Sanofi remains obligated to fund agreed-upon REGN475 development costs through the end of 2012 and is entitled to receive a mid-single digit royalty on any future sales of REGN475.

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10. REGN728

     In the fourth quarter of 2010, clinical trials began with REGN728, a fully human monoclonal antibody generated using our VelocImmune® technology, against an undisclosed target. REGN728 is being developed in collaboration with Sanofi.

11. REGN1033

     In December 2011, the FDA accepted our investigational new drug (IND) filing for REGN1033 and in January 2012, we initiated a Phase 1 clinical study. REGN1033 is a fully human monoclonal antibody generated using our VelocImmune® technology, against an undisclosed target. REGN1033 is being developed in collaboration with Sanofi.

12. REGN846

     REGN846 is a fully human monoclonal antibody generated using our VelocImmune® technology, against an undisclosed target, and is being evaluated in a Phase 2a study in patients with atopic dermatitis. In July 2011, Sanofi elected not to continue co-development of REGN846, and Regeneron now has sole global rights to REGN846. Under the terms of our agreement, Sanofi remains obligated to fund REGN846 clinical costs through conclusion of a planned proof-of-concept trial and is entitled to receive a mid-single digit royalty on any future sales of REGN846.

13. REGN1154

     REGN1154 is a fully human monoclonal antibody generated using our VelocImmune® technology, against an undisclosed target. In December 2011, we submitted a Phase 1 clinical trial protocol in Australia for REGN1154 under the clinical trial notification (CTN) regulatory process. We plan to initiate human studies in the first quarter of 2012 in Australia. Sanofi decided not to opt-in to the REGN1154 program and we have sole global rights. Under the terms of our agreement, Sanofi is entitled to receive a mid-single digit royalty on any future sales of REGN1154.

Research and Development Technologies:

     Many proteins that are either on the surface of or secreted by cells play important roles in biology and disease. One way that a cell communicates with other cells is by releasing specific signaling proteins, either locally or into the bloodstream. These proteins have distinct functions and are classified into different “families” of molecules, such as peptide hormones, growth factors, and cytokines. All of these secreted (or signaling) proteins travel to and are recognized by another set of proteins, called “receptors,” which reside on the surface of responding cells. These secreted proteins impact many critical cellular and biological processes, causing diverse effects ranging from the regulation of growth of particular cell types to inflammation mediated by white blood cells. Secreted proteins can at times be overactive and thus result in a variety of diseases. In these disease settings, blocking the action of specific secreted proteins can have clinical benefit. In other cases, proteins on the cell-surface can mediate the interaction between cells, such as the processes that give rise to inflammation and autoimmunity.

     Our scientists have developed two different technologies to design protein therapeutics to block the action of specific cell surface or secreted proteins. The first technology, termed the “Trap” technology, was used to generate our two approved products, ARCALYST® and EYLEA®, as well as ZALTRAP®, which is in Phase 3 clinical trials. These novel “Traps” are composed of fusions between two distinct receptor components and the constant region of an antibody molecule called the “Fc region”, resulting in high affinity product candidates. VelociSuiteTM is our second technology platform; it is used for discovering, developing, and producing fully human monoclonal antibodies that can address both secreted and cell-surface targets.

VelociSuiteTM

     VelociSuiteTM consists of VelocImmune®, VelociGene®, VelociMouse®, and VelociMab®. The VelocImmune® mouse platform is utilized to produce fully human monoclonal antibodies. VelocImmune® was generated by exploiting our VelociGene® technology (see below), in a process in which six megabases of mouse immune gene loci were replaced, or “humanized,” with corresponding human immune gene loci. VelocImmune® mice can be used to generate efficiently fully human monoclonal antibodies to targets of therapeutic interest. VelocImmune® and our entire VelociSuiteTM offer the potential to increase the speed and efficiency through which human monoclonal antibody therapeutics may be discovered and validated, thereby improving the overall efficiency of our early stage drug development activities. We are utilizing the VelocImmune® technology to produce our next generation of drug candidates for preclinical and clinical development.

     Our VelociGene® platform allows custom and precise manipulation of very large sequences of DNA to produce highly customized alterations of a specified target gene, or genes, and accelerates the production of knock-out and transgenic expression models without using either positive/negative selection or isogenic DNA. In producing knock-out models, a color or fluorescent marker may be substituted in place of the actual gene sequence, allowing for high-resolution visualization of precisely where the gene is active in the body during normal body functioning as well as in disease processes. For the optimization of preclinical development and pharmacology programs, VelociGene® offers the opportunity to humanize targets by replacing the mouse gene with the human homolog. Thus, VelociGene® allows scientists to rapidly identify the physical and biological effects of deleting or over-expressing the target gene, as well as to characterize and test potential therapeutic molecules.

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     Our VelociMouse® technology platform allows for the direct and immediate generation of genetically altered mice from embryonic stem cells (ES cells), thereby avoiding the lengthy process involved in generating and breeding knockout mice from chimeras. Mice generated through this method are normal and healthy and exhibit a 100% germ-line transmission. Furthermore, mice developed using our VelociMouse® technology are suitable for direct phenotyping or other studies. We have also developed our VelociMab® platform for the rapid screening of antibodies and rapid generation of expression cell lines for our Traps and our VelocImmune® human monoclonal antibodies.

Antibody Collaboration and License Agreements

     Sanofi. In November 2007, we and Sanofi entered into a global, strategic collaboration to discover, develop, and commercialize fully human monoclonal antibodies. The collaboration is governed by a Discovery and Preclinical Development Agreement and a License and Collaboration Agreement. In connection with the execution of the discovery agreement in 2007, we received a non-refundable, up-front payment of $85.0 million from Sanofi. Pursuant to the collaboration, Sanofi is funding our research to identify and validate potential drug discovery targets and develop fully human monoclonal antibodies against these targets. We lead the design and conduct of research activities under the collaboration, including target identification and validation, antibody development, research and preclinical activities through filing of an Investigational New Drug Application (IND) or its equivalent, toxicology studies, and manufacture of preclinical and clinical supplies.

     For each drug candidate identified through discovery research under the discovery agreement, Sanofi has the option to license rights to the candidate under the license agreement. If it elects to do so, Sanofi will co-develop the drug candidate with us through product approval. Development costs for the drug candidate are shared between the companies, with Sanofi generally funding these costs up front, except that following receipt of the first positive Phase 3 trial results for a co-developed drug candidate, subsequent Phase 3 trial-related costs for that drug candidate are shared 80% by Sanofi and 20% by us. We are generally responsible for reimbursing Sanofi for half of the total development costs for all collaboration antibody products from our share of profits from commercialization of collaboration products to the extent they are sufficient for this purpose. However, we are not required to apply more than 10% of our share of the profits from collaboration products in any calendar quarter towards reimbursing Sanofi for these development costs.

     Sanofi will lead commercialization activities for products developed under the license agreement, subject to our right to co-promote such products. The parties will equally share profits and losses from sales within the United States. The parties will share profits outside the United States on a sliding scale based on sales starting at 65% (Sanofi)/35% (us) and ending at 55% (Sanofi)/45% (us), and will share losses outside the United States at 55% (Sanofi)/45% (us). In addition to profit sharing, we are entitled to receive up to $250 million in sales milestone payments, with milestone payments commencing after aggregate annual sales outside the United States exceed $1.0 billion on a rolling 12-month basis.

     In November 2009, we and Sanofi amended these agreements to expand and extend our antibody collaboration. The goal of the expanded collaboration is to advance a total of 20 to 30 new antibody product candidates into clinical development from 2010 through 2017.

     Under the amended discovery agreement, Sanofi agreed to fund up to $160 million per year of our antibody discovery activities over the period from 2010-2017, subject to a one-time option for Sanofi to adjust the maximum reimbursement amount down to $120 million per year commencing in 2014 if over the prior two years certain specified criteria were not satisfied. Sanofi has an option to extend the discovery program for up to an additional three years after 2017 for further antibody development and preclinical activities. Pursuant to the collaboration, Sanofi is also obligated to fund up to $30 million of agreed-upon costs we incur to expand our manufacturing capacity at our Rensselaer, New York facilities.

     In 2010, as we scaled up our capacity to conduct antibody discovery activities, Sanofi funded $137.7 million of our preclinical research under the expanded collaboration. The balance between that amount and $160 million, or $22.3 million, has been added to the funding otherwise available to us in 2011-2012 under the amended discovery agreement.

     From the collaboration's inception in November 2007 through December 31, 2011, Sanofi has funded a total of $474.6 million of our costs under the discovery agreement and a total of $400.4 million of our development costs under the license agreement, or a total of $875.0 million in funding for our antibody research and development activities during this period.

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     In August 2008, we entered into an agreement with Sanofi to use our VelociGene® platform to supply Sanofi with genetically modified mammalian models of gene function and disease. Under this agreement, Sanofi is required to pay us a minimum of $21.5 million for the term of the agreement, which extends through December 2012, for knock-out and transgenic models of gene function for target genes identified by Sanofi. Sanofi will use these models for its internal research programs that are outside of the scope of our antibody collaboration.

     Astellas Pharma Inc. In March 2007, we entered into a six-year, non-exclusive license agreement with Astellas Pharma Inc. to allow Astellas to utilize our VelocImmune® technology in its internal research programs to discover human monoclonal antibodies. Under the terms of the agreement, Astellas made a $20.0 million annual, non-refundable payment to us in each of the second quarters of 2007, 2008, 2009, and 2010. In July 2010, the license agreement with Astellas was amended and extended through June 2023. Under the terms of the amended agreement, Astellas made a $165.0 million up-front payment to us in August 2010. In addition, Astellas will make a $130.0 million second payment to us in June 2018 unless the license agreement has been terminated prior to that date. Astellas has the right to terminate the agreement at any time by providing 90 days’ advance written notice. Under certain limited circumstances, such as our material breach of the agreement, Astellas may terminate the agreement and receive a refund of a portion of its up-front payment or, if such termination occurs after June 2018, a portion of its second payment, to us under the July 2010 amendment to the agreement. We are entitled to receive a mid-single digit royalty on any future sales of antibody products discovered by Astellas using our VelocImmune® technology.

     AstraZeneca UK Limited. In February 2007, we entered into a six-year, non-exclusive license agreement with AstraZeneca UK Limited to allow AstraZeneca to utilize our VelocImmune® technology in its internal research programs to discover human monoclonal antibodies. Under the terms of the agreement, AstraZeneca made a $20.0 million annual, non-refundable payment to us in each of the first quarters of 2007, 2008, 2009, and 2010. In November 2010, as permitted by the agreement, MedImmune Limited (as successor by novation from AstraZeneca) gave written notice of voluntary termination of the agreement, effective in February 2011, thereby canceling its obligation to make either of the final two annual payments. We remain entitled to receive a mid-single digit royalty on any future sales of antibody products discovered by MedImmune using our VelocImmune® technology.

Royalty Agreement with Novartis Pharma AG

     Under a June 2009 agreement with Novartis (that replaced a previous collaboration and license agreement), we receive royalties on worldwide sales of Novartis’ canakinumab, a fully human anti-interleukin-IL1β antibody. The royalty rates in the agreement start at 4% and reach 15% when annual sales exceed $1.5 billion. Canakinumab is marketed for the treatment of CAPS, has completed Phase 3 development for gout, and is in earlier stage development for atherosclerosis and other inflammatory diseases. We are unable to predict whether canakinumab will be approved for gout or any other indication in addition to CAPS, or whether, even if approved, canakinumab for such indication(s) will be successfully commercialized. Accordingly, we are unable to predict whether these royalties will ever contribute materially to our results of operations or financial condition. To date these royalties have been minimal.

National Institutes of Health Grant

     In September 2006, we were awarded a five-year grant from the National Institutes of Health (NIH) as part of the NIH’s Knockout Mouse Project. The goal of the Knockout Mouse Project was to build a comprehensive and broadly available resource of knockout mice to accelerate the understanding of gene function and human diseases. Under the NIH grant, as amended, amounts received or receivable by us from the grant’s inception through December 31, 2011 totaled $25.1 million. No further funding will be received by us in connection with the NIH Grant.

Research Programs

     Our preclinical research programs are in the areas of oncology and angiogenesis, ophthalmology, metabolic and related diseases, muscle diseases and disorders, inflammation and immune diseases, bone and cartilage, pain, cardiovascular diseases, and infectious diseases.

Sales and Marketing

     We have a New Products Marketing and Planning group and a Market Research group to evaluate commercial opportunities for our targets and drug candidates, assess the competitive environment, and analyze the commercial potential of our product portfolio. This group works in close collaboration with our collaborators for co-developed products to develop marketing plans and forecasts and to develop and execute pre-launch market development programs.

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     In connection with the sales and marketing of ARCALYST® for CAPS, we have a small marketing, trade, reimbursement, and distribution group to provide case management and reimbursement services to patients with CAPS and their treating physicians.

     In preparation for the launch of EYLEA® for wet AMD in 2011, we hired and trained a full-service commercialization group to execute the launch of EYLEA®. The group includes experienced professionals in the fields of marketing, communications, professional education, patient education and advocacy, reimbursement and managed markets, trade and distribution, commercial operations, commercial analytics, market research, and forecasting. Moreover, we have hired, trained, and deployed a field-based organization of approximately 75 individuals, including regional sales directors, medical sales specialists, and reimbursement managers, each with 7+ years of experience in the biopharmaceutical industry in a variety of therapeutic areas including oncology, ophthalmology, immunology, and inflammation. We outsource the warehousing and distribution of our finished drug products.

Manufacturing

     Our manufacturing facilities are located in Rensselaer, New York and consist of three buildings totaling approximately 395,000 square feet of research, manufacturing, office, and warehouse space. We currently have approximately 54,000 liters of cell culture capacity at these facilities. At December 31, 2011, we employed 439 people at our Rensselaer facilities. There were no impairment losses associated with long-lived assets at these facilities as of December 31, 2011.

     Among the conditions for regulatory marketing approval of a medicine is the requirement that the prospective manufacturer's quality control and manufacturing procedures conform to the good manufacturing practice (GMP) regulations of the health authority. In complying with standards set forth in these regulations, manufacturers must continue to expend time, money, and effort in the areas of production and quality control to ensure full technical compliance. Manufacturing establishments, both foreign and domestic, are also subject to inspections by or under the authority of the FDA and by other national, federal, state, and local agencies. We are approved to manufacture our marketed products at our Rensselaer facilities. If our manufacturing facilities fail to maintain compliance with FDA and other regulatory requirements, we may be required to suspend manufacturing. This would likely have a material adverse effect on our business, operating results, financial condition, and cash flows.

Competition

     We face substantial competition from pharmaceutical, biotechnology, and chemical companies (see Item 1A. “Risk Factors – Risks Related to Commercialization of EYLEA® for the Treatment of Wet AMD and Risks Related to Commercialization of Products”). Our competitors include Genentech (a member of the Roche group), Novartis, Pfizer Inc., Bayer HealthCare, Onyx Pharmaceuticals, Inc., Eli Lilly and Company, Abbott Laboratories, Sanofi, Merck & Co., Inc., Amgen Inc., AstraZeneca, Bristol-Myers Squibb, Johnson & Johnson, GlaxoSmithKline, and others. Many of our competitors have substantially greater research, preclinical, and clinical product development and manufacturing capabilities, and financial, marketing, and human resources than we do. Competition from smaller competitors may also be or become more significant if those competitors acquire or discover patentable inventions, form collaborative arrangements, or merge with large pharmaceutical companies. Even if we are able to commercialize additional product candidates, one or more of our competitors may have brought a competitive product to market earlier than us or may have obtained or obtain patent protection that dominates or adversely affects our activities or products. Our ability to compete will depend, to a great extent, on how fast we can develop safe and effective product candidates, complete clinical testing and approval processes, and supply commercial quantities of the product to the market. Competition among product candidates approved for sale will also be based on efficacy, safety, reliability, availability, price, patent position, and other factors.

     EYLEA®. The market for eye disease products is very competitive. Novartis and Genentech are collaborating on the commercialization and further development of a VEGF antibody fragment (Lucentis®) for the treatment of wet AMD, DME, RVO, and other eye indications. Lucentis® was approved by the FDA in June 2006 for the treatment of wet AMD and in June 2010 for the treatment of macular edema following retinal vein occlusion (RVO). Lucentis® was approved by the European Medicines Agency (EMA) for wet AMD in January 2007, for the treatment of DME in January 2011, and for the treatment of RVO in June 2011. Many other companies, including Genentech, are working on the development of product candidates and extended delivery devices for the potential treatment of wet AMD, DME, and RVO including those that act by blocking VEGF and VEGF receptors, as well as use of small interfering ribonucleic acids (siRNAs) that modulate gene expression. For example, in January, 2012, Genentech submitted an IND for an extended delivery device. In addition, ophthalmologists are using off-label, with success for the treatment of wet AMD, DME, and RVO, a third-party repackaged version of Genentech’s approved VEGF antagonist, Avastin® (bevacizumab). The relatively low cost of therapy with Avastin® in patients with wet AMD presents a significant competitive challenge in this indication. The National Eye Institute (NEI) and others are conducting long-term, controlled clinical trials comparing Lucentis® to Avastin® in the treatment of wet AMD. One-year data from the Comparison of Age-Related Macular Degeneration Treatments Trial (CATT) were reported in April 2011 and indicated that Avastin® dosed monthly was non-inferior to Lucentis® dosed monthly in the primary efficacy endpoint of mean visual acuity gain at 52 weeks. Avastin® is also being evaluated in eye diseases in trials that have been initiated in the United Kingdom, Canada, Brazil, Mexico, Germany, Israel, and other areas. It may be difficult for EYLEA® to compete in this or other eye indications for which it may be approved against Lucentis® and off-label use of Avastin® because doctors and patients have had significant experience using these medicines and because of the relatively low cost of Avastin®. Moreover, the recently reported results of the CATT study, combined with the relatively low cost of Avastin® in treating patients with wet AMD, may well exacerbate the competitive challenge which EYLEA® will face in this or other eye indications for which it may be approved. In addition, while we believe that ZALTRAP® would not be well tolerated if administered directly to the eye, if ZALTRAP® is approved for the treatment of certain cancers, there is a risk that third parties will attempt to repackage ZALTRAP® for off-label use and sale for the treatment of wet AMD and other diseases of the eye, which would present a potential low-cost competitive threat to EYLEA® for wet AMD or other eye indications.

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     ARCALYST®. In 2009, Novartis received regulatory approval in the United States and Europe for canakinumab, a fully human anti-interleukin-IL1ß antibody, for the treatment of CAPS. In January 2011, Novartis announced that it had submitted an application to the EMA for approval of canakinumab in the treatment of gout flares. Novartis submitted a supplemental BLA to the FDA in the first quarter of 2011 for approval of canakinumab in gout, which was denied in August 2011 based upon safety concerns. Canakinumab is also in development for atherosclerosis and a number of other inflammatory diseases. In addition, there are both small molecules and antibodies in development by other third parties that are designed to block the synthesis of IL-1 or inhibit the signaling of IL-1. For example, Xoma Ltd., in collaboration with Servier, is developing an antibody to IL-1, and both Amgen and MedImmune are developing antibodies to the IL-1 receptor. These drug candidates could offer competitive advantages over ARCALYST®. The successful development and/or commercialization of these competing molecules could adversely affect sales of ARCALYST® for CAPS and delay or impair our ability to commercialize ARCALYST® for indications other than CAPS.

     ZALTRAP®. Many companies are developing therapeutic molecules designed to block the actions of VEGF specifically and angiogenesis in general. A variety of approaches have been employed, including antibodies to VEGF, antibodies to the VEGF receptor, small molecule antagonists to the VEGF receptor tyrosine kinase, and other anti-angiogenesis strategies. Many of these alternative approaches may offer competitive advantages to aflibercept in efficacy, side-effect profile, durability of effect, or method of delivery. Additionally, some of these molecules are already approved for marketing and have a broader range of indications than our product candidate.

     In particular, Genentech has an approved VEGF antagonist, Avastin®, on the market for treating certain cancers and a number of pharmaceutical and biotechnology companies are working to develop competing VEGF antagonists, including Novartis, Amgen, Imclone LLC/Eli Lilly, Pfizer, AstraZeneca, and GlaxoSmithKline. Many of these molecules are further along in development than ZALTRAP® and may offer competitive advantages over our molecule. Pfizer, Onyx (together with its partner Bayer HealthCare), and GlaxoSmithKline are selling and marketing oral medications that target tumor cell growth and new vasculature formation that fuels the growth of tumors.

     Monoclonal Antibodies. Our clinical candidates in development are all fully human monoclonal antibodies which were generated using our VelocImmune® technology. Our antibody generation technologies and clinical candidates face competition from many pharmaceutical and biotechnology companies using various technologies.

     Numerous other companies are developing therapeutic antibody products. Companies such as Pfizer, Johnson & Johnson, AstraZeneca, Amgen, Biogen Idec, Inc., Novartis, Genentech, Bristol-Myers Squib, Abbott, and GlaxoSmithKline have generated therapeutic products that are currently in development or on the market that are derived from recombinant DNA that comprise human antibody sequences. As noted above, Astellas has licensed our VelocImmune® technology as part of their internal antibody development programs.

     We are aware of several pharmaceutical and biotechnology companies actively engaged in the research and development of antibody products against targets that are also the targets of our early-stage product candidates. For example, Pfizer, Johnson & Johnson, and Abbott are developing antibody product candidates against NGF. Genentech is marketing an antibody against IL-6R (tocilizumab) for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, and several other companies, including Centocor Ortho Biotech, Inc. and Bristol-Myers Squibb, have antibodies against IL-6 in clinical development for this disease. GlaxoSmithKline, in partnership with OncoMed Pharmaceuticals, Inc., has a Dll4 antibody in clinical development for the treatment of solid tumors. Aerovance has completed initial clinical trials of two formulations of a biologic directed against IL-4. Amgen previously had an antibody against IL-4R in clinical development for the treatment of asthma. Amgen and Pfizer have development programs for antibodies against PCSK9; Alnylam has a clinical program underway with an RNAi molecule against PCSK9. Amgen, Pfizer, and AstraZeneca have development programs underway for antibodies against ANG2.

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     Other Areas. Many pharmaceutical and biotechnology companies are attempting to discover new therapeutics for indications in which we invest substantial time and resources. In these and related areas, intellectual property rights have been sought and certain rights have been granted to competitors and potential competitors of ours, and we may be at a substantial competitive disadvantage in such areas as a result of, among other things, our lack of experience, trained personnel, and expertise. A number of corporate and academic competitors are involved in the discovery and development of novel therapeutics that are the focus of other research or development programs we are now conducting. These competitors include Amgen and Roche, as well as many others. Many firms and entities are engaged in research and development in the areas of cytokines, interleukins, angiogenesis, and muscle conditions. Some of these competitors are currently conducting advanced preclinical and clinical research programs in these areas. These and other competitors may have established substantial intellectual property and other competitive advantages.

     If any of these or other competitors announces a successful clinical study involving a product that may be competitive with one of our product candidates or the grant of marketing approval by a regulatory agency for a competitive product, such developments may have an adverse effect on our business, operating results, financial condition, cash flows, or future prospects.

     We also compete with academic institutions, governmental agencies, and other public or private research organizations, which conduct research, seek patent protection, and establish collaborative arrangements for the development and marketing of products that would provide royalties or other consideration for use of their technology. These institutions are becoming more active in seeking patent protection and licensing arrangements to collect royalties or other consideration for use of the technology they have developed. Products developed in this manner may compete directly with products we develop. We also compete with others in acquiring technology from these institutions, agencies, and organizations.

Patents, Trademarks, and Trade Secrets

     Our success depends, in part, on our ability to obtain patents, maintain trade secret protection, and operate without infringing on the proprietary rights of third parties (see Item 1A. “Risk Factors – Risks Related to Intellectual Property and Market Exclusivity – We may be restricted in our development, manufacturing, and/or commercialization activities by, and could be subject to damage awards if we are found to have infringed, third-party patents or other proprietary rights, and the costs and expenses of ongoing patent litigation have been and will likely continue to be significant.”). Our policy is to file patent applications to protect technology, inventions, and improvements that we consider important to our business and operations. As of December 31, 2011, we held an ownership interest in a total of approximately 186 issued patents in the United States and approximately 570 issued patents in foreign countries with respect to our products and technologies. In addition, we hold an ownership interest in hundreds of patent applications in the United States and foreign countries.

     Our patent portfolio includes granted patents and pending patent applications covering our VelociSuite™ technologies, including our VelocImmune® mouse platform which produces fully human monoclonal antibodies. Our issued patents covering these technologies generally expire between 2020 and 2028. However, we continue to file patent applications directed to improvements to these technology platforms.

     Our patent portfolio also includes issued patents and pending applications relating to our marketed products, ARCALYST® and EYLEA®, and our product candidates in clinical development. These patents cover the proteins and DNA encoding the proteins, manufacturing patents, method of use patents, and pharmaceutical compositions, as well as various methods of using the products. For each of ARCALYST®, EYLEA® and our late-stage product candidate, ZALTRAP®, these patents generally expire between 2020 and 2028. However, the projected patent terms may be subject to extension based on potential patent term extensions in countries where such extensions are available.

     We also are the nonexclusive licensee of a number of additional patents and patent applications. In December 2011, we and Genentech entered into a Non-Exclusive License and Partial Settlement Agreement relating to ophthalmic sales of EYLEA® in the United States. Pursuant to this agreement, we received a non-exclusive license to certain patents relating to VEGF receptor proteins, known as the Davis-Smyth patents, and other technology patents. Under the terms of the agreement, we agreed to make payments to Genentech based on U.S. sales of EYLEA® commencing upon FDA approval of EYLEA® in November 2011 through May 7, 2016. We will be required to make a one-time, non-refundable $60 million payment upon cumulative U.S. sales of EYLEA® reaching $400 million. In addition, we agreed to pay royalties of 4.75% on cumulative U.S. sales of EYLEA® between $400 million and $3 billion and 5.5% on any cumulative U.S. sales of EYLEA® over $3 billion.

     In July 2008 we entered into an Amended and Restated Non-Exclusive License Agreement with Cellectis S.A. pursuant to which we licensed certain patents and patent applications relating to a process for the specific replacement of a copy of a gene in the receiver genome by homologous recombination. Pursuant to this agreement, we agreed to pay Cellectis a low, single-digit royalty based on any future revenue received by us from any future licenses or sales of our VelociGene® or VelocImmune® products or services. No royalties are payable to Cellectis on any revenue from commercial sales of antibodies from our VelocImmune® technology, including antibodies developed under our collaboration with Sanofi. We also have non-exclusive license agreements with Amgen and other organizations for patent rights related to ARCALYST®. In connection with these licenses, we pay a combined mid-single digit royalty on net sales of ARCALYST®.

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     Patent law relating to the patentability and scope of claims in the biotechnology field is evolving and our patent rights are subject to this additional uncertainty. The degree of patent protection that will be afforded to our products in the United States and other important commercial markets is uncertain and is dependent upon the scope of protection decided upon by the patent offices, courts, and governments in these countries. There is no certainty that our existing patents or others, if obtained, will provide us protection from competition or provide commercial benefit.

     Others may independently develop similar products or processes to those developed by us, duplicate any of our products or processes or, if patents are issued to us, design around any products and processes covered by our patents. We expect to continue, when appropriate, to file product and process applications with respect to our inventions. However, we may not file any such applications or, if filed, the patents may not be issued. Patents issued to or licensed by us may be infringed by the products or processes of others.

     Defense and enforcement of our intellectual property rights is expensive and time consuming, even if the outcome is favorable to us. It is possible that patents issued or licensed to us will be successfully challenged, that a court may find that we are infringing validly issued patents of third parties, or that we may have to alter or discontinue the development of our products or pay licensing fees to take into account patent rights of third parties (see Item 1A. “Risk Factors - Risks Related to Intellectual Property and Market Exclusivity – We may be restricted in our development, manufacturing, and/or commercialization activities by, and could be subject to damage awards if we are found to have infringed, third-party patents or other proprietary rights, and the costs and expenses of ongoing patent litigation have been and will likely continue to be significant.”).

Government Regulation

     Regulation by government authorities in the United States and foreign countries is a significant factor in the research, development, manufacture, and marketing of ARCALYST®, EYLEA®, and our product candidates (see Item 1A. “Risk Factors – Risks Related to Commercialization of EYLEA® for Wet AMD - Our regulatory approval for sales of EYLEA® is limited to the treatment of wet AMD and is limited to sales in the United States. If we don't receive approval for EYLEA® for other indications, or if approvals are not obtained for sales in other countries, our sales and profits will be limited and Risks Related to the Development and Approval of Our Product Candidates and New Indications for Our Marketed Products – If we do not obtain regulatory approval for our product candidates or new indications for our marketed products, or maintain regulatory approval for EYLEA® in the United States, we will not be able to market or sell them, which would materially and negatively impact our business, results of operations, and prospects.”). All of our product candidates will require regulatory approval before they can be commercialized. In particular, human therapeutic products are subject to rigorous preclinical and clinical trials and other pre-market approval requirements by the FDA and foreign authorities. Many aspects of the structure and substance of the FDA and foreign pharmaceutical regulatory practices have been reformed during recent years, and continued reform is under consideration in a number of jurisdictions. The ultimate outcome and impact of such reforms and potential reforms cannot be predicted.

     The activities required before a product candidate may be marketed in the United States begin with preclinical tests. Preclinical tests include laboratory evaluations and animal studies to assess the potential safety and efficacy of the product candidate and its formulations. The results of these studies must be submitted to the FDA as part of an IND, which must be reviewed by the FDA before proposed clinical testing can begin. Typically, clinical testing involves a three-phase process. In Phase 1, trials are conducted with a small number of subjects to determine the early safety profile of the product candidate. In Phase 2, clinical trials are conducted with subjects afflicted with a specific disease or disorder to provide enough data to evaluate the preliminary safety, tolerability, and efficacy of different potential doses of the product candidate. In Phase 3, large-scale clinical trials are conducted with patients afflicted with the specific disease or disorder in order to provide enough data to understand the efficacy and safety profile of the product candidate, as required by the FDA. The results of the preclinical and clinical testing of a biologic product candidate are then submitted to the FDA in the form of a BLA for evaluation to determine whether the product candidate may be approved for commercial sale. In responding to a BLA, the FDA may grant marketing approval, request additional information, or deny the application.

     Any approval required by the FDA for any of our product candidates may not be obtained on a timely basis, or at all. The designation of a clinical trial as being of a particular phase is not necessarily indicative that such a trial will be sufficient to satisfy the parameters of a particular phase, and a clinical trial may contain elements of more than one phase notwithstanding the designation of the trial as being of a particular phase. The results of preclinical studies or early stage clinical trials may not predict long-term safety or efficacy of our compounds when they are tested or used more broadly in humans.

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     Approval of a product candidate by comparable regulatory authorities in foreign countries is generally required prior to commencement of marketing of the product in those countries. The approval procedure varies among countries and may involve additional testing, and the time required to obtain such approval may differ from that required for FDA approval.

     Various federal, state, and foreign statutes and regulations also govern or influence the research, manufacture, safety, labeling, storage, record keeping, marketing, transport, and other aspects of pharmaceutical product candidates. The lengthy process of seeking these approvals and the compliance with applicable statutes and regulations require the expenditure of substantial resources. Any failure by us or our collaborators or licensees to obtain, or any delay in obtaining, regulatory approvals could adversely affect the manufacturing or marketing of our products and our ability to receive product or royalty revenue.

     In addition to the foregoing, our present and future business will be subject to regulation under the United States Atomic Energy Act, the Clean Air Act, the Clean Water Act, the Comprehensive Environmental Response, Compensation and Liability Act, the National Environmental Policy Act, the Toxic Substances Control Act, the Resource Conservation and Recovery Act, national restrictions, and other current and potential future local, state, federal, and foreign regulations.

Business Segments

     We manage our business as one segment which includes all activities related to the discovery of pharmaceutical products for the treatment of serious medical conditions and the development and commercialization of these discoveries. This segment also includes revenues and expenses related to (i) research and development activities conducted under our collaboration agreements with third parties and our grant from the NIH, (ii) product sales, including EYLEA® for the treatment of wet AMD and ARCALYST® for the treatment of CAPS, (iii) licensing agreements to utilize our VelocImmune® technology, and (iv) the supply of specified, ordered research materials using our VelociGene® technology platform.

Employees

     As of December 31, 2011, we had 1,704 full-time employees, of whom 330 held a Ph.D. and/or M.D., or PharmD degree. We believe that we have been successful in attracting skilled and experienced personnel in a highly competitive environment; however, competition for these personnel is intense. None of our personnel are covered by collective bargaining agreements and our management considers its relations with our employees to be good.

Available Information

     We make available free of charge on or through our Internet website (http://www.regeneron.com) our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and, if applicable, amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act, as soon as reasonably practicable after we electronically file such material with, or furnish it to, the Securities and Exchange Commission (SEC).

ITEM 1A. RISK FACTORS

     We operate in an environment that involves a number of significant risks and uncertainties. We caution you to read the following risk factors, which have affected, and/or in the future could affect, our business, prospects, operating results, and financial condition. The risks described below include forward-looking statements, and actual events and our actual results may differ materially from these forward-looking statements. Additional risks and uncertainties not currently known to us or that we currently deem immaterial may also impair our business, prospects, operating results, and financial condition. Furthermore, additional risks and uncertainties are described under other captions in this report and should also be considered by our investors.

Risks Related to Our Financial Results and Need for Additional Financing

We have had a history of operating losses and we may never achieve profitability. If we continue to incur operating losses, we may be unable to continue our operations.

     From inception on January 8, 1988 through December 31, 2011, we had a cumulative loss of $1.3 billion. If we continue to incur operating losses and fail to become a profitable company, we may be unable to continue our operations. In the absence of substantial revenue from the sale of products, including our current sales of EYLEA®, and ARCALYST® or from other sources, the amount, timing, nature or source of which cannot be predicted, our substantial losses will continue as we conduct our research and development activities, commercialize our approved products, and prepare for possible commercialization of our other product candidates and new indications of our marketed products.

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We may need additional funding in the future, which may not be available to us, and which may force us to delay, reduce or eliminate our product development programs or commercialization efforts.

     We will need to expend substantial resources for research and development, including costs associated with clinical testing of our product candidates and new indications of our marketed products, continued commercialization of EYLEA® in the United States, to prepare for potential commercialization of our late-stage product candidates and new indications for our marketed products and, if one or more of those product candidates or additional indications receive(s) regulatory approval, to fund the launch of those product(s) or new indications. We believe our existing capital resources, together with funds generated by anticipated EYLEA® net product sales and funding we are entitled to receive under our collaboration agreements, will enable us to meet our anticipated operating needs; however, one or more of our collaboration agreements may terminate, our revenues may fall short of our projections or be delayed, or our expenses may increase, which could result in our capital being consumed significantly faster than anticipated. Our expenses may increase for many reasons, including expenses in connection with the launch and marketing of EYLEA® and the potential commercial launches of our late-stage product candidates and new indications for our marketed products, manufacturing scale-up, expenses related to clinical trials testing ARCALYST®, EYLEA®, REGN475, REGN846, or REGN1154, and expenses related to the potential requirement for us to fund 20% of Phase 3 clinical trial costs for any of our antibody product candidates being developed in collaboration with Sanofi.

     We may require additional financing in the future and we may not be able to raise additional funds. If we are able to obtain additional financing through the sale of equity or convertible debt securities, such sales will likely be dilutive to our shareholders. Debt financing arrangements, if available given the current uncertainties in the global credit and financial markets, may require us to pledge certain assets or enter into covenants that would restrict our business activities or our ability to incur further indebtedness and may be at interest rates and contain other terms that are not favorable to our shareholders. Should we require and be unable to (i) raise sufficient funds to complete the development of our product candidates, (ii) to successfully commercialize our late-stage product candidates or new indications for our marketed products if they obtain regulatory approval, and (iii) to continue our manufacturing and marketing of EYLEA® for the treatment of wet AMD, we may face delay, reduction, or elimination of our research and development or preclinical or clinical programs and our commercialization activities, which would significantly limit our potential to generate revenue. We cannot be certain how profitable, if at all, our current marketing of EYLEA® for the treatment of wet AMD will be and, even if we obtain regulatory approval for our product candidates or new indications for our marketed products, they may never be successfully launched or become profitable, in which case our business, prospects, operating results, and financial condition may be materially harmed.

The value of our investment portfolio is influenced by varying economic and market conditions and may experience losses.

     As of December 31, 2011, our cash, cash equivalents, and marketable securities totaled $810.6 million (including $7.7 million of restricted cash and marketable securities). We have invested our excess cash primarily in direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities. We consider assets classified as marketable securities to be “available-for-sale,” as defined by FASB authoritative guidance. Unrestricted and restricted marketable securities totaled $325.2 million at December 31, 2011, are carried at fair value, and the unrealized gains and losses are included in other accumulated comprehensive income (loss) as a separate component of stockholders’ equity. If the decline in the value of a security in our investment portfolio is deemed to be other-than-temporary, we write down the security to its current fair value and recognize a loss which may be fully charged against income. The current economic environment and the volatility of securities markets increase the risk that we may not recover the principal we invested and/or there may be further declines in the market value of securities in our investment portfolio. As a result, we may incur additional charges against income in future periods for other-than-temporary impairments or realized losses upon a security’s sale or maturity, and such amounts may be material.

Risks Related to the Development and Approval of Our Product Candidates and New Indications for Our Marketed Products

We believe that a significant portion of the value attributed to our company by investors is based on the commercial potential of EYLEA®. If approval for EYLEA® is not obtained in countries outside the United States, or approval is not obtained for other indications, or if we fail to maintain regulatory compliance and lose the marketing approval we have in the United States, or if the product is withdrawn for any reason, our business, prospects, operating results, and financial condition will be materially harmed.

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     Whether EYLEA® is approved by regulatory authorities outside the United States or approved by the FDA for new indications, and the timing thereof, will depend on many factors, including the following:

  • whether or not the FDA determines that the evidence gathered in well-controlled clinical trials, other clinical trials and nonclinical studies of EYLEA® demonstrates that it is safe and effective as a treatment for the indication under review; and
  • whether or not the FDA is satisfied that the manufacturing facilities, processes, and controls for EYLEA® are adequate, that the labeling is satisfactory, and that plans for post-marketing studies, safety monitoring, and risk evaluation and management are sufficient;

     In June 2011, Bayer HealthCare submitted regulatory applications for marketing approval of ELYEA® in wet AMD in the European Union and Japan. Analogous regulatory authorities in these and other countries outside the United States have similar discretion to the FDA as to approval of EYLEA® in those countries.

     If Bayer HealthCare does not obtain approval to market EYLEA® in the European Union, Japan, or other countries, or if there are material delays in obtaining such approvals, our business, prospects, operating results, and financial condition will be materially harmed.

If we do not obtain regulatory approval for our product candidates or new indications for our marketed products, or maintain regulatory approval for EYLEA® in the United States, we will not be able to market or sell them, which would materially and negatively impact our business, results of operations, and prospects.

     We cannot sell or market products without regulatory approval. If we do not obtain and maintain regulatory approval for our product candidates, including ARCALYST® for the treatment of diseases other than CAPS, EYLEA® for the treatment of ophthalmologic diseases other than wet AMD, and/or ZALTRAP® for one or more oncology indications, the value of our company, our results of operations, and our prospects will be materially harmed. Our product candidates, including ZALTRAP® for previously treated mCRC, EYLEA® for CRVO and DME, and ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering therapy, may not receive regulatory approval. If we are unable to obtain such approval(s), or if we are materially delayed in doing so, our business, prospects, results of operations, and financial condition will be materially harmed. In addition, if we fail to maintain regulatory approval for EYLEA® for the treatment of wet AMD, we may lose marketing approval and the ability to generate EYLEA® product sales revenue, which would materially and negatively impact our business, prospects, results of operations, and financial condition.

Obtaining and maintaining regulatory approval for drug products is costly, time-consuming, and highly uncertain.

     In the United States, we must obtain and maintain approval from the FDA for each drug we intend to sell. Obtaining FDA approval is typically a lengthy and expensive process, and approval is highly uncertain. Foreign governments also regulate drugs distributed in their country and approval in any country is likely to be a lengthy and expensive process, and approval is highly uncertain.

     The FDA enforces Good Clinical Practices (GCPs) and other regulations through periodic inspections of trial sponsors, clinical research organizations (CROs), principal investigators, and trial sites. If we or any of the third parties conducting our clinical studies are determined to have failed to fully comply with GCPs, the study protocol or applicable regulations, the clinical data generated in those studies may be deemed unreliable. This could result in non-approval of our product candidates by the FDA, or we or the FDA may decide to conduct additional audits or require additional clinical studies, which would delay our development programs, require us to incur additional costs, and could substantially harm our business.

     Before approving a new drug or biologic product, the FDA requires that the facilities at which the product will be manufactured or advanced through the supply chain be in compliance with current Good Manufacturing Practices, or cGMP, requirements and regulations governing the shipment and storage of the product. Manufacturing product candidates in compliance with these regulatory requirements is complex, time-consuming, and expensive. To be successful, our products must be manufactured for development, and following approval in commercial quantities, in compliance with regulatory requirements, and at competitive costs. If we or any of our product collaborators, or third-party manufacturers, product packagers, labelers, or other parties performing steps in the supply chain are unable to maintain regulatory compliance, the FDA can impose regulatory sanctions, including, among other things, refusal to approve a pending application for a new drug or biologic product, or revocation of a pre-existing approval. As a result, our business, prospects, operating results, and financial condition may be materially harmed.

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     In addition to the FDA and other regulatory agency regulations in the United States, we are subject to a variety of foreign regulatory requirements governing human clinical trials, manufacturing, marketing and approval of drugs, and commercial sale and distribution of drugs in foreign countries. The foreign regulatory approval process and requirements include all of the risks associated with FDA approval as well as country specific regulations, and actions by a regulatory agency in a country or region with respect to a product candidate may have an impact on the approval process for that product candidate in another country or region. Whether or not we obtain FDA approval for a product in the United States, we must obtain approval of the product by the comparable regulatory authorities in foreign countries before we can conduct clinical trials of or market that product or any other product in those countries.

Clinical trials required for our product candidates and new indications of our marketed products are expensive and time-consuming, and their outcome is highly uncertain. If any of our drug trials are delayed or yield unfavorable results, regulatory approval for our product candidates or new indications of our marketed products may be delayed or become unobtainable.

     As described above, we must conduct extensive testing of our product candidates and new indications of our marketed products before we can obtain regulatory approval to market and sell them. We need to conduct both preclinical animal testing and human clinical trials. Conducting these trials is a lengthy, time-consuming, and expensive process. These tests and trials may not achieve favorable results for many reasons, including, among others, failure of the product candidate to demonstrate safety or efficacy, the development of serious or life-threatening adverse events (or side effects) caused by or connected with exposure to the product candidate, difficulty in enrolling and maintaining subjects in the clinical trial, lack of sufficient supplies of the product candidate or comparator drug, and the failure of clinical investigators, trial monitors, contractors, consultants, or trial subjects to comply with the trial plan, protocol, or applicable regulations related to GCPs. A clinical trial may fail because it did not include and retain a sufficient number of patients to detect the endpoint being measured or reach statistical significance. A clinical trial may also fail because the dose(s) of the investigational drug included in the trial were either too low or too high to determine the optimal effect of the investigational drug in the disease setting.

     We will need to reevaluate any drug candidate that does not test favorably and either conduct new trials, which are expensive and time consuming, or abandon that drug development program. The failure of clinical trials to demonstrate the safety and effectiveness of our clinical candidates for the desired indication(s) would preclude the successful development of those candidates for such indication(s), in which event our business, prospects, operating results, and financial condition may be materially harmed.

Successful development of our current and future product candidates is uncertain.

     Only a small minority of all research and development programs ultimately result in commercially successful drugs. We are testing ZALTRAP® and EYLEA® in a number of late-stage clinical trials in various indications and ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering drug therapy. Clinical trials may not demonstrate statistically sufficient effectiveness and safety to obtain the requisite regulatory approvals for these product candidates in these indications. In a number of instances, we have terminated the development of product candidates due to a lack of or only modest effectiveness. Moreover, even if we obtain positive results from preclinical testing or clinical trials, we may not achieve the same success in future trials. Many companies in the biopharmaceutical industry, including our company, have suffered significant setbacks in clinical trials, even after promising results have been obtained in earlier trials.

     In April 2011 we announced that our Phase 3 VELOUR trial of ZALTRAP® met its primary endpoint of improving overall survival in the treatment of patients with previously treated mCRC. Based upon these positive results, we and Sanofi submitted regulatory applications for marketing approval to the FDA and EMA. In January 2012, Roche announced that a Phase 3 trial of Avastin® (bevacizumab) had met the primary endpoint of overall survival in mCRC in patients who had previously received Avastin® with standard chemotherapy. The positive results of this trial in a similar patient population could impact the potential commercial opportunity for ZALTRAP® in mCRC. ZALTRAP® is also in a Phase 3 clinical trial in combination with a standard chemotherapy regimen for the treatment of first-line androgen independent prostate cancer. We do not have proof of concept data from early-stage, double-blind, controlled clinical trials that ZALTRAP® will be safe or effective in this cancer setting. In March 2010, Genentech announced that a Phase 3 trial of Avastin®, in combination with chemotherapy in men with prostate cancer, did not meet its primary endpoint. This trial had a very similar design to our ongoing Phase 3 trial of ZALTRAP® in prostate cancer.

     We also reported positive Phase 3 trial results with EYLEA® in CRVO after six months of treatment and, based on these results, have submitted a supplemental BLA filing to the FDA for marketing approval in the United States of EYLEA® in CRVO. Under PDUFA, we were granted a target date for an FDA decision on our EYLEA® in CRVO supplemental BLA of September 23, 2012. However, this expected timing for an FDA decision may not be met, and the FDA may not grant such approval or such approval may be substantially delayed. The FDA could also require us to provide additional clinical data in connection with this application. There can be no assurance that we will receive regulatory approval for EYLEA® in CRVO.

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     We also reported positive results of a Phase 2 trial of EYLEA® for the treatment of DME and that we have initiated a Phase 3 program in that indication. A number of other potential new drugs and biologics which showed promising results in Phase 1 and 2 clinical trials subsequently failed to establish sufficient safety and efficacy data to obtain necessary regulatory approvals, and this could occur with respect to subsequent clinical trials of EYLEA® for the treatment of DME.

     Based on the results of three Phase 3 studies, we have submitted a supplemental BLA filing to the FDA seeking approval of ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering drug therapy and, under PDUFA, we were granted a target date for an FDA decision on our ARCALYST® supplemental BLA of July 30, 2012. However, this expected timing for an FDA decision may not be met, and the FDA may not grant such approval or such approval may be substantially delayed. The FDA could also require us to provide additional clinical data in connection with this application. For example, in June 2011, following two positive Phase 3 trials, the Arthritis Advisory Committee of the FDA, voted to recommend against approval in a gout indication for Ilaris® (canikinumab), Novartis’ IL-1 inhibitor which works through a similar mechanism as ARCALYST® and, in August 2011, Novartis received a Complete Response letter from the FDA requesting additional information, including clinical data to evaluate the benefit-risk profile of Ilaris® in refractory patients.

     Many of our clinical trials are conducted under the oversight of IDMCs. These independent oversight bodies are made up of external experts who review the progress of ongoing clinical trials, including available safety and efficacy data, and make recommendations concerning a trial’s continuation, modification, or termination based on interim, unblinded data. Any of our ongoing clinical trials may be discontinued or amended in response to recommendations made by responsible IDMCs based on their review of such interim trial results. For example, in September 2009, a Phase 3 trial that was evaluating ZALTRAP® as a first-line treatment for metastic pancreatic cancer in combination with gemcitabine was discontinued at the recommendation of an IDMC after a planned analysis of interim efficacy data determined that the trial would not meet its efficacy endpoint. The recommended termination of any of our ongoing late-stage clinical trials by an IDMC could negatively impact the future development of our product candidate(s), and our business may be materially harmed.

     We are studying our antibody candidates in a wide variety of indications in clinical trials. Many of these trials are exploratory studies designed to evaluate the safety profile of these compounds and to identify what diseases and uses, if any, are best suited for these product candidates. These product candidates may not demonstrate the requisite efficacy and/or safety profile to support continued development for some or all of the indications that are being, or are planned to be, studied, which would diminish our clinical “pipeline” and could negatively affect our future prospects and the value of our company.

Serious complications or side effects in connection with the use of our products and in clinical trials for our product candidates and new indications for our marketed products could cause our regulatory approvals to be revoked or limited or lead to delay or discontinuation of development of our product candidates or new indications for our marketed products, which could severely harm our business.

     During the conduct of clinical trials, patients report changes in their health, including illnesses, injuries, and discomforts, to their study doctor. Often, it is not possible to determine whether or not the drug candidate being studied caused these conditions. Various illnesses, injuries, and discomforts have been reported from time-to-time during clinical trials of our product candidates and new indications for our marketed products. It is possible that as we test our drug candidates or new indications in larger, longer, and more extensive clinical programs, or as use of these drugs becomes more widespread if they receive regulatory approval, illnesses, injuries, and discomforts that were observed in earlier trials, as well as conditions that did not occur or went undetected in previous trials, will be reported by patients. Many times, side effects are only detectable after investigational drugs are tested in large scale, Phase 3 clinical trials or, in some cases, after they are made available to patients after approval. If additional clinical experience indicates that any of our product candidates or new indications for our marketed products has many side effects or causes serious or life-threatening side effects, the development of the product candidate may fail or be delayed, or if the product candidate has received regulatory approval such approval may be revoked, which would severely harm our business.

     ZALTRAP® is being studied for the potential treatment of certain types of cancer and EYLEA® is being studied in diseases of the eye in addition to wet AMD. There are many potential safety concerns associated with significant blockade of VEGF that may limit our ability to successfully develop ZALTRAP® and EYLEA® in each of the indications for which we are studying these product candidates. These serious and potentially life-threatening risks, based on clinical and preclinical experience of VEGF inhibitors, include bleeding, intestinal perforation, hypertension, proteinuria, congestive heart failure, heart attack, and stroke. In addition, patients given infusions of any protein, including ZALTRAP® delivered through intravenous administration, may develop severe hypersensitivity reactions or infusion reactions. Other VEGF blockers have reported side effects that became evident only after large scale trials or after marketing approval when large numbers of patients were treated. There are risks inherent in the intravitreal administration of drugs like EYLEA®, which can cause injury to the eye and other complications. For example, in our Phase 3 trials of EYLEA® in wet AMD, the most frequent ocular adverse events were conjunctival hemorrhage, macular degeneration, eye pain, retinal hemorrhage, and vitreous floaters. These and other complications or side effects could harm the development and/or commercialization of ZALTRAP® for the treatment of cancer or EYLEA® for the treatment of diseases of the eye.

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     As more patients begin to use ARCALYST® if it receives regulatory approval for the prevention of gout flares in patients initiating uric acid-lowering therapy, and to the extent it is tested in new disease settings, new risks and side effects associated with ARCALYST® may be discovered, and risks previously viewed as inconsequential could be determined to be significant. Like cytokine antagonists such as Ilaris® (canakinumab), a registered trademark of Novartis, Kineret® (anakinra) and Enbrel® (etanercept), registered trademarks of Amgen, and Remicade® (infliximab) a registered trademark of Centocor Ortho Biotech, ARCALYST® affects the immune defense system of the body by blocking some of its functions. Therefore, ARCALYST® may interfere with the body’s ability to fight infections. As noted above, in June 2011, following two positive Phase 3 trials, the Arthritis Advisory Committee of the FDA voted to recommend against approval in a gout indication for Ilaris®, Novartis’ IL-1 inhibitor which works through a similar mechanism as ARCALYST® and, in August 2011, Novartis received a Complete Response letter from the FDA requesting additional information, including clinical data to evaluate the benefit-risk profile of Ilaris® in refractory patients.

     Treatment with Kineret®, a medication that works through the inhibition of IL-1, has been associated with an increased risk of serious infections, and serious, life threatening infections have been reported in patients taking ARCALYST®. These or other complications or side effects could cause regulatory authorities to revoke approvals of ARCALYST® for the treatment of CAPS or deny the approval of ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering treatment or other disease settings. Alternatively, we may be required to conduct additional clinical trials, make changes in the labeling of our product, or limit or abandon our efforts to develop ARCALYST® in new disease settings. Any such side effects may also result in a reduction, or even the elimination, of sales of ARCALYST® in the current or future approved indications.

     We are studying REGN475, a fully human monoclonal antibody to NGF, in a variety of pain indications, including osteoarthritis of the knee. In December 2010, we were informed by the FDA that a case confirmed as avascular necrosis of a joint was seen in another company’s anti-NGF program. The FDA believes this case, which follows previously-reported cases of joint replacements in patients on an anti-NGF drug candidate being developed by another pharmaceutical company, provides evidence to suggest a class-effect and placed REGN475 on clinical hold. The FDA Arthritis Advisory Committee is scheduled for March 12, 2012 to discuss possible safety issues related to anti-NGF compounds. There are currently no ongoing trials with REGN475 that are either enrolling or treating patients.

Our product candidates in development are recombinant proteins that could cause an immune response, resulting in the creation of harmful or neutralizing antibodies against the therapeutic protein.

     In addition to the safety, efficacy, manufacturing, and regulatory hurdles faced by our product candidates, the administration of recombinant proteins frequently causes an immune response, resulting in the creation of antibodies against the therapeutic protein. The antibodies can have no effect or can totally neutralize the effectiveness of the protein, or require that higher doses be used to obtain a therapeutic effect. In some cases, the antibody can cross react with the patient’s own proteins, resulting in an “auto-immune” type disease. Whether antibodies will be created can often not be predicted from preclinical or clinical experiments, and their detection or appearance is often delayed, so neutralizing antibodies may be detected at a later date, in some cases even after pivotal clinical trials have been completed.

We may be unable to formulate or manufacture our product candidates in a way that is suitable for clinical or commercial use, which would delay or prevent continued development of such candidates and/or receipt of regulatory approval or commercial sale, which could materially harm our business.

     If we are unable to continue to develop suitable product formulations or manufacturing processes to support large scale clinical testing of our product candidates, including our antibody candidates, we may be unable to supply necessary materials for our clinical trials, which would delay or prevent the development of our product candidates. Similarly, if we are unable, directly or through our collaborators or third parties, to supply sufficient quantities of our products or develop formulations of our product candidates suitable for commercial use, we will be unable to obtain regulatory approval for those product candidates.

Risks Related to Commercialization of EYLEA® for the Treatment of Wet AMD

We are subject to significant ongoing regulatory obligations and oversight with respect to EYLEA® for the treatment of wet AMD. If we fail to maintain regulatory compliance for EYLEA®, we may lose marketing approval, which would materially harm our business, prospects, operating results, and financial condition.

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     EYLEA® is currently approved for treatment of wet AMD in the United States and Bayer HealthCare is seeking approval in other countries. We are subject to significant ongoing regulatory obligations with respect to EYLEA® for the treatment of wet AMD in the United States, and, if approved outside the United States, commercialization of EYLEA® will be subject to significant ongoing regulatory obligations and oversight in those countries where approval is obtained as well. If we fail to maintain regulatory compliance for EYLEA® for the treatment of wet AMD, we may lose marketing approval, which would materially harm our business, prospects, operating results, and financial condition. Failure to comply may also subject us to sanctions, product recalls, or withdrawals of previously approved marketing applications. See also “If we fail to meet the stringent requirements of governmental regulation in the manufacture of drug products or product candidates, we could incur substantial remedial costs, delays in the development or approval of our product candidates and/or in their commercial launch if they obtain regulatory approval, and a reduction in sales.”

Serious complications or side effects in connection with the use of EYLEA® could materially harm our business, prospects, operating results, and financial condition.

     There are risks inherent in intravitreal injections, including with EYLEA®, such as intraocular inflammation, sterile and culture positive endophthalmitis, corneal decomposition, retinal detachment, retinal tear, and other side effects, all of which are reported from time to time to the FDA. Serious complications or serious, unexpected side effects in connection with the use of EYLEA® could materially harm our business, prospects, operating results, and financial condition.

Our regulatory approval for sales of EYLEA® is limited to the treatment of wet AMD and is limited to sales in the United States. If we don't receive approval for EYLEA® for other indications, or if approvals are not obtained for sales in other countries, sales and profits will be limited.

     We have received regulatory approval for sale of EYLEA® for the treatment of wet AMD only in the United States. If we do not receive approval for EYLEA® for other uses, or if approvals for sales in other countries are not obtained, sales will be limited and our potential for profits will be limited. As a result, our business, prospects, results of operations, and financial condition would be materially impacted.

Our sales of EYLEA® for the treatment of wet AMD are dependent on the availability and extent of reimbursement from third party payers, and changes to such reimbursement may materially harm our sales and potential revenue and harm our business, prospects, operating results, and financial condition.

     Our current sales in the United States of EYLEA® for the treatment of wet AMD are dependent, in part, on the availability and extent of reimbursement from third-party payers, including government programs such as Medicare and Medicaid and private payer healthcare and insurance programs. If approved for sale in other countries, such sales will be dependent, in part, on similar programs in these countries. In the United States, there is an increased focus from the federal government and others on analyzing the impact of various regulatory programs on the federal deficit, which could result in increased pressure on federal programs to reduce costs, including limiting federal healthcare expenditures. Economic pressure on state budgets may also have a similar impact. A reduction in the availability or extent of reimbursement from U.S. government programs could have a material adverse effect on the sales of EYLEA®. Since EYLEA® for the treatment of wet AMD is too expensive for most patients to afford without health insurance coverage, if adequate coverage and reimbursement by third-party payers, including Medicare and Medicaid in the United States, is not available, our ability to successfully commercialize EYLEA® will be materially adversely impacted. Our sales and potential profits and our business, prospects, operating results, and financial condition would be materially harmed. See also "The successful commercialization of EYLEA® for the treatment of wet AMD as well as our late-stage product candidates or new indications for our marketed products, if approved, will depend on obtaining coverage and reimbursement for use of these products from third-party payers, including Medicare and Medicaid in the United States, and these payers may not agree to cover or adequately reimburse for use of our products or may do so at levels that make our products uncompetitive and/or unprofitable, which would materially harm our business, prospects, operating results, and financial condition."

     The status of a J-code for EYLEA® could also affect reimbursement. J-codes are permanent reimbursement codes maintained by Centers for Medicare and Medicaid Services (CMS) that are a component of the Healthcare Common Procedure Coding System (HCPCS), and are typically used to report injectable drugs that ordinarily cannot be self-administered. We do not currently have a J-Code for EYLEA®, although we anticipate assignment of a J-Code for EYLEA® in January 2013. Without a unique J-code identifier, EYLEA® must be billed using a non-specific miscellaneous J-code. Since such codes may be used for a wide variety of products, health plans may have more difficulty determining the actual product used and billed for the patient. As a result, these claims must often be submitted with additional information and manually processed, which can create delays in claims processing times as well as increasing the likelihood for claim errors.

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The commercial success of EYLEA® currently being marketed for the treatment of wet AMD is subject to strong competition.

     The market for eye disease products is very competitive. Novartis and Genentech are collaborating on the commercialization and further development of a VEGF antibody fragment, Lucentis® for the treatment of wet AMD, CRVO, DME, and other eye indications. Lucentis® was approved by the FDA in June 2006 for the treatment of wet AMD and in June 2010 for the treatment of macular edema following retinal vein occlusion (RVO), CRVO, and branch retinal vein occlusion (BRVO). Lucentis® was also approved by the EMA for wet AMD in January 2007 and for DME in January 2011. Many other companies are working on the development of product candidates for the potential treatment of wet AMD and DME including those that act by blocking VEGF and VEGF receptors, as well as small interfering ribonucleic acids (siRNAs) that modulate gene expression. In addition, ophthalmologists are using off-label, with success for the treatment of wet AMD, DME, and RVO, third-party repackaged versions of Genentech’s approved VEGF antagonist, Avastin®. The relatively low cost of therapy with Avastin® in patients with wet AMD presents a significant competitive challenge in this indication.

     The National Eye Institute (NEI) and others are conducting long-term, controlled clinical trials comparing Lucentis® to Avastin® in the treatment of wet AMD. One-year data from the CATT were reported in April 2011 and indicated that Avastin® dosed monthly was non-inferior to Lucentis® dosed monthly in the primary efficacy endpoint of mean visual acuity gain at 52 weeks. Avastin® is also being evaluated in eye diseases in trials that have been initiated in the United Kingdom, Canada, Brazil, Mexico, Germany, Israel, and other countries. It may be difficult for EYLEA® in this or other eye indications for which it may be approved to compete against Lucentis® and off-label use of Avastin® because doctors and patients have had significant experience using these medicines. Moreover, the recently reported results of the CATT study, combined with the relatively low cost of Avastin® in treating patients with wet AMD, may well exacerbate the competitive challenge which EYLEA® will face in this or other eye indications for which it may be approved. In addition, while we believe that ZALTRAP® would not be well tolerated if administered directly to the eye, if ZALTRAP® is approved for the treatment of certain cancers, there is a risk that third parties will attempt to repackage ZALTRAP® for off-label use and sale for the treatment of wet AMD and other diseases of the eye, which would present a potential low-cost competitive threat to EYLEA® for wet AMD or other eye indications. See also “The commercial success of EYLEA® currently being marketed for the treatment of wet AMD, and for our other product candidates or new indications for our marketed products, if any are approved for marketing, is highly uncertain given their method of administration, and because our competitors have received approval for and may be marketing products with a similar mechanism of action or may enter the marketplace with better or lower cost drugs.”

Risks Related to Intellectual Property and Market Exclusivity

If we cannot protect the confidentiality of our trade secrets or our patents are insufficient to protect our proprietary rights, our business and competitive position will be harmed.

     Our business requires using sensitive and proprietary technology and other information that we protect as trade secrets. We seek to prevent improper disclosure of these trade secrets through confidentiality agreements. If our trade secrets are improperly disclosed, by our own employees, our collaborators or otherwise, it would help our competitors and adversely affect our business. We will be able to protect our proprietary rights from unauthorized use by third parties only to the extent that our rights are covered by valid and enforceable patents or are effectively maintained as trade secrets. The patent position of biotechnology companies, including our company, involves complex legal and factual questions and, therefore, enforceability cannot be predicted with certainty. Our patents may be challenged, invalidated, or circumvented. Patent applications filed outside the United States may be challenged by third parties who file an opposition. Such opposition proceedings are increasingly common in the European Union and are costly to defend. We have pending patent applications in the European Patent Office and it is likely that we will need to defend patent applications from third-party challengers from time to time in the future. Patent applications filed in the United States may also be challenged by third parties who file a request for post-grant review under the America Invents Act of 2011, beginning on September 16, 2012. We expect that post-grant review proceedings will become common in the United States and will be costly to defend. We have pending patent applications in the United States Patent and Trademark Office and it is likely that we will need to defend patent applications from third-party challengers from time to time in the future. Our patent rights may not provide us with a proprietary position or competitive advantages against competitors. Furthermore, even if the outcome is favorable to us, the enforcement of our intellectual property rights can be extremely expensive and time consuming.

We may be restricted in our development, manufacturing, and/or commercialization activities by, and could be subject to damage awards if we are found to have infringed, third-party patents or other proprietary rights, and the costs and expenses of ongoing patent litigation have been and will likely continue to be significant.

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     Our commercial success depends significantly on our ability to operate without infringing the patents and other proprietary rights of third parties. Other parties may allege that they have blocking patents to our products in clinical development or even to products that have received regulatory approval and are being or have been commercialized, either because they claim to hold proprietary rights to the composition of a product or the way it is manufactured or used. Moreover, other parties may allege that they have blocking patents to antibody products made using our VelocImmune® technology, either because of the way the antibodies are discovered or produced or because of a proprietary composition covering an antibody or the antibody’s target.

     We are aware of issued patents and pending patent applications owned by Genentech that claim certain chimeric VEGF receptors. We do not believe that ZALTRAP® or EYLEA® infringe any valid claim in these patents or patent applications. We are involved in five patent litigations with Genentech, two in the United States and three in Europe. In November 2010, we commenced a lawsuit against Genentech in the U.S. District Court for the Southern District of New York (the Court), seeking a declaratory judgment that no activities relating to our VEGF Trap infringe any valid claim of certain Genentech patents referred to as the Davis-Smyth patents (the First Davis-Smyth Case). Genentech answered the complaint and asserted counterclaims that our prior or planned activities relating to VEGF Trap have infringed or will infringe claims of four of the five Davis-Smyth patents and requested a judgment against us for damages, including for willful infringement, and other relief as the Court deems appropriate.

     On December 31, 2011, we entered into a non-exclusive license and partial settlement agreement (the “Agreement”) with Genentech that covers making, using, and selling EYLEA® in the United States for the prevention and treatment of human eye diseases and disorders in the United States. Under the Agreement, we received a non-exclusive license to the Davis-Smyth patents, and certain other technology patents owned or co-owned by Genentech. The Agreement does not cover any non-U.S. patent rights or non-U.S. patent disputes, and does not cover any use of aflibercept other than for prevention and treatment of human eye diseases and disorders in the United States. The First Davis-Smyth Case is continuing with respect to matters not covered by the Agreement. The Agreement provides for us to make payments to Genentech based on U.S. sales of EYLEA® through May 7, 2016, the date the Davis-Smyth patents expire. We will make a lump-sum payment of $60 million once cumulative U.S. sales of EYLEA® reach $400 million. We will also pay royalties of 4.75% on cumulative U.S. sales of EYLEA® between $400 million and $3 billion and 5.5% on any cumulative U.S. sales of EYLEA® over $3 billion. As a result of the Agreement, on January 17, 2012 Genentech filed a second amended answer and counterclaim in the First Davis-Smyth Case, in which it amended its counterclaims alleging infringement of four of the five Davis-Smyth patents. On December 23, 2011, Genentech initiated a related case in the Court against Regeneron and Sanofi alleging infringement of four of the five Davis-Smyth Patents by activities relating to VEGF Trap (but excluding EYLEA®) (the Second Davis-Smyth Case). As in the First Davis-Smyth Case, in the new complaint Genentech requests a judgment against us for damages, including for willful infringement, and other relief as the Court deems appropriate.

     We believe Genentech's claims in the First Davis Smyth Case and the Second Davis Smyth Case are without merit and intend to continue to defend against all of Genentech’s remaining claims vigorously. However, it is possible that there could be an adverse determination or judgment in either or both cases that would materially harm our business by requiring us to seek a license for matters not covered by the Agreement, which may not be available at all or on reasonable terms, or precluding the manufacture, further development, or sale of EYLEA® outside the United States or ZALTRAP®, or resulting in a damage award. In addition, irrespective of the outcome of the Davis-Smyth cases, we have incurred and will likely continue to incur significant costs and expenses associated with them, which have negatively affected, and will likely continue to negatively affect, our results of operations. An adverse determination in any of the proceedings described herein may have a material adverse effect on our business, prospects, results of operations, and financial condition.

     We have initiated patent-related actions against Genentech in Germany, the United Kingdom, and Italy, and may initiate other actions in other countries outside the United States, which could have similar or other adverse outcomes that would materially harm our business and which, irrespective of the outcomes, may also entail significant costs and expenses.

     We are aware of patents and pending applications owned by Roche that claim antibodies to IL-6R and methods of treating rheumatoid arthritis with such antibodies. We are developing sarilumab, an antibody to IL-6R, for the treatment of rheumatoid arthritis. Although we do not believe that sarilumab infringes any valid claim in these patents or patent applications, Roche could initiate a lawsuit for patent infringement and assert its patents are valid and cover sarilumab.

     We are aware of a U.S. patent jointly owned by Genentech and City of Hope relating to the production of recombinant antibodies in host cells. We currently produce our antibody product candidates using recombinant antibodies from host cells and may choose to produce additional antibody product candidates in this manner. Neither ARCALYST®, ZALTRAP®, nor EYLEA® are recombinant antibodies. If any of our antibody product candidates are produced in a manner subject to valid claims in the Genentech patent, then we may need to obtain a license from Genentech, should one be available. Genentech has licensed this patent to several different companies under confidential license agreements. If we desire a license for any of our antibody product candidates and are unable to obtain a license on commercially reasonable terms or at all, we may be restricted in our ability to use Genentech’s techniques to make recombinant antibodies in or to import them into the United States.

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     Further, we are aware of a number of other third-party patent applications that, if granted with claims as currently drafted, may cover our current or planned activities. It could be determined that our products and/or actions in manufacturing or selling our product candidates infringe such patents.

     Patent holders in addition to Genentech could assert claims against us for damages and seek to prevent us from manufacturing, selling, or developing our drug candidates, and a court may find that we are infringing validly issued patents of third parties. In the event that the manufacture, use, or sale of any of our drug candidates, including EYLEA® or our other late-stage product candidates, infringes on the patents or violates other proprietary rights of third parties, we may be prevented from pursuing product development, manufacturing, and commercialization of those drugs and may be required to pay costly damages. Such a result may materially harm our business, prospects, operating results, and financial condition. In any event, legal disputes are likely to be costly and time consuming to defend.

     We seek to obtain licenses to patents when, in our judgment, such licenses are needed or advisable. If any licenses are required, we may not be able to obtain such licenses on commercially reasonable terms, if at all. The failure to obtain any such license could prevent us from developing or commercializing any one or more of our product candidates, which could severely harm our business.

Loss or limitation of patent rights, and new regulatory pathways for biosimilar competition, could reduce the duration of market exclusivity for our products.

     In the pharmaceutical and biotechnology industries, the majority of an innovative product’s commercial value is usually realized during the period in which it has market exclusivity. In the United States and some other countries, when market exclusivity expires and generic versions of a product are approved and marketed, there usually are very substantial and rapid declines in the product’s sales.

     If our late-stage product candidates or other clinical candidates are approved for marketing in the U.S or elsewhere, market exclusivity for those products will generally be based upon patent rights and/or certain regulatory forms of exclusivity. As described above under "If we cannot protect the confidentiality of our trade secrets or our patents are insufficient to protect our proprietary rights, our business and competitive position will be harmed", the scope and enforceability of our patent rights may vary from country to country. The failure to obtain patent and other intellectual property rights, or limitations on the use, or the loss, of such rights could be material to us. Absent patent protection or regulatory exclusivity for our products, it is possible, both in the United States and elsewhere, that generic and/or biosimilar versions of those products may be approved and marketed which would likely result in substantial and rapid reductions in revenues from sales of those products.

     Under the federal Patient Protection and Affordable Care Act, or PPACA, enacted in 2010, there is now a new, abbreviated path in the United States for regulatory approval of biosimilar versions of biological products. The PPACA provides a regulatory mechanism that allows for FDA approval of biologic drugs that are similar to (but not generic copies of) innovative drugs on the basis of less extensive data than is required by a full BLA. Under this new regulation, an application for approval of a biosimilar may be filed four years after approval of the innovator product. However, qualified innovative biological products will receive 12 years of regulatory exclusivity, meaning that the FDA may not approve a biosimilar version until 12 years after the innovative biological product was first approved by the FDA. However, the term of regulatory exclusivity may not remain at 12 years in the United States and could be shortened.

     The increased likelihood of biosimilar competition has increased the risk of loss of innovators’ market exclusivity. Due to this risk, and uncertainties regarding patent protection, if our late-stage product candidates or other clinical candidates are approved for marketing, it is not possible to predict the length of market exclusivity for a particular product with certainty based solely on the expiration of the relevant patent(s) or the current forms of regulatory exclusivity. It is also not possible to predict changes in United States regulatory law that might reduce biological product regulatory exclusivity. The loss of market exclusivity for a product would likely materially and negatively affect revenues from product sales of that product and thus our financial results and condition.

Risks Related to Manufacturing and Supply

We rely on limited internal and contracted manufacturing and supply chain capacity, which could result in our being unable to continue to successfully commercialize EYLEA® and to commercialize our other product candidates or other indications for our marketed products if they receive regulatory approval and are unable to continue to develop our clinical candidates.

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     Our manufacturing facility would be inadequate to produce the active pharmaceutical ingredients of (a) EYLEA®, ZALTRAP®, and ARCALYST® for the treatment of gout flares in sufficient commercial quantities if these late-stage product candidates were all to receive regulatory approval, and (b) our earlier stage product candidates in sufficient clinical quantities if our clinical pipeline advances as planned. In addition to expanding our internal capacity, we intend to rely on our corporate collaborators, as well as contract manufacturers, to produce commercial quantities of drug material needed for commercialization of our products to the extent such quantities are not manufactured at our own facility. We rely entirely on third-parties and our collaborators for filling and finishing services. Generally, in order for other parties to perform any step in the manufacturing and supply chain, we must transfer technology to the other party which can be time consuming and may not be successfully accomplished without considerable cost and expense, or at all. We will have to depend on these other parties to perform effectively on a timely basis and to comply with regulatory requirements. If for any reason they are unable to do so, and as a result we are unable to directly or through such third parties manufacture and supply sufficient commercial quantities of our products on acceptable terms, or if we should encounter delays or other difficulties in our relationships with our corporate collaborators, third-party manufacturers, or other parties involved in our supply chain which adversely affect the timely manufacture and supply of our products, our business, prospects, operating results, and financial condition may be materially harmed.

Expanding our manufacturing capacity will be costly and we may be unsuccessful in doing so in a timely manner, which could delay or prevent the launch and successful commercialization of our late-stage product candidates or other indications for our marketed products if they are approved for marketing and could jeopardize our current and future clinical development programs.

     Expanding our manufacturing capacity to supply commercial quantities of the active pharmaceutical ingredients for our late-stage product candidates if they are approved for marketing, and to supply clinical drug material to support the continued growth of our clinical programs, will require substantial additional expenditures, and we will need to hire and train significant numbers of employees and managerial personnel to staff our manufacturing and supply chain operations. Start-up costs can be large and scale-up entails significant risks related to process development and manufacturing yields. In addition, we may face difficulties or delays in developing or acquiring the necessary production equipment and technology to manufacture sufficient quantities of our product candidates at reasonable costs and in compliance with applicable regulatory requirements. The FDA and analogous foreign regulatory authorities must determine that our existing and any expanded manufacturing facilities comply, or continue to comply, with cGMP requirements for both clinical and commercial production and license them, or continue to license them, accordingly, and such facilities must also comply with applicable environmental, safety, and other governmental permitting requirements. We may not successfully expand or establish sufficient manufacturing capabilities or manufacture our products economically or in compliance with cGMPs and other regulatory requirements, and we and our collaborators may not be able to build or procure additional capacity in the required timeframe to meet commercial demand for our late-stage product candidates if they receive regulatory approval, and to continue to meet the requirements of our clinical programs. This would interfere with our efforts to successfully commercialize EYLEA®, ZALTRAP®, and ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering treatment if they receive regulatory approval, and could also delay or require us to discontinue one or more of our clinical development programs. As a result, our business, prospects, operating results, and financial condition could be materially harmed.

Our ability to manufacture our products may be impaired if any of our manufacturing activities, or the activities of third parties involved in our manufacture and supply chain, are found to infringe third-party patents.

     Our ability to continue to manufacture ARCALYST®, EYLEA®, and ZALTRAP® in our Rensselaer, New York facilities, or to utilize third parties to produce our products or perform fill/finish services or other steps in our manufacture and supply chain, depends on our and their ability to operate without infringing the patents or other intellectual property rights of third parties. Other parties may allege that our manufacturing activities, or the activities of third parties involved in our manufacture and supply chain, infringe patents or other intellectual property rights. A judicial decision in favor of one or more parties making such allegations could preclude the manufacture of our products where those intellectual property rights apply which could materially harm our business, results of operations, and prospects.

If sales of EYLEA® for the treatment of wet AMD do not meet the levels currently expected, or if the launch of our late-stage product candidates or new indications of our marketed products, or any of our clinical programs, are delayed or discontinued, we may face costs related to unused capacity at our manufacturing facilities and at the facilities of third parties.

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     We have large-scale manufacturing operations in Rensselaer, New York. We use our facilities to produce bulk product of ARCALYST® for the treatment of CAPS, bulk product of EYLEA® for the treatment of wet AMD and clinical and preclinical candidates for ourselves and our collaborations, and plan to use such facilities to produce bulk product for commercial supply of our late-stage product candidates or new indications of our marketed products if they are approved for marketing. If our clinical candidates are discontinued or their clinical development is delayed, if the launch of any of our late-stage product candidates or new indications or our marketed products is delayed or does not occur, or if such products are launched and subsequently recalled or marketing approval is rescinded, we may have to absorb one hundred percent of related overhead costs and inefficiencies, as well as similar costs of third-party contract manufacturers performing services for us.

Third-party service or supply failures, or other failures, business interruptions, or natural disasters affecting our manufacturing facilities in Rensselaer, New York or the facilities of any other party participating in the supply chain, would adversely affect our ability to supply our products.

     We manufacture all of our bulk drug materials at our manufacturing facilities in Rensselaer, New York. We would be unable to manufacture these materials if our Rensselaer facilities were to cease production due to regulatory requirements or action, business interruptions, labor shortages or disputes, contaminations, fire, natural disasters, or other problems at the facilities.

     Also, certain raw materials necessary for the manufacture and formulation of ARCALYST® and EYLEA® and of our product candidates, including ZALTRAP®, are provided by single-source unaffiliated third-party suppliers. In addition, we rely on certain third parties to perform filling, finishing, distribution, laboratory testing, and other services related to the manufacture of ARCALYST® and our product candidates. We would be unable to obtain these raw materials or services for an indeterminate period of time if any of these third parties were to cease or interrupt production or otherwise fail to supply these materials, products, or services to us for any reason, including due to regulatory requirements or action, adverse financial developments at or affecting the supplier, failure by the supplier to comply with cGMPs, business interruptions, or labor shortages or disputes. This, in turn, could materially and adversely affect our ability to manufacture or supply ARCALYST® for the treatment of CAPS and EYLEA® for the treatment of wet AMD and to manufacture and supply commercial quantities of EYLEA® for other ophthalmologic diseases, ZALTRAP®, and ARCALYST® for the prevention of gout flares if they receive regulatory approval, which could materially and adversely affect our business and future prospects.

     Certain of the raw materials required in the manufacture and the formulation of our product candidates may be derived from biological sources, including mammalian tissues, bovine serum, and human serum albumin. There are certain European regulatory restrictions on using these biological source materials. If we are required to substitute for these sources to comply with European regulatory requirements, our clinical development activities may be delayed or interrupted.

If we fail to meet the stringent requirements of governmental regulation in the manufacture of drug products or product candidates, we could incur substantial remedial costs, delays in the development or approval of our product candidates or new indications for our marketed products and/or in their commercial launch if they obtain regulatory approval, and a reduction in sales.

     We and our third-party providers are required to maintain compliance with cGMP, and are subject to inspections by the FDA or comparable agencies in other jurisdictions to confirm such compliance. Changes of suppliers or modifications of methods of manufacturing may require amending our application(s) to the FDA or such comparable foreign agencies and acceptance of the change by the FDA or such comparable foreign agencies prior to release of product(s). Because we produce multiple product candidates at our facility in Rensselaer, New York, including ARCALYST®, EYLEA®, and ZALTRAP®, there are increased risks associated with cGMP compliance. Our inability, or the inability of our third-party fill/finish or other service providers, to demonstrate ongoing cGMP compliance could require us to engage in lengthy and expensive remediation efforts, withdraw or recall product, halt or interrupt clinical trials, and/or interrupt commercial supply of any marketed products, and could also delay or prevent our obtaining regulatory approval for our late-stage product candidates or new indications for our marketed products. Any delay, interruption, or other issue that arises in the manufacture, fill/finish, packaging, or storage of any drug product or product candidate as a result of a failure of our facilities or the facilities or operations of third parties to pass any regulatory agency inspection or maintain cGMP compliance could significantly impair our ability to develop, obtain approval for, and successfully commercialize our products, which would substantially harm our business and prospects. Any finding of non-compliance could also increase our costs, cause us to delay the development of our product candidates, result in delay in our obtaining, or our not obtaining, regulatory approval of product candidates or new indications for our marketed products, and cause us to lose revenue from any marketed products, which could be seriously detrimental to our business, prospects, and financial condition.

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Risks Related to Commercialization of Products

We may be unsuccessful in continuing our commercialization of EYLEA® for the treatment of wet AMD or commercializing our late stage product candidates or new indications for our marketed products, if approved, which would materially delay or prevent our achieving profitability.

     Even if clinical trials demonstrate the safety and effectiveness of any of our product candidates for a specific disease and the necessary regulatory approvals are obtained, the commercial success of any of our product candidates or new indications for our marketed products will depend upon, among other things, their acceptance by patients, the medical community, and third-party payers and on our and our collaborators' ability to successfully manufacture and commercialize those products or new indications. Even if we obtain regulatory approval for our product candidates or new indications, if they are not successfully commercialized, we will not be able to recover the significant investment we have made in developing such products and our business, prospects, operating results, and financial condition would be severely harmed.

     In particular, we are in the early stages of commercialization and cannot be sure that EYLEA® for the treatment of wet AMD will be commercially successful in the pharmaceutical market. In addition to the challenges we face related to a company launching its first major commercial drug, as described in detail in the risk factor immediately below, we and Bayer HealthCare will face intense competition from Lucentis® and from off-label use of Avastin®, both of which have been on the market for a number of years. We expect that the initial commercial success of EYLEA® for the treatment of wet AMD will depend on many factors, including the following:

  • the effectiveness of our and Bayer HealthCare's commercial strategies for the launch and marketing of EYLEA® in and outside the United States, respectively, including pricing strategy and the effectiveness of efforts to obtain, and the timing of obtaining, adequate third-party reimbursements;
  • maintaining and successfully monitoring commercial manufacturing arrangements for EYLEA® with third parties who perform fill/finish or other steps in the manufacture of EYLEA® to ensure that they meet our standards and those of regulatory authorities, including the FDA, which extensively regulate and monitor pharmaceutical manufacturing facilities;
  • our ability to meet the demand for commercial supplies of EYLEA®;
  • our ability to effectively communicate to the marketplace the benefits of the dosing regimen of EYLEA® of every 2 months after three initial monthly doses as compared to the monthly dosing regimen of Lucentis®, and the willingness of retinal specialists and patients to switch from Lucentis® or off-label use of Avastin® to EYLEA® for the treatment of wet AMD;
  • the ability of patients, retinal specialists, and other providers to obtain and maintain sufficient coverage and reimbursement from third-party payors, including Medicare and Medicaid in the United States and other government and private payors in the United States and foreign jurisdictions; and
  • the effect of new health care legislation currently being implemented in the United States.

     While we believe that EYLEA® for the treatment of wet AMD has a commercially competitive profile, we cannot predict whether ophthalmologists, particularly retinal specialists, and patients, will accept or utilize EYLEA®. Our and Bayer HealthCare's efforts to educate the relevant medical community and third-party payors regarding the benefits of EYLEA® for the treatment of wet AMD will require significant resources and may not be successful in achieving our objectives. If EYLEA® is approved for marketing but does not achieve significant market acceptance for the treatment of wet AMD, our ability to achieve profitability would be materially impaired or delayed.

If we are unable to establish, and effectively deploy and manage, sales, marketing, and distribution capabilities in the applicable markets or to enter into agreements with third parties to do so, we will not generate our expected sales of EYLEA® for treatment of wet AMD or successfully launch and commercialize our late-stage product candidates or new indications for our marketed products if they receive regulatory approval, which would materially harm our business, prospects, operating results, and financial condition.

     We currently sell EYLEA® in the United States to three distributors and several specialty pharmacies. We currently sell ARCALYST® for the treatment of CAPS in the United States to two specialty pharmacies. Under these distribution models, we enter into written contracts with our distributors and specialty pharmacies (collectively, our “customers”), and our customers generally take physical delivery of product. For EYLEA®, the distributors and specialty pharmacies generally sell the product directly to healthcare providers, whereas for ARCALYST®, the specialty pharmacies sell the product directly to patients.

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     We have established our own sales and marketing organization for EYLEA® in the United States for the treatment of wet AMD, and in anticipation of filing for and receiving regulatory approval to market and sell EYLEA® in the United States for the treatment of CRVO. However, we may be unsuccessful in achieving a successful commercialization of EYLEA® in the United States, which would materially harm our business, prospects, operating results, and financial condition.

     We will have to rely on a third party or devote significant resources to develop our own sales and marketing capabilities, and our distribution network, for ARCALYST® for patients with gout initiating uric acid-lowering drug therapy if it receives regulatory approval. If we are unable to obtain these capabilities, either by developing our own organizations or entering into agreements with others to provide these functions, even if ARCALYST® for the prevention of gout flares receives marketing approval, we will not be able to successfully launch and commercialize this product, which would also materially harm our business, prospects, operating results, and financial condition.

     We have limited experience in sales, marketing, or distribution of products in substantial commercial quantities or in establishing and managing the required infrastructure to do so, including large-scale information technology systems and a large-scale distribution network, and we may be unable to establish such infrastructure on a timely basis. To the extent we determine to utilize third parties to provide sales, marketing, or distribution capabilities for ARCALYST® for the prevention of gout flares or any of our other product candidates or new indications for marketed products if they receive regulatory approval, we may encounter difficulties in retaining such parties on acceptable terms. Even if we hire qualified sales and marketing personnel, and establish the required infrastructure we need to support our objectives, or enter into marketing and distribution agreements with third parties on acceptable terms, we may not do so in an efficient manner or on a timely basis. We may not be able to correctly judge the size and experience of the sales and marketing force and the scale of distribution capabilities necessary to successfully market and sell in the United States EYLEA®, ARCALYST® for the prevention of gout flares, or any of our other product candidates or new indications if they receive regulatory approval in the United States and as to which we retain sales and marketing responsibility in that market. Establishing and maintaining sales, marketing, and distribution capabilities are expensive and time-consuming. Our expenses associated with building up and maintaining a sales force and distribution capabilities may be disproportional, particularly in the near term, compared to the revenues we may be able to generate on sales in the United States of EYLEA® or ARCALYST® for the prevention of gout flares. Ultimately neither we nor our collaborators may be successful in commercializing EYLEA®, ZALTRAP®, ARCALYST® for the prevention of gout flares, or any of our other product candidates.

     Under the terms of our collaboration agreement, Sanofi has primary responsibility for sales, marketing, and distribution of ZALTRAP® in cancer indications, should it be approved in the future by regulatory authorities for marketing.

     We currently have no sales, marketing, commercial, or distribution capabilities outside the United States. Under the terms of our license and collaboration agreement with Bayer HealthCare, we will rely on Bayer HealthCare for sales, marketing, and distribution of EYLEA® in countries outside the United States should it be approved for marketing in such countries.

The commercial success of EYLEA® currently being marketed for the treatment of wet AMD, and for our other product candidates or new indications for our marketed products, if any are approved for marketing, is highly uncertain given their method of administration, and because our competitors have received approval for and may be marketing products with a similar mechanism of action or may enter the marketplace with better or lower cost drugs.

     Our product candidates are delivered either by intravenous infusion or by intravitreal or subcutaneous injections, which are generally less well received by patients than tablet or capsule delivery and this could adversely affect the commercial success of those products if they receive marketing approval.

     There is substantial competition in the biotechnology and pharmaceutical industries from biotechnology, pharmaceutical, and chemical companies. Many of our competitors have substantially greater research, preclinical and clinical product development and manufacturing capabilities, and financial, marketing, and human resources than we do. Our smaller competitors may also enhance their competitive position if they acquire or discover patentable inventions, form collaborative arrangements, or merge with large pharmaceutical companies. Even if we achieve commercialization of our product candidates, our competitors have achieved, and may continue to achieve, product commercialization before our products are approved for marketing and sale.

     As previously noted, Genentech has an approved VEGF antagonist, Avastin®, on the market for treating certain cancers and many different pharmaceutical and biotechnology companies are working to develop competing VEGF antagonists, including Novartis, Amgen, Imclone LLC/Eli Lilly, Pfizer, AstraZeneca, and GlaxoSmithKline. Some of these molecules are further along in development than ZALTRAP® and may offer competitive advantages over our molecule. Each of Pfizer, Onyx (together with its partner Bayer HealthCare), and GlaxoSmithKline are marketing and selling oral medications that target tumor cell growth and new vasculature formation that fuels the growth of tumors. The marketing approvals for Genentech’s VEGF antagonist, Avastin®, and their extensive, ongoing clinical development plan for Avastin® in other cancer indications, make it more difficult for us to enroll patients in clinical trials to support ZALTRAP® for those indications and to obtain regulatory approval of ZALTRAP® in those indications. This may delay or impair our ability to successfully develop and commercialize ZALTRAP® for various cancer indications. In addition, even if ZALTRAP® is approved for sale for the treatment of certain cancers, it will be difficult for our drug to compete against Avastin® and the FDA approved kinase inhibitors, because doctors and patients will have significant experience using these medicines. In addition, an oral medication may be considerably less expensive for patients than a biologic medication, providing a competitive advantage to companies that market such products.

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     The market for eye disease products is also very competitive. Novartis and Genentech are collaborating on the commercialization and further development of a VEGF antibody fragment, Lucentis® for the treatment of wet AMD, CRVO, DME, and other eye indications. Lucentis® was approved by the FDA in June 2006 for the treatment of wet AMD and in June 2010 for the treatment of macular edema following retinal vein occlusion (RVO), CRVO, and branch retinal vein occlusion (BRVO). Lucentis® was also approved by the EMA for wet AMD in January 2007 and for DME in January 2011. Many other companies are working on the development of product candidates for the potential treatment of wet AMD and DME including those that act by blocking VEGF and VEGF receptors, as well as small interfering ribonucleic acids (siRNAs) that modulate gene expression. In addition, ophthalmologists are using off-label, with success for the treatment of wet AMD, DME, and RVO, third-party repackaged versions of Genentech’s approved VEGF antagonist, Avastin®.

     The National Eye Institute (NEI) and others are conducting long-term, controlled clinical trials comparing Lucentis® to Avastin® in the treatment of wet AMD. One-year data from the Comparison of Age-Related Macular Degeneration Treatments Trial (CATT) were reported in April 2011 and indicated that Avastin® dosed monthly was non-inferior to Lucentis® dosed monthly in the primary efficacy endpoint of mean visual acuity gain at 52 weeks. It may be difficult for EYLEA® in this or other eye indications for which it may be approved to compete against Lucentis® and off-label use of Avastin® because doctors and patients have had significant experience using these medicines. Moreover, the recently reported results of the CATT study, combined with the relatively low cost of Avastin® in treating patients with wet AMD, may well exacerbate the competitive challenge which EYLEA® will face in this or other eye indications for which it may be approved. In addition, while we believe that ZALTRAP® would not be well tolerated if administered directly to the eye, if ZALTRAP® is approved for the treatment of certain cancers, there is a risk that third parties will attempt to repackage ZALTRAP® for off-label use and sale for the treatment of wet AMD and other diseases of the eye, which would present a potential low-cost competitive threat to EYLEA® for wet AMD or other eye indications.

     The availability of highly effective FDA approved Tumor Necrosis Factors-antagonists (TNF-antagonists) such as Enbrel®, Remicade®, Humira® (adalimumab), a registered trademark of Abbott Laboratories, Simponi® (golimumab), a registered trademark of Johnson & Johnson, the IL-1 receptor antagonist Kineret®, Ilaris® (canakinumab), and other marketed therapies makes it more difficult to successfully develop and commercialize ARCALYST® in indications other than CAPS, and this is one of the reasons we discontinued the development of ARCALYST® in adult rheumatoid arthritis. In addition, even if ARCALYST® is ever approved for sale in indications where TNF-antagonists are approved, it will be difficult for our drug to compete against these FDA approved TNF-antagonists because doctors and patients have had significant experience using these effective medicines. Moreover, in such indications these approved therapeutics may offer competitive advantages over ARCALYST®, such as requiring fewer injections.

     There are both small molecules and antibodies in development by other companies that are designed to block the synthesis of IL-1 or inhibit the signaling of IL-1. For example, Eli Lilly, Xoma (in collaboration with Servier), and Novartis are each developing antibodies to IL-1 and both Amgen and MedImmune are developing antibodies to the IL-1 receptor. In 2009, Novartis received regulatory approval in the United States and Europe for Ilaris®, a fully human anti-interleukin-IL1ß antibody, for the treatment of CAPS. Ilaris® is also in development for atherosclerosis and a number of other inflammatory diseases. Novartis’ IL-1 antibody and these other drug candidates could offer competitive advantages over ARCALYST®. For example, Ilaris® is dosed once every eight weeks compared to the once-weekly dosing regimen for ARCALYST®. The successful development and/or commercialization of these competing molecules could adversely affect sales of ARCALYST® for the treatment of CAPS and delay or impair our ability to commercialize ARCALYST® for indications other than CAPS.

     We are developing ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering therapy and have submitted a supplemental BLA filing for U.S. regulatory approval in this indication. In January 2011, Novartis announced that the results of two Phase 3 studies with Ilaris® focused on reducing pain and preventing recurrent attacks or “flares” in patients with hard-to-treat gout were positive. Novartis has also reported that regulatory filings for the use of Ilaris® in gouty arthritis have been completed in the European Union in 2010 and in the United States in the first quarter of 2011, based on the results of these two Phase 3 studies. Ilaris® is dosed less frequently for the treatment of CAPS, and if it is approved for the treatment of gout, it may be perceived by some physicians as offering competitive advantages over ARCALYST®, which would make it difficult for us to successfully commercialize ARCALYST® in that disease.

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     Currently, inexpensive, oral therapies such as analgesics and other NSAIDS, are used as the standard of care to treat the symptoms of gout diseases. These established, inexpensive, orally delivered drugs may make it difficult for us to successfully commercialize ARCALYST® in these diseases.

     Our earlier-stage clinical candidates in development are all fully human monoclonal antibodies, which were generated using our VelocImmune® technology. Our antibody generation technologies and earlier-stage clinical candidates face competition from many pharmaceutical and biotechnology companies using various technologies.

     Numerous other companies are developing therapeutic antibody products. Companies such as Pfizer, Johnson & Johnson, AstraZeneca, Amgen, Biogen Idec, Novartis, Genentech/Roche, Bristol-Myers Squib, Abbott, and GlaxoSmithKline have generated therapeutic products that are currently in development or on the market that are derived from recombinant DNA that comprise human antibody sequences.

     We are aware of several pharmaceutical and biotechnology companies actively engaged in the research and development of antibody products against targets that are also the targets of our early-stage product candidates. For example, Pfizer, Johnson & Johnson, and Abbott are developing antibody product candidates against NGF. Genentech/Roche is marketing an antibody against IL-6R (tocilizumab) for the treatment of rheumatoid arthritis, and several other companies, including Centocor/Johnson & Johnson, and Bristol-Myers Squibb, have antibodies against IL-6 in clinical development for this disease. GlaxoSmithKline, in partnership with OncoMed Pharmaceuticals, has a Dll4 antibody in clinical development for the treatment of solid tumors. Aerovance has two formulations of a biologic directed against IL-4 in clinical development. Amgen previously had an antibody against IL-4R in clinical development for the treatment of asthma. We believe that several companies, including Amgen and Pfizer, have development programs for antibodies against PCSK9. Amgen, Pfizer, and AstraZeneca have development programs underway for antibodies against ANG2. If any of these or other competitors announces a successful clinical study involving a product that may be competitive with one of our product candidates or the grant of marketing approval by a regulatory agency for a competitive product, such developments may have an adverse effect on our business or future prospects.

The successful commercialization of EYLEA® for the treatment of wet AMD as well as our late-stage product candidates or new indications for our marketed products, if approved, will depend on obtaining coverage and reimbursement for use of these products from third-party payers, including Medicare and Medicaid in the United States, and these payers may not agree to cover or adequately reimburse for use of our products or may do so at levels that make our products uncompetitive and/or unprofitable, which would materially harm our business, prospects, operating results, and financial condition.

     Our product candidates, if commercialized, may be significantly more expensive than traditional drug treatments. For example, we are developing ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering drug therapy. Patients suffering from this gout indication are currently treated with inexpensive therapies, including NSAIDS. These existing treatment options are likely to be considerably less expensive and may be preferable to a biologic medication for some patients. Our future revenues and profitability will be adversely affected in a material manner if United States and foreign governmental, private third-party insurers and payers, and other third-party payers, including Medicare and Medicaid, do not agree to defray or reimburse the cost of our products to the patients. If these entities do not provide coverage and reimbursement with respect to our products or provide an insufficient level of coverage and reimbursement, our products may be too costly for many patients to afford them, and physicians may not prescribe them. Many third-party payers cover only selected drugs, making drugs that are not preferred by such payers more expensive for patients, and require prior authorization or failure on another type of treatment before covering a particular drug. In particular, payers may impose these obstacles to coverage on higher-priced drugs, as our product candidates are likely to be.

     Government and other third-party payers are challenging the prices charged for healthcare products and increasingly limiting, and attempting to limit, both coverage and level of reimbursement for prescription drugs. In March 2010, the PPACA and a related reconciliation bill were enacted in the United States. This legislation imposes cost containment measures that are likely to adversely affect the amount of reimbursement for our future products. The full effects of this legislation are unknown at this time and will not be known until regulations and guidance are issued by CMS and other federal and state agencies. Further, in September 2011 the Office of Inspector General (OIG) of the Department of Health and Human Services issued a report entitled “Review of Medicare Part B Avastin and Lucentis Treatments for Age-Related Macular Degeneration” in which the OIG details possible savings to the Medicare program by using off-label Avastin® rather than Lucentis® for the treatment of wet AMD. Some states are also considering legislation that would control the prices of drugs, and state Medicaid programs are increasingly requesting manufacturers to pay supplemental rebates and requiring prior authorization by the state program for use of any drug for which supplemental rebates are not being paid. It is likely that federal and state legislatures and health agencies will continue to focus on additional health care reform in the future that will impose additional constraints on prices and reimbursements for our products.

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     Since EYLEA® for the treatment of wet AMD and other eye diseases, ZALTRAP® for oncology indications, and ARCALYST® for the prevention of gout flares will likely be too expensive for most patients to afford without health insurance coverage, if these products are unable to obtain adequate coverage and reimbursement by third-party payers, including Medicare and Medicaid in the United States, our ability to successfully commercialize these products would be materially adversely impacted. The status of a J-code for our marketed products could also affect reimbursement. J-codes are permanent reimbursement codes maintained by CMS that are a component of HCPCS, and are typically used to report injectable drugs that ordinarily cannot be self-administered. Although we have a J-Code for ARCALYST®, we do not currently have a J-Code for EYLEA®, although we anticipate assignment of a J-Code for EYLEA® in January 2013. Without a unique J-code identifier, EYLEA® must be billed using a non-specific miscellaneous J-code. Since such codes may be used for a wide variety of products, health plans may have more difficulty determining the actual product used and billed for the patient. As a result, these claims must often be submitted with additional information and manually processed, which can create delays in claims processing times as well as increasing the likelihood for claim errors. Third-party payers, including Medicare and Medicaid in the United States, may not cover and/or reimburse for these products at levels required for us to successfully commercialize these products. Any limitation imposed by third-party payers on the use of our products if they are approved for marketing, any action or decision by CMS or analogous foreign agencies or authorities which for any reason denies coverage or reimbursement for our products or provides coverage or reimbursement at levels that harm our products’ competitiveness or leads to lower prices for those products, will have a material negative effect on our ability to achieve profitability. In certain foreign countries, pricing, coverage, and level of reimbursement of prescription drugs are subject to governmental control, and we and our collaborators may be unable to obtain coverage, pricing, and/or reimbursement on terms that are favorable to us or necessary for us or our collaborators to successfully commercialize our products in those countries. In some foreign countries, the proposed pricing for a drug must be approved before it may be lawfully marketed. The requirements governing drug pricing vary widely from country to country. For example, the European Union provides options for its member states to restrict the range of medicinal products for which their national health insurance systems provide reimbursement and to control the prices of medicinal products for human use. A member state may approve a specific price for the medicinal product or it may instead adopt a system of direct or indirect controls on the profitability of the company placing the medicinal product on the market. Our results of operations may suffer if we or our collaborators are unable to market our products in foreign countries or if coverage and reimbursement for our products in foreign countries is limited or delayed.

Regulatory and Litigation Risks

   If the testing or use of our products harms people, we could be subject to costly and damaging product liability claims.

     The testing, manufacturing, marketing, and sale of drugs for use in people expose us to product liability risk. Any informed consent or waivers obtained from people who enroll in our clinical trials may not protect us from liability or the cost of litigation. We may also be subject to claims by patients who use our approved products, ARCALYST® for the treatment of CAPS, or EYLEA® for the treatment of wet AMD, or EYLEA® for other indications, ZALTRAP®, or ARCALYST® for the prevention of gout flares if those product candidates receive regulatory approval and become commercially available, that they have been injured by a side effect associated with the drug. We may face product liability claims and be found responsible even if injury arises from the acts or omissions of our third-party fill/finish or other providers. Our product liability insurance may not cover all potential liabilities or may not completely cover any liability arising from any such litigation. Moreover, in the future we may not have access to liability insurance or be able to maintain our insurance on acceptable terms.

If we market and sell approved products, in a way that violates federal or state healthcare laws, we may be subject to civil or criminal penalties.

     In addition to FDA and related regulatory requirements, we are subject to health care “fraud and abuse” laws, such as the federal False Claims Act, the anti-kickback provisions of the federal Social Security Act, and other state and federal laws and regulations. Federal and state anti-kickback laws prohibit, among other things, payments or other remuneration to induce or reward someone to purchase, prescribe, endorse, or recommend a product that is reimbursed under federal or state healthcare programs. If we provide payments or other remuneration to a healthcare professional to induce the prescribing of our products, we could face liability under state and federal anti-kickback laws.

     Federal false claims laws prohibit any person from knowingly presenting, or causing to be presented, a false claim for payment to the federal government, or knowingly making, or causing to be made, a false statement to get a false claim paid. Pharmaceutical companies have been prosecuted under these laws for a variety of alleged promotional and marketing activities, such as allegedly providing free product to customers with the expectation that the customers would bill federal programs for the product; reporting to pricing services inflated average wholesale prices that were then used by federal programs to set reimbursement rates; engaging in promotion for uses that the FDA has not approved, known as off-label uses, that caused claims to be submitted to Medicaid for non-covered off-label uses, and submitting inflated best price information to the Medicaid Rebate program.

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     The majority of states also have statutes or regulations similar to the federal anti-kickback law and false claims laws, which apply to items and services reimbursed under Medicaid and other state programs, or, in several states, apply regardless of the payer. Sanctions under these federal and state laws may include civil monetary penalties, exclusion of a manufacturer’s products from reimbursement under government programs, criminal fines, and imprisonment.

     Even if it is determined that we have not violated these laws, government investigations into these issues typically require the expenditure of significant resources and generate negative publicity, which would harm our business and financial results and condition. Because of the breadth of these laws and the narrowness of the safe harbors, it is possible that some of our business activities could be challenged under one or more of such laws.

     In recent years, several states and localities, including California, the District of Columbia, Massachusetts, Minnesota, Nevada, New Mexico, Vermont, and West Virginia, have enacted legislation requiring pharmaceutical companies to establish marketing compliance programs, and file periodic reports with the state or make periodic public disclosures on sales, marketing, pricing, clinical trials, and other activities. Similar requirements are being considered in other states. In addition, as part of the PPACA, pharmaceutical companies will be required to file reports with the federal government regarding payments made to healthcare professionals. Many of these requirements are new and uncertain, and the penalties for failure to comply with these requirements are unclear. Nonetheless, if we are found not to be in full compliance with these laws, we could face enforcement actions, fines, and other penalties, and could receive adverse publicity, which would harm our business and financial results and condition.

Risks from the improper conduct of employees, agents or contractors or collaborators could adversely affect our business or reputation.

     We cannot ensure that our compliance controls, policies, and procedures will in every instance protect us from acts committed by our employees, agents, contractors, or collaborators that would violate the laws or regulations of the jurisdictions in which we operate, including without limitation, healthcare, employment, foreign corrupt practices, environmental, competition, and privacy laws. Such improper actions could subject us to civil or criminal investigations, monetary and injunctive penalties and could adversely impact our ability to conduct business, results of operations, and reputation.

Our operations may involve hazardous materials and are subject to environmental, health, and safety laws and regulations. Compliance with these laws and regulations is costly, and we may incur substantial liability arising from our activities involving the use of hazardous materials.

     As a biopharmaceutical company with significant manufacturing operations, we are subject to extensive environmental, health, and safety laws and regulations, including those governing the use of hazardous materials. Our research and development and manufacturing activities involve the controlled use of chemicals, viruses, radioactive compounds, and other hazardous materials. The cost of compliance with environmental, health, and safety regulations is substantial. If an accident involving these materials or an environmental discharge were to occur, we could be held liable for any resulting damages, or face regulatory actions, which could exceed our resources or insurance coverage.

Our business is subject to increasingly complex corporate governance, public disclosure, and accounting requirements and regulations that could adversely affect our business and financial results and condition.

     We are subject to changing rules and regulations of various federal and state governmental authorities as well as the stock exchange on which our Common Stock is listed. These entities, including the Public Company Accounting Oversight Board (PCAOB), the Securities and Exchange Commission (SEC), and The NASDAQ Stock Market LLC, have issued a significant number of new and increasingly complex requirements and regulations over the course of the last several years and continue to develop additional requirements and regulations in response to laws enacted by Congress, including the Sarbanes-Oxley Act of 2002 and, most recently, the Dodd-Frank Wall Street Reform and Protection Act, or the Dodd-Frank Act. There are significant corporate governance and executive compensation-related provisions in the Dodd-Frank Act that expressly authorized or required the SEC to adopt additional rules in these areas, such as shareholder approval of executive compensation (so-called “say on pay”) and proxy access. On January 25, 2011, the SEC adopted final rules concerning “say on pay”. Our efforts to comply with these requirements and regulations have resulted in, and are likely to continue to result in, an increase in expenses and a diversion of management’s time from other business activities.

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   Changes in laws and regulations affecting the healthcare industry could adversely affect our business.

     All aspects of our business, including research and development, manufacturing, marketing, pricing, sales, litigation, and intellectual property rights, are subject to extensive legislation and regulation. Changes in applicable federal and state laws and agency regulations could have a materially negative impact on our business. These include:

  • changes in the FDA and foreign regulatory processes for new therapeutics that may delay or prevent the approval of any of our current or future product candidates;
  • new laws, regulations, or judicial decisions related to healthcare availability or the payment for healthcare products and services, including prescription drugs, that would make it more difficult for us to market and sell products once they are approved by the FDA or foreign regulatory agencies;
  • changes in FDA and foreign regulations that may require additional safety monitoring prior to or after the introduction of new products to market, which could materially increase our costs of doing business; and
  • changes in FDA and foreign cGMPs that may make it more difficult and costly for us to maintain regulatory compliance and/or manufacture our marketed product and product candidates in accordance with cGMPs.

     As described above, the PPACA and potential regulations thereunder easing the entry of competing follow-on biologics into the marketplace, other new legislation or implementation of existing statutory provisions on importation of lower-cost competing drugs from other jurisdictions, and legislation on comparative effectiveness research are examples of previously enacted and possible future changes in laws that could adversely affect our business.

Risks Related to Our Reliance on Third Parties

If our antibody collaboration with Sanofi is terminated, our business operations and financial condition, and our ability to discover, develop, manufacture, and commercialize our pipeline of product candidates in the time expected, or at all, would be materially harmed.

     We rely heavily on funding from Sanofi to support our target discovery and antibody research and development programs. Sanofi has committed to pay up to $160 million per year, or a total of $1.28 billion, between 2010 and 2017 to fund our efforts to identify and validate drug discovery targets and pre-clinically develop fully human monoclonal antibodies against such targets. Sanofi has a one-time option to adjust the maximum reimbursement amount down to $120 million per year commencing in 2014 if over the prior two years certain specified criteria are not satisfied. If this downward adjustment occurs, it will reduce our resources available for antibody discovery activities and negatively affect our clinical pipeline. Sanofi also initially funds almost all of the development expenses incurred by both companies in connection with the clinical development of antibodies that Sanofi elects to co-develop with us. We rely on Sanofi to fund these activities. In addition, with respect to those antibodies that Sanofi elects to co-develop with us, such as sarilumab, REGN727, REGN668, REGN421, REGN910, REGN728, and REGN1033, we rely on Sanofi to lead much of the clinical development efforts and assist with obtaining regulatory approval, particularly outside the United States. We also rely on Sanofi to lead the commercialization efforts to support all of the antibody products that are co-developed by Sanofi and us if they receive regulatory approval. If Sanofi does not elect to co-develop the antibodies that we discover or opts-out of their development, we would be required to fund and oversee on our own the clinical trials, any regulatory responsibilities, and the ensuing commercialization efforts to support those antibody products. For example, during 2011 and 2012 to date, Sanofi elected not to continue co-development of REGN846 and REGN475, and decided not to opt-in to the REGN1154 program. If Sanofi terminates the antibody collaboration or fails to comply with its payment obligations thereunder, our business, prospects, operating results, and financial condition would be materially harmed. We would be required to either expend substantially more resources than we have anticipated to support our research and development efforts, which could require us to seek additional funding that might not be available on favorable terms or at all, or materially cut back on such activities. Even though none of the antibodies from this collaboration may ever be successfully developed and commercialized, if Sanofi does not perform its obligations with respect to antibodies that it elects to co-develop, our ability to develop, manufacture, and commercialize these antibody product candidates will be significantly adversely affected.

If our collaboration with Sanofi for ZALTRAP® is terminated, or Sanofi materially breaches its obligations thereunder, our business operations, prospects, and financial condition, and our ability to develop, manufacture, and commercialize ZALTRAP® in the time expected, or at all, would be materially harmed.

     We rely heavily on Sanofi to lead much of the development of ZALTRAP®. Sanofi initially funds all of the development expenses incurred by both companies in connection with the ZALTRAP® program. If the ZALTRAP® program continues, we will rely on Sanofi to assist with funding the ZALTRAP® program, provide commercial manufacturing capacity, enroll and monitor clinical trials, obtain regulatory approval, particularly outside the United States, and lead the commercialization of ZALTRAP®. While ZALTRAP® may not ever be successfully developed and commercialized, if Sanofi fails to perform its obligations in a timely manner, or at all, our ability to develop, manufacture, and commercialize ZALTRAP® in cancer indications will be significantly adversely affected. Sanofi has the right to terminate its collaboration agreement with us at any time upon twelve months advance notice. If Sanofi were to terminate its collaboration agreement with us, we would not have the resources or skills to replace those of our partner, which could require us to seek additional funding that might not be available on favorable terms or at all, and could cause significant delays in the development and/or manufacture of ZALTRAP® and result in substantial additional costs to us. We have limited commercial capabilities and would have to develop or outsource these capabilities. Termination of the Sanofi collaboration agreement for ZALTRAP® would create substantial new and additional risks to the successful development and commercialization of ZALTRAP®.

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If our collaboration with Bayer HealthCare for EYLEA® is terminated, or Bayer HealthCare materially breaches its obligations thereunder, our business operations, prospects, and financial condition, and our ability to continue to develop EYLEA® and commercialize EYLEA® outside the United States in the time expected, or at all, would be materially harmed.

     We rely heavily on Bayer HealthCare to assist with the development, and the commercialization outside the United States, of EYLEA®. Under our agreement with them, Bayer HealthCare is required to fund approximately half of the development expenses incurred by both companies in connection with the global EYLEA® development program. As the EYLEA® program continues, we will continue to rely on Bayer HealthCare to assist with funding the EYLEA® development program, continue to lead the development of EYLEA® outside the United States, obtain regulatory approval outside the United States, and provide all sales, marketing, and commercial support for the product outside the United States. In particular, Bayer HealthCare has responsibility for selling EYLEA® outside the United States using its sales force. While we cannot assure you that EYLEA® will receive regulatory approval in or outside the United States or be successfully commercialized, if Bayer HealthCare does not perform its obligations in a timely manner, or at all, our ability to develop, manufacture, and commercialize EYLEA® outside the United States will be significantly adversely affected. Bayer HealthCare has the right to terminate its collaboration agreement with us at any time upon six or twelve months advance notice, depending on the circumstances giving rise to termination. If Bayer HealthCare were to terminate its collaboration agreement with us, we would not have the resources or skills to replace those of our partner, which could require us to seek additional funding or another collaboration that might not be available on favorable terms or at all, and could cause significant delays in the development and/or commercialization of EYLEA® outside the United States and result in substantial additional costs to us. We currently have limited commercial capabilities and would have to develop or outsource these capabilities outside the United States. Termination of the Bayer HealthCare collaboration agreement would create substantial new and additional risks to the successful development and commercialization of EYLEA®, particularly outside the United States.

Our collaborators and service providers may fail to perform adequately in their efforts to support the development, manufacture, and commercialization of our drug candidates and current and future products.

     We depend upon third-party collaborators, including Sanofi, Bayer HealthCare, and service providers such as CROs, outside testing laboratories, clinical investigator sites, and third-party manufacturers, fill/finish, and product packagers and labelers, to assist us in the manufacture and preclinical and clinical development of our product candidates. We also depend, or will depend, on some of these third parties in connection with the commercialization of EYLEA® for the treatment of wet AMD, ARCALYST® for the treatment of CAPS, and our late-stage product candidates and new indications for our marketed products if they are approved for marketing. If any of our existing collaborators or service providers breaches or terminates its agreement with us or does not perform its development or manufacturing services under an agreement in a timely manner or in compliance with applicable GMPs, Good Laboratory Practices (GLPs), or GCP Standards, we could experience additional costs, delays, and difficulties in the manufacture or development of, or in obtaining approval by regulatory authorities for and successfully commercializing, our product candidates.

     We rely on third-party service providers to support the distribution of EYLEA® and ARCALYST® and for many other related activities in connection with the commercialization of these marketed products. Despite our arrangements with them, these third parties may not perform adequately. If these service providers do not perform their services adequately, our sales of EYLEA® for the treatment of wet AMD and ARCALYST® for the treatment of CAPS will suffer.

Risk Related to Employees

We are dependent on our key personnel and if we cannot recruit and retain leaders in our research, development, manufacturing, and commercial organizations, our business will be harmed.

     We are highly dependent on certain of our executive officers, other key members of our senior management team, and our Chairman. If we are not able to retain any of these persons, our business may suffer. In particular, we depend on the services of P. Roy Vagelos, M.D., the Chairman of our board of directors, Leonard S. Schleifer, M.D., Ph.D., our President and Chief Executive Officer, George D. Yancopoulos, M.D., Ph.D., our Executive Vice President, Chief Scientific Officer and President, Regeneron Research Laboratories, and Neil Stahl, Ph.D., our Senior Vice President, Research and Development Sciences. As we commercialize EYLEA® in the United States for the treatment of wet AMD and prepare for commercialization in the United States of EYLEA® for the treatment of CRVO and ARCALYST® for the treatment of gout flares in patients initiating uric acid-lowering therapy, should they receive regulatory approval, we will also be highly dependent on the expertise and services of members of our senior management leading these commercialization efforts. There is intense competition in the biotechnology industry for qualified scientists and managerial personnel in the development, manufacture, and commercialization of drugs. We may not be able to continue to attract and retain the qualified personnel necessary to continue to advance our business and achieve our strategic objectives.

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Information Technology Risks

   Significant disruptions of information technology systems or breaches of data security could adversely affect our business.

     Our business is increasingly dependent on critical, complex, and interdependent information technology systems, including Internet-based systems, to support business processes as well as internal and external communications. The size and complexity of our computer systems make them potentially vulnerable to breakdown, malicious intrusion, and computer viruses which may result in the impairment of production and key business processes.

     In addition, our systems are potentially vulnerable to data security breaches—whether by employees or others—which may expose sensitive data to unauthorized persons. Such data security breaches could lead to the loss of trade secrets or other intellectual property, or could lead to the public exposure of personal information (including sensitive personal information) of our employees, clinical trial patients, customers, and others.

     Such disruptions and breaches of security could have a material adverse effect on our business, prospects, operating results, and financial condition.

Risks Related to Our Common Stock

   Our stock price is extremely volatile.

     There has been significant volatility in our stock price and generally in the market prices of biotechnology companies’ securities. Various factors and events may have a significant impact on the market price of our Common Stock. These factors include, by way of example:

  • announcement of actions by the FDA or foreign regulatory authorities or their respective advisory committees regarding our, or our collaborators’ currently pending or future application(s) for regulatory approval of our product candidate(s) or new indications for our marketed products;
  • announcement of submission of an application for regulatory approval of one or more of our product candidates or new indications for our marketed products;
  • progress, delays, or adverse results in clinical trials;
  • announcement of technological innovations or product candidates by us or competitors;
  • fluctuations in our operating results; in particular, net product sales of, and profits from, EYLEA® and, if any of our product candidates or our new indications for our marketed products receive regulatory approval, net product sales of, and profits from, these product candidates and new indications;
  • market acceptance of, and fluctuations in market share for, our marketed products, especially EYLEA®, and whether these factors, including our net products sales, underperform, meet, or exceed the expectations of investors or analysts;
  • third-party claims that our products or technologies infringe their patents;
  • third-party challenges to our patents in the European Patent Office and in the U.S. Patent and Trademark Office;
  • public concern as to the safety or effectiveness of any of our marketed products or product candidates or new indications for our marketed products, including EYLEA®, ZALTRAP®, or ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering therapy;
  • pricing or reimbursement actions or decisions by government authorities or insurers affecting the coverage or reimbursement of any of our marketed products or competitors’ products;
  • our ability to raise additional capital as needed on favorable terms;
  • developments in our relationship with collaborative partners;
  • developments in the biotechnology industry or in government regulation of healthcare;
  • large sales of our Common Stock by our executive officers, directors, or significant shareholders;
  • arrivals and departures of key personnel; and
  • general market conditions.

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     The trading price of our Common Stock has been, and could continue to be, subject to wide fluctuations in response to these and other factors, including the sale or attempted sale of a large amount of our Common Stock in the market. Broad market fluctuations may also adversely affect the market price of our Common Stock.

Future sales of our Common Stock by our significant shareholders or us may depress our stock price and impair our ability to raise funds in new share offerings.

     A small number of our shareholders beneficially own a substantial amount of our Common Stock. As of December 31, 2011, our six largest shareholders plus Leonard S. Schleifer, M.D, Ph.D., our Chief Executive Officer, beneficially owned 61.9% of our outstanding shares of Common Stock, assuming, in the case of our Chief Executive Officer, the conversion of his Class A Stock into Common Stock and the exercise of all options held by him which are exercisable within 60 days of December 31, 2011. In September 2003, Sanofi (then Aventis Pharmaceuticals Inc.) purchased 2,799,552 newly issued, unregistered shares of our Common Stock, and in December 2007 Sanofi purchased an additional 12,000,000 newly issued, unregistered shares of our Common Stock. Under our investor agreement, as amended, with Sanofi, these shares may not be sold until December 20, 2017 except under limited circumstances and subject to earlier termination of these restrictions upon the occurrence of certain events. In addition, in October 2010, Sanofi purchased an additional 1,017,401 shares of Common Stock in our underwritten public offering. As of December 31, 2011, Sanofi beneficially owned 15,816,953 shares of our Common Stock, representing approximately 17.4% of the shares of Common Stock then outstanding. If Sanofi, or our other significant shareholders or we, sell substantial amounts of our Common Stock in the public market, or the perception that such sales may occur exists, the market price of our Common Stock could fall. Sales of Common Stock by our significant shareholders, including Sanofi, also might make it more difficult for us to raise funds by selling equity or equity-related securities in the future at a time and price that we deem appropriate.

Our existing shareholders may be able to exert significant influence over matters requiring shareholder approval.

     Holders of Class A Stock, who are generally the shareholders who purchased their stock from us before our initial public offering, are entitled to ten votes per share, while holders of Common Stock are entitled to one vote per share. As of December 31, 2011, holders of Class A Stock held 18.9% of the combined voting power of all shares of Common Stock and Class A Stock then outstanding. These shareholders, if acting together, would be in a position to significantly influence the election of our directors and the vote on certain corporate transactions that require majority or supermajority approval of the combined classes, including mergers and other business combinations. This may result in our taking corporate actions that other shareholders may not consider to be in their best interest and may affect the price of our Common Stock. As of December 31, 2011:

  • our current executive officers and directors beneficially owned 12.0% of our outstanding shares of Common Stock, assuming conversion of their Class A Stock into Common Stock and the exercise of all options held by such persons which are exercisable within 60 days of December 31, 2011, and 25.0% of the combined voting power of our outstanding shares of Common Stock and Class A Stock, assuming the exercise of all options held by such persons which are exercisable within 60 days of December 31, 2011; and
  • our six largest shareholders plus Leonard S. Schleifer, M.D., Ph.D. our Chief Executive Officer, beneficially owned 61.9% of our outstanding shares of Common Stock, assuming, in the case of our Chief Executive Officer, the conversion of his Class A Stock into Common Stock and the exercise of all options held by him which are exercisable within 60 days of December 31, 2011. In addition, these seven shareholders held 65.1% of the combined voting power of our outstanding shares of Common Stock and Class A Stock, assuming the exercise of all options held by our Chief Executive Officer which are exercisable within 60 days of December 31, 2011.

     Pursuant to an investor agreement, as amended, Sanofi has agreed to vote its shares, at Sanofi’s election, either as recommended by our board of directors or proportionally with the votes cast by our other shareholders, except with respect to certain change of control transactions, liquidation or dissolution, stock issuances equal to or exceeding 10% of the then outstanding shares or voting rights of Common Stock and Class A Stock, and new equity compensation plans or amendments if not materially consistent with our historical equity compensation practices.

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      The anti-takeover effects of provisions of our charter, by-laws, and of New York corporate law and the contractual “standstill” provisions in our investor agreement with Sanofi, could deter, delay, or prevent an acquisition or other “change in control” of us and could adversely affect the price of our Common Stock.

           Our restated certificate of incorporation, our by-laws, and the New York Business Corporation Law contain various provisions that could have the effect of delaying or preventing a change in control of our company or our management that shareholders may consider favorable or beneficial. Some of these provisions could discourage proxy contests and make it more difficult for shareholders to elect directors and take other corporate actions. These provisions could also limit the price that investors might be willing to pay in the future for shares of our Common Stock. These provisions include:

      • authorization to issue “blank check” preferred stock, which is preferred stock that can be created and issued by the board of directors without prior shareholder approval, with rights senior to those of our Common Stock and Class A Stock;
      • a staggered board of directors, so that it would take three successive annual meetings to replace all of our directors;
      • a requirement that removal of directors may only be effected for cause and only upon the affirmative vote of at least eighty percent (80%) of the outstanding shares entitled to vote for directors, as well as a requirement that any vacancy on the board of directors may be filled only by the remaining directors;
      • a provision whereby any action required or permitted to be taken at any meeting of shareholders may be taken without a meeting, only if, prior to such action, all of our shareholders consent, the effect of which is to require that shareholder action may only be taken at a duly convened meeting;
      • a requirement that any shareholder seeking to bring business before an annual meeting of shareholders must provide timely notice of this intention in writing and meet various other requirements; and
      • under the New York Business Corporation Law, in addition to certain restrictions which may apply to “business combinations” involving our company and an “interested shareholder”, a plan of merger or consolidation of our company must be approved by two-thirds of the votes of all outstanding shares entitled to vote thereon. See the risk factor immediately above captioned “Our existing shareholders may be able to exert significant influence over matters requiring shareholder approval.”

           Until the later of the fifth anniversaries of the expiration or earlier termination of our antibody collaboration agreements with Sanofi or our ZALTRAP® collaboration with Sanofi, Sanofi will be bound by certain “standstill” provisions, as amended, which contractually prohibit Sanofi from acquiring more than certain specified percentages of our Class A Stock and Common Stock (taken together) or otherwise seeking to obtain control of our company.

           In addition, we have a Change in Control Severance Plan and our Chief Executive Officer has an employment agreement that provides severance benefits in the event our officers are terminated as a result of a change in control of our company. Many of our stock options issued under our 2000 Long-Term Incentive Plan, as amended and restated, may become fully vested in connection with a “change in control” of our company, as defined in the plan. These contractual provisions may also have the effect of deterring, delaying, or preventing an acquisition or other change in control.

      Risks Relating to Our Convertible Senior Notes and Related Hedge Transactions

      The convertible note hedges and warrant transactions we entered into in connection with our 1.875% Convertible Senior Notes issuance may affect the trading price of our Common Stock.

           In connection with our offering of our 1.875% Convertible Senior Notes due October 1, 2016, we entered into convertible note hedge transactions with four financial institutions (the “hedge counterparties”). The convertible note hedge transactions are expected to reduce the potential dilution to our Common Stock and/or offset potential cash payments in excess of the principal amount of the notes, as the case may be upon conversion of the notes. In the event that the hedge counterparties fail to deliver shares to us or potential cash payments as the case may be as required under the convertible note hedge documents, we would not receive the benefit of such transactions. Separately, we also entered into warrant transactions with the hedge counterparties. The warrant transactions could separately have a dilutive effect from the issuance of Common Stock pursuant to the warrants.

           In connection with hedging these transactions, the hedge counterparties and/or their affiliates may enter into various derivative transactions with respect to our Common Stock, and may enter into, or may unwind, various derivative transactions and/or purchase or sell our Common Stock or other securities of ours in secondary market transactions prior to maturity of the notes (and are likely to do so during any conversion period related to any conversion of the notes). These activities could have the effect of increasing or preventing a decline in, or could have a negative effect on, the value of our Common Stock and could have the effect of increasing or preventing a decline in the value of our Common Stock during any cash settlement averaging period related to a conversion of the notes.

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           In addition, we intend to exercise options under the convertible note hedge transactions whenever notes are converted. In order to unwind its hedge position with respect to the options we exercise, the hedge counterparties and/or their affiliates may sell shares of our Common Stock or other securities in secondary market transactions or unwind various derivative transactions with respect to our Common Stock during the cash settlement averaging period for the converted notes. The effect, if any, of any of these transactions and activities on the trading price of our Common Stock or the notes will depend in part on market conditions and cannot be ascertained at this time, but any of these activities could adversely affect the value of our Common Stock and the value of the notes. The derivative transactions that the hedge counterparties and/or their affiliates expect to enter into to hedge these transactions may include cash-settled equity swaps referenced to our Common Stock. In certain circumstances, the hedge counterparties and/or their affiliates may have derivative positions that, when combined with the hedge counterparties’ and their affiliates’ ownership of our Common Stock, if any, would give them economic exposure to the return on a significant number of shares of our Common Stock.

      The fundamental change provisions of our 1.875% Convertible Senior Notes and certain of the terms of the convertible note hedge and warrant transactions may delay or prevent an otherwise beneficial takeover attempt of us.

           The fundamental change purchase rights, which will allow noteholders to require us to purchase all or a portion of their notes upon the occurrence of a fundamental change, as defined in the indenture governing the notes, and the provisions requiring an increase to the conversion rate for conversions in connection with make-whole fundamental changes, as set forth in the indenture, may in certain circumstances delay or prevent a takeover of us and the removal of incumbent management that might otherwise be beneficial to investors. In addition, upon the occurrence of certain extraordinary events, the convertible note hedge transactions would be exercised upon the conversion of notes, and the warrant transactions may be terminated. It is possible that the proceeds we receive upon the exercise of the convertible note hedge transactions would be significantly lower than the amounts we would be required to pay upon termination of the warrant transactions. Such differences may result in the acquisition of us being on terms less favorable to our shareholders than it would otherwise be.

      ITEM 1B. UNRESOLVED STAFF COMMENTS

           None.

      ITEM 2. PROPERTIES

           We conduct our research, development, manufacturing, and administrative activities at our owned and leased facilities. Under our lease in Tarrytown, New York, as amended, we lease approximately 553,000 square feet of laboratory and office facilities. In addition, in September 2011 we entered into a lease amendment under our Tarrytown lease for approximately 40,000 additional square feet of space, which will commence contingent upon certain building improvements being completed by our landlord. We currently expect our landlord to complete these improvements during the first half of 2012. The term of the Tarrytown, New York lease will expire in June 2024. The lease contains three renewal options to extend the term of the lease by five years each and early termination options on approximately 323,000 square feet of space. The lease provides for monthly payments over its term and additional charges for utilities, taxes, and operating expenses.

           In July 2011, we leased approximately 19,600 square feet of office space in Liberty Corner, New Jersey. The term of the lease expires in January 2017.

           The following table summarizes information regarding our current real property leases:

      Current Monthly
      Square Base Rental   Renewal Option
      Location         Footage       Expiration       Charges(1)       Available
      Tarrytown, New York 553,000 June 2024   $ 1,843,000 Three 5-year terms
      Liberty Corner, New Jersey   19,600 January 2017 $ 37,200 Two 5-year terms
      ____________________
       
            (1)       Excludes additional charges for utilities, real estate taxes, and operating expenses, as defined.

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           We own facilities in Rensselaer, New York, consisting of three buildings totaling approximately 395,000 square feet of research, manufacturing, office, and warehouse space.

           We believe that our existing owned and leased facilities are adequate for ongoing research, development, manufacturing, and administrative activities. In the future, we may lease, operate, or purchase additional facilities in which to conduct expanded research and development and manufacturing activities and support commercial operations.

      ITEM 3. LEGAL PROCEEDINGS

           From time to time, we are a party to legal proceedings in the course of our business. We do not expect any such current ordinary course legal proceedings to have a material adverse effect on our business or financial condition.

      Genentech Patent Litigation

           We are aware of issued patents and pending patent applications owned by Genentech that claim certain chimeric VEGF receptors. We do not believe that ZALTRAP® or EYLEA® infringe any valid claim in these patents or patent applications. We are involved in five patent litigations with Genentech, two in the United States and three in Europe. In November 2010, we commenced a lawsuit against Genentech in the U.S. District Court for the Southern District of New York (the Court), seeking a declaratory judgment that no activities relating to our VEGF Trap infringe any valid claim of certain Genentech patents referred to as the Davis-Smyth patents (the First Davis-Smyth Case). Genentech answered the complaint and asserted counterclaims that our prior or planned activities relating to VEGF Trap have infringed or will infringe claims of four of the five Davis-Smyth patents and requested a judgment against us for damages, including for willful infringement, and other relief as the Court deems appropriate.

           On December 31, 2011, we entered into a non-exclusive license and partial settlement agreement (the Agreement) with Genentech that covers making, using, and selling EYLEA® in the United States for the prevention and treatment of human eye diseases and disorders in the United States. Under the Agreement, we received a non-exclusive license to the Davis-Smyth patents, and certain other technology patents owned or co-owned by Genentech. The Agreement does not cover any non-U.S. patent rights or non-U.S. patent disputes, and does not cover any use of aflibercept other than for prevention and treatment of human eye diseases and disorders in the United States. The First Davis-Smyth Case is continuing with respect to matters not covered by the Agreement. The Agreement provides for us to make payments to Genentech based on U.S. sales of EYLEA® through May 7, 2016, the date the Davis-Smyth patents expire. We will make a lump-sum payment of $60 million once cumulative U.S. sales of EYLEA® reach $400 million. We will also pay royalties of 4.75% on cumulative U.S. sales of EYLEA® between $400 million and $3 billion and 5.5% on any cumulative U.S. sales of EYLEA® over $3 billion. As a result of the Agreement, on January 17, 2012 Genentech filed a second amended answer and counterclaim in the First Davis-Smyth Case, in which it amended its counterclaims alleging infringement of four of the five Davis-Smyth patents. On December 23, 2011, Genentech initiated a related case in the Court against Regeneron and Sanofi alleging infringement of four of the five Davis-Smyth Patents by activities relating to VEGF Trap (but excluding EYLEA®) (the Second Davis-Smyth Case). As in the First Davis-Smyth Case, in the new complaint Genentech requests a judgment against us for damages, including for willful infringement, and other relief as the Court deems appropriate.

           We believe Genentech's claims in the First Davis Smyth Case and the Second Davis Smyth Case are without merit and intend to continue to defend against all of Genentech’s remaining claims vigorously.

           We have initiated patent-related actions against Genentech in Germany, the United Kingdom, and Italy, and may initiate other actions in other countries outside the United States, which could have similar or other adverse outcomes that would materially harm our business and which, irrespective of the outcomes, may also entail significant costs and expenses.

      ITEM 4. NOT APPLICABLE

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      PART II

      ITEM 5. 

      MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS, AND ISSUER PURCHASES OF EQUITY SECURITIES


      Market for Registrant’s Common Equity

           Our Common Stock is quoted on The NASDAQ Global Select Market under the symbol “REGN.” Our Class A Stock, par value $.001 per share, is not publicly quoted or traded.

           The following table sets forth, for the periods indicated, the range of high and low sales prices for our Common Stock as reported by The NASDAQ Global Select Market:

            High       Low
      2010  
             First Quarter $ 30.51 $ 23.42
             Second Quarter 30.58   22.32
             Third Quarter   27.53   20.45
             Fourth Quarter 33.94 24.29
       
      2011
             First Quarter $ 45.11 $ 32.32
             Second Quarter 71.74 41.83
             Third Quarter 79.90 42.83
             Fourth Quarter 66.47 49.58

           As of February 10, 2012, there were 392 shareholders of record of our Common Stock and 45 shareholders of record of our Class A Stock.

           We have never paid cash dividends and do not anticipate paying any in the foreseeable future.

           The information under the heading “Equity Compensation Plan Information” in our definitive proxy statement with respect to our 2012 Annual Meeting of Shareholders to be filed with the SEC is incorporated herein by reference.

      Issuer Purchases of Equity Securities

           The following table reflects shares of Common Stock withheld by us for employees to satisfy their tax withholding obligations arising upon the vesting of restricted equity awards granted under our Amended and Restated Long-Term Incentive Plan.

      Maximum Number (or
      Total Number of Approximate Dollar
      Shares (or Units) Value) of Shares (or
      Total Number of Average Price Purchased as Part of   Units) that May Yet Be
        Shares (or Units) Paid per Share   Publically Announced Purchased Under the
      Period       Purchased       (or Unit)       Plans or Programs       Plans or Programs
      12/1/2011-12/31/2011 51,549 51.18 -- --

      Recent Sales of Unregistered Securities

           There were no unregistered sales of equity securities in 2011 that have not been previously reported in a Quarterly Report on Form 10-Q.

      43


      STOCK PERFORMANCE GRAPH

           Set forth below is a line graph comparing the cumulative total shareholder return on Regeneron's Common Stock with the cumulative total return of (i) The NASDAQ Pharmaceuticals Stocks Index and (ii) The NASDAQ Stock Market (U.S.) Index for the period from December 31, 2006 through December 31, 2011. The comparison assumes that $100 was invested on December 31, 2006 in our Common Stock and in each of the foregoing indices. All values assume reinvestment of the pre-tax value of dividends paid by companies included in these indices. The historical stock price performance of our Common Stock shown in the graph below is not necessarily indicative of future stock price performance.

            12/31/2006       12/31/2007       12/31/2008       12/31/2009       12/31/2010       12/31/2011
      Regeneron   $ 100.00 $ 120.33   $ 91.48   $ 120.48 $ 163.58   $ 276.18
      NASDAQ Pharm   100.00   105.17   97.85   109.95   119.19 127.71
      NASDAQ US 100.00 108.47 135.11 95.38 113.19 113.81

      44


      Item 6. Selected Financial Data

           The selected financial data set forth below for the years ended December 31, 2011, 2010, and 2009 and at December 31, 2011 and 2010 are derived from and should be read in conjunction with our audited financial statements, including the notes thereto, included elsewhere in this report. The selected financial data for the years ended December 31, 2008 and 2007 and at December 31, 2009, 2008, and 2007 are derived from our audited financial statements not included in this report.

      Year Ended December 31,
            2011       2010       2009       2008       2007
      (In thousands, except per share data)
      Statement of Operations Data
      Revenues    
             Collaboration revenue $ 369,681 $ 386,725 $ 314,457 $ 185,138 $ 87,648
             Net product sales 44,686   25,254   18,364 6,249
             Technology licensing 24,858 40,150   40,013   40,000   28,421
             Contract research and other 6,599   6,945 6,434 7,070 8,955
      445,824 459,074 379,268 238,457 125,024
       
      Expenses
             Research and development 529,506 489,252 398,762 274,903 202,468
             Selling, general, and administrative 117,261 65,201 52,923 48,880 37,929
             Cost of goods sold 4,216 2,093 1,686 923
      650,983 556,546 453,371 324,706 240,397
       
      Loss from operations (205,159 ) (97,472 ) (74,103 ) (86,249 ) (115,373 )
       
      Other income (expense)
             Investment income 3,549 2,122 4,488 18,161 20,897
             Interest expense (21,282 ) (9,118 ) (2,337 ) (7,752 ) (12,043 )
             Loss on early extinguishment of debt (938 )
      (17,733 ) (6,996 ) 2,151 9,471 8,854
       
      Net loss before income tax (benefit) expense (222,892 ) (104,468 ) (71,952 ) (76,778 ) (106,519 )
       
      Income tax (benefit) expense (1,132 ) (4,122 ) 2,351
       
      Net loss $ (221,760 ) $ (104,468 ) $ (67,830 ) $ (79,129 ) $ (106,519 )
       
      Net loss per share, basic and diluted $ (2.45 ) $ (1.26 ) $ (0.85 ) $ (1.00 ) $ (1.61 )

      At December 31,
            2011       2010       2009       2008       2007
      (In thousands)
      Balance Sheet Data
      Unrestricted and restricted cash, cash equivalents, and
             marketable securities (current and non-current) $ 810,550 $ 626,939 $ 390,010 $ 527,461 $ 846,279
      Total assets 1,323,583 1,089,432 741,202 724,220 957,881
      Notes payable (current and non-current) 275,019 200,000
      Facility lease obligations (current and non-current) 160,514 160,030 109,022 54,182 21,623
      Capital lease obligations (current and non-current) 2,506 2,829
      Stockholders' equity 485,732 527,815 396,762 421,514 459,348

      45


      ITEM 7. 

      MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

      Overview

           We are a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. We currently have two marketed products in the United States, EYLEA® (aflibercept) Injection and ARCALYST® (rilonacept), and a late-stage product candidate, ZALTRAP® (aflibercept), which has been submitted for marketing approval in the United States and the European Union by our collaborator Sanofi, as described below.

           In November 2011, we received U.S. marketing approval from the FDA for EYLEA® for the treatment of patients with wet AMD. Wet AMD is the leading cause of acquired blindness for people over the age of 65 in the United States and Europe. In the United States, the wet AMD market is approximately $1.5 billion. Our net product sales of EYLEA® in the fourth quarter of 2011 were $24.8 million. Our operating results over the next several years will be largely dependent upon our ability to successfully commercialize EYLEA® and the market penetration it achieves.

           In 2011, Bayer HealthCare submitted regulatory applications for marketing approval of EYLEA® in wet AMD in the European Union, Japan, and other countries. In addition, we submitted a supplemental BLA to the FDA for marketing approval of EYLEA® in CRVO in the United States and, under PDUFA, were granted a target date for an FDA decision on our EYLEA® supplemental BLA of September 23, 2012. Bayer HealthCare also plans to submit regulatory applications in this indication in Europe in late 2012 or early 2013.

           ARCALYST® (rilonacept) Injection for Subcutaneous Use is available by prescription in the United States for the treatment of CAPS, including FCAS and MWS in adults and children 12 and older. CAPS are a group of rare, inherited, auto-inflammatory conditions that afflict a small patient population. Net product sales of ARCALYST® in 2011 were $19.9 million, and we do not expect future net product sales of ARCALYST® for the treatment of CAPS to be significant. In November 2011, the FDA accepted for review a supplemental BLA for marketing approval in the United States of ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering therapy. Under PDUFA, we were granted a target date for an FDA decision on our ARCALYST® supplemental BLA of July 30, 2012.

           Sanofi submitted a regulatory application for marketing approval of ZALTRAP® for the treatment of previously-treated mCRC patients to the European Medicines Agency (EMA) in the fourth quarter of 2011, and the FDA in early February 2012.

           We expect to incur substantial costs to prepare for potential commercialization of ARCALYST® for the treatment of gout flares in patients initiating uric acid-lowering therapy and ZALTRAP® for the treatment of previously-treated mCRC patients and, if one or both receive regulatory approval, to fund the launch of the product(s). Since inception, we have not generated any significant sales or profits from the commercialization of EYLEA®, ARCALYST®, or any of our other product candidates.

           We have 13 product candidates in clinical development, all of which were discovered in our research laboratories. Our Trap-based, late-stage programs are:

      • EYLEA®, which is being developed for the treatment of additional serious eye diseases;
      • ZALTRAP®, which is being developed in oncology in collaboration with Sanofi; and
      • ARCALYST®, which is being developed for the prevention of gout flares in patients initiating uric acid-lowering treatment.

      46


           Our antibody-based clinical programs include the following fully human monoclonal antibodies:

      • Sarilumab (REGN88), an antibody to the interleukin-6 receptor (IL-6R), which is being developed in rheumatoid arthritis;
      • REGN727, an antibody to Proprotein Convertase Substilisin/Kexin type 9 (PCSK9), which is being developed for low-density lipoprotein (LDL) cholesterol reduction;
      • REGN668, an antibody to the interleukin-4 receptor (IL-4R), which is being developed in atopic dermatitis and eosinophilic asthma;
      • REGN421, an antibody to Delta-like ligand-4 (Dll4), a novel angiogenesis target, which is being developed in oncology;
      • REGN910, an antibody to Angiopoietin-2 (ANG2), another novel angiogenesis target, which is being developed in oncology;
      • REGN475, an antibody to Nerve Growth Factor (NGF), which is being developed for the treatment of pain (currently on clinical hold);
      • REGN728, an antibody in clinical development against an undisclosed target;
      • REGN1033, an antibody in clinical development against an undisclosed target;
      • REGN846, an antibody in clinical development against an undisclosed target, which is being developed in atopic dermatitis; and
      • REGN1154, an antibody in clinical development against an undisclosed target.

           With the exception of REGN475, REGN846, and REGN1154, which we are developing independently, all of these antibodies are being developed in collaboration with Sanofi.

           Developing and commercializing new medicines entails significant risk and expense. Before significant revenues from the commercialization of our antibody candidates or new indications for our marketed products can be realized, we (or our collaborators) must overcome a number of hurdles which include successfully completing research and development and obtaining regulatory approval from the FDA and regulatory authorities in other countries. In addition, the biotechnology and pharmaceutical industries are rapidly evolving and highly competitive, and new developments may render our products and technologies uncompetitive or obsolete.

           Historically, we have generally incurred net losses and negative cash flows from operations since our inception in 1988. Our potential to generate profits and positive cash flow from operations over the next several years depends significantly on our success in commercializing EYLEA®; otherwise, we expect to continue to incur operating losses. We expect to continue to incur substantial expenses related to our research and development activities, a significant portion of which we expect to be reimbursed by our collaborators. Also, our research and development activities outside our collaborations, the costs of which are not reimbursed, may expand and require additional resources. Our operating results may fluctuate from quarter to quarter and will depend on, among other factors, the net sales of our marketed products, as well as the scope and progress of our research and development efforts, the timing of certain expenses, and the amount of reimbursement that we receive from collaborators. We cannot predict whether or when ZALTRAP® or new indications for our marketed products will receive regulatory approval or, if any such approval is received, whether we will be able to successfully commercialize such product(s) and whether or when they may become profitable.

           A primary driver of our expenses is our number of full-time employees. Our annual average headcount in 2011 was 1,568 compared with 1,249 in 2010 and 980 in 2009. In 2011, our average headcount increased primarily to support our expanded research and development activities in connection with our antibody collaboration with Sanofi and in connection with commercializing EYLEA® for the treatment of wet AMD. In 2012, we expect our average headcount to increase to approximately 1,800-1,850, primarily to support antibody manufacturing at our Rensselaer, New York manufacturing facilities, and activities in connection with preparing for the potential commercialization of ARCALYST® for the prevention of gout flares in patients initiating uric acid-lowering treatment.

           The planning, execution, and results of our clinical programs are significant factors that can affect our operating and financial results. In our clinical programs, key events in 2011 and 2012 to date were, and plans for the remainder of 2012 are, as follows:

      47


      Trap-based Clinical Programs:

      2011 and 2012 Events to Date 2012 Plans

             EYLEA®

      • Submitted a BLA to the U.S. FDA for the treatment of wet AMD
      • FDA accepted BLA for wet AMD and granted our request for Priority Review
      • FDA Advisory Committee unanimously recommended FDA approval of BLA for the treatment of wet AMD
      • FDA approved EYLEA® for the treatment of wet AMD in the U.S. and product was launched
      • Bayer HealthCare submitted regulatory applications for marketing approval for EYLEA® for the treatment of wet AMD in the European Union, Japan, and other countries
      • Reported positive two-year data from Phase 3 VIEW 1 and VIEW 2 trials in wet AMD
      • Reported positive results in the Phase 3 COPERNICUS and GALILEO trials in CRVO
      • Submitted a supplemental BLA to the FDA for the treatment of CRVO
      • Initiated Phase 3 trials in DME in the U.S. (VISTA) and outside the U.S. (VIVID)
      • Bayer HealthCare initiated a Phase 3 trial in Asia in CNV of the retina as a result of pathologic myopia
      • Bayer HealthCare initiated Phase 3 SIGHT trial in China in wet AMD
      • Initiate Phase 3 study in BRVO in the first quarter of 2012
      • EMA decision on regulatory application for the treatment of wet AMD
      • Japan authority decision on regulatory application for the treatment of wet AMD
      • Target date for FDA decision on supplemental BLA for the treatment of CRVO is September 23, 2012
       

             ZALTRAP®

      • Presented positive results from the Phase 3 VELOUR trial in previously treated mCRC patients
      • IDMC reviewed interim results for the Phase 3 VENICE trial in prostate cancer and recommended study continue to completion
      • Reported that the VITAL trial in non-small cell lung cancer did not meet its primary endpoint
      • Reported initial results in the Phase 2 AFFIRM trial in first-line mCRC
      • Submitted regulatory applications for marketing approval to the EMA and FDA for the treatment of mCRC
      • Report final results in the Phase 3 VENICE trial in prostate cancer in the second quarter of 2012
       

      ARCALYST®

      • Reported positive results from two Phase 3 studies for the prevention of gout flares (PRE-SURGE 2 and RE-SURGE)
      • Submitted a supplemental BLA for U.S. regulatory approval for the prevention of gout flares
      • Initiated a long-term safety study for the prevention of gout flares (UPSURGE)
      • Target date for FDA decision on ARCALYST® supplemental BLA is July 30, 2012
       

      48


      Antibody-based Clinical Programs:

      2011 and 2012 Events to Date 2012 Plans

      Sarilumab
      (IL-6R Antibody)

      • Reported positive Phase 2b data from the MOBILITY trial in rheumatoid arthritis
      • Reported that the Phase 2b trial in ankylosing spondylitis did not meet its primary endpoint
      • Initiated the Phase 3 stage of the Phase 2/3 MOBILITY trial
      • Initiate additional Phase 3 studies
       

      REGN727
      (PCSK9 Antibody)

      • Initiated three Phase 2 studies for LDL cholesterol reduction
      • Reported positive initial data from two of the Phase 2 studies
      • Report final data from three Phase 2 studies for LDL cholesterol reduction
      • Initiate Phase 3 program for LDL cholesterol reduction
       

      REGN668
      (IL-4R Antibody)

      • Initiated Phase 1b study in atopic dermatitis
      • Initiated Phase 2 proof of concept study in eosinophilic asthma
      • Report initial results for Phase 1b study in atopic dermatitis and initiate Phase 2 program
      • Report initial results for Phase 2 study in eosinophilic asthma
       

      REGN421
      (Dll4 Antibody)

      • Continued patient enrollment in Phase 1 program
      • Initiate a Phase 1b program in advanced malignancies
       

      REGN910
      (ANG2 Antibody)
      • Continued patient enrollment in Phase 1 program
       

      REGN475
      (NGF Antibody)

      • Anti-NGF class of antibodies is on clinical hold
      • Sanofi elected not to co-develop REGN475
      • FDA Advisory Committee meeting scheduled for March 2012 to review safety of anti-NGF class of antibodies
       

      REGN728
      (target not disclosed)

      • Continued patient enrollment in Phase 1 program
       

      REGN846
      (target not disclosed)

      • Continued patient enrollment in Phase 1 program
      • Sanofi elected not to co-develop REGN846
      • Initiated Phase 2a program in atopic dermatitis
       

      REGN1033
      (target not disclosed)
      • IND accepted by the FDA
      • Initiated Phase 1 program
       

      REGN1154
      (target not disclosed)

      • Initiate Phase 1 program
       

      49


      Critical Accounting Policies and Use of Estimates

           A summary of the significant accounting policies that impact us is provided in Note 2 to our Financial Statements, beginning on page F-7. The preparation of financial statements in accordance with accounting principles generally accepted in the United States of America (GAAP) requires management to make estimates and assumptions that affect reported amounts and related disclosures in the financial statements. Management considers an accounting estimate to be critical if:

      • It requires an assumption (or assumptions) regarding a future outcome; and
      • Changes in the estimate or the use of different assumptions to prepare the estimate could have a material effect on our results of operations or financial condition.

           Management believes the current assumptions used to estimate amounts reflected in our financial statements are appropriate. However, if actual experience differs from the assumptions used in estimating amounts reflected in our financial statements, the resulting changes could have a material adverse effect on our results of operations, and in certain situations, could have a material adverse effect on our liquidity and financial condition. The critical accounting estimates that impact our financial statements are described below.

      Revenue Recognition

      Collaboration Revenue

           We earn collaboration revenue in connection with collaboration agreements to develop and commercialize product candidates and utilize our technology platforms. We currently have collaboration agreements with Sanofi and Bayer HealthCare. The terms of collaboration agreements typically include non-refundable up-front licensing payments, research progress (milestone) payments, and payments for development activities. Non-refundable up-front license payments, where continuing involvement is required of us, are deferred and recognized over the related performance period. We estimate our performance period based on the specific terms of each agreement, and adjust the performance periods, if appropriate, based on the applicable facts and circumstances. Although we did not enter into, or materially modify, any collaboration arrangements with multiple-deliverables in 2011, any future arrangements with multiple deliverables will be divided into separate units of accounting if the deliverables in the arrangement meet certain criteria, including whether the delivered item or items has value to the collaborator on a standalone basis. Payments which are based on achieving a specific performance milestone, involving a degree of risk, are recognized as revenue when the milestone is achieved and the related payment is due and non-refundable, provided there is no future service obligation associated with that milestone. Substantive performance milestones typically consist of significant achievements in the development life-cycle of the related product candidate, such as completion of clinical trials, filing for approval with regulatory agencies, and receipt of approvals by regulatory agencies. In determining whether a payment is deemed to be a substantive performance milestone, we take into consideration (i) the enhancement in value to the related development product candidate, (ii) our performance and the relative level of effort required to achieve the milestone, (iii) whether the milestone relates solely to past performance, and (iv) whether the milestone payment is considered reasonable relative to all of the deliverables and payment terms. Payments for achieving milestones which are not considered substantive are deferred and recognized over the related performance period.

           We enter into collaboration agreements that include varying arrangements regarding which parties perform and bear the costs of research and development activities. We may share the costs of research and development activities with our collaborator, such as in our EYLEA® collaboration with Bayer HealthCare, or we may be reimbursed for all or a significant portion of the costs of our research and development activities, such as in our ZALTRAP® and antibody collaborations with Sanofi. We record our internal and third-party development costs associated with these collaborations as research and development expenses. When we are entitled to reimbursement of all or a portion of the research and development expenses that we incur under a collaboration, we record those reimbursable amounts as collaboration revenue proportionately as we recognize our expenses. If the collaboration is a cost-sharing arrangement in which both we and our collaborator perform development work and share costs, in periods when our collaborator incurs development expenses that benefit the collaboration and Regeneron, we also recognize, as additional research and development expense, the portion of the collaborator’s development expenses that we are obligated to reimburse. In certain cases, we may also share the costs of pre-launch commercialization activities with our collaborators. We record our share of these costs as a reduction of collaboration revenue.

      50


           In connection with non-refundable licensing payments, our performance period estimates are principally based on projections of the scope, progress, and results of our research and development activities. Due to the variability in the scope of activities and length of time necessary to develop a drug product, changes to development plans as programs progress, and uncertainty in the ultimate requirements to obtain governmental approval for commercialization, revisions to performance period estimates are likely to occur periodically, and could result in material changes to the amount of revenue recognized each year in the future. In addition, our estimated performance periods may change if development programs encounter delays or we and our collaborators decide to expand or contract our clinical plans for a drug candidate in various disease indications. Also, if a collaborator terminates an agreement in accordance with the terms of the agreement, we would recognize any unamortized remainder of an up-front or previously deferred payment at the time of the termination.

      Product Revenue

           Product sales consist of U.S. sales of our two marketed products, EYLEA® and ARCALYST®. Revenue from product sales is recognized when persuasive evidence of an arrangement exists, title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, we have no further performance obligations, and returns can be reasonably estimated. Our written contracts with our distributors and specialty pharmacies (collectively, our “customers”) stipulate that product is shipped freight on board destination (FOB destination). We record revenue from product sales upon delivery to our customers.

           We sell EYLEA® in the United States to three distributors and several specialty pharmacies. We sell ARCALYST® in the United States to two specialty pharmacies. Under these distribution models, the distributors and specialty pharmacies generally take physical delivery of product. For EYLEA®, the distributors and specialty pharmacies generally sell the product directly to healthcare providers, whereas for ARCALYST®, the specialty pharmacies sell the product directly to patients.

           Revenue from product sales are recorded net of applicable provisions for prompt pay discounts, rebates and chargebacks under governmental programs (including Medicaid), product returns, distribution-related fees, and other sales-related deductions. Calculating these provisions involves estimates and judgments. We review our estimates of rebates, chargebacks, and other applicable provisions each period and record any necessary adjustments in the current period’s net product sales.

           Prompt Pay Discounts: No prompt pay discounts are currently offered to our customers on sales of EYLEA®. In connection with sales of ARCALYST®, we offer discounts to our customers for prompt payments. We estimate these discounts based on customer terms and historical experience, and expect that our customers will always take advantage of this discount. Therefore, we accrue 100% of the prompt pay discount that is based on the gross amount of each ARCALYST® invoice at the time of sale. Our accrual for prompt pay discounts was not material at December 31, 2011 and 2010.

           Government Rebates and Chargebacks: We estimate reductions to product sales for Medicaid and Veterans’ Administration (VA) programs, and for certain other qualifying federal and state government programs. Based upon our contracts with government agencies, statutorily-defined discounts applicable to government-funded programs, historical experience, and, in the case of EYLEA®, estimated payer mix based on third-party market research data, we estimate and record an allowance for rebates and chargebacks. Our liability for Medicaid rebates consists of estimates for claims that a state will make for a current quarter, claims for prior quarters that have been estimated for which an invoice has not been received, and invoices received for claims from prior quarters that have not been paid. Our reserves related to discounted pricing offered to VA, Public Health Services (PHS), and other institutions (collectively, “qualified healthcare providers”) represent our estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices we charge to our customers. Our customers charge us for the difference between what they pay for the products and the ultimate selling price to the qualified healthcare providers. Our reserve for this discounted pricing is based on expected sales to qualified healthcare providers and the chargebacks that customers have already claimed. Our government rebate and chargeback accruals were $0.6 million at December 31, 2011, which was based on a percentage of gross sales. Government rebate and chargeback accruals were not material at December 31, 2010.

      51


           Product Returns: Consistent with industry practice, we offer our customers a limited right to return product purchased directly from us, which is principally based upon the product’s expiration date. We will accept returns for three months prior to and up to six months after the product expiration date. Product returned is generally not resalable given the nature of our products and method of administration. We develop estimates for product returns based upon historical experience, inventory levels in the distribution channel, and other relevant factors.

           We have developed estimates for EYLEA® product returns, based on several factors, including (i) our historical experience to date, and our expectation, that our customers will not stock significant supplies of EYLEA® due to contractual limitations and other mitigating circumstances, (ii) historical industry information regarding product return rates for similar specialty products, and (iii) the shelf life of the product. Estimates for ARCALYST® product returns have been developed based primarily on our historical returns experience; to date, actual ARCALYST® product returns have been negligible. We monitor product supply levels in the distribution channel, as well as sales by our customers of EYLEA® to healthcare providers and ARCALYST® to patients using product-specific data provided by our customers. If necessary, our estimates of product returns may be adjusted in the future based on actual returns experience, known or expected changes in the marketplace, or other factors. Our product returns accruals were not material at December 31, 2011 or 2010.

           Distribution-Related Fees: We have written contracts with our customers that include terms for distribution-related fees. We estimate and record distribution and related fees due to our customers based on a percentage of gross sales. Our accrual for distribution-related fees was $1.5 million at December 31, 2011. Our accrual for distribution-related fees at December 31, 2010 was not material.

      Clinical Trial Expenses

           Clinical trial costs are a significant component of research and development expenses and include costs associated with third-party contractors. We outsource a substantial portion of our clinical trial activities, utilizing external entities such as CROs, independent clinical investigators, and other third-party service providers to assist us with the execution of our clinical studies. For each clinical trial that we conduct, certain clinical trial costs are expensed immediately, while others are expensed over time based on the expected total number of patients in the trial, the rate at which patients enter the trial, and the period over which clinical investigators or CROs are expected to provide services.

           Clinical activities which relate principally to clinical sites and other administrative functions to manage our clinical trials are performed primarily by CROs. CROs typically perform most of the start-up activities for our trials, including document preparation, site identification, screening and preparation, pre-study visits, training, and program management. On a budgeted basis, these start-up costs are typically 10% to 20% of the total contract value. On an actual basis, this percentage range can be significantly wider, as many of our contracts with CROs are either expanded or reduced in scope compared to the original budget, while start-up costs for the particular trial may not change materially. These start-up costs usually occur within a few months after the contract has been executed and are event driven in nature. The remaining activities and related costs, such as patient monitoring and administration, generally occur ratably throughout the life of the individual contract or study. In the event of early termination of a clinical trial, we accrue and recognize expenses in an amount based on our estimate of the remaining non-cancelable obligations associated with the winding down of the clinical trial and/or penalties.

           For clinical study sites, where payments are made periodically on a per-patient basis to the institutions performing the clinical study, we accrue expense on an estimated cost-per-patient basis, based on subject enrollment and activity in each quarter. The amount of clinical study expense recognized in a quarter may vary from period to period based on the duration and progress of the study, the activities to be performed by the sites each quarter, the required level of patient enrollment, the rate at which patients actually enroll in and drop-out of the clinical study, and the number of sites involved in the study. Clinical trials that bear the greatest risk of change in estimates are typically those that have a significant number of sites, require a large number of patients, have complex patient screening requirements, and span multiple years. During the course of a trial, we adjust our rate of clinical expense recognition if actual results differ from our estimates. Our estimates and assumptions for clinical expense recognition could differ significantly from our actual results, which could cause material increases or decreases in research and development expenses in future periods when the actual results become known. No material adjustments to our past clinical trial accrual estimates were made during the years ended December 31, 2011, 2010, or 2009.

      52


      Stock-based Compensation

           We recognize stock-based compensation expense for grants of stock option awards and restricted stock under our long-term incentive plans to employees and non-employee members of our board of directors based on the grant-date fair value of those awards. The grant-date fair value of an award is generally recognized as compensation expense over the award’s requisite service period.

           We use the Black-Scholes model to compute the estimated fair value of stock option awards. Using this model, fair value is calculated based on assumptions with respect to (i) expected volatility of our Common Stock price, (ii) the periods of time over which employees and members of our board of directors are expected to hold their options prior to exercise (expected lives), (iii) expected dividend yield on our Common Stock, and (iv) risk-free interest rates, which are based on quoted U.S. Treasury rates for securities with maturities approximating the options’ expected lives. Expected volatility has been estimated based on actual movements in our stock price over the most recent historical periods equivalent to the options’ expected lives. Expected lives are principally based on our historical exercise experience with previously issued employee and board of directors option grants. The expected dividend yield is zero as we have never paid dividends and do not currently anticipate paying any in the foreseeable future. Stock-based compensation expense also includes an estimate, which is made at the time of grant, of the number of awards that are expected to be forfeited. This estimate is revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.

           The assumptions used in computing the fair value of option awards reflect our best estimates but involve uncertainties related to market and other conditions, many of which are outside of our control. Changes in any of these assumptions may materially affect the fair value of stock options granted and the amount of stock-based compensation recognized in future periods.

           In addition, we have granted performance-based stock option awards which vest based upon the optionee satisfying certain performance and service conditions as defined in the agreements. Potential compensation cost, measured on the grant date, related to these performance options will be recognized only if, and when, we estimate that these options will vest, which is based on whether we consider the options’ performance conditions to be probable of attainment. Our estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods. Changes in these estimates may materially affect the amount of stock-based compensation that we recognize in future periods related to performance-based options.

      Marketable Securities

           We have invested our excess cash primarily in direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities. We consider our marketable securities to be “available-for-sale,” as defined by authoritative guidance issued by the Financial Accounting Standards Board (FASB). These assets are carried at fair value and the unrealized gains and losses are included in other accumulated comprehensive income (loss) as a separate component of stockholders’ equity. If the decline in the value of a marketable security in our investment portfolio is deemed to be other-than-temporary, we write down the security to its current fair value and recognize a loss that may be charged against income.

           We review our portfolio of marketable securities, using both quantitative and qualitative factors, to determine if declines in fair value below cost are other-than-temporary. Such factors include the length of time and the extent to which market value has been less than cost, financial condition and near-term prospects of the issuer, recommendations of investment advisors, and forecasts of economic, market, or industry trends. With respect to debt securities, this review process also includes an evaluation of our intent to sell an individual debt security or our need to sell the debt security before its anticipated recovery or maturity. With respect to equity securities, this review process includes an evaluation of our ability and intent to hold the securities until their full value can be recovered. This review is subjective and requires a high degree of judgment. We recorded no charges for other-than-temporary impairment of our marketable securities during 2011, and inconsequential charges for other-than-temporary impairment of our marketable securities during 2010 and 2009.

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      Depreciation of Property, Plant, and Equipment

           Property, plant, and equipment are stated at cost, net of accumulated depreciation. Depreciation is provided on a straight-line basis over the estimated useful lives of the assets. In some situations, the life of the asset may be extended or shortened if circumstances arise that would lead us to believe that the estimated life of the asset has changed. The life of leasehold improvements may change based on the extension of lease contracts with our landlords. Changes in the estimated lives of assets will result in an increase or decrease in the amount of depreciation recognized in future periods.

      Results of Operations

      Years Ended December 31, 2011 and 2010

      Net Loss

           We reported a net loss of $221.8 million, or $2.45 per share (basic and diluted), for the year ended December 31, 2011, compared to a net loss of $104.5 million, or $1.26 per share (basic and diluted) for 2010. The increase in our net loss in 2011 was principally due to higher selling, general, and administrative expenses, partly in connection with commercializing EYLEA® for wet AMD, and higher research and development expenses.

      Revenues

           Revenues in 2011 and 2010 consist of the following:

      (In millions) 2011 2010
      Collaboration revenue            
             Sanofi $ 326.6 $ 311.3
             Bayer HealthCare 43.1 75.4
                    Total collaboration revenue 369.7 386.7
      Net product sales   44.7 25.3
      Technology licensing revenue 24.8   40.2
      Contract research and other revenue 6.6 6.9
                    Total revenue $ 445.8 $ 459.1

      Sanofi Collaboration Revenue

           The collaboration revenue we earned from Sanofi, as detailed below, consisted primarily of reimbursement for research and development expenses and recognition of revenue related to non-refundable up-front payments of $105.0 million related to the ZALTRAP® collaboration and $85.0 million related to the antibody collaboration.

      Years ended
      Sanofi Collaboration Revenue   December 31,
      (In millions) 2011       2010
      ZALTRAP®:      
             Regeneron expense reimbursement $ 16.9 $ 16.5
             Recognition of deferred revenue related to up-front payments 9.9 9.9
             Regeneron share of ZALTRAP® commercialization expenses   (9.3 )    
                    Total ZALTRAP® 17.5 26.4
      Antibody:
             Regeneron expense reimbursement 299.3 276.0
             Recognition of deferred revenue related to up-front and other
                    payments 8.2 7.3
             Recognition of revenue related to VelociGene® agreement 1.6 1.6
                    Total antibody 309.1 284.9
      Total Sanofi collaboration revenue $ 326.6 $ 311.3

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           Sanofi’s reimbursement of our ZALTRAP® expenses increased slightly in 2011 compared to 2010, primarily due to higher costs related to manufacturing ZALTRAP® supplies, offset by a decrease in other research and development activities. Effective in 2011, we and Sanofi began equally sharing pre-launch commercialization expenses related to ZALTRAP® in accordance with the companies’ collaboration agreement. Our share of these expenses was $9.3 million in 2011, which reduced our Sanofi collaboration revenue. In connection with recognition of deferred revenue related to ZALTRAP®, as of December 31, 2011, $22.6 million of the original $105.0 million of up-front payments was deferred and will be recognized as revenue in future periods.

           In 2011, Sanofi’s reimbursement of our antibody expenses consisted of $161.9 million under the discovery agreement and $137.4 million of development costs under the license agreement, compared to $137.7 million and $138.3 million, respectively, in 2010. The higher reimbursement amount under the discovery agreement in 2011 compared to 2010 was primarily due to an increase in our antibody discovery activities. The slightly lower reimbursement of development costs in 2011 compared to 2010 was primarily due to a decrease in development activities related to REGN475, which is currently on clinical hold, offset generally by increases in development activities for other antibody candidates.

           Recognition of deferred revenue related to Sanofi’s $85.0 million up-front payment and other payments increased in 2011 compared to 2010. In connection with the November 2009 amendment of the discovery agreement, Sanofi is funding up to $30 million of agreed-upon costs incurred by us to expand our manufacturing capacity at our Rensselaer, New York facilities, of which $28.2 million was received or receivable as of December 31, 2011. Revenue related to such funding from Sanofi is deferred and recognized as collaboration revenue prospectively over the related performance period in conjunction with the recognition of the original $85.0 million up-front payment. As of December 31, 2011, $76.4 million of these up-front and other payments was deferred and will be recognized as revenue in future periods.

           In August 2008, we entered into a separate VelociGene® agreement with Sanofi. In 2011 and 2010, we recognized $1.6 million in revenue related to this agreement.

      Bayer HealthCare Collaboration Revenue

           The collaboration revenue we earned from Bayer HealthCare, as detailed below, consisted of cost sharing of Regeneron EYLEA® development expenses, substantive performance milestone payments, and recognition of revenue related to a non-refundable $75.0 million up-front payment received in October 2006 and a $20.0 million milestone payment received in August 2007 (which, for the purpose of revenue recognition, was not considered substantive).

      Years ended
      Bayer HealthCare Collaboration Revenue   December 31,
      (In millions) 2011       2010
      Cost-sharing of Regeneron EYLEA® development expenses       $ 33.7 $ 45.5
      Substantive performance milestone payments 20.0
      Recognition of deferred revenue related to up-front and other milestone    
             payments 9.4 9.9
             Total Bayer HealthCare collaboration revenue $ 43.1 $ 75.4

           Cost-sharing of our global EYLEA® development expenses with Bayer HealthCare decreased in 2011 compared to 2010 due primarily to lower clinical development costs in connection with our Phase 3 VIEW 1 trial in wet AMD and our Phase 2 trial in DME. In the fourth quarter of 2010, we earned two $10.0 million substantive milestone payments from Bayer HealthCare for achieving positive 52-week results in the VIEW 1 study and positive 6-month results in the COPERNICUS study. Recognition of deferred revenue related to the up-front and August 2007 milestone payments from Bayer HealthCare decreased in 2011 from 2010 due to an extension of the estimated performance period over which this deferred revenue is being recognized, effective in the fourth quarter of 2011. As of December 31, 2011, $42.4 million of these up-front and milestone payments was deferred and will be recognized as revenue in future periods.

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      Net Product Sales

           Product sales consist of U.S. sales of our two marketed products, EYLEA® and ARCALYST®. We record product sales net of allowances and accruals for prompt pay discounts, rebates and chargebacks under governmental programs (including Medicaid), product returns, and distribution-related fees. We expect our customers to stock limited supplies of our products due to (i) contractual limitations that we and our customers establish, (ii) our products’ specialty nature, sales price, and distribution channels, and (iii) our historical experience to date.

           In November 2011, we received marketing approval from the FDA for EYLEA® for the treatment of wet AMD, at which time product sales commenced. For the year ended December 31, 2011, we recognized as revenue $24.8 million of EYLEA® net product sales.

           In 2011 and 2010, we recognized as revenue $19.9 million and $25.3 million, respectively, of ARCALYST® net product sales. ARCALYST® for the treatment of CAPS, a group of rare, inherited auto-inflammatory diseases that affect a very small group of people, was our first commercialized drug product. ARCALYST® net product sales in 2010 included $20.5 million of ARCALYST® net product sales made in 2010 and $4.8 million of previously deferred net product sales.

           At December 31, 2011 and 2010, there was no deferred revenue related to net product sales.

      Technology Licensing Revenue

           In connection with our VelocImmune® license agreement with Astellas, the $20.0 million non-refundable payment received in the second quarter of 2010 was deferred upon receipt and recognized as revenue ratably over the ensuing year. In addition, in connection with the amendment and extension of our license agreement with Astellas, in August 2010, we received a $165.0 million up-front payment, which was deferred upon receipt and is being recognized as revenue ratably over a seven-year period beginning in June 2011. In connection with our VelocImmune license agreement with AstraZeneca, which terminated effective as of February 2011, the $20.0 million non-refundable payment received in the first quarter of 2010 was deferred upon receipt and recognized as revenue ratably through February 2011. In 2011 and 2010, we recognized $24.8 million and $40.0 million, respectively, of technology licensing revenue related to these agreements. As of December 31, 2011, $151.7 million of the August 2010 technology licensing payment received from Astellas was deferred and will be recognized as revenue in future periods.

      Contract Research and Other Revenue

           Contract research and other revenue in 2011 and 2010 included $3.6 million and $4.6 million, respectively, recognized in connection with our five-year grant from the NIH, which we were awarded in September 2006 as part of the NIH’s Knockout Mouse Project. As of the end of 2011, no further revenue will be recognized by us in connection with this NIH Grant. In addition, under a June 2009 agreement with Novartis, we receive royalties on worldwide sales of Novartis’ canakinumab. In 2011 and 2010, contract research and other revenue included $2.3 million and $0.7 million, respectively, of royalties from Novartis.

      Expenses

           Total operating expenses increased to $651.0 million in 2011 from $556.5 million in 2010. Our average headcount in 2011 increased to 1,568 from 1,249 in 2010 principally as a result of our expanding research and development activities, which were primarily attributable to our antibody collaboration with Sanofi, and 2011 activities in connection with commercializing EYLEA® in wet AMD.

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           Operating expenses in 2011 and 2010 included a total of $56.1 million and $39.9 million, respectively, of non-cash compensation expense related to employee stock option and restricted stock awards (Non-cash Compensation Expense), as detailed below:

      For the year ended December 31, 2011
      Expenses before
      inclusion of Non-cash Non-cash
      Expenses   Compensation Compensation Expenses as
      (In millions) Expense Expense Reported
      Research and development       $ 496.7       $ 32.8       $ 529.5
      Selling, general, and administrative 94.0 23.3 117.3
      Cost of goods sold 4.2 4.2
             Total operating expenses $ 594.9 $ 56.1 $ 651.0
       
      For the year ended December 31, 2010
      Expenses before
      inclusion of Non-cash Non-cash
      Expenses   Compensation Compensation Expenses as
      (In millions) Expense Expense Reported
      Research and development $ 466.9 $ 22.3 $ 489.2
      Selling, general, and administrative 47.6 17.6 65.2
      Cost of goods sold   2.1     2.1
             Total operating expenses $ 516.6 $ 39.9 $ 556.5

           The increase in total Non-cash Compensation Expense in 2011 was primarily attributable to (i) the recognition of higher expense in 2011 in connection with performance-based stock options that we estimate will vest, (ii) the higher fair market value of our Common Stock on the date of our annual employee option grants made in December 2010 compared to recent prior years, and (iii) the recognition of higher expense related to grants of restricted stock in December 2010.

      Research and Development Expenses

           Research and development expenses increased to $529.5 million in 2011 from $489.2 million in 2010. The following table summarizes the major categories of our research and development expenses in 2011 and 2010:

      Research and Development Expenses* Year Ended December 31, Increase
      (In millions) 2011       2010       (Decrease)
      Payroll and benefits (1)       $ 168.9 $ 131.7 $ 37.2
      Clinical trial expenses 67.6 86.4 (18.8 )
      Clinical manufacturing costs (2) 123.0 116.1 6.9  
      Research and other development costs   60.4 53.8 6.6
      Occupancy and other operating costs 61.8 52.3 9.5  
      Cost-sharing of Bayer HealthCare EYLEA®  
             development expenses (3) 47.8   48.9 (1.1 )
             Total research and development expenses $ 529.5 $ 489.2 $ 40.3
      ____________________

      * Certain prior year amounts have been reclassified to conform to the current year’s presentation.

            (1)       Includes $29.3 million and $19.3 million of Non-cash Compensation Expense in 2011 and 2010, respectively.
      (2) Represents the full cost of manufacturing drug for use in research, preclinical development, and clinical trials, including related payroll and benefits, Non-cash Compensation Expense, manufacturing materials and supplies, drug filling, packaging, and labeling costs, depreciation, and occupancy costs of our Rensselaer manufacturing facility. Includes $3.5 million and $3.0 million of Non-cash Compensation Expense in 2011 and 2010, respectively.
      (3) Under our collaboration with Bayer HealthCare, in periods when Bayer HealthCare incurs EYLEA® development expenses, we also recognize, as additional research and development expense, the portion of Bayer HealthCare’s EYLEA® development expenses that we are obligated to reimburse. Bayer HealthCare provides us with estimated EYLEA® development expenses for the most recent fiscal quarter. Bayer HealthCare’s estimate is reconciled to its actual expenses for such quarter in the subsequent fiscal quarter and our portion of its global EYLEA® development expenses that we are obligated to reimburse is adjusted accordingly.

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           Payroll and benefits increased principally due to increases in employee headcount and Non-cash Compensation Expense for the reasons described above. Clinical trial expenses decreased due primarily to lower costs related to our Phase 3 clinical development program for ARCALYST® for the prevention of gout flares in patients initiated uric acid-lowering therapy, our VIEW 1 trial for EYLEA® in wet AMD, our Phase 2 trial for EYLEA® in DME, and our clinical development program for REGN475, which is currently on clinical hold, partly offset by higher costs related to our Phase 3 VISTA-DME study for EYLEA®. Clinical manufacturing costs increased primarily due to higher costs related to manufacturing supplies of EYLEA®, ZALTRAP®, and antibody candidates, partly offset by lower costs related to manufacturing clinical supplies of ARCALYST®. Research and other development costs increased primarily due to higher costs associated with our antibody programs and regulatory submissions for marketing approvals for EYLEA® in wet AMD and CRVO, and ARCALYST® for the prevention of gout flares in patients initiated uric acid-lowering therapy. Occupancy and other operating costs increased principally in connection with our higher headcount, expanded research and development activities, and new and expanded leased facilities in Tarrytown, New York. Cost-sharing of Bayer HealthCare’s EYLEA® development expenses decreased primarily due to lower costs related to Bayer HealthCare’s VIEW 2 trial in wet AMD, partly offset by higher costs in connection with Bayer HealthCare’s Phase 3 VIVID-DME trial.

           We prepare estimates of research and development costs for projects in clinical development, which include direct costs and allocations of certain costs such as indirect labor, Non-cash Compensation Expense, and manufacturing and other costs related to activities that benefit multiple projects, and, under our collaboration with Bayer HealthCare, the portion of Bayer HealthCare’s EYLEA® development expenses that we are obligated to reimburse. Our estimates of research and development costs for clinical development programs are shown below:

      Project Costs   Year ended December 31, Increase
      (In millions)       2011       2010       (Decrease)
      ARCALYST® $ 43.2 $ 56.8 $ (13.6 )
      EYLEA® 147.6 138.5 9.1
      ZALTRAP®   17.1 13.5 3.6
      Sarilumab 27.3 25.0 2.3
      REGN727 33.9 36.0   (2.1 )
      Other antibody candidates in clinical development 74.7 65.5 9.2
      Other research programs & unallocated costs 185.7   153.9 31.8
             Total research and development expenses $ 529.5 $ 489.2 $ 40.3

           Drug development and approval in the United States is a multi-step process regulated by the FDA. The process begins with discovery and preclinical evaluation, leading up to the submission of an IND to the FDA which, if successful, allows the opportunity for study in humans, or clinical study, of the potential new drug. Clinical development typically involves three phases of study: Phases 1, 2, and 3. The most significant costs in clinical development are in Phase 3 clinical trials, as they tend to be the longest and largest studies in the drug development process. Following successful completion of Phase 3 clinical trials for a biological product, a BLA must be submitted to, and accepted by, the FDA, and the FDA must approve the BLA prior to commercialization of the drug. It is not uncommon for the FDA to request additional data following its review of a BLA, which can significantly increase the drug development timeline and expenses. We may elect either on our own, or at the request of the FDA, to conduct further studies that are referred to as Phase 3b and 4 studies. Phase 3b studies are initiated and either completed or substantially completed while the BLA is under FDA review. These studies are conducted under an IND. Phase 4 studies, also referred to as post-marketing studies, are studies that are initiated and conducted after the FDA has approved a product for marketing. In addition, as discovery research, preclinical development, and clinical programs progress, opportunities to expand development of drug candidates into new disease indications can emerge. We may elect to add such new disease indications to our development efforts (with the approval of our collaborator for joint development programs), thereby extending the period in which we will be developing a product. For example, we, and our collaborators where applicable, continue to explore further development of ARCALYST®, ZALTRAP®, and EYLEA® in different disease indications.

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           There are numerous uncertainties associated with drug development, including uncertainties related to safety and efficacy data from each phase of drug development, uncertainties related to the enrollment and performance of clinical trials, changes in regulatory requirements, changes in the competitive landscape affecting a product candidate, and other risks and uncertainties described in Item 1A, “Risk Factors” under “Risks Related to the Development and Approval of Our Product Candidates and New Indications for Our Marketed Products,” “Risks Related to Commercialization of Products”, and “Regulatory and Litigation Risks.” The lengthy process of seeking FDA approvals, and subsequent compliance with applicable statutes and regulations, require the expenditure of substantial resources. Any failure by us to obtain, or delay in obtaining, regulatory approvals could materially adversely affect our business.

           For these reasons and due to the variability in the costs necessary to develop a pharmaceutical product and the uncertainties related to future indications to be studied, the estimated cost and scope of the projects, and our ultimate ability to obtain governmental approval for commercialization, accurate and meaningful estimates of the total cost to bring our product candidates to market are not available. Similarly, we are currently unable to reasonably estimate if our product candidates in clinical development will generate material product revenues and net cash inflows.

      Selling, General, and Administrative Expenses

           Selling, general, and administrative expenses increased to $117.3 million in 2011 from $65.2 million in 2010 due primarily to increases in compensation expense and recruitment costs, principally in connection with higher headcount in 2011, higher commercialization costs primarily in connection with EYLEA® for wet AMD, an increase in Non-cash Compensation Expense for the reasons described above, and higher legal expenses in connection with patent-related litigation with Genentech.

      Cost of Goods Sold

           Cost of goods sold increased to $4.2 million in 2011 from $2.1 million in 2010, due primarily to our launch of EYLEA® for the treatment of wet AMD in November 2011. Cost of goods sold in 2011 and 2010 primarily consisted of royalties and the costs of producing EYLEA® and ARCALYST® commercial supplies.

      Other Income and Expense

           Investment income increased to $3.5 million in 2011 from $2.1 million in 2010 due to higher average balances of cash and marketable securities during 2011.

           Interest expense increased to $21.3 million in 2011 from $9.1 million in 2010. In October 2011, we issued $400.0 million aggregate principal amount of 1.875% convertible senior notes. Total interest expense in 2011 associated with these notes, including amortization of the note discount and debt issuance costs, was $5.4 million. In addition, interest expense includes the imputed interest portion of payments to our landlord to lease laboratory and office facilities in Tarrytown, New York, which totaled $15.6 million in 2011 and $9.1 million in 2010. The increase is due to our occupying in February 2011 an additional new building in Tarrytown and, therefore, we began recognizing interest expense on the related payments to our landlord.

      Income Tax Expense (Benefit)

           In 2011, we recognized a $1.1 million income tax benefit, which consisted primarily of $0.7 million related to tax legislation that allowed us to claim a refund for a portion of our unused pre-2006 research tax credits.

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      Years Ended December 31, 2010 and 2009

      Net Loss

           Regeneron reported a net loss of $104.5 million, or $1.26 per share (basic and diluted), for the year ended December 31, 2010, compared to a net loss of $67.8 million, or $0.85 per share (basic and diluted) for 2009. The increase in our net loss in 2010 was principally due to higher research and development expenses, partly offset by higher collaboration revenue in connection with our antibody collaboration with Sanofi.

      Revenues

           Revenues in 2010 and 2009 consist of the following:

      (In millions) 2010 2009
      Collaboration revenue
             Sanofi       $ 311.3       $ 247.2
             Bayer HealthCare 75.4   67.3
                    Total collaboration revenue 386.7 314.5
      Net product sales 25.3 18.4
      Technology licensing revenue 40.2 40.0
      Contract research and other revenue   6.9 6.4
                    Total revenue $ 459.1 $ 379.3

      Sanofi Collaboration Revenue

           The collaboration revenue we earned from Sanofi, as detailed below, consisted primarily of reimbursement for research and development expenses and recognition of revenue related to non-refundable up-front payments of $105.0 million related to the ZALTRAP® collaboration and $85.0 million related to the antibody collaboration.

      Years ended
      Sanofi Collaboration Revenue   December 31,
      (In millions) 2010       2009
      ZALTRAP®:      
             Regeneron expense reimbursement $ 16.5 $ 26.6
             Recognition of deferred revenue related to up-front payments 9.9 9.9
                    Total ZALTRAP® 26.4 36.5
      Antibody:
             Regeneron expense reimbursement 276.0 198.1
             Recognition of deferred revenue related to up-front and other  
                    payments 7.3 9.9
             Recognition of revenue related to VelociGene® agreement 1.6 2.7
                    Total antibody   284.9 210.7
      Total Sanofi collaboration revenue $ 311.3 $ 247.2

           Sanofi’s reimbursement of our ZALTRAP® expenses decreased in 2010 compared to 2009, primarily due to lower costs related to internal research activities and manufacturing ZALTRAP® clinical supplies.

           In 2010, Sanofi’s reimbursement of our antibody expenses consisted of $137.7 million under the discovery agreement and $138.3 million of development costs under the license agreement, compared to $99.8 million and $98.3 million, respectively, in 2009. The higher reimbursement amounts in 2010 compared to 2009 were due to an increase in our research activities conducted under the discovery agreement and increases in our development activities for antibody candidates under the license agreement.

           Recognition of deferred revenue related to Sanofi’s $85.0 million up-front payment decreased in 2010 compared to 2009 due to the November 2009 amendments to expand and extend the companies’ antibody collaboration. In connection with the November 2009 amendment of the discovery agreement, Sanofi is funding up to $30 million of agreed-upon costs incurred by us to expand our manufacturing capacity at our Rensselaer, New York facilities, of which $23.4 million was received or receivable from Sanofi as of December 31, 2010. Revenue related to these payments for such funding from Sanofi is deferred and recognized as collaboration revenue prospectively over the related performance period in conjunction with the recognition of the original $85.0 million up-front payment.

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           In August 2008, we entered into a separate VelociGene® agreement with Sanofi. In 2010 and 2009, we recognized $1.6 million and $2.7 million, respectively, in revenue related to this agreement.

      Bayer HealthCare Collaboration Revenue

           The collaboration revenue we earned from Bayer HealthCare, as detailed below, consisted of cost sharing of Regeneron EYLEA® development expenses, substantive performance milestone payments, and recognition of revenue related to a non-refundable $75.0 million up-front payment received in October 2006 and a $20.0 million milestone payment received in August 2007 (which, for the purpose of revenue recognition, was not considered substantive).

      Years ended
      Bayer HealthCare Collaboration Revenue December 31,
      (In millions) 2010        2009
      Cost-sharing of Regeneron EYLEA® development expenses $ 45.5 $ 37.4
      Substantive performance milestone payments 20.0 20.0
      Recognition of deferred revenue related to up-front and other milestone    
             payments 9.9 9.9
             Total Bayer HealthCare collaboration revenue $ 75.4 $ 67.3

           Cost-sharing of our EYLEA® development expenses with Bayer HealthCare increased in 2010 compared to 2009 due to higher internal development activities and higher clinical development costs in connection with our Phase 3 COPERNICUS trial in CRVO. In the fourth quarter of 2010, we earned two $10.0 million substantive milestone payments from Bayer HealthCare for achieving positive 52-week results in the VIEW 1 study and positive 6-month results in the COPERNICUS study. In July 2009, we earned a $20.0 million substantive performance milestone payment from Bayer HealthCare in connection with the dosing of the first patient in the COPERNICUS study.

      Net Product Sales

           In 2010 and 2009, we recognized as revenue $25.3 million and $18.4 million, respectively, of ARCALYST® net product sales. We had limited historical returns experience for ARCALYST® beginning with initial sales in 2008 through the end of 2009; therefore, ARCALYST® net product sales were deferred until the right of return no longer existed and rebates could be reasonably estimated. Effective in the first quarter of 2010, we determined that we had accumulated sufficient historical data to reasonably estimate both product returns and rebates of ARCALYST®. As a result, $4.8 million of previously deferred ARCALYST® net product sales were recognized as revenue in the first quarter of 2010. The effect of recognizing the previously deferred ARCALYST® net product sales revenue was to lower our net loss per share by $0.06 in 2010. At December 31, 2010, there was no deferred revenue related to ARCALYST® net product sales.

      Technology Licensing Revenue

           In connection with our VelocImmune® license agreements with AstraZeneca and Astellas, each of the $20.0 million annual, non-refundable payments were deferred upon receipt and recognized as revenue ratably over approximately the ensuing year of each agreement. In both 2010 and 2009, we recognized $40.0 million of technology licensing revenue related to these agreements. In addition, in connection with the amendment and extension of our license agreement with Astellas, in August 2010, we received a $165.0 million up-front payment, which was deferred upon receipt and will be recognized as revenue ratably over a seven-year period beginning in June 2011.

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      Contract Research and Other Revenue

           Contract research and other revenue in 2010 and 2009 included $4.6 million and $5.5 million, respectively, recognized in connection with our five-year grant from the NIH, which we were awarded in September 2006 as part of the NIH’s Knockout Mouse Project.

      Expenses

           Total operating expenses increased to $556.5 million in 2010 from $453.4 million in 2009. Our average headcount in 2010 increased to 1,249 from 980 in 2009 principally as a result of our expanded research and development activities, which were primarily attributable to our antibody collaboration with Sanofi.

           Operating expenses in 2010 and 2009 included a total of $39.9 million and $31.3 million, respectively, of Non-cash Compensation Expense, as detailed below:

      For the year ended December 31, 2010
      Expenses before
            inclusion of Non-cash       Non-cash      
      Expenses Compensation Compensation Expenses as
      (In millions) Expense Expense Reported
      Research and development   $ 466.9   $ 22.3 $ 489.2
      Selling, general, and administrative 47.6   17.6 65.2
      Cost of goods sold 2.1     2.1
             Total operating expenses $ 516.6 $ 39.9 $ 556.5
       
      For the year ended December 31, 2009
      Expenses before
            inclusion of Non-cash       Non-cash      
      Expenses Compensation Compensation Expenses as
      (In millions) Expense Expense Reported
      Research and development   $ 380.0   $ 18.8 $ 398.8
      Selling, general, and administrative 40.4   12.5 52.9
      Cost of goods sold 1.7     1.7
             Total operating expenses $ 422.1 $ 31.3 $ 453.4

           The increase in total Non-cash Compensation Expense in 2010 was primarily attributable to (i) the recognition of higher expense in 2010 in connection with performance-based stock options that we estimate will vest, (ii) the increase in stock option awards in 2010, due in part to the increase in headcount, and (iii) the higher fair market value of our Common Stock on the date of our annual employee option grants made in December 2009 compared to December 2008.

      Research and Development Expenses

           Research and development expenses increased to $489.2 million in 2010 from $398.8 million in 2009. The following table summarizes the major categories of our research and development expenses in 2010 and 2009:

      Research and Development Expenses*       Year Ended December 31,       Increase
      (In millions) 2010 2009 (Decrease)
      Payroll and benefits (1) $ 131.7 $ 99.9 $ 31.8
      Clinical trial expenses 86.4 98.5          (12.1 )
      Clinical manufacturing costs (2) 116.1 79.8 36.3
      Research and other development costs 53.8 42.3 11.5
      Occupancy and other operating costs 52.3   40.6   11.7
      Cost-sharing of Bayer HealthCare EYLEA®  
             development expenses (3) 48.9 37.7 11.2
             Total research and development expenses $ 489.2 $ 398.8 $ 90.4  
      ____________________

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      * Certain prior year amounts have been reclassified to conform to the current year’s presentation.

            (1)       Includes $19.3 million and $16.2 million of Non-cash Compensation Expense in 2010 and 2009, respectively.
      (2) Represents the full cost of manufacturing drug for use in research, preclinical development, and clinical trials, including related payroll and benefits, Non-cash Compensation Expense, manufacturing materials and supplies, drug filling, packaging, and labeling costs, depreciation, and occupancy costs of our Rensselaer manufacturing facility. Includes $3.0 million and $2.6 million of Non-cash Compensation Expense in 2010 and 2009, respectively.
      (3) Under our collaboration with Bayer HealthCare, in periods when Bayer HealthCare incurs EYLEA® development expenses, we also recognize, as additional research and development expense, the portion of Bayer HealthCare’s EYLEA® development expenses that we are obligated to reimburse. Bayer HealthCare provides us with estimated EYLEA® development expenses for the most recent fiscal quarter. Bayer HealthCare’s estimate is reconciled to its actual expenses for such quarter in the subsequent fiscal quarter and our portion of its global EYLEA® development expenses that we are obligated to reimburse is adjusted accordingly.

           Payroll and benefits increased principally due to the increase in employee headcount, as described above. Clinical trial expenses decreased due primarily to lower costs related to our Phase 3 clinical development program for ARCALYST® in gout, partly offset by higher costs related to our clinical development programs for EYLEA®, principally in connection with our COPERNICUS trial in CRVO. Clinical manufacturing costs increased due to higher facility-related costs in connection with the expansion of our manufacturing capacity at our Rensselaer facility and higher costs related to manufacturing clinical supplies of monoclonal antibodies, partly offset by lower costs related to manufacturing ZALTRAP® clinical supplies. Research and other development costs increased primarily due to higher costs associated with our antibody programs. Occupancy and other operating costs increased principally in connection with our higher headcount, expanded research and development activities, and new and expanded leased laboratory and office facilities in Tarrytown, New York. Cost-sharing of Bayer HealthCare’s EYLEA® development expenses increased primarily due to higher costs in connection with Bayer HealthCare’s VIEW 2 trial in wet AMD.

           We prepare estimates of research and development costs for projects in clinical development, which include direct costs and allocations of certain costs such as indirect labor, Non-cash Compensation Expense, and manufacturing and other costs related to activities that benefit multiple projects, and, under our collaboration with Bayer HealthCare, the portion of Bayer HealthCare’s EYLEA® development expenses that we are obligated to reimburse. Our estimates of research and development costs for clinical development programs are shown below:

      Project Costs       Year ended December 31, Increase
      (In millions) 2010       2009       (Decrease)
      ARCALYST® $ 56.8 $ 67.7 $           (10.9 )
      EYLEA®   138.5 109.8 28.7
      ZALTRAP® 13.5 23.3 (9.8 )
      Sarilumab 25.0 36.9 (11.9 )
      REGN727 36.0 21.1 14.9
      Other antibody candidates in clinical development 65.5 53.3 12.2
      Other research programs & unallocated costs 153.9 86.7 67.2  
             Total research and development expenses $ 489.2 $ 398.8 $ 90.4

           For the reasons described above under “Research and Development Expenses” for the years ended December 31, 2011 and 2010, and due to the variability in the costs necessary to develop a pharmaceutical product and the uncertainties related to future indications to be studied, the estimated cost and scope of the projects, and our ultimate ability to obtain governmental approval for commercialization, accurate and meaningful estimates of the total cost to bring our product candidates to market are not available. Similarly, we are currently unable to reasonably estimate if our product candidates in clinical development will generate material product revenues and net cash inflows.

      Selling, General, and Administrative Expenses

           Selling, general, and administrative expenses increased to $65.2 million in 2010 from $52.9 million in 2009 due primarily to increases in compensation expense and recruitment costs, principally in connection with higher headcount in 2010, and an increase in Non-cash Compensation Expense for the reasons described above.

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      Cost of Goods Sold

           Cost of goods sold in 2010 and 2009 was $2.1 million and $1.7 million, respectively, and consisted primarily of royalties and other period costs related to ARCALYST® commercial supplies. During 2010 and 2009, ARCALYST® shipments to our customers primarily consisted of supplies of inventory manufactured and expensed as research and development costs prior to FDA approval in 2008; therefore, the costs of these supplies were not included in costs of goods sold.

      Other Income and Expense

           Investment income decreased to $2.1 million in 2010 from $4.5 million in 2009, due primarily to lower yields on, and lower average balances of, cash and marketable securities.

           Interest expense increased to $9.1 million in 2010 from $2.3 million in 2009. Interest expense is primarily attributable to the imputed interest portion of payments to our landlord, commencing in the third quarter of 2009, to lease newly constructed laboratory and office facilities in Tarrytown, New York.

      Income Tax Expense (Benefit)

           In 2010, we did not recognize any income tax expense or benefit. In 2009, we recognized a $4.1 million income tax benefit, consisting primarily of (i) $2.7 million resulting from tax legislation that allowed us to claim a refund of U.S. federal alternative minimum tax that we paid in 2008, and (ii) $0.7 million resulting from tax legislation that allowed us to claim a refund for a portion of our unused pre-2006 research tax credits.

      Liquidity and Capital Resources

           Since our inception in 1988, we have financed our operations primarily through offerings of our equity securities, private placements of convertible debt, purchases of our equity securities by our collaborators, including Sanofi, revenue earned under our past and present research and development agreements, including our agreements with Sanofi and Bayer HealthCare, EYLEA® and ARCALYST® product revenue, our technology licensing agreements, our past contract manufacturing agreements, and investment income.

      Sources and Uses of Cash for the Years Ended December 31, 2011, 2010, and 2009

           At December 31, 2011, we had $810.6 million in cash, cash equivalents, and marketable securities (including $7.7 million of restricted cash and marketable securities) compared with $626.9 million at December 31, 2010 (including $7.5 million of restricted cash and marketable securities) and $390.0 million (including $1.6 million of restricted cash) at December 31, 2009. In October 2011, we completed a private placement of $400.0 million aggregate principal amount of 1.875% convertible senior notes and received net proceeds of approximately $391.1 million after deducting the initial purchaser’s discount and issuance costs. In connection with the offering of the convertible senior notes, we entered into convertible note hedge and warrant transactions, which had a net cost to us of $23.7 million. In October 2010, we completed an underwritten public offering of 6,325,000 shares of Common Stock and received net proceeds of $174.8 million. In connection with the July 2010 amendment and extension of our non-exclusive license agreement with Astellas, we received a $165.0 million up-front payment from Astellas in August 2010.

      Cash (Used in) Provided by Operations

           Net cash used in operations was $141.7 million in 2011 and $69.9 million in 2009, and net cash provided by operations was $99.2 million in 2010. Our net losses of $221.8 million in 2011, $104.5 million in 2010, and $67.8 million in 2009 included $56.1 million, $39.9 million, and $31.3 million, respectively, of Non-cash Compensation Expense. Our net losses also included depreciation and amortization of $31.1 million, $19.7 million, and $14.2 million in 2011, 2010, and 2009, respectively.

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           At December 31, 2011, Sanofi and trade accounts receivable increased by $21.1 million, compared to end-of-year 2010, primarily due to EYLEA® product sales, which commenced in November 2011. Due to the payment terms granted to our customers, our EYLEA® product sales in 2011, generally, had not yet been collected as of December 31, 2011. Our deferred revenue at December 31, 2011 decreased by $40.3 million, compared to end-of-year 2010, primarily due to (i) amortization of the $165.0 million up-front payment from Astellas, as described above, which was initially deferred and is being recognized ratably over the seven-year period that commenced in mid-2011, and (ii) amortization of previously deferred payments under our Sanofi and Bayer HealthCare collaborations. Accounts payable, accrued expenses, and other liabilities increased $50.0 million at December 31, 2011, compared to end-of-year 2010, primarily in connection with (i) higher payroll-related liabilities, due in part to funding payment of our year-end 2010 employee cash bonuses prior to December 31, 2010 whereas year-end 2011 employee cash bonuses were funded subsequent to December 31, 2011 and (ii) our expanded levels of activities and expenditures, partly in connection with EYLEA® commercialization activities.

           At December 31, 2010, Sanofi and trade accounts receivable increased by $17.5 million, compared to end-of-year 2009, primarily due to a higher receivable balance related to our antibody collaboration with Sanofi. Our deferred revenue at December 31, 2010 increased by $158.2 million, compared to end-of-year 2009, primarily due to (i) the receipt of the $165.0 million up-front payment from Astellas, as described above, which was deferred, and (ii) Sanofi’s funding of $22.9 million of agreed-upon costs incurred by us during 2010 to expand our manufacturing capacity at our Rensselaer facilities, which was deferred and is being recognized as collaboration revenue prospectively over the related performance period in conjunction with the original $85.0 million up-front payment received from Sanofi. These increases were partly offset by amortization of previously received deferred payments under our Sanofi and Bayer HealthCare collaborations.

           At December 31, 2009, Sanofi and trade accounts receivable increased by $30.5 million, compared to end-of-year 2008, primarily due to a higher receivable balance related to our antibody collaboration with Sanofi. Our deferred revenue at December 31, 2009 decreased by $27.5 million, compared to end-of-year 2008, primarily due to the amortization of previously received deferred payments under our collaborations with Sanofi and Bayer HealthCare. Accounts payable, accrued expenses, and other liabilities increased $12.6 million at December 31, 2009, compared to end-of-year 2008, primarily in connection with our expanded levels of activities and expenditures, including higher liabilities for clinical-related expenses, which were partly offset by an $8.6 million decrease in the cost-sharing payment due to Bayer HealthCare in connection with our EYLEA® collaboration.

      Cash Provided by (Used in) Investing Activities

           Net cash provided by investing activities was $128.5 million in 2011, compared with net cash used in investing activities of $437.0 million and $2.1 million in 2010 and 2009, respectively. Sales or maturities of marketable securities exceeded purchases by $186.0 million in 2011 and $95.1 million in 2009. In 2010, purchases of marketable securities exceeded sales or maturities by $331.4 million. Capital expenditures of $57.2 million, $99.7 million, and $97.3 million in 2011, 2010, and 2009, respectively, included costs in connection with expanding our manufacturing capacity at our Rensselaer, New York facilities and tenant improvements and related costs in connection with our leased facilities in Tarrytown, New York.

      Cash Provided by Financing Activities

           Net cash provided by financing activities was $384.2 million in 2011, $243.3 million in 2010 and $31.4 million in 2009. As described above, in October 2011, we completed a private placement of convertible senior notes and received net proceeds of $391.1 million, and entered into convertible note hedge and warrant transactions, which had a net cost to us of $23.7 million. Also as described above, in October 2010, we completed an offering of our Common Stock and received net proceeds of $174.8 million. In addition, net proceeds from issuances of Common Stock in connection with exercises of stock options were $18.5 million in 2011, $22.0 million in 2010, and $8.6 million in 2009. In 2010 and 2009, we received $47.5 million and $23.6 million, respectively, of tenant improvement reimbursements from our landlord in connection with our Tarrytown facilities, which we are deemed to own in accordance with FASB authoritative guidance.

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      Fair Value of Marketable Securities

           At December 31, 2011 and 2010, we held marketable securities whose aggregate fair value totaled $325.2 million and $513.9 million, respectively. The composition of our portfolio of marketable securities on these dates was as follows:

            2011       2010
      Investment type Fair Value       Percent Fair Value       Percent
      Unrestricted
      U.S. government obligations $ 284.9 87 % $ 434.4 85 %
      U.S. government guaranteed corporate bonds 15.3 5 % 64.0 13 %
      Municipal bonds   15.3 5 % 1.6
      Equity securities 3.0 1 % 3.6 1 %
      U.S. government guaranteed collateralized mortgage    
             obligations 0.6     2.1
      Mortgage-backed securities 0.1 1.1
             Total unrestricted marketable securities 319.2 98 % 506.8 99 %
       
      Restricted
      U.S. government obligations 6.0 2 % 7.1 1 %
       
             Total marketable securities $ 325.2 100 % $ 513.9 100 %

           In addition, at December 31, 2011 and 2010, we had $485.4 million and $113.0 million, respectively, of cash, cash equivalents, and restricted cash, primarily held in money market funds that invest in U.S. government securities.

           We classify our investments using a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value. The three tiers are Level 1, defined as observable inputs such as quoted prices in active markets; Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions. Our methods for valuing our marketable securities are described in Note 6 to our financial statements included in this Annual Report on Form 10-K.

           We held one Level 3 marketable security, which had no fair value at December 31, 2011 and 2010. This Level 3 security was valued using information provided by our investment advisors and other sources, including quoted bid prices which took into consideration the securities’ lack of liquidity. During the year ended December 31, 2009, we recorded charges for other-than-temporary impairment of this Level 3 marketable security totaling $0.1 million; therefore, as of December 31, 2009, the fair value of this security had been written down to zero. There were no purchases, sales, or maturities of Level 3 marketable securities and no unrealized gains or losses related to Level 3 marketable securities for the years ended December 31, 2011 and 2010. There were no transfers of marketable securities between Levels 1, 2, or 3 classifications during the years ended December 31, 2011 and 2010.

      Collaborations with Sanofi

      ZALTRAP®(aflibercept)

           In September 2003, we entered into a collaboration agreement with Aventis Pharmaceuticals Inc. (predecessor to Sanofi U.S.) to collaborate on the development and commercialization of ZALTRAP® in all countries other than Japan, where we retained the exclusive right to develop and commercialize ZALTRAP®. Sanofi made a non-refundable up-front payment of $80.0 million and purchased 2,799,552 newly issued unregistered shares of our Common Stock for $45.0 million.

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           In January 2005, we and Sanofi amended the collaboration agreement to exclude, from the scope of the collaboration, the development and commercialization of ZALTRAP® for intraocular delivery to the eye. In connection with this amendment, Sanofi made a $25.0 million non-refundable payment to us.

           In December 2005, we and Sanofi amended our collaboration agreement to expand the territory in which the companies are collaborating on the development of ZALTRAP® to include Japan. In connection with this amendment, Sanofi agreed to make a $25.0 million non-refundable up-front payment to us, which was received in January 2006. Under the collaboration agreement, as amended, we and Sanofi will share co-promotion rights and profits on sales, if any, of ZALTRAP® outside of Japan for disease indications included in our collaboration. In Japan, we are entitled to a royalty of approximately 35% on annual sales of ZALTRAP®. We may also receive up to $400 million in substantive milestone payments upon receipt of specified marketing approvals, including up to $360 million in milestone payments related to the receipt of marketing approvals for up to eight ZALTRAP® oncology and other indications in the United States or the European Union and up to $40 million related to the receipt of marketing approvals for up to five ZALTRAP® oncology indications in Japan.

           We have agreed to manufacture clinical supplies of ZALTRAP® at our plant in Rensselaer, New York. Sanofi has agreed to be responsible for providing commercial scale manufacturing capacity for ZALTRAP®.

           Under the collaboration agreement, as amended, agreed-upon worldwide ZALTRAP® development expenses incurred by both companies during the term of the agreement, including costs associated with the manufacture of clinical drug supply, will be funded by Sanofi. If the collaboration becomes profitable, we will be obligated to reimburse Sanofi for 50% of these development expenses in accordance with a formula based on the amount of development expenses and our share of the collaboration profits and Japan royalties, or at a faster rate at our option. Since inception of the collaboration agreement through December 31, 2011, we and Sanofi have incurred $763.4 million in agreed-upon development expenses related to ZALTRAP®. If the collaboration becomes profitable, we will also be obligated to reimburse Sanofi for 50% of the $25.0 million payment received in connection with the January 2005 amendment to our collaboration agreement. In addition, if the first commercial sale of an aflibercept product for intraocular delivery to the eye predates the first commercial sale of a ZALTRAP® product under the collaboration by two years, we will begin reimbursing Sanofi for up to $7.5 million of ZALTRAP® development expenses in accordance with a formula until the first commercial ZALTRAP® sale under the collaboration occurs. As described above under Item 1. “Business – Clinical Programs,” based upon the positive findings in the Phase 3 VELOUR study, Sanofi has submitted a regulatory application for marketing approval of ZALTRAP® for the treatment of previously-treated mCRC patients to the EMA in the fourth quarter of 2011 and the FDA in February 2012. In addition, the Phase 3 VENICE study for the first-line treatment for hormone-refractory metastatic prostate cancer in combination with docetaxel/prednisone is ongoing.

           Sanofi funded $16.9 million, $16.5 million, and $26.6 million, respectively, of our ZALTRAP® development costs in 2011, 2010, and 2009. In addition, in 2011, we and Sanofi began equally sharing ZALTRAP® pre-launch commercialization expenses under the collaboration agreement; as a result, we funded $9.3 million of Sanofi’s ZALTRAP® pre-launch commercialization expenses in 2011. At December 31, 2011, there was a net payable of $3.7 million to Sanofi in connection with the companies’ ZALTRAP® collaboration, and at December 31, 2010 and 2009, amounts receivable from Sanofi in connection with the ZALTRAP® collaboration were $3.9 million and $3.6 million, respectively. In addition, the up-front payments from Sanofi of $80.0 million in September 2003 and $25.0 million in January 2006 were recorded to deferred revenue and are being recognized as contract research and development revenue over the period during which we expect to perform services. In 2011, 2010, and 2009, we recognized $9.9 million per year of revenue, respectively, related to these up-front payments.

           Sanofi has the right to terminate the agreement without cause with at least twelve months advance notice. Upon termination of the agreement for any reason, any remaining obligation to reimburse Sanofi for 50% of ZALTRAP® development expenses will terminate and we will retain all rights to ZALTRAP®.

      Antibodies

           In November 2007, we and Sanofi entered into a global, strategic collaboration to discover, develop, and commercialize fully human monoclonal antibodies. The collaboration is governed by a Discovery and Preclinical Development Agreement and a License and Collaboration Agreement. In connection with the execution of the discovery agreement in 2007, we received a non-refundable up-front payment of $85.0 million from Sanofi. Pursuant to the collaboration, Sanofi is funding our research to identify and validate potential drug discovery targets and develop fully human monoclonal antibodies against these targets. In November 2009, we and Sanofi amended these collaboration agreements to expand and extend our antibody collaboration. Under the amended discovery agreement, Sanofi agreed to fund up to $160 million per year of our antibody discovery activities in 2010 through 2017, subject to a one-time option for Sanofi to adjust the maximum reimbursement amount down to $120 million per year commencing in 2014 if over the prior two years certain specified criteria were not satisfied. In 2010, as we scaled up our capacity to conduct antibody discovery activities, Sanofi funded $137.7 million of our preclinical research under the amended discovery agreement. The balance between that amount and $160 million, or $22.3 million, has been added to the funding otherwise available to us in 2011-2012 under the amended discovery agreement. The amended discovery agreement will expire on December 31, 2017; however, Sanofi has an option to extend the agreement for up to an additional three years for further antibody development and preclinical activities.

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           For each drug candidate identified through discovery research under the discovery agreement, Sanofi has the option to license rights to the candidate under the license agreement. If it elects to do so, Sanofi will co-develop the drug candidate with us through product approval. Under certain defined circumstances, upon exercising its option to license rights to particular candidates, Sanofi must make a $10 million substantive milestone payment to us. Under the license agreement, agreed upon worldwide development expenses incurred by both companies during the term of the agreement are funded by Sanofi, except that following receipt of the first positive Phase 3 trial results for a co-developed drug candidate, subsequent Phase 3 trial-related costs for that drug candidate (called Shared Phase 3 Trial Costs) are shared 80% by Sanofi and 20% by us. If the collaboration becomes profitable, we will be obligated to reimburse Sanofi for 50% of development expenses that were fully funded by Sanofi (or half of $582.3 million as of December 31, 2011) and 30% of Shared Phase 3 Trial Costs, in accordance with a defined formula based on the amounts of these expenses and our share of the collaboration profits from commercialization of collaboration products. However, we are not required to apply more than 10% of our share of the profits from collaboration products in any calendar quarter towards reimbursing Sanofi for these development costs. If Sanofi does not exercise its option to license rights to a particular drug candidate under the license agreement, we retain the exclusive right to develop and commercialize such drug candidate, and Sanofi will receive a royalty on sales, if any.

           Sanofi will lead commercialization activities for products developed under the license agreement, subject to our right to co-promote such products. The parties will equally share profits and losses from sales within the United States. The parties will share profits outside the United States on a sliding scale based on sales starting at 65% (Sanofi)/35% (us) and ending at 55% (Sanofi)/45% (us), and losses outside the United States at 55% (Sanofi)/45% (us). In addition to profit sharing, we are entitled to receive up to $250 million in sales milestone payments, with milestone payments commencing only if and after aggregate annual sales outside the United States exceed $1.0 billion on a rolling 12-month basis.

           We are obligated to use commercially reasonable efforts to supply clinical requirements of each drug candidate under the collaboration until commercial supplies of that drug candidate are being manufactured. In connection with the November 2009 amendment of the collaboration’s discovery agreement, Sanofi is funding up to $30 million of agreed-upon costs incurred by us to expand our manufacturing capacity at our Rensselaer, New York facilities, of which $28.2 million was received or receivable as of December 31, 2011.

           In 2011, 2010, and 2009, Sanofi funded $161.9 million, $137.7 million, and $99.8 million, respectively, of our expenses under the collaboration’s discovery agreement and $137.4 million, $138.3 million, and $98.3 million, respectively, of our development costs under the license agreement. Of these amounts, $75.6 million, $73.4 million and $57.9 million were included in accounts receivable as of December 31, 2011, 2010, and 2009, respectively. The $85.0 million up-front payment received from Sanofi in December 2007 was recorded to deferred revenue and is being recognized as collaboration revenue over the period during which we expect to perform services. In addition, reimbursements by Sanofi of our costs to expand our manufacturing capacity are recorded to deferred revenue and recognized prospectively as collaboration revenue over the same period applicable to recognition of the $85.0 million up-front payment. In 2011, 2010, and 2009, we recognized $8.2 million, $7.3 million, and $9.9 million of revenue, respectively, related to these deferred payments.

           In connection with the antibody collaboration, in August 2008, we entered into a separate agreement with Sanofi to use our proprietary VelociGene® technology platform to supply Sanofi with genetically modified mammalian models of gene function and disease. The agreement provides for minimum annual order quantities for the term of the agreement, which extends through December 2012, for which we expect to receive payments totaling a minimum of $21.5 million, of which $12.7 million had been received as of December 31, 2011.

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           With respect to each antibody product which enters development under the license agreement, Sanofi or we may, by giving twelve months notice, opt-out of further development and/or commercialization of the product, in which event the other party retains exclusive rights to continue the development and/or commercialization of the product. We may also opt-out of the further development of an antibody product if we give notice to Sanofi within thirty days of the date that Sanofi elects to jointly develop such antibody product under the license agreement. Each of the discovery agreement and the license agreement contains other termination provisions, including for material breach by the other party. Prior to December 31, 2017, Sanofi has the right to terminate the amended discovery agreement without cause with at least three months advance written notice; however, except under defined circumstances, Sanofi would be obligated to immediately pay to us the full amount of unpaid research funding during the remaining term of the research agreement through December 31, 2017. Upon termination of the collaboration in its entirety, our obligation to reimburse Sanofi for development costs out of any future profits from collaboration products will terminate.

           In December 2007, we sold Sanofi 12 million newly issued, unregistered shares of Common Stock at an aggregate cash price of $312.0 million, or $26.00 per share of Common Stock. As a condition to the closing of this transaction, Sanofi entered into an investor agreement with us. This agreement, which was amended in November 2009, contains certain demand rights, “stand-still provisions”, and other restrictions, which are more fully described in Note 13 to our Financial Statements. In addition, in October 2010, Sanofi purchased 1,017,401 shares of Common Stock in our underwritten public offering.

      Collaboration with Bayer HealthCare

           In October 2006, we entered into a license and collaboration agreement with Bayer HealthCare to globally develop, and commercialize outside the United States, EYLEA®. Under the terms of the agreement, Bayer HealthCare made a non-refundable up-front payment to us of $75.0 million. In August 2007, we received a $20.0 million milestone payment (which, for the purpose of revenue recognition, was not considered substantive) from Bayer HealthCare following dosing of the first patient in the VIEW 1 study of EYLEA® in wet AMD. In July 2009, we received a $20.0 million substantive performance milestone payment from Bayer HealthCare following dosing of the first patient in the COPERNICUS study of EYLEA® in CRVO. In both December 2010 and January 2011, we received a $10.0 million substantive milestone payment (for a total of $20.0 million) from Bayer HealthCare for achieving positive 52-week results in the VIEW 1 study and positive 6-month results in the COPERNICUS study, respectively. We are eligible to receive up to $50 million in future substantive milestone payments related to marketing approvals of EYLEA® in major market countries outside the United States. We are also eligible to receive up to $135 million in sales milestone payments if total annual sales of EYLEA® outside the United States achieve certain specified levels starting at $200 million.

           We will share equally with Bayer HealthCare in any future profits arising from the commercialization of EYLEA® outside the United States. If EYLEA® is granted marketing authorization in a major market country outside the United States and the collaboration becomes profitable, we will be obligated to reimburse Bayer HealthCare out of our share of the collaboration profits for 50% of the agreed-upon development expenses that Bayer HealthCare has incurred (or half of $370.9 million at December 31, 2011) in accordance with a formula based on the amount of development expenses that Bayer HealthCare has incurred and our share of the collaboration profits, or at a faster rate at our option. Within the United States, we are responsible for any commercialization of EYLEA® and retain exclusive rights to any future profits from such commercialization in the United States. In June 2011, Bayer HealthCare submitted regulatory applications for marketing approval of EYLEA® in wet AMD in the European Union, Japan, and other countries. We and Bayer HealthCare continue to evaluate EYLEA® in certain Phase 3 programs in patients with wet AMD, and are evaluating EYLEA® in Phase 3 programs in patients with CRVO, DME, and CNV of the retina as a result of pathologic myopia. We are also obligated to use commercially reasonable efforts to supply clinical and commercial product requirements.

           The $75.0 million up-front payment and the $20.0 million milestone payment received in August 2007 from Bayer HealthCare were recorded to deferred revenue. In 2011, 2010, and 2009, we recognized $9.4 million, $9.9 million, and $9.9 million, respectively, of revenue related to these payments. The $10.0 million substantive milestone payments received from Bayer HealthCare in each of December 2010 and January 2011 were recognized as collaboration revenue in 2010, and the $20.0 million substantive performance milestone payment received from Bayer HealthCare in July 2009 was recognized as collaboration revenue in 2009.

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           Under the terms of the agreement, in 2009 and thereafter, all agreed upon EYLEA® development expenses incurred by both companies under a global development plan will be shared equally. Primarily in connection with sharing development expenses in 2011, 2010, and 2009, net amounts paid or payable to Bayer HealthCare were $8.3 million, $2.6 million, and $0.3 million, respectively. At December 31, 2011, $4.5 million was receivable from Bayer HealthCare, and at December 31, 2010, $2.3 million was payable to Bayer HealthCare, in connection with cost-sharing of EYLEA® expenses under the collaboration.

           Bayer HealthCare has the right to terminate the agreement without cause with at least six months or twelve months advance notice depending on defined circumstances at the time of termination. In the event of termination of the agreement for any reason, we retain all rights to EYLEA®.

      License Agreement with Astellas

           Under this non-exclusive license agreement, Astellas made a $20.0 million annual, non-refundable payment to us in each of 2010, 2009, 2008, and 2007. In July 2010, the license agreement with Astellas was amended and extended through June 2023. Under the terms of the amended agreement, Astellas made a $165.0 million up-front payment to us in August 2010. In addition, Astellas will make a $130.0 million second payment to us in June 2018 unless the license agreement has been terminated prior to that date. Astellas has the right to terminate the agreement at any time by providing 90 days’ advance written notice. Under certain limited circumstances, such as our material breach of the agreement, Astellas may terminate the agreement and receive a refund of a portion of its up-front payment or, if such termination occurs after June 2018, a portion of its second payment, to us under the July 2010 amendment to the agreement. We are entitled to receive a mid-single digit royalty on any future sales of antibody products discovered by Astellas using our VelocImmune® technology.

      License Agreement with AstraZeneca

           Under this non-exclusive license agreement, AstraZeneca made a $20.0 million annual, non-refundable payment to us in each of 2010, 2009, 2008, and 2007. In November 2010, as permitted by the agreement, MedImmune Limited (as successor by novation from AstraZeneca) gave written notice of voluntary termination of the agreement, effective in February 2011. We remain entitled to receive mid-single digit royalties on any future sales of antibody products discovered by MedImmune using our VelocImmune® technology.

      National Institutes of Health Grant

           Under our five-year grant from the NIH, as amended, we were entitled to receive a minimum of $25.3 million over the five-year period beginning in September 2006, subject to compliance with the grant’s terms and annual funding approvals, including $1.5 million to optimize our existing C57BL/6 ES cell line and its proprietary growth medium. In 2011, 2010, and 2009, we earned $3.6 million, $4.6 million, and $5.5 million, respectively, of funding under the NIH Grant, of which $0.4 million and $1.0 million, respectively, was receivable at the end of 2011 and 2010. Other than the amount receivable at the end of 2011, no further funding will be received by us in connection with the NIH Grant.

      License Agreement with Cellectis

           In July 2008, we and Cellectis S.A. entered into an Amended and Restated Non-Exclusive License Agreement. The amended license agreement resolved a dispute between the parties related to the interpretation of a license agreement entered into by the parties in December 2003 pursuant to which we licensed certain patents and patent applications relating to a process for the specific replacement of a copy of a gene in the receiver genome by homologous recombination. Pursuant to the amended license agreement, in July 2008, we made a non-refundable $12.5 million payment to Cellectis and agreed to pay Cellectis a low single-digit royalty based on revenue received by us from any future licenses or sales of our VelociGene® or VelocImmune® products and services. No royalties are payable to Cellectis with respect to our VelocImmune® license agreements with AstraZeneca and Astellas or our antibody collaboration with Sanofi. In addition, no royalties are payable to Cellectis on any revenue from commercial sales of antibodies from our VelocImmune® technology. We are amortizing our $12.5 million payment to Cellectis in proportion to past and anticipated future revenues under our license agreements with AstraZeneca and Astellas and our antibody discovery agreement with Sanofi (as amended in November 2009).

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      License and Partial Settlement Agreement with Genentech

           In December 2011, we and Genentech entered into a Non-Exclusive License and Partial Settlement Agreement relating to ophthalmic sales of EYLEA® in the United States. Pursuant to the agreement, we received a non-exclusive license to certain patents relating to VEGF receptor proteins, known as the Davis-Smyth patents, and other technology patents. The Davis-Smyth patents are the subject of patent litigation between us and Genentech now pending in the United States District Court, Southern District of New York. Patent litigation is continuing with respect to matters not covered by the Genentech Agreement (see Item 3. “Legal Proceedings”).

           Under the terms of the agreement with Genentech, we agreed to make payments to Genentech based on U.S. sales of EYLEA® commencing upon FDA approval of EYLEA® in November 2011 through May 7, 2016. We will be required to make a one-time, non-refundable $60 million payment upon cumulative U.S. sales of EYLEA® reaching $400 million. In addition, we agreed to pay royalties of 4.75% on cumulative U.S. sales of EYLEA® between $400 million and $3 billion and 5.5% on any cumulative U.S sales of EYLEA® over $3 billion. As we record net product sales of EYLEA®, we are recognizing expense in connection with the Genentech Agreement using a blended mid-single digit royalty rate that reflects both the $60 million payment and the royalties payable on cumulative sales and that is based upon our estimate of cumulative EYLEA® sales through May 7, 2016.

      Lease – Tarrytown, New York Facilities

           We lease approximately 553,000 square feet of laboratory and office space at facilities in Tarrytown, New York, under a December 2006 lease agreement, as amended. These facilities include approximately 230,000 square feet of newly constructed space in two new buildings (Buildings A and B) that were completed during the third quarter of 2009 and approximately 131,000 square feet of additional new space in a third new building (Building C), that was completed in early 2011. The lease will expire in June 2024 and contains three renewal options to extend the term of the lease by five years each, as well as early termination options on approximately 323,000 square feet of space. The lease provides for monthly payments over its term and additional charges for utilities, taxes, and operating expenses. In connection with the lease, we have issued a $3.4 million letter of credit to our landlord, which is fully collateralized by cash and marketable securities.

           Certain premises under the lease are accounted for as operating leases. However, for Buildings A, B, and C that we are leasing, we are deemed, in substance, to be the owner of the landlord’s buildings in accordance with the application of FASB authoritative guidance. As a result, we capitalized the landlord’s costs of constructing these new facilities and recognized a corresponding facility lease obligation. We also recognized, as additional facility lease obligation, reimbursements from our landlord for tenant improvement costs that we incurred since, under FASB authoritative guidance, such payments that we receive from our landlord are deemed to be a financing obligation. Monthly lease payments on these facilities are allocated between the land element of the lease (which is accounted for as an operating lease) and the facility lease obligation, based on the estimated relative fair values of the land and buildings.

           As of December 31, 2010, we had capitalized the landlord’s costs of constructing Buildings A and B, which totaled $58.4 million, and of constructing Building C, which totaled $27.8 million. Reimbursements from our landlord for Buildings A and B tenant improvement costs totaled $56.9 million and were received by us during 2010 and 2009. Reimbursements for Building C tenant improvement costs totaled $14.2 million and were received by us during 2010. With respect to Buildings A and B, monthly lease payments commenced in August 2009, the buildings were placed in service by us in September 2009, and the imputed interest rate applicable to our facility lease obligation is approximately 11%. With respect to Building C, monthly lease payments commenced in January 2011, the building was placed in service by us in February 2011, and the imputed interest rate applicable to our facility lease obligation is approximately 9%. At December 31, 2011 and 2010, the Buildings A and B facility lease obligation balance was $113.0 million and $113.7 million, respectively, and the Building C facility lease obligation balance was $47.5 million and $46.4 million, respectively.

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      Capital Expenditures

           Our cash expenditures for property, plant, and equipment totaled $57.2 million in 2011, $99.7 million in 2010, and $97.3 million in 2009. We received $47.5 million in 2010 and $23.6 million in 2009 from our landlord in connection with tenant improvement costs in Buildings A, B, and C in Tarrytown, as described above. In addition, in connection with the companies’ antibody collaboration, Sanofi funded $4.8 million in 2011, $22.9 million in 2010, and $0.5 million in 2009 of agreed-upon capital expenditures incurred by us to expand our manufacturing capacity at our Rensselaer facilities, of which $1.7 million was receivable at December 31, 2011.

           We expect to incur capital expenditures of approximately $50 to $70 million in 2012, primarily in connection with tenant improvements at our leased Tarrytown facilities, capital improvements at our Rensselaer, New York manufacturing facilities, and purchases of equipment. We expect to be reimbursed for a small portion of these capital expenditures for our Rensselaer facilities by Sanofi, with the remaining amount to be funded by our existing capital resources.

      Offering of Convertible Senior Notes

           In October 2011, we issued $400.0 million aggregate principal amount of 1.875% convertible senior notes in a private placement. The notes were offered by the initial purchaser only to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933.

           The notes will pay interest semi-annually on April 1 and October 1, beginning April 1, 2012, and will mature on October 1, 2016, unless earlier converted or repurchased. The notes will be convertible, subject to certain conditions, into cash, shares of our Common Stock, or a combination of cash and shares of Common Stock, at our option. The initial conversion rate for the notes will be 11.9021 shares of Common Stock (subject to adjustment in certain circumstances) per $1,000 principal amount of the notes, which is equal to an initial conversion price of approximately $84.02 per share. A holder of the notes may surrender their notes at their option any time prior to the close of business on the business day immediately preceding July 1, 2016, only under the following circumstances: (i) during any calendar quarter commencing after the calendar quarter ending on December 31, 2011 (and only during such calendar quarter), if the last reported sale price of our Common Stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day; (ii) during the five business day period after any ten consecutive trading day period (the “measurement period”) in which the trading price, as defined, of the notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our Common Stock and the conversion rate on each such trading day; (iii) if we elect to issue to all or substantially all holders of our Common Stock any rights, options, or warrants (other than pursuant to a rights plan) entitling them for a period of not more than 60 calendar days after the record date for such issuance, to subscribe for or purchase shares of our Common Stock, at a price per share less than the average of the last reported sales prices of our Common Stock for the ten consecutive day period ending on, and including, the trading day immediately preceding the declaration date for such issuance; (iv) upon specified distributions to our shareholders; or (v) upon the occurrence of specified corporate transactions, such as a fundamental change (i.e., a change in control), or our Common Stock ceasing to be listed on at least one U.S. national securities exchange. On or after July 1, 2016, holders may convert their notes at the conversion rate at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date irrespective of the foregoing conditions. In the event that a fundamental change, as defined in the indenture under which the notes have been issued, occurs prior to maturity of the notes, the initial conversion rate may be increased to include additional shares upon conversion, or holders can require us to purchase from them all or a portion of their notes for 100% of the principal value plus any accrued and unpaid interest.

           In connection with the offering of the convertible senior notes, we entered into convertible note hedge (call option) and warrant transactions with multiple counterparties, including an affiliate of the initial purchaser. The convertible note hedge transactions cover, subject to customary anti-dilution adjustments, the number of shares of our Common Stock that initially underlie the notes, and are intended to reduce the potential dilutive impact of the conversion feature of the notes. The convertible note hedge will terminate upon the earlier of the maturity date of the notes or the first day the notes are no longer outstanding. The warrant transactions have an initial strike price of approximately $103.41 per share, and may be settled in cash or shares of our Common Stock, at our option. The warrants expire at various dates during 2017.

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           The net proceeds from the convertible senior notes offering were $391.1 million after deducting the initial purchaser's discount and issuance costs. In addition, the net cost of the convertible note hedge transactions, after taking into account the proceeds received by us from the warrant transactions, was $23.7 million. We intend to use the remaining net proceeds from the issuance of the notes for general corporate purposes.

      Funding Requirements

           We expect to continue to incur substantial funding requirements for our research and development activities (including preclinical and clinical testing). As described above, research and development expenses that we incur in connection with our ZALTRAP® and antibodies collaborations are generally funded by Sanofi. In addition, as described above, we and Bayer HealthCare share agreed-upon development expenses that both companies incur in connection with our EYLEA® collaboration. After taking into account anticipated reimbursements from our collaborators, we currently estimate that approximately 40-50% of our funding requirements for 2012 will be directed toward technology development, basic research and early preclinical activities, and the preclinical and clinical development of our product candidates. For 2012, we also currently estimate that approximately 20-25% of our funding requirements will be directed toward the planned commercialization of new indications for our marketed products and ZALTRAP®; approximately 15-20% of our funding requirements will be applied to capital expenditures (as described above); and the remainder of our funding requirements will be used for general corporate purposes.

           In connection with our funding requirements, the following table summarizes our contractual obligations as of December 31, 2011. These obligations and commitments assume non-termination of agreements and represent expected payments based on current operating forecasts, which are subject to change:

      Payments Due by Period
      Less than Greater than
      (In millions)         Total       one year       1 to 3 years       3 to 5 years       5 years
      Convertible senior notes (1) $ 437.0 $ 7.1 $ 15.0 $ 414.9
      Operating leases (2) 97.2   7.3 15.0   15.3 $ 59.6
      Capital leases   2.5   1.2   1.3  
      Purchase obligations (3) 148.0 91.7   49.3   7.0      
      Other long-term liabilities (4)   240.7 15.7 35.3 36.8 152.9
      Total contractual obligations $ 925.4 $ 123.0 $ 115.9 $ 474.0 $ 212.5
      ____________________
       
            (1)       Consists of $400.0 million aggregate principal amount of 1.875% convertible senior notes that mature on October 1, 2016, unless earlier converted or repurchased. The amounts in the table above assume the payment of interest on our convertible senior notes through their maturity date and the payment of the principal amount of the notes at their maturity date. Interest on the notes is payable semi-annually. The convertible senior notes will be convertible, subject to certain conditions, into cash, shares of our Common Stock, or a combination of cash and shares of Common Stock, at our option.
      (2) Excludes future contingent costs for utilities, real estate taxes, and operating expenses. In 2011, these costs were $9.3 million. See Note 12(a) to our Financial Statements.
      (3) Purchase obligations primarily relate to (i) research and development commitments, including those related to clinical trials, (ii) capital expenditures for equipment acquisitions, and (iii) license payments. Our obligation to pay certain of these amounts may increase or be reduced based on certain future events. Open purchase orders for the acquisition of goods and services in the ordinary course of business are excluded from the table above.
      (4) Represents payments with respect to facility lease obligations in connection with our lease of facilities in Tarrytown, New York, as described above. See Note 12(a) to our Financial Statements.

           Under our collaboration with Bayer HealthCare, over the next several years we and Bayer HealthCare will share agreed-upon EYLEA® development expenses incurred by both companies, under a global development plan, as described above. In addition, under our collaboration agreements with Sanofi and Bayer HealthCare, if the applicable collaboration becomes profitable, we have contingent contractual obligations to reimburse Sanofi and Bayer HealthCare for a defined percentage (generally 50%) of agreed-upon development expenses incurred by Sanofi and Bayer HealthCare, respectively. Profitability under each collaboration will be measured by calculating net sales less agreed-upon expenses. These reimbursements would be deducted from our share of the collaboration profits (and, for our ZALTRAP® collaboration with Sanofi, royalties on product sales in Japan) otherwise payable to us, unless, in some cases, we elect to reimburse these expenses at a faster rate. Given the uncertainties related to drug development (including the development of ZALTRAP® and co-developed antibody candidates in collaboration with Sanofi and EYLEA® in collaboration with Bayer HealthCare), such as the variability in the length of time necessary to develop a product candidate and the ultimate ability to obtain governmental approval for commercialization, we are currently unable to reliably estimate if our collaborations with Sanofi and Bayer HealthCare will become profitable.

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           The amount we need to fund operations will depend on various factors, including revenues from net product sales, the potential regulatory approval and commercialization of our product candidates and new indications for our marketed products, and the timing thereof, the status of competitive products, the success of our research and development programs, the potential future need to expand our professional and support staff and facilities, the status of patents and other intellectual property rights (and pending or future litigation related thereto), the delay or failure of a clinical trial of any of our potential drug candidates, and the continuation, extent, and success of our collaborations with Sanofi and Bayer HealthCare. Clinical trial costs are dependent, among other things, on the size and duration of trials, fees charged for services provided by clinical trial investigators and other third parties, the costs for manufacturing the product candidate for use in the trials, and for supplies, laboratory tests, and other expenses. The amount of funding that will be required for our clinical programs depends upon the results of our research and preclinical programs and early-stage clinical trials, regulatory requirements, the duration and results of clinical trials underway and of additional clinical trials that we decide to initiate, and the various factors that affect the cost of each trial as described above. Our commercialization costs over approximately the next few years will depend on, among other things, whether or not new indications for our marketed products or our late-stage product candidates receive regulatory approval, the market potential for such new indications or product candidates, and the commercialization terms of our collaboration agreements, if applicable (whereby some or all commercialization costs may be shared with our collaborators). Currently, we are required to pay royalties on product sales of EYLEA® for the treatment of wet AMD and ARCALYST® for the treatment of CAPS. In the future, if we are able to successfully develop, market, and sell EYLEA® or ARCALYST® for other indications, or certain of our product candidates, we may be required to pay royalties or share the profits from such sales pursuant to our license or collaboration agreements.

           We expect that expenses related to the filing, prosecution, defense, and enforcement of patents and other intellectual property will continue to be substantial.

           We believe that our existing capital resources, together with funds generated by anticipated EYLEA® net product sales and funding we are entitled to receive under our collaboration agreements, will enable us to meet our projected operating needs. However, this is a forward-looking statement based on our current operating plan, and there may be a change in projected revenues or expenses that would lead to our capital being consumed significantly before such time. For example, in connection with preparing to commercialize and launch potential products that are not licensed to a third party, we could incur substantial pre-marketing and commercialization expenses that could lead us to consume our cash at a faster rate. If there is insufficient capital to fund all of our planned operations and activities, we anticipate that we would (i) seek sources of additional capital through collaborative arrangements and/or additional public or private financing, including debt and equity financing and/or (ii) prioritize available capital to fund selected preclinical and clinical development programs and/or preparations for the potential commercialization of our late-stage product candidates, or license selected products.

           Other than letters of credits totaling $4.2 million, including the $3.4 million letter of credit issued in connection with our lease for facilities in Tarrytown, New York, as described above, we have no off-balance sheet arrangements. In addition, we do not guarantee the obligations of any other entity. As of December 31, 2011, we had no other established banking arrangements through which we could obtain short-term financing or a line of credit. In October 2011, we completed a private placement of convertible senior notes, as described above. In addition, in October 2010, we filed a shelf registration statement on Form S-3 registering the sale, in one or more offerings, of an indeterminate amount of equity or debt securities, together or separately, and our October 2010 public offering of approximately 6.3 million shares of Common Stock was completed under this shelf registration statement. There is no assurance, however, that we will be able to complete any additional offerings of securities. Factors influencing the availability of additional financing include our progress in product development and commercialization, investor perception of our prospects, and the general condition of the financial markets. We may not be able to secure additional funding through new collaborative arrangements or additional public or private offerings. If we cannot raise adequate funds to satisfy our capital requirements, we may have to delay, scale-back, or eliminate certain of our research and development activities or future operations. This could materially harm our business.

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      Future Impact of Recently Issued Accounting Standards

      Fees paid to the federal government by pharmaceutical manufacturers

           In December 2010, the FASB provided authoritative guidance on how pharmaceutical manufacturers should recognize and classify in their income statement annual fees mandated by the Patient Protection and Affordable Care Act as amended by the Health Care and Education Reconciliation Act. This guidance became effective for calendar years beginning after December 31, 2010. The adoption of this guidance did not have an impact on our financial statements for the year ended December 31, 2011, and we do not anticipate that this guidance will have a material impact on our financial statements for the year ended December 31, 2012, since (i) ARCALYST® for the treatment of CAPS, has been approved as an orphan drug and orphan drugs are not subject to this annual fee and (ii) EYLEA® received regulatory approval from the FDA, and was launched, in November 2011.

      Presentation of comprehensive income

           In June 2011, the FASB amended its authoritative guidance on the presentation of comprehensive income. Under the amendment, an entity will have the option to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. This amendment, therefore, eliminates the currently available option to present the components of other comprehensive income as part of the statement of changes in stockholders' equity. The amendment does not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income. We will adopt this amended guidance for the fiscal year beginning January 1, 2012. As this guidance relates to presentation only, the adoption of this guidance will not have any other effect on our financial statements.

      Item 7A. Quantitative and Qualitative Disclosures About Market Risk

      Interest Rate Risk

           Our earnings and cash flows are subject to fluctuations due to changes in interest rates, principally in connection with our investments in marketable securities, which consist primarily of direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities. We do not believe we are materially exposed to changes in interest rates. Under our current policies, we do not use interest rate derivative instruments to manage exposure to interest rate changes. We estimate that a one percent unfavorable change in interest rates would have resulted in approximately a $1.4 million and $5.9 million decrease in the fair value of our unrestricted investment portfolio at December 31, 2011 and 2010, respectively. The decrease in interest rate risk year over year is due primarily to lower balances of marketable debt securities with maturities in excess of one year that we held at December 31, 2011 compared to 2010.

      Credit Quality Risk

           We have an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification. Nonetheless, deterioration of the credit quality of an investment security subsequent to purchase may subject us to the risk of not being able to recover the full principal value of the security. We have recognized other-than-temporary impairment charges related to certain marketable securities of $0.1 million in 2010 and 2009. During 2011, we did not recognize any other-than-temporary impairment charges.

           We are also subject to credit risk in connection with accounts receivable from our product sales of EYLEA® and ARCALYST®. Our marketed products are sold in the United States, and related accounts receivable are due from three distributors and several specialty pharmacies, who are our customers. We have contractual payment terms with each of our customers. We monitor our customers’ financial performance and credit worthiness so that we can properly assess and respond to any changes in their credit profile. During 2011, 2010, and 2009 we did not recognize any charges for write-offs of accounts receivable related to our marketed products.

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      Item 8. Financial Statements and Supplementary Data

           The financial statements required by this Item are included on pages F-1 through F-38 of this report. The supplementary financial information required by this Item is included at page F-38 of this report.

      Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

           Not applicable.

      Item 9A. Controls and Procedures

      Evaluation of Disclosure Controls and Procedures

           The Company’s management, with the participation of our chief executive officer and chief financial officer, conducted an evaluation of the effectiveness of the Company’s disclosure controls and procedures (as such term is defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934 (the “Exchange Act”)) as of the end of the period covered by this Annual Report on Form 10-K. Based on this evaluation, our chief executive officer and chief financial officer each concluded that, as of the end of such period, our disclosure controls and procedures were effective in ensuring that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized, and reported on a timely basis, and is accumulated and communicated to the Company’s management, including the Company’s chief executive officer and chief financial officer, as appropriate to allow timely decisions regarding required disclosure.

      Management Report on Internal Control over Financial Reporting

           Our management is responsible for establishing and maintaining adequate internal control over financial reporting, as such term is defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act. Our management conducted an evaluation of the effectiveness of our internal control over financial reporting using the framework in Internal Control – Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission. Based on that evaluation, our management has concluded that our internal control over financial reporting was effective as of December 31, 2011. The effectiveness of our internal control over financial reporting as of December 31, 2011 has been audited by PricewaterhouseCoopers LLP, an independent registered public accounting firm, as stated in their report which appears herein.

           Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

      Changes in Internal Control over Financial Reporting

           There has been no change in our internal control over financial reporting (as such term is defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) during the quarter ended December 31, 2011 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

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           Our management, including our chief executive officer and chief financial officer, does not expect that our disclosure controls and procedures or internal controls over financial reporting will prevent all errors and all fraud. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the system are met and cannot detect all deviations. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud or deviations, if any, within the company have been detected. Projections of any evaluation of effectiveness to future periods are subject to the risks that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

      Item 9B. Other Information

           None.

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      PART III

      Item 10. Directors, Executive Officers and Corporate Governance

           The information required by this item (other than the information set forth in the next paragraph in this Item 10) will be included in our definitive proxy statement with respect to our 2012 Annual Meeting of Shareholders to be filed with the SEC, and is incorporated herein by reference.

           We have adopted a code of business conduct and ethics that applies to our officers, directors, and employees. The full text of our code of business conduct and ethics can be found on our website (http://www.regeneron.com) under the “Investors” heading on the “Corporate Governance” page. We may satisfy the disclosure requirements under Item 5.05 of Form 8-K regarding an amendment to, or a waiver from, a provision of our code of business conduct and ethics that applies to our principal executive officer, principal financial officer, principal accounting officer, or controller, or persons performing similar functions, by posting such information on our website where it is accessible through the same link noted above.

      Item 11. Executive Compensation

           The information called for by this item will be included in our definitive proxy statement with respect to our 2012 Annual Meeting of Shareholders to be filed with the SEC, and is incorporated herein by reference.

      Item 12. 

      Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

           The information called for by this item will be included in our definitive proxy statement with respect to our 2012 Annual Meeting of Shareholders to be filed with the SEC, and is incorporated herein by reference.

      Item 13. Certain Relationships and Related Transactions, and Director Independence

           The information required by this item will be included in our definitive proxy statement with respect to our 2012 Annual Meeting of Shareholders to be filed with the SEC, and is incorporated herein by reference.

      Item 14. Principal Accountant Fees and Services

           The information called for by this item will be included in our definitive proxy statement with respect to our 2012 Annual Meeting of Shareholders to be filed with the SEC, and is incorporated herein by reference.

      PART IV

      Item 15. Exhibits and Financial Statement Schedules

           (a) 1. Financial Statements

      The financial statements filed as part of this report are listed on the Index to Financial Statements on page F-1.

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                2. Financial Statement Schedules

      All schedules for which provision is made in the applicable accounting regulations of the Securities and Exchange Commission are not required under the related instructions or are inapplicable and, therefore, have been omitted.

                3. Exhibits

      Exhibit
      Number       Description
      3.1 (m)       -      

      Restated Certificate of Incorporation.

      3.2 (a) - By-Laws, as amended.
      4.1 (z) - Indenture, dated as of October 21, 2011, between Regeneron Pharmaceuticals, Inc. and Wells Fargo Bank, National Association, as Trustee.
      4.2 (z) - Form of 1.875% Convertible Senior Note due October 1, 2016.
      10.1+ (y)   - The Second Amended and Restated 2000 Long-Term Incentive Plan.
      10.1.1+ (b) - Form of option agreement and related notice of grant for use in connection with the grant of options to the Registrant’s non-employee directors and named executive officers.
      10.1.2+ (b) - Form of option agreement and related notice of grant for use in connection with the grant of options to the Registrant’s executive officers other than the named executive officers.
      10.1.3+ (c) - Form of restricted stock award agreement and related notice of grant for use in connection with the grant of restricted stock awards to the Registrant’s executive officers.
      10.1.4+   (c) - Form of option agreement and related notice of grant for use in connection with the grant of stock options to certain of the Registrant’s executive officers in connection with a January 2005 Option Exchange Program.
      10.1.5+ (q) - Form of option agreement and related notice of grant for use in connection with the grant of time based vesting stock options to the Registrant's non-employee directors and executive officers.
      10.1.6+ (q) - Form of option agreement and related notice of grant for use in connection with the grant of performance based vesting stock options to the Registrant's executive officers.
      10.1.7+ (x) - Form of restricted stock award agreement and related notice of grant for use in connection with the grant of restricted stock awards to the Registrant's executive officers (revised).
      10.1.8+ (x) -   Form of option agreement and related notice of grant for use in connection with the grant of performance based vesting stock options to the Registrant's executive officers (revised).
      10.1.9+ -

      Form of option agreement and related notice of grant for use in connection with the grant of time based vesting stock options to the Registrant's non-employee directors (revised).

      10.2+ (p) - Amended and Restated Employment Agreement, dated as of November 14, 2008, between the Registrant and Leonard S. Schleifer, M.D., Ph.D.
      10.3*+ (d) - Employment Agreement, dated as of December 31, 1998, between the Registrant and P. Roy Vagelos, M.D.
      10.4+ (p) - Regeneron Pharmaceuticals, Inc. Change in Control Severance Plan, amended and restated effective as of November 14, 2008.
      10.5* (e) - IL-1 License Agreement, dated June 26, 2002, by and among the Registrant, Immunex Corporation, and Amgen Inc.
      10.6* (r) - IL-1 Antibody Termination Agreement by and between Novartis Pharma AG, Novartis Pharmaceuticals Corporation and the Registrant, dated as of June 8, 2009.
      10.7* (r) - Trap-2 Termination Agreement by and between Novartis Pharma AG, Novartis Pharmaceuticals Corporation and the Registrant, dated as of June 8, 2009.
      10.8* (f) - Collaboration Agreement, dated as of September 5, 2003, by and between Aventis Pharmaceuticals Inc. and the Registrant.
      10.8.1* (d) - Amendment No. 1 to Collaboration Agreement, by and between Aventis Pharmaceuticals Inc. and the Registrant, effective as of December 31, 2004
      10.8.2 (g) - Amendment No. 2 to Collaboration Agreement, by and between Aventis Pharmaceuticals Inc. and the Registrant, effective as of January 7, 2005.

      79


      10.8.3*       (h)       -       Amendment No. 3 to Collaboration Agreement, by and between Aventis Pharmaceuticals Inc. and the Registrant, effective as of December 21, 2005.
      10.8.4*   (h) - Amendment No. 4 to Collaboration Agreement, by and between sanofi-aventis U.S., LLC (successor in interest to Aventis Pharmaceuticals, Inc.) and the Registrant, effective as of January 31, 2006.
      10.9* (i) - License and Collaboration Agreement, dated as of October 18, 2006, by and between Bayer HealthCare LLC and the Registrant.
      10.10 (k) - Lease, dated as of December 21, 2006, by and between BMR-Landmark at Eastview LLC and the Registrant.
      10.10.1* (l) - First Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, effective as of October 24, 2007.
      10.10.2 (o) - Second Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, effective as of September 30, 2008.
      10.10.3 (q) - Third Amendment to lease, by and between BMR-Landmark at Eastview LLC and the Registrant, entered into as of April 29, 2009.
      10.10.4 (s) - Fourth Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, effective as of December 3, 2009.
      10.10.5 (t) - Fifth Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, entered into as of February 11, 2010.
      10.10.6 (v) - Sixth Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, entered into as of June 4, 2010.
      10.10.7 (x) - Seventh Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, entered into as of December 22, 2010.
      10.10.8 (aa) -

      Eighth Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, entered into as of August 1, 2011.

      10.10.9 (aa) -

      Ninth Amendment to Lease, by and between BMR-Landmark at Eastview LLC and the Registrant, entered into as of September 30, 2011.

      10.11* (k) - Non Exclusive License and Material Transfer Agreement, dated as of March 30, 2007, by and between Astellas Pharma Inc. and the Registrant.
      10.11.1* (w) - Amendment to the Non Exclusive License and Material Transfer Agreement, dated as of March 30, 2007 by and between Astellas Pharma Inc. and the Registrant, dated as of July 28, 2010.
      10.12* (u) - Amended and Restated Discovery and Preclinical Development Agreement, dated as of November 10, 2009, by and between Aventis Pharmaceuticals Inc. and the Registrant.
      10.13* (u) - Amended and Restated License and Collaboration Agreement, dated as of November 10, 2009, by and among Aventis Pharmaceuticals Inc., sanofi-aventis Amerique Du Nord, and the Registrant.
      10.14 (m) - Stock Purchase Agreement, dated as of November 28, 2007, by and among sanofi-aventis Amerique Du Nord, sanofi-aventis US LLC, and the Registrant.
      10.15 (m) - Investor Agreement, dated as of December 20, 2007, by and among sanofi-aventis, sanofi-aventis US LLC, Aventis Pharmaceuticals Inc., sanofi-aventis Amerique du Nord, and the Registrant.
      10.15.1 (u) - First Amendment to the December 20, 2007 Investor Agreement, dated as of November 10, 2009, by and among sanofi-aventis US LLC, Aventis Pharmaceuticals, Inc., sanofi-aventis Amerique du Nord, and the Registrant.
      10.16* (n) - Amended and Restated Non-Exclusive License Agreement, dated as of July 1, 2008 by and between Cellectis, S.A. and the Registrant.
      10.17 (z) -

      Purchase Agreement, dated as of October 18, 2011, between Regeneron Pharmaceuticals, Inc. and Goldman, Sachs & Co.

      10.18 (z) -

      Master Terms and Conditions for Convertible Note Hedging Transactions, dated October 18, 2011, between Goldman, Sachs & Co. and Regeneron Pharmaceuticals, Inc.

      10.19 (z) -

      Master Terms and Conditions for Base Warrants, dated October 18, 2011, between Goldman, Sachs & Co. and Regeneron Pharmaceuticals, Inc.

      10.20 (z) -

      Master Terms and Conditions for Convertible Note Hedging Transactions, dated October 18, 2011, between Citibank, N.A. and Regeneron Pharmaceuticals, Inc.

      10.21 (z) -

      Master Terms and Conditions for Base Warrants, dated October 18, 2011, between Citibank, N.A. and Regeneron Pharmaceuticals, Inc.

      10.22 (z) -

      Master Terms and Conditions for Convertible Note Hedging Transactions, dated October 18, 2011, between Credit Suisse International and Regeneron Pharmaceuticals, Inc.

      10.23 (z) -

      Master Terms and Conditions for Base Warrants, dated October 18, 2011, between Credit Suisse International and Regeneron Pharmaceuticals, Inc.

      10.24 (z) -

      Master Terms and Conditions for Convertible Note Hedging Transactions, dated October 18, 2011, between Morgan Stanley & Co. International plc and Regeneron Pharmaceuticals, Inc.

      10.25 (z) -

      Master Terms and Conditions for Base Warrants, dated October 18, 2011, between Morgan Stanley & Co. International plc and Regeneron Pharmaceuticals, Inc.

      10.26**   -

      Non-exclusive License and Partial Settlement Agreement with Genentech, Inc.

      23.1 - Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
      24.1 - Power of Attorney (included on the signature page of this Annual Report on Form 10-K).
      31.1   -   Certification of CEO pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
      31.2   - Certification of CFO pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
      32 - Certification of CEO and CFO pursuant to 18 U.S.C. Section 1350.
      101 - Interactive Data File

      80


             101.INS          -       XBRL Instance Document
             101.SCH          -       XBRL Taxonomy Extension Schema
             101.CAL -   XBRL Taxonomy Extension Calculation Linkbase
             101.LAB - XBRL Taxonomy Extension Label Linkbase
             101.PRE - XBRL Taxonomy Extension Presentation Linkbase
             101.DEF   - XBRL Taxonomy Extension Definition Document
      ____________________
       
            (a)       Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed November 13, 2007.
       
      (b) Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed December 16, 2005.
       
      (c) Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed December 13, 2004.
       
      (d) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2004, filed March 11, 2005.
       
      (e) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended June 30, 2002, filed August 13, 2002.
       
      (f) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended September 30, 2003, filed November 12, 2003.
       
      (g) Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed January 11, 2005.
       
      (h) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2005, filed February 28, 2006.
       
      (i) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended September 30, 2006, filed November 6, 2006.
       
      (j) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2006, filed March 12, 2007.
       
      (k) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended March 31, 2007, filed May 4, 2007.
       
      (l) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended September 30, 2007, filed November 7, 2007.
       
      (m) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2007, filed February 27, 2008.
       
      (n) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended June 30, 2008, filed August 1, 2008.

      81


            (o)       Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended September 30, 2008, filed November 5, 2008.
       
      (p) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2008, filed February 26, 2009.
       
      (q) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended March 31, 2009, filed April 30, 2009.
       
      (r) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended June 30, 2009, filed August 4, 2009.
       
      (s) Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed December 8, 2009.
       
      (t) Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed February 16, 2010.
       
      (u) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2009, filed February 18, 2010.
       
      (v) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended June 30, 2010, filed July 28, 2010.
       
      (w) Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended September 30, 2010, filed October 28, 2010.
       
      (x) Incorporated by reference from the Form 10-K for Regeneron Pharmaceuticals, Inc., for the year ended December 31, 2010, filed February 17, 2011.
             
        (y)   Incorporated by reference from the Registration Statement on Form S-8 for Regeneron Pharmaceuticals, Inc., filed June 13, 2011.
             
        (z)   Incorporated by reference from the Form 8-K for Regeneron Pharmaceuticals, Inc., filed October 24, 2011.
             
        (aa)   Incorporated by reference from the Form 10-Q for Regeneron Pharmaceuticals, Inc., for the quarter ended September 30, 2011, filed October 27, 2011.
      ____________________
       
                  *       Portions of this document have been omitted and filed separately with the Commission pursuant to requests for confidential treatment pursuant to Rule 24b-2.
       
      ** The Company has requested confidential treatment of certain information contained in this exhibit. Such information has been filed separately with the Commission pursuant to the Company’s application for confidential treatment.
         
      + Indicates a management contract or compensatory plan or arrangement.

      82


      SIGNATURES

           Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

        REGENERON PHARMACEUTICALS, INC.
           
        By:      /s/ LEONARD S. SCHLEIFER       
            Leonard S. Schleifer, M.D., Ph.D.  
            President and Chief Executive Officer  
       
      Dated:    Tarrytown, New York
        February 21, 2012

      POWER OF ATTORNEY

           KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Leonard S. Schleifer, President and Chief Executive Officer, and Murray A. Goldberg, Senior Vice President, Finance & Administration, Chief Financial Officer, Treasurer, and Assistant Secretary, and each of them, his true and lawful attorney-in-fact and agent, with the full power of substitution and resubstitution, for him and in his name, place, and stead, in any and all capacities therewith, to sign any and all amendments to this annual report on Form 10-K, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that each said attorney-in-fact and agent, or either of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

           Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:

      Signature       Title
             /s/    Leonard S. Schleifer   President, Chief Executive Officer, and
      Leonard S. Schleifer, M.D., Ph.D.   Director (Principal Executive Officer)
       
             /s/    Murray A. Goldberg     Senior Vice President, Finance &
      Murray A. Goldberg Administration, Chief Financial Officer,
      Treasurer, and Assistant Secretary
      (Principal Financial Officer)
       
             /s/    Douglas S. McCorkle     Vice President, Controller, and
        Douglas S. McCorkle Assistant Treasurer
      (Principal Accounting Officer)
       
             /s/    George D. Yancopoulos   Executive Vice President, Chief Scientific
      George D. Yancopoulos, M.D., Ph.D. Officer, President, Regeneron Research
      Laboratories, and Director
       
             /s/    P. Roy Vagelos   Chairman of the Board
      P. Roy Vagelos, M.D.

      83


             /s/    Charles A. Baker   Director
      Charles A. Baker  
       
             /s/    Michael S. Brown     Director
      Michael S. Brown, M.D.
       
             /s/    Alfred G. Gilman   Director
      Alfred G. Gilman, M.D., Ph.D.
       
             /s/    Joseph L. Goldstein   Director
      Joseph L. Goldstein, M.D.
       
             /s/    Christine A. Poon   Director
      Christine A. Poon
       
             /s/    Arthur F. Ryan   Director
      Arthur F. Ryan  
       
             /s/    Eric M. Shooter     Director
      Eric M. Shooter, Ph.D.
       
             /s/    George L. Sing   Director
      George L. Sing
       
             /s/    Marc Tessier-Lavigne   Director
      Marc Tessier-Lavigne, Ph.D.

      84


      REGENERON PHARMACEUTICALS, INC.

      INDEX TO FINANCIAL STATEMENTS

      Page
      REGENERON PHARMACEUTICALS, INC.   Numbers
             Report of Independent Registered Public Accounting Firm F-2
             Balance Sheets at December 31, 2011 and 2010 F-3
             Statements of Operations for the years ended December 31, 2011, 2010, and 2009 F-4
             Statements of Stockholders' Equity for the years ended December 31, 2011, 2010, and 2009 F-5
             Statements of Cash Flows for the years ended December 31, 2011, 2010, and 2009 F-6
             Notes to Financial Statements F-7 to F-38

      F-1


      REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

      To the Board of Directors and Stockholders of
      Regeneron Pharmaceuticals, Inc.:

      In our opinion, the accompanying balance sheets and the related statements of operations, stockholders' equity and cash flows present fairly, in all material respects, the financial position of Regeneron Pharmaceuticals, Inc., (the “Company”), at December 31, 2011 and December 31, 2010, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2011 in conformity with accounting principles generally accepted in the United States of America. Also in our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2011, based on criteria established in Internal Control - Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). The Company's management is responsible for these financial statements, for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting, included in Management's Report on Internal Control over Financial Reporting appearing under Item 9A. Our responsibility is to express opinions on these financial statements and on the Company's internal control over financial reporting based on our integrated audits. We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audits to obtain reasonable assurance about whether the financial statements are free of material misstatement and whether effective internal control over financial reporting was maintained in all material respects. Our audits of the financial statements included examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. Our audit of internal control over financial reporting included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audits also included performing such other procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinions.

      A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (iii) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

      Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

      /s/ PricewaterhouseCoopers LLP

      New York, New York
      February 21, 2012

      F-2


      REGENERON PHARMACEUTICALS, INC.
      BALANCE SHEETS
      December 31, 2011 and 2010
      (In thousands, except share data)

      2011 2010
      ASSETS
      Current assets
             Cash and cash equivalents       $ 483,610       $ 112,572
             Marketable securities   43,332 136,796
             Accounts receivable from Sanofi 74,781 79,603
             Accounts receivable - trade, net 28,254   2,314
             Prepaid expenses and other current assets 22,898 26,337
                    Total current assets 652,875 357,622
       
      Restricted cash and marketable securities 7,721 7,518
      Marketable securities 275,887 370,053  
      Property, plant, and equipment, at cost, net of accumulated
             depreciation and amortization 367,955 347,450
      Other assets 19,145 6,789
                    Total assets $ 1,323,583 $ 1,089,432
           
      LIABILITIES and STOCKHOLDERS' EQUITY
      Current liabilities
             Accounts payable and accrued expenses $ 95,625 $ 53,658
             Deferred revenue from Sanofi, current portion 20,011 19,506
             Deferred revenue - other, current portion 31,629 35,217
             Facility lease obligations, current portion 1,006 675
                    Total current liabilities 148,271 109,056
        
      Deferred revenue from Sanofi 86,017 97,081
      Deferred revenue - other 162,593 188,775
      Facility lease obligations 159,508 159,355
      Convertible senior notes 275,019
      Other long term liabilities 6,443 7,350
                    Total liabilities 837,851 561,617
        
      Commitments and contingencies (Note 12)
        
      Stockholders' equity
             Preferred stock, $.01 par value; 30,000,000 shares authorized; issued and outstanding - none
             Class A Stock, convertible, $.001 par value: 40,000,000 shares authorized;
                    shares issued and outstanding - 2,109,512 in 2011 and 2,182,036 in 2010 2 2
             Common Stock, $.001 par value; 160,000,000 shares authorized;
                    shares issued and outstanding - 90,692,071 in 2011 and 87,238,301 in 2010 91 87
             Additional paid-in capital 1,754,824 1,575,780
             Accumulated deficit (1,267,323 ) (1,045,563 )
             Accumulated other comprehensive loss (1,862 ) (2,491 )
                    Total stockholders' equity 485,732 527,815
                    Total liabilities and stockholders' equity $ 1,323,583 $ 1,089,432

      The accompanying notes are an integral part of the financial statements.

      F-3


      REGENERON PHARMACEUTICALS, INC.
      STATEMENTS OF OPERATIONS
      For the Years Ended December 31, 2011, 2010, and 2009
      (In thousands, except per share data)

      2011 2010 2009
      Revenues
             Sanofi collaboration revenue $ 326,609 $ 311,332 $ 247,140
             Other collaboration revenue 43,072 75,393 67,317
             Net product sales 44,686 25,254 18,364
             Technology licensing 24,858 40,150 40,013
             Contract research and other 6,599 6,945 6,434
        445,824 459,074 379,268
        
      Expenses
             Research and development 529,506 489,252 398,762
             Selling, general, and administrative 117,261 65,201 52,923
             Cost of goods sold 4,216 2,093 1,686
        650,983 556,546 453,371
        
      Loss from operations (205,159 ) (97,472 ) (74,103 )
       
      Other income (expense)
             Investment income 3,549 2,122 4,488
             Interest expense (21,282 ) (9,118 ) (2,337 )
        (17,733 ) (6,996 ) 2,151
       
      Net loss before income tax benefit (222,892 ) (104,468 ) (71,952 )
       
      Income tax benefit (1,132 ) (4,122 )
       
      Net loss       $ (221,760 )       $ (104,468 )       $ (67,830 )
       
      Net loss per share, basic and diluted $ (2.45 ) $ (1.26 ) $ (0.85 )
       
      Weighted average shares outstanding, basic and diluted 90,610 82,926 79,782

      The accompanying notes are an integral part of the financial statements.

      F-4


      REGENERON PHARMACEUTICALS, INC.
      STATEMENTS OF STOCKHOLDERS' EQUITY
      For the Years Ended December 31, 2011, 2010, and 2009
      (In thousands)

      Accumulated
      Additional Other Total
      Class A Stock Common Stock Paid-in Accumulated Comprehensive Stockholders' Comprehensive
      Shares Amount Shares Amount Capital Deficit Income (Loss) Equity Loss
      Balance, December 31, 2008 2,249 $      2 77,642 $        78 $ 1,294,813 $      (873,265 ) $              (114 ) $            421,514
       
      Issuance of Common Stock in connection with
             exercise of stock options, net of shares tendered 1,134 1 9,269 9,270
      Issuance of Common Stock in connection with
             Company 401(k) Savings Plan contribution 81 1,391 1,391
      Conversion of Class A Stock to Common Stock (4 ) 4
      Stock-based compensation charges 31,259 31,259
      Net loss, 2009 (67,830 ) (67,830 ) $           (67,830 )
      Change in net unrealized gain (loss) on marketable
             securities, net of tax effect of $0.7 million 1,158 1,158 1,158
        
      Balance, December 31, 2009      2,245 2 78,861 79 1,336,732 (941,095 ) 1,044 396,762 $ (66,672 )
        
      Issuance of Common Stock in a public offering, net of
             issuance costs 6,325 6 174,822 174,828
      Issuance of Common Stock in connection with
             exercise of stock options, net of shares tendered 1,533 2 21,462 21,464
      Issuance of Common Stock in connection with
             Company 401(k) Savings Plan contribution 111 2,867 2,867
      Issuance of restricted Common Stock under
             Long-Term Incentive Plan 345
      Conversion of Class A Stock to Common Stock (63 ) 63
      Stock-based compensation charges 39,897 39,897
      Net loss, 2010 (104,468 ) (104,468 ) $ (104,468 )
      Change in net unrealized gain (loss) on marketable
             securities (3,535 ) (3,535 ) (3,535 )
        
      Balance, December 31, 2010 2,182 2        87,238 87 1,575,780 (1,045,563 ) (2,491 ) 527,815 $ (108,003 )
       
      Issuance of Common Stock in connection with
             exercise of stock options, net of shares tendered 3,324 4 21,171 21,175
      Issuance of Common Stock in connection with
             Company 401(k) Savings Plan contribution 92 6,979 6,979
      Issuance of restricted Common Stock under
             Long-Term Incentive Plan 16
      Restricted Common Stock tendered upon vesting in
             connection with employee tax obligations (51 ) (2,638 ) (2,638 )
      Conversion of Class A Stock to Common Stock (73 ) 73
      Stock-based compensation charges 56,609 56,609
      Equity component of convertible senior notes, net of issuance costs 120,623   120,623
      Purchase of convertible note hedges (117,500 ) (117,500 )
      Issuance of warrants in connection with issuance of convertible      
             senior notes 93,800   93,800
      Net loss, 2011   (221,760 ) (221,760 ) $ (221,760 )
      Change in net unrealized gain (loss) on marketable
             securities, net of tax effect of $0.4 million   629 629 629
        
      Balance, December 31, 2011       2,109         $ 2       90,692         $ 91       $ 1,754,824       $ (1,267,323 )       $ (1,862 )       $ 485,732       $ (221,131 )

      The accompanying notes are an integral part of the financial statements.

      F-5


      REGENERON PHARMACEUTICALS, INC.
      STATEMENTS OF CASH FLOWS
      For the Years Ended December 31, 2011, 2010, and 2009
      (In thousands)

      2011 2010 2009
      Cash flows from operating activities
             Net loss $ (221,760 ) $ (104,468 ) $ (67,830 )
             Adjustments to reconcile net loss to net cash (used in)
                    provided by operating activities
                           Depreciation and amortization 31,082 19,687 14,247
                           Non-cash compensation expense 56,094 39,897 31,259
                           Other non-cash charges and expenses, net 10,366 3,171 2,238
                           Changes in assets and liabilities
                                  Increase in Sanofi and trade accounts receivable (21,118 ) (17,518 ) (30,494 )
                                  Increase in prepaid expenses and other assets (6,033 ) (7,303 ) (4,436 )
                                  (Decrease) increase in deferred revenue (40,329 ) 158,151 (27,497 )
                                  Increase in accounts payable, accrued expenses,
                                         and other liabilities 50,016 7,605 12,577
                                                Total adjustments 80,078 203,690 (2,106 )
                                                Net cash (used in) provided by operating activities (141,682 ) 99,222 (69,936 )
         
      Cash flows from investing activities
             Purchases of marketable securities (240,391 ) (605,124 ) (199,997 )
             Sales or maturities of marketable securities 426,356 273,723 295,117
             (Increase) decrease in restricted cash and marketable securities (277 ) (5,941 ) 50
             Capital expenditures (57,217 ) (99,689 ) (97,318 )
                                                Net cash provided by (used in) investing activities 128,471 (437,031 ) (2,148 )
        
      Cash flows from financing activities
             Proceeds in connection with facility lease obligation 47,544 23,640
             Payments in connection with facility lease obligation (674 ) (924 ) (875 )
             Payments in connection with capital lease obligation (993 ) (104 )
             Proceeds in connection with issuance of convertible notes, net of debt issuance costs 391,107
             Proceeds in connection with issuance of warrants 93,800
             Payment in connection with purchase of convertible note hedges (117,500 )
             Net proceeds in connection with issuances of Common Stock 18,509 196,790 8,598
                                                Net cash provided by financing activities 384,249 243,306 31,363
       
      Net increase (decrease) in cash and cash equivalents 371,038 (94,503 ) (40,721 )
       
      Cash and cash equivalents at beginning of period 112,572 207,075 247,796
       
      Cash and cash equivalents at end of period $ 483,610 $ 112,572 $ 207,075
       
      Supplemental disclosure of cash flow information
             Cash paid for interest       $ 14,725         $ 12,737         $ 2,525  

      The accompanying notes are an integral part of the financial statements.

      F-6


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS
      For the years ended December 31, 2011, 2010, and 2009
      (Unless otherwise noted, dollars in thousands, except per share data)

      1. Organization and Business

           Regeneron Pharmaceuticals, Inc. (the “Company” or “Regeneron”) was incorporated in January 1988 in the State of New York. The Company is a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. In 2008, the Company received marketing approval from the U.S. Food and Drug Administration (“FDA”) for the Company’s first commercial drug product, ARCALYST® (rilonacept) Injection for Subcutaneous Use for the treatment of Cryopyrin-Associated Periodic Syndromes (“CAPS”). In November 2011, the Company received marketing approval from the FDA for EYLEA® (aflibercept) Injection for the treatment of neovascular wet age-related macular degeneration (“wet AMD”). The Company's facilities are primarily located in New York. The Company’s business is subject to certain risks including, but not limited to, uncertainties relating to conducting pharmaceutical research, obtaining regulatory approvals, commercializing products, and obtaining and enforcing patents.

      2. Summary of Significant Accounting Policies

      Cash and Cash Equivalents

           For purposes of the statement of cash flows and the balance sheet, the Company considers all highly liquid debt instruments with a maturity of three months or less when purchased to be cash equivalents. The carrying amount reported in the balance sheet for cash and cash equivalents approximates its fair value.

      Marketable Securities

           The Company has an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification. The Company has invested its excess cash primarily in direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities. The Company considers its marketable securities to be “available-for-sale,” as defined by authoritative guidance issued by the Financial Accounting Standards Board (“FASB”). These assets are carried at fair value and the unrealized gains and losses are included in accumulated other comprehensive income (loss) as a separate component of stockholders’ equity. If the decline in the value of a marketable security in the Company’s investment portfolio is deemed to be other-than-temporary, the Company writes down the security to its current fair value and recognizes a loss as a charge against income. As described under “Use of Estimates” below, the Company reviews its portfolio of marketable securities, using both quantitative and qualitative factors, to determine if declines in fair value below cost are other-than-temporary.

      Accounts Receivable - Trade

           The Company’s trade accounts receivable represents amounts due from its distributors and specialty pharmacies (collectively, the Company’s “customers”), which are all located in the United States. The Company monitors the financial performance and credit worthiness of its large customers so that it can properly assess and respond to changes in their credit profile. The Company provides reserves against trade receivables for estimated losses that may result from a customer’s inability to pay. Amounts determined to be uncollectible are written-off against the reserve. As of December 31, 2011 and 2010, there were no reserves against trade accounts receivable. In addition, during the years ended December 31, 2011, 2010 and 2009, no trade accounts receivable were written-off.

      Inventory

           Inventories are stated at the lower of cost or estimated realizable value. The Company determines the cost of inventory using the first-in, first-out, or FIFO, method. The Company capitalizes inventory costs associated with the Company’s products prior to regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized; otherwise, such costs are expensed as research and development. The Company periodically analyzes its inventory levels to identify inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, and writes-down such inventories as appropriate. In addition, the Company’s products are subject to strict quality control and monitoring which the Company performs throughout the manufacturing process. If certain batches or units of product no longer meet quality specifications or become obsolete due to expiration, the Company records a charge to cost of goods sold to write down such unmarketable inventory to its estimated realizable value.

      F-7


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      Property, Plant, and Equipment

           Property, plant, and equipment are stated at cost, net of accumulated depreciation. Depreciation is provided on a straight-line basis over the estimated useful lives of the assets. Expenditures for maintenance and repairs which do not materially extend the useful lives of the assets are charged to expense as incurred. The cost and accumulated depreciation or amortization of assets retired or sold are removed from the respective accounts, and any gain or loss is recognized in operations. The estimated useful lives of property, plant, and equipment are as follows:

      Building and improvements 10-40 years
      Laboratory and other equipment 3-10 years
      Furniture and fixtures 5 years

           Leasehold improvements are amortized over the shorter of the estimated useful lives of the assets or the lease term, without assuming renewal features, if any, are exercised. Costs of construction of certain long-lived assets include capitalized interest which is amortized over the estimated useful life of the related asset.

      Accounting for the Impairment of Long-Lived Assets

           The Company periodically assesses the recoverability of long-lived assets, such as property, plant, and equipment, and evaluates such assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. Asset impairment is determined to exist if estimated future undiscounted cash flows are less than the carrying amount. For all periods presented, no impairment losses were recorded.

      Patents

           As a result of the Company’s research and development efforts, the Company obtains and applies for patents to protect proprietary technology and inventions. All costs associated with patents for product candidates under development are expensed as incurred. Patent costs related to commercial products are capitalized and amortized over the shorter of their estimated useful life or the remaining patent term. To date, the Company has no capitalized patent costs.

      Operating Leases

           On certain of its operating lease agreements, the Company may receive rent holidays and other incentives. The Company recognizes operating lease costs on a straight-line basis without regard to deferred payment terms, such as rent holidays, that defer the commencement date of required payments. In addition, lease incentives that the Company receives are treated as a reduction of rent expense over the term of the related agreements.

      Revenue Recognition

      a. Collaboration Revenue

           The Company earns collaboration revenue in connection with collaboration agreements to develop and commercialize product candidates and utilize the Company’s technology platforms. The terms of these agreements typically include non-refundable up-front licensing payments, research progress (milestone) payments, and payments for development activities. Non-refundable up-front license payments, where continuing involvement is required of the Company, are deferred and recognized over the related performance period. The Company estimates its performance period based on the specific terms of each agreement, and adjusts the performance periods, if appropriate, based on the applicable facts and circumstances. Although the Company did not enter into, or materially modify, any collaboration arrangements with multiple-deliverables during the year ended December 31, 2011, any future arrangements with multiple deliverables will be divided into separate units of accounting if the deliverables in the arrangement meet certain criteria, including whether the delivered item or items has value to the collaborator on a standalone basis. Payments which are based on achieving a specific performance milestone, involving a degree of risk, are recognized as revenue when the milestone is achieved and the related payment is due and non-refundable, provided there is no future service obligation associated with that milestone. Substantive performance milestones typically consist of significant achievements in the development life-cycle of the related product candidate, such as completion of clinical trials, filing for approval with regulatory agencies, and receipt of approvals by regulatory agencies. In determining whether a payment is deemed to be a substantive performance milestone, the Company takes into consideration (i) the enhancement in value to the related development product candidate, (ii) the Company’s performance and relative level of effort required to achieve the milestone, (iii) whether the milestone relates solely to past performance, and (iv) whether the milestone payment is considered reasonable relative to all of the deliverables and payment terms. Payments for achieving milestones which are not considered substantive are deferred and recognized over the related performance period.

      F-8


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The Company enters into collaboration agreements that include varying arrangements regarding which parties perform and bear the costs of research and development activities. The Company may share the costs of research and development activities with a collaborator, such as in the Company’s EYLEA® collaboration with Bayer HealthCare LLC, or the Company may be reimbursed for all or a significant portion of the costs of the Company’s research and development activities, such as in the Company’s ZALTRAP® (aflibercept) and antibody collaborations with Sanofi. The Company records its internal and third-party development costs associated with these collaborations as research and development expenses. When the Company is entitled to reimbursement of all or a portion of the research and development expenses that it incurs under a collaboration, the Company records those reimbursable amounts as collaboration revenue proportionately as the Company recognizes its expenses. If the collaboration is a cost-sharing arrangement in which both the Company and its collaborator perform development work and share costs, in periods when the Company’s collaborator incurs development expenses that benefit the collaboration and Regeneron, the Company also recognizes, as additional research and development expense, the portion of the collaborator’s development expenses that the Company is obligated to reimburse. In certain cases, the Company may also share the costs of pre-launch commercialization activities with its collaborators. The Company records its share of these costs as a reduction of collaboration revenue.

           In connection with non-refundable licensing payments, the Company’s performance period estimates are principally based on projections of the scope, progress, and results of its research and development activities. Due to the variability in the scope of activities and length of time necessary to develop a drug product, changes to development plans as programs progress, and uncertainty in the ultimate requirements to obtain governmental approval for commercialization, revisions to performance period estimates are likely to occur periodically, and could result in material changes to the amount of revenue recognized each year in the future. In addition, estimated performance periods may change if development programs encounter delays, or the Company and its collaborators decide to expand or contract the clinical plans for a drug candidate in various disease indications. Also, if a collaborator terminates an agreement in accordance with the terms of the agreement, the Company would recognize any unamortized remainder of an up-front or previously deferred payment at the time of the termination.

      b. VelocImmune® Technology Licensing

           The Company enters into non-exclusive license agreements with third parties that allow the third party to utilize the Company’s VelocImmune® technology in its internal research programs. The terms of these agreements include up-front payments and entitle the Company to receive royalties on any future sales of products discovered by the third party using the Company’s VelocImmune® technology. Up-front payments under these agreements, where continuing involvement is required of the Company, are deferred and recognized ratably over their respective license periods.

      c. Product Revenue

           Product sales consist of U.S. sales of the Company’s two marketed products, EYLEA® and ARCALYST®. Revenue from product sales is recognized when persuasive evidence of an arrangement exists, title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, the Company has no further performance obligations, and returns can be reasonably estimated. The Company’s written contracts with its customers stipulate product is shipped freight on board destination (FOB destination). The Company records revenue from product sales upon delivery to its customers.

           The Company sells EYLEA® in the United States to three distributors and several specialty pharmacies. The Company sells ARCALYST® in the United States to two specialty pharmacies. Under these distribution models, the distributors and specialty pharmacies generally take physical delivery of product. For EYLEA®, the distributors and specialty pharmacies generally sell the product directly to healthcare providers; whereas for ARCALYST®, the specialty pharmacies sell the product directly to patients.

      F-9


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Revenue from product sales are recorded net of applicable provisions for prompt pay discounts, rebates and chargebacks under governmental programs (including Medicaid), product returns, distribution-related fees, and other sales-related deductions. Calculating these provisions involves estimates and judgments. The Company reviews its estimates of rebates, chargebacks, and other applicable provisions each period and records any necessary adjustments in the current period’s net product sales.

           Prompt Pay Discounts: No prompt pay discounts are currently offered to the Company’s customers on sales of EYLEA®. In connection with sales of ARCALYST®, the Company offers discounts to its customers for prompt payments. The Company estimates these discounts based on customer terms and historical experience, and expects that its customers will always take advantage of this discount. Therefore, the Company accrues 100% of the prompt pay discount that is based on the gross amount of each ARCALYST® invoice, at the time of sale.

           The Company’s accrual for prompt pay discounts was not material at December 31, 2011 and 2010.

           Government Rebates and Chargebacks: The Company estimates reductions to product sales for Medicaid and Veterans’ Administration (VA) programs, and for certain other qualifying federal and state government programs. Based upon the Company’s contracts with government agencies, statutorily-defined discounts applicable to government-funded programs, historical experience, and, in the case of EYLEA®, estimated payer mix based on third-party market research data, the Company estimates and records an allowance for rebates and chargebacks. The Company’s liability for Medicaid rebates consists of estimates for claims that a state will make for a current quarter, claims for prior quarters that have been estimated for which an invoice has not been received, and invoices received for claims from prior quarters that have not been paid. The Company’s reserves related to discounted pricing offered to VA, Public Health Services (PHS), and other institutions (collectively, “qualified healthcare providers”) represent the Company’s estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices the Company charges to its customers (i.e., distributors and specialty pharmacies). The Company’s customers charge the Company for the difference between what they pay for the products and the ultimate selling price to the qualified healthcare providers. The Company’s reserve for this discounted pricing is based on expected sales to qualified healthcare providers and the chargebacks that customers have already claimed.

           The Company’s government rebate and chargeback accruals were $0.6 million at December 31, 2011, which was based on a percentage of gross sales. Government rebate and chargeback accruals were not material at December 31, 2010.

           Product Returns: Consistent with industry practice, the Company offers its customers a limited right to return product purchased directly from the Company, which is principally based upon the product’s expiration date. The Company will accept returns for three months prior to and up to six months after the product expiration date. Product returned is generally not resalable given the nature of the Company’s products and method of administration. The Company develops estimates for product returns based upon historical experience, inventory levels in the distribution channel, and other relevant factors.

           The Company has developed estimates for EYLEA® product returns, based on several factors, including (i) the Company’s historical experience to date, and the Company’s expectation, that its customers will not stock significant supplies of EYLEA® due to contractual limitations and other mitigating circumstances, (ii) historical industry information regarding product return rates for similar specialty products, and (iii) the shelf life of the product. Estimates for ARCALYST® product returns have been developed based primarily on historical returns experience; to date, actual ARCALYST® product returns have been negligible. The Company monitors product supply levels in the distribution channel, as well as sales by its customers of EYLEA® to healthcare providers and ARCALYST® to patients using product-specific data provided by its customers. If necessary, the Company’s estimates of product returns may be adjusted in the future based on actual returns experience, known or expected changes in the marketplace, or other factors.

           The Company’s product returns accruals were not material at December 31, 2011 and 2010.

           Distribution-Related Fees: The Company has written contracts with its customers that include terms for distribution-related fees. The Company estimates and records distribution and related fees due to its customers based on a percentage of gross sales. The Company’s accrual for distribution-related fees was $1.5 million at December 31, 2011. The Company’s accrual for distribution-related fees at December 31, 2010 was not material.

      F-10


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      Investment Income

           Interest income, which is included in investment income, is recognized as earned.

      Research and Development Expenses

           Research and development expenses include costs directly attributable to the conduct of research and development programs, including the cost of salaries, payroll taxes, employee benefits, materials, supplies, depreciation on and maintenance of research equipment, costs related to research collaboration and licensing agreements, the cost of services provided by outside contractors, including services related to the Company’s clinical trials, clinical trial expenses, the full cost of manufacturing drug for use in research, preclinical development, and clinical trials, amounts that the Company is obligated to reimburse to collaborators for research and development expenses that they incur, and the allocable portions of facility costs, such as rent, utilities, insurance, repairs and maintenance, depreciation, and general support services. All costs associated with research and development are expensed.

           Clinical trial costs are a significant component of research and development expenses and include costs associated with third-party contractors. The Company outsources a substantial portion of its clinical trial activities, utilizing external entities such as contract research organizations (“CROs”), independent clinical investigators, and other third-party service providers to assist the Company with the execution of its clinical studies. For each clinical trial that the Company conducts, certain clinical trial costs are expensed immediately, while others are expensed over time based on the expected total number of patients in the trial, the rate at which patients enter the trial, and/or the period over which clinical investigators or CROs are expected to provide services.

           Clinical activities which relate principally to clinical sites and other administrative functions to manage the Company’s clinical trials are performed primarily by CROs. CROs typically perform most of the start-up activities for the Company’s trials, including document preparation, site identification, screening and preparation, pre-study visits, training, and program management. On a budgeted basis, these start-up costs are typically 10% to 20% of the total contract value. On an actual basis, this percentage range can be significantly wider, as many of the Company’s contracts with CROs are either expanded or reduced in scope compared to the original budget, while start-up costs for the particular trial may not change materially. These start-up costs usually occur within a few months after the contract has been executed and are event driven in nature. The remaining activities and related costs, such as patient monitoring and administration, generally occur ratably throughout the life of the individual contract or study. In the event of early termination of a clinical trial, the Company accrues and recognizes expenses in an amount based on its estimate of the remaining non-cancelable obligations associated with the winding down of the clinical trial and/or penalties.

           For clinical study sites, where payments are made periodically on a per-patient basis to the institutions performing the clinical study, the Company accrues expense on an estimated cost-per-patient basis, based on subject enrollment and activity in each quarter. The amount of clinical study expense recognized in a quarter may vary from period to period based on the duration and progress of the study, the activities to be performed by the sites each quarter, the required level of patient enrollment, the rate at which patients actually enroll in and drop-out of the clinical study, and the number of sites involved in the study. Clinical trials that bear the greatest risk of change in estimates are typically those that have a significant number of sites, require a large number of patients, have complex patient screening requirements, and span multiple years. During the course of a trial, the Company adjusts its rate of clinical expense recognition if actual results differ from the Company’s estimates. The Company’s estimates and assumptions for clinical expense recognition could differ significantly from its actual results, which could cause material increases or decreases in research and development expenses in future periods when the actual results become known.

      Stock-based Compensation

           The Company recognizes stock-based compensation expense for grants of stock option awards and restricted stock under the Company’s Long-Term Incentive Plan to employees and non-employee members of the Company’s board of directors based on the grant-date fair value of those awards. The grant-date fair value of an award is generally recognized as compensation expense over the award’s requisite service period. In addition, the Company has granted performance-based stock option awards which vest based upon the optionee satisfying certain performance and service conditions as defined in the agreements. Potential compensation cost, measured on the grant date, related to these performance options will be recognized only if, and when, the Company estimates that these options will vest, which is based on whether the Company consider the options’ performance conditions to be probable of attainment. The Company’s estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods.

      F-11


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The Company uses the Black-Scholes model to compute the estimated fair value of stock option awards. Using this model, fair value is calculated based on assumptions with respect to (i) expected volatility of the Company’s Common Stock price, (ii) the periods of time over which employees and members of the board of directors are expected to hold their options prior to exercise (expected lives), (iii) expected dividend yield on the Common Stock, and (iv) risk-free interest rates. Stock-based compensation expense also includes an estimate, which is made at the time of grant, of the number of awards that are expected to be forfeited. This estimate is revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.

      Income Taxes

           The Company recognizes deferred tax liabilities and assets for the expected future tax consequences of events that have been included in the financial statements or tax returns. Under this method, deferred tax liabilities and assets are determined on the basis of the difference between the tax basis of assets and liabilities and their respective financial reporting amounts (“temporary differences”) at enacted tax rates in effect for the years in which the differences are expected to reverse. A valuation allowance is established for deferred tax assets for which it is more likely than not that some portion or all of the deferred tax assets will not be realized.

           Uncertain tax positions are accounted for in accordance with FASB authoritative guidance, which prescribes a comprehensive model for the manner in which a company should recognize, measure, present, and disclose in its financial statements all material uncertain tax positions that the company has taken or expects to take on a tax return. Those positions, for which management's assessment is that there is more than a 50% probability of sustaining the position upon challenge by a taxing authority based upon its technical merits, are subjected to certain measurement criteria.

           The Company’s policy is to recognize interest and penalties related to income tax matters in income tax expense.

      Comprehensive Income (Loss)

           Comprehensive income (loss) of the Company includes net income (loss) adjusted for the change in net unrealized gain or loss on marketable securities, net of any tax effect. Comprehensive income (loss) for the years ended December 31, 2011, 2010, and 2009 have been included in the Statements of Stockholders’ Equity.

      Concentration of Credit Risk

           Financial instruments which potentially subject the Company to concentrations of credit risk consist of cash, cash equivalents, marketable securities (see Note 6), and accounts receivable.

      Per Share Data

           Net income (loss) per share, basic and diluted, is computed on the basis of the net income (loss) for the period divided by the weighted average number of shares of Common Stock and Class A Stock outstanding during the period. Basic net income (loss) per share excludes restricted stock awards until vested. Diluted net income per share is based upon the weighted average number of shares of Common Stock and Class A Stock outstanding, and of common stock equivalents outstanding when dilutive. Common stock equivalents include: (i) outstanding stock options and restricted stock awards under the Company’s Long-Term Incentive Plans, which are included under the “treasury stock method” when dilutive, (ii) Common Stock to be issued upon the assumed conversion of the Company’s convertible senior notes, which are included under the “if-converted method” when dilutive, and (iii) Common Stock to be issued upon the exercise of outstanding warrants, which are included under the “treasury stock method” when dilutive. The computation of diluted net loss per share for the years ended December 31, 2011, 2010, and 2009 does not include common stock equivalents, since such inclusion would be antidilutive.

      F-12


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      Risks and Uncertainties

           Developing and commercializing new medicines entails significant risk and expense. Before revenues from the commercialization of the Company’s current or future product candidates can be realized, the Company (or its collaborators) must overcome a number of hurdles which include successfully completing research and development and obtaining regulatory approval from the FDA and regulatory authorities in other countries. In addition, the biotechnology and pharmaceutical industries are rapidly evolving and highly competitive, and new developments may render the Company’s products and technologies uncompetitive or obsolete. The Company may be subject to legal claims by third parties seeking to enforce patents to limit or prohibit the Company from marketing or selling its products. The Company is also dependent upon the services of its employees, consultants, collaborators, and certain third-party suppliers, including single-source unaffiliated third-party suppliers of certain raw materials and equipment. Regeneron, as licensee, licenses certain technologies that are important to the Company’s business which impose various obligations on the Company. If Regeneron fails to comply with these requirements, licensors may have the right to terminate the Company’s licenses.

           The Company has generally incurred net losses and negative cash flows from operations since its inception. The Company received regulatory approval from the FDA for ARCALYST® for the treatment of CAPS in February 2008 and EYLEA® for the treatment of wet AMD in November 2011; however, the Company has not generated significant sales or profits to date from these two drug products. Revenues to date have principally been limited to (i) up-front, license, milestone, and reimbursement payments from the Company’s collaborators and other entities related to the Company’s development activities and technology platforms, (ii) ARCALYST® and EYLEA® product sales, (iii) payments for past contract manufacturing activities, and (iv) investment income. Collaboration revenue in 2011 was earned from Sanofi and Bayer HealthCare under collaboration agreements (see Note 3 for the terms of these agreements). These collaboration agreements contain early termination provisions that are exercisable by Sanofi or Bayer HealthCare, as applicable.

      Use of Estimates

           The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates. Estimates which could have a significant impact on the Company’s financial statements include:

      • Product rebates, chargebacks, and returns in connection with the recognition of product sales revenue.
      • Periods over which payments, including non-refundable up-front, license, and milestone payments, are recognized as revenue in connection with collaboration and other agreements to develop and commercialize product candidates and utilize the Company’s technology platforms.
      • Periods over which certain clinical trial costs, including costs for clinical activities performed by contract research organizations, are recognized as research and development expenses.
      • In connection with the recognition of expense, using a blended royalty rate, related to the Company’s non-exclusive license with Genentech, Inc. the Company’s estimate of cumulative EYLEA® sales through May 7, 2016 (see Note 12b).
      • In connection with stock option awards, (i) the fair value of stock options on their date of grant using the Black-Scholes option-pricing model, based on assumptions with respect to (a) expected volatility of the Company’s Common Stock price, (b) the periods of time for which employees and members of the Company’s board of directors are expected to hold their options prior to exercise (expected lives), (c) expected dividend yield on the Company’s Common Stock, and (d) risk-free interest rates, which are based on quoted U.S. Treasury rates for securities with maturities approximating the options’ expected lives; (ii) the number of stock option awards that are expected to be forfeited; and (iii) with respect to performance-based stock option awards, if and when the options’ performance conditions are considered to be probable of attainment.
      • The Company’s determination of whether marketable securities are other-than-temporarily impaired. The Company conducts a review of its portfolio of marketable securities, using both quantitative and qualitative factors, to determine, for securities whose current fair value is less than their cost, whether the decline in fair value below cost is other-than-temporary. In making this determination, the Company considers factors such as the length of time and the extent to which fair value has been less than cost, financial condition and near-term prospects of the issuer, recommendations of investment advisors, and forecasts of economic, market, or industry trends. This review process also includes an evaluation of the Company’s ability and intent to hold individual securities until they mature or their full value can be recovered. This review is subjective and requires a high degree of judgment.
      • Useful lives of property, plant, and equipment.
      • Inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, which is written-down, as appropriate. In addition, capitalization of inventory costs associated with the Company’s products prior to regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized.
      • The extent to which deferred tax assets and liabilities are offset by a valuation allowance.

      F-13


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           In addition, the Company’s share of EYLEA® development expenses incurred by Bayer HealthCare, including the Company’s share of Bayer HealthCare’s estimated EYLEA® development expenses for the most recent fiscal quarter, are included in research and development expenses. The Bayer HealthCare estimate for the most recent fiscal quarter is adjusted in the subsequent quarter to reflect actual expenses for the quarter. Also, the Company’s share of ZALTRAP® pre-launch commercialization expenses incurred by Sanofi, including the Company’s share of Sanofi’s estimated ZALTRAP® pre-launch commercialization expenses for the most recent fiscal quarter, are included as a reduction of Sanofi collaboration revenue. The Sanofi estimate for the most recent fiscal quarter is adjusted in the subsequent quarter to reflect actual expenses for the quarter.

      Impact of Recently Issued Accounting Standards

      Multiple-deliverable revenue arrangements

           During the first quarter of 2011 the Company adopted amended authoritative guidance issued by the FASB on multiple-deliverable revenue arrangements. The amended guidance provides greater ability to separate and allocate consideration to be received in a multiple-deliverable revenue arrangement by requiring the use of estimated selling prices to allocate the consideration, thereby eliminating the use of the residual method of allocation. The amended guidance also requires expanded qualitative and quantitative disclosures surrounding multiple-deliverable revenue arrangements. The Company is applying this amended guidance prospectively for new or materially modified arrangements, of which there were none during the year ended December 31, 2011; therefore, the adoption of this guidance did not have an impact on the Company’s financial statements.

      Milestone method of revenue recognition

           During the first quarter of 2011, the Company adopted amended authoritative guidance issued by the FASB codifying the milestone method of revenue recognition as an acceptable revenue recognition model when a milestone is deemed to be substantive. The Company earns substantive performance milestone payments in connection with its collaboration agreements to develop and commercialize product candidates with Sanofi and Bayer HealthCare. Descriptions of these collaboration agreements, including various financial terms and conditions, are provided in Note 3. Since the Company has historically accounted for milestones under the milestone method, the adoption of this guidance did not have a material impact on the Company’s financial statements.

      Fees paid to the federal government by pharmaceutical manufacturers

           In December 2010, the FASB provided authoritative guidance on how pharmaceutical manufacturers should recognize and classify in their income statement annual fees mandated by the Patient Protection and Affordable Care Act as amended by the Health Care and Education Reconciliation Act. This guidance became effective for calendar years beginning after December 31, 2010. The adoption of this guidance did not have an impact on the Company’s financial statements for the year ended December 31, 2011, since (i) ARCALYST® for the treatment of CAPS, has been approved as an orphan drug and orphan drugs are not subject to this annual fee and (ii) since EYLEA® received regulatory approval from the FDA, and was launched, in November 2011.

      Presentation of comprehensive income

           In June 2011, the FASB amended its authoritative guidance on the presentation of comprehensive income. Under the amendment, an entity will have the option to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements. This amendment, therefore, eliminates the currently available option to present the components of other comprehensive income as part of the statement of changes in stockholders' equity. The amendment does not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income. The Company will adopt this amended guidance for the fiscal year beginning January 1, 2012. As this guidance relates to presentation only, the adoption of this guidance will not have any other effect on the Company's financial statements.

      F-14


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      Reclassifications

           Certain reclassifications have been made to prior period amounts to conform with the current period’s presentation.

      3. Collaboration and Contract Research Agreements

           The Company has entered into various agreements related to its activities to develop and commercialize product candidates and utilize its technology platforms. Significant agreements of this kind are described below.

      a. Sanofi

           As described in Note 13, Sanofi has purchased a total of 15,816,953 shares of the Company’s Common Stock, principally in connection with the companies’ ZALTRAP® and antibody collaborations described below. Total Company-incurred expenses associated with these Sanofi collaborations, which include reimbursable and non-reimbursable amounts and an allocable portion of general and administrative costs, were $318.2 million in 2011, $282.4 million in 2010, and $209.4 million in 2009.

           ZALTRAP® (aflibercept)

           In September 2003, the Company entered into a collaboration agreement (the “ZALTRAP® Agreement”) with Aventis Pharmaceuticals Inc. (predecessor to Sanofi U.S.), to jointly develop and commercialize ZALTRAP®. In connection with this agreement, Sanofi made a non-refundable up-front payment of $80.0 million and purchased 2,799,552 newly issued unregistered shares of the Company’s Common Stock for $45.0 million.

           In January 2005, the Company and Sanofi amended the ZALTRAP® Agreement to exclude intraocular delivery of aflibercept to the eye (“Intraocular Delivery”) from joint development under the agreement, and product rights to aflibercept in Intraocular Delivery reverted to Regeneron. In connection with this amendment, Sanofi made a $25.0 million non-refundable payment to Regeneron (the “Intraocular Termination Payment”).

           In December 2005, the Company and Sanofi amended the ZALTRAP® Agreement to expand the territory in which the companies are collaborating on the development of ZALTRAP® to include Japan. In connection with this amendment, Sanofi agreed to make a $25.0 million non-refundable up-front payment to the Company, which was received in January 2006. Under the ZALTRAP® Agreement, as amended, the Company and Sanofi will share co-promotion rights and profits on sales, if any, of ZALTRAP® outside of Japan, for disease indications included in the companies’ collaboration. The Company is entitled to a royalty of approximately 35% on annual sales of ZALTRAP® in Japan, subject to certain potential adjustments. The Company may also receive up to $400 million in substantive milestone payments upon receipt of specified marketing approvals, including up to $360 million in milestone payments related to the receipt of marketing approvals for up to eight ZALTRAP® oncology and other indications in the United States or the European Union and up to $40 million related to the receipt of marketing approvals for up to five ZALTRAP® oncology indications in Japan.

           Under the ZALTRAP® Agreement, as amended, agreed upon worldwide development expenses incurred by both companies during the term of the agreement will be funded by Sanofi. If the collaboration becomes profitable, Regeneron will be obligated to reimburse Sanofi for 50% of these development expenses, or half of $763.4 million as of December 31, 2011, in accordance with a formula based on the amount of development expenses and Regeneron’s share of the collaboration profits and Japan royalties, or at a faster rate at Regeneron’s option. Regeneron has the option to conduct additional pre-Phase III studies at its own expense. In connection with the January 2005 amendment to the ZALTRAP® Agreement, the Intraocular Termination Payment of $25.0 million will also be subject to 50% reimbursement by Regeneron to Sanofi if the collaboration becomes profitable. In addition, if the first commercial sale of an aflibercept product in Intraocular Delivery predates the first commercial sale of a ZALTRAP® product under the collaboration by two years, Regeneron will begin reimbursing Sanofi for up to $7.5 million of ZALTRAP® development expenses in accordance with a formula until the first commercial ZALTRAP® sale under the collaboration occurs.

      F-15


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Sanofi has the right to terminate the agreement without cause with at least twelve months advance notice. Upon termination of the agreement for any reason, Regeneron’s obligation to reimburse Sanofi, for 50% of ZALTRAP® development expenses will terminate, and the Company will retain all rights to ZALTRAP®.

           In accordance with the Company’s revenue recognition policy described in Note 2, the up-front payments received in September 2003 and January 2006, of $80.0 million and $25.0 million, respectively, and reimbursement of Regeneron-incurred development expenses, are being recognized as collaboration revenue over the related performance period. In addition, in 2011, the Company and Sanofi began equally sharing ZALTRAP®pre-launch commercialization expenses under the ZALTRAP® Agreement. The Company’s share of these expenses was $9.3 million in 2011, which reduced collaboration revenue in connection with the ZALTRAP® Agreement.

           The Company recognized $17.5 million, $26.4 million, and $36.5 million of collaboration revenue in 2011, 2010, and 2009, respectively, in connection with the ZALTRAP® Agreement, as amended. In connection with the ZALTRAP® Agreement, (i) at December 31, 2011, there was a net payable of $3.7 million to Sanofi, (ii) at December 31, 2010, amounts receivable from Sanofi were $3.9 million, and (iii) deferred revenue at December 31, 2011 and 2010 was $22.9 million and $32.6 million, respectively.

           Antibodies

           In November 2007, the Company entered into a global, strategic collaboration (the “Antibody Collaboration”) with Sanofi to discover, develop, and commercialize fully human monoclonal antibodies. In connection with the collaboration, in December 2007, Sanofi purchased 12 million newly issued, unregistered shares of the Company’s Common Stock for $312.0 million (see Note 13).

           The Antibody Collaboration is governed by a Discovery and Preclinical Development Agreement (the “Discovery Agreement”) and a License and Collaboration Agreement (the “License Agreement”). In connection with the execution of the Discovery Agreement in 2007, the Company received a non-refundable up-front payment of $85.0 million from Sanofi. In addition, under the Discovery Agreement, Sanofi is funding the Company’s research to identify and validate potential drug discovery targets and develop fully human monoclonal antibodies against these targets. In November 2009, the Company and Sanofi amended these collaboration agreements to expand and extend the Antibody Collaboration. Pursuant to the Discovery Agreement, as amended, Sanofi agreed to fund up to $160 million per year of the Company’s research activities in 2010 through 2017, subject to a one-time option for Sanofi to adjust the maximum reimbursement amount down to $120 million per year commencing in 2014 if over the prior two years certain specified criteria were not satisfied. In 2010, as the Company scaled up its capacity to conduct antibody discovery activities, Sanofi funded $137.7 million of the Company’s preclinical research under the amended Discovery Agreement. The balance between that amount and $160 million, or $22.3 million, has been added to the funding otherwise available to the Company in 2011-2012 under the amended Discovery Agreement. The amended Discovery Agreement will expire on December 31, 2017; however, Sanofi has an option to extend the agreement for up to an additional three years for further antibody development and preclinical activities.

           For each drug candidate identified under the Discovery Agreement, Sanofi has the option to license rights to the candidate under the License Agreement. If it elects to do so, Sanofi will co-develop the drug candidate with the Company through product approval. Under certain defined circumstances, upon exercising its option to license rights to particular candidates, Sanofi must make a $10 million substantive milestone payment to the Company. If Sanofi does not exercise its option to license rights to a particular drug candidate under the License Agreement, the Company retains the exclusive right to develop and commercialize such drug candidate, and Sanofi will receive a royalty on sales, if any. The Company and Sanofi are currently co-developing seven therapeutic antibodies under the License Agreement.

           Under the License Agreement, agreed upon worldwide development expenses incurred by both companies during the term of the agreement are funded by Sanofi, except that following receipt of the first positive Phase 3 trial results for a co-developed drug candidate, subsequent Phase 3 trial-related costs for that drug candidate (“Shared Phase 3 Trial Costs”) are shared 80% by Sanofi and 20% by Regeneron. If the Antibody Collaboration becomes profitable, Regeneron will be obligated to reimburse Sanofi for 50% of development expenses that were fully funded by Sanofi (or half of $582.3 million as of December 31, 2011) and 30% of Shared Phase 3 Trial Costs, in accordance with a defined formula based on the amounts of these expenses and the Company’s share of collaboration profits from commercialization of collaboration products. However, the Company is not required to apply more than 10% of its share of the profits from the antibody collaboration in any calendar quarter to reimburse Sanofi for these development costs.

      F-16


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Sanofi will lead commercialization activities for products developed under the License Agreement, subject to the Company’s right to co-promote such products. The parties will equally share profits and losses from sales within the United States. The parties will share profits outside the United States on a sliding scale based on sales starting at 65% (Sanofi)/35% (Regeneron) and ending at 55% (Sanofi)/45% (Regeneron), and losses outside the United States at 55% (Sanofi)/45% (Regeneron). In addition to profit sharing, the Company is entitled to receive up to $250 million in sales milestone payments, with milestone payments commencing only if and after aggregate annual sales outside the United States exceed $1.0 billion on a rolling 12-month basis.

           Regeneron is obligated to use commercially reasonable efforts to supply clinical requirements of each drug candidate under the Antibody Collaboration until commercial supplies of that drug candidate are being manufactured. In connection with the November 2009 amendment of the collaboration’s Discovery Agreement, Sanofi is funding up to $30 million of agreed-upon costs incurred by the Company to expand its manufacturing capacity at the Company’s Rensselaer, New York facilities, of which $28.2 million has been received or is receivable at December 31, 2011.

           With respect to each antibody product which enters development under the License Agreement, Sanofi or the Company may, by giving twelve months notice, opt-out of further development and/or commercialization of the product, in which event the other party retains exclusive rights to continue the development and/or commercialization of the product. The Company may also opt-out of the further development of an antibody product if it gives notice to Sanofi within thirty days of the date that Sanofi enters joint development of such antibody product under the License Agreement. Each of the Discovery Agreement and the License Agreement contains other termination provisions, including for material breach by the other party. Prior to December 31, 2017, Sanofi has the right to terminate the amended Discovery Agreement without cause with at least three months advance written notice; however, except under defined circumstances, Sanofi would be obligated to immediately pay to the Company the full amount of unpaid research funding during the remaining term of the research agreement through December 31, 2017. Upon termination of the collaboration in its entirety, the Company’s obligation to reimburse Sanofi for development costs out of any future profits from collaboration products will terminate. Upon expiration of the amended Discovery Agreement, Sanofi has an option to license the Company’s VelocImmune® technology for agreed upon consideration.

           In connection with the Antibody Collaboration, in August 2008, the Company entered into a separate agreement with Sanofi to use Regeneron's proprietary VelociGene® technology platform to supply Sanofi with genetically modified mammalian models of gene function and disease (the “VelociGene® Agreement”). The VelociGene® Agreement provides for minimum annual order quantities for the term of the agreement, which extends through December 2012, for which the Company expects to receive payments totaling a minimum of $21.5 million.

           In accordance with the Company’s revenue recognition policy described in Note 2, the (i) $85.0 million up-front payment received in December 2007, (ii) reimbursement of Regeneron-incurred expenses under the Discovery and License Agreements, (iii) $21.5 million of aggregate minimum payments under the VelociGene® Agreement, and (iv) reimbursement of agreed-upon costs to expand the Company’s manufacturing capacity are being recognized as collaboration revenue over the related performance period. In connection with the amendments to expand and extend the Company’s antibody collaboration with Sanofi, during the fourth quarter of 2009, the Company extended its estimated performance period related to the $85.0 million up-front payment received from Sanofi under the Discovery Agreement and the $21.5 million of aggregate minimum payments under the VelociGene® Agreement. The effect of this change in estimate resulted in the recognition of $5.3 million less in collaboration revenue in both 2011 and 2010, compared to 2009.

           In connection with the Antibody Collaboration, the Company recognized $309.1 million, $284.9 million, and $210.7 million of collaboration revenue in 2011, 2010, and 2009, respectively. In addition, at December 31, 2011 and 2010, amounts receivable from Sanofi totaled $78.5 million and $75.7 million and deferred revenue was $83.1 million and $84.0 million, respectively.

      F-17


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      b. Bayer HealthCare LLC

           In October 2006, the Company entered into a license and collaboration agreement with Bayer HealthCare for the global development and commercialization outside the United States of EYLEA®. Under the terms of the agreement,   Bayer HealthCare made a non-refundable up-front payment to the Company of $75.0 million. In August 2007, the Company received a $20.0 million milestone payment from Bayer HealthCare following dosing of the first patient in a Phase 3 study of EYLEA® in the neovascular form of wet AMD. In July 2009, the Company received a $20.0 million substantive milestone payment from Bayer HealthCare following dosing of the first patient in a Phase 3 study of EYLEA® in central retinal vein occlusion (“CRVO”). In the fourth quarter of 2010, the Company earned two $10.0 million substantive milestone payments (for a total of $20.0 million) from Bayer HealthCare for achieving positive 52-week results in the Phase 3 study of EYLEA® in wet AMD and positive 6-month results in the Phase 3 study of EYLEA® in CRVO. One of these $10.0 million payments was received in December 2010 and the other $10.0 million payment was received in January 2011. The Company is eligible to receive up to $50 million in future substantive milestone payments related to marketing approvals of EYLEA® in major market countries outside the United States. The Company is also eligible to receive up to $135 million in sales milestone payments when and if total annual sales of EYLEA® outside the United States achieve certain specified levels starting at $200 million.

           The Company will share equally with Bayer HealthCare in any future profits arising from the commercialization of EYLEA® outside the United States. If EYLEA® is granted marketing authorization in a major market country outside the United States and the collaboration becomes profitable, the Company will be obligated to reimburse Bayer HealthCare out of its share of the collaboration profits for 50% of the agreed upon development expenses that Bayer HealthCare has incurred (or half of $370.9 million as of December 31, 2011) in accordance with a formula based on the amount of development expenses that Bayer HealthCare has incurred and the Company’s share of the collaboration profits, or at a faster rate at the Company’s option. Within the United States, the Company is responsible for commercialization of EYLEA® and retains exclusive rights to any profits from such commercialization in the United States.

           Starting in 2009, all agreed upon EYLEA® development expenses incurred by the Company and Bayer HealthCare, under a global development plan, are being shared equally. The Company is also obligated to use commercially reasonable efforts to supply clinical and commercial product requirements.

           Bayer HealthCare has the right to terminate the Bayer Agreement without cause with at least six months or twelve months advance notice depending on defined circumstances at the time of termination. In the event of termination of the agreement for any reason, the Company retains all rights to EYLEA®.

           The $75.0 million up-front licensing payment and the $20.0 million milestone payment received in August 2007 from Bayer HealthCare are being recognized as collaboration revenue over the related estimated performance period in accordance with the Company’s revenue recognition policy as described in Note 2. In periods when the Company recognizes EYLEA® development expenses that the Company incurs under the collaboration, the Company also recognizes, as collaboration revenue, the portion of those EYLEA® development expenses that is reimbursable from Bayer HealthCare. In periods when Bayer HealthCare incurs agreed upon EYLEA® development expenses that benefit the collaboration and Regeneron, the Company also recognizes, as additional research and development expense, the portion of Bayer HealthCare’s EYLEA® development expenses that the Company is obligated to reimburse.

           The Company recognized $43.1 million, $75.4 million, and $67.3 million of collaboration revenue from Bayer HealthCare in 2011, 2010, and 2009, respectively. In both 2010 and 2009, collaboration revenue from Bayer HealthCare included $20.0 million in milestone payments, as described above, which, for the purpose of revenue recognition, were considered substantive. In addition, in 2011, 2010, and 2009, the Company recognized as additional research and development expense $47.8 million, $48.9 million, and $37.7 million, respectively, of EYLEA® development expenses that the Company was obligated to reimburse to Bayer HealthCare.

           In connection with cost-sharing of EYLEA® expenses under the collaboration, $4.5 million was receivable from Bayer HealthCare at December 31, 2011 and $2.3 million was payable to Bayer HealthCare at December 31, 2010. In addition, at December 31, 2011 and 2010, deferred revenue from the Company’s collaboration with Bayer HealthCare was $42.4 million and $47.0 million, respectively.

      F-18


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      c. National Institute of Health

           In September 2006, the Company was awarded a grant from the National Institutes of Health (“NIH”) as part of the NIH’s Knockout Mouse Project. As amended, the NIH grant provided a minimum of $25.3 million in funding over a five-year period, including $1.5 million in funding to optimize certain existing technology, subject to compliance with its terms and annual funding approvals, for the Company’s use of its VelociGene® technology to generate a collection of targeting vectors and targeted mouse embryonic stem cells which can be used to produce knockout mice. The Company records revenue in connection with the NIH grant using a proportional performance model as it incurs expenses related to the grant, subject to the grant’s terms and annual funding approvals. In 2011, 2010, and 2009, the Company recognized contract research revenue of $3.6 million, $4.6 million, and $5.5 million, respectively, from the NIH Grant. As of the end of 2011, no further revenue will be recognized by the Company in connection with this NIH Grant.

      4. Technology Licensing Agreements

           In March 2007, the Company entered into a six-year, non-exclusive license agreement with Astellas Pharma Inc. to allow Astellas to utilize the Company’s VelocImmune® technology in its internal research programs to discover human monoclonal antibodies. Under the terms of the agreement, Astellas made a $20.0 million annual, non-refundable payment to the Company in each of 2010, 2009, 2008, and 2007. In July 2010, the license agreement with Astellas was amended and extended through June 2023. Under the terms of the amended agreement, Astellas made a $165.0 million up-front payment to the Company in August 2010, which was deferred upon receipt and will be recognized as revenue ratably over the seven-year period beginning in mid-2011. In addition, Astellas will make a $130.0 million second payment to the Company in June 2018 unless the license agreement has been terminated prior to that date. Astellas has the right to terminate the agreement at any time by providing 90 days’ advance written notice. Under certain limited circumstances, such as a material breach of the agreement by the Company, Astellas may terminate the agreement and receive a refund of a portion of its up-front payment or, if such termination occurs after June 2018, a portion of its second payment, to the Company under the July 2010 amendment to the agreement. The Company is entitled to receive a mid-single digit royalty on any future sales of antibody products discovered by Astellas using the Company’s VelocImmune® technology. In connection with the Astellas license agreement, for each of the years ended December 31, 2011, 2010, and 2009, the Company recognized $22.0 million, $20.0 million, and $20.0 million of technology licensing revenue, respectively. In addition, deferred revenue at December 31, 2011 and 2010 was $151.7 million and $173.7 million, respectively.

           In February 2007, the Company entered into a six-year, non-exclusive license agreement with AstraZeneca UK Limited to allow AstraZeneca to utilize the Company’s VelocImmune® technology in its internal research programs to discover human monoclonal antibodies. Under the terms of the agreement, AstraZeneca made a $20.0 million annual, non-refundable payment to the Company in each of 2010, 2009, 2008, and 2007. Each annual payment was deferred and recognized as revenue ratably over approximately the ensuing twelve-month period. In November 2010, as permitted by the agreement, MedImmune Limited (as successor by novation from AstraZeneca) gave written notice of voluntary termination of the agreement, effective in February 2011, thereby canceling its obligation to make either of the final two annual payments. Regeneron remains entitled to receive mid-single digit royalties on any future sales of antibody products discovered by MedImmune/AstraZeneca using the VelocImmune® technology. In connection with the AstraZeneca license agreement, for the years ended December 31, 2011, 2010, and 2009, the Company recognized $2.9 million, $20.0 million, and $20.0 million, respectively, of technology licensing revenue.

      5. Product Revenue

           In November 2011, the Company received marketing approval from the FDA for EYLEA® for the treatment of wet AMD. In accordance with the Company’s revenue recognition policy described in Note 2, the Company recorded EYLEA® net product sales of $24.8 million for the year ended December 31, 2011.

           In February 2008, the Company received marketing approval from the FDA for ARCALYST® Injection for Subcutaneous Use for the treatment of CAPS. ARCALYST® net product sales totaled $19.9 million, $25.3 million, and $18.4 million for the years ended December 31, 2011, 2010, and 2009, respectively. The Company had limited historical returns experience for ARCALYST® beginning with initial sales in 2008 through the end of 2009; therefore, ARCALYST® net product sales were deferred until the right of return no longer existed and rebates could be reasonably estimated. Effective in the first quarter of 2010, the Company determined that it had accumulated sufficient historical data to reasonably estimate both product returns and rebates of ARCALYST®. As a result, ARCALYST® net product sales during 2010 included $20.5 million of net product sales made during this period and $4.8 million of previously deferred net product sales. The effect of recognizing the previously deferred ARCALYST® net product sales revenue was to lower the Company’s net loss per share by $0.06 in 2010.

      F-19


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      6. Marketable Securities

           Marketable securities at December 31, 2011 and 2010 consisted of debt securities, as detailed below, and equity securities. The aggregate fair value of the equity securities was $3.0 million and $3.6 million at December 31, 2011 and 2010, respectively, and the aggregate cost basis was $4.0 million at both December 31, 2011 and 2010. The Company also held restricted marketable securities at both December 31, 2011 and December 31, 2010, which consisted of debt securities, as detailed below, that collateralize letters of credit and lease obligations.

           The following tables summarize the amortized cost basis of debt securities included in marketable securities, the aggregate fair value of those securities, and gross unrealized gains and losses on those securities at December 31, 2011 and 2010. The Company classifies its debt securities, other than mortgage-backed securities, based on their contractual maturity dates. Maturities of mortgage-backed securities have been estimated based primarily on repayment characteristics and experience of the senior tranches that the Company holds.

      Amortized Fair Unrealized
      At December 31, 2011   Cost Basis       Value       Gains (Losses) Net
      Unrestricted                  
      Maturities within one year
             U.S. government obligations $ 12,025 $ 12,067 $ 42 $ 42
             U.S. government guaranteed corporate
                    bonds 15,263 15,316 53 53
             U.S. government guaranteed collateralized
                    mortgage obligations 623 622 (1 ) (1 )
             Municipal bonds 15,314 15,326 13 (1 ) 12
      43,225 43,331 108 (2 ) 106
       
      Maturities after one year through five years
             U.S. government obligations 272,433 272,752 400 (81 ) 319
             Mortgage-backed securities 104 28 (76 ) (76 )
      272,537 272,780 400 (157 ) 243
       
      Maturities after five years through ten years
             Mortgage-backed securities 164 87 (77 ) (77 )
      315,926 316,198 508 (236 ) 272
       
      Restricted
      Maturities within one year    
             U.S. government obligations 3,347 3,357 10 10
       
      Maturities after one year through five years
             U.S. government obligations 2,572   2,583   11     11
      5,919 5,940 21 21
       
      $ 321,845 $ 322,138 $ 529 $ (236 ) $ 293

      F-20


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      Amortized Fair Unrealized
      At December 31, 2010         Cost Basis       Value       Gains       (Losses)       Net
      Unrestricted
      Maturities within one year
             U.S. government obligations $ 83,635 $ 83,684 $ 54 $ (5 ) $ 49
             U.S. government guaranteed corporate
                    bonds 48,173 48,531 358 358
             U.S. government guaranteed collateralized  
                    mortgage obligations 2,027 2,131 104 104
             Municipal bonds 1,597 1,603 6 6
             Mortgage-backed securities 875 847 (28 ) (28 )
      136,307 136,796 522 (33 ) 489
       
      Maturities after one year through five years
             U.S. government obligations 352,345 350,683 64 (1,726 ) (1,662 )
             U.S. government guaranteed corporate
                    bonds 15,522 15,477 (45 ) (45 )
             Mortgage-backed securities 110 38 (72 ) (72 )
      367,977 366,198 64 (1,843 ) (1,779 )
       
      Maturities after five years through ten years
             Mortgage-backed securities 284   243 (41 ) (41 )
      504,568 503,237 586 (1.917 ) (1,331 )
       
      Restricted
      Maturities within one year
             U.S. government obligations 2,922   2,921 (1 ) (1 )
       
      Maturities after one year through five years      
             U.S. government obligations   4,135 4,118       (17 )     (17 )
      7,057 7,039     (18 ) (18 )
       
      $ 511,625 $ 510,276 $ 586 $ (1,935 ) $ (1,349 )

      F-21


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           At December 31, 2011 and 2010, marketable securities included an additional unrealized loss of $1.0 million and $0.4 million, respectively, related to one equity security in the Company’s marketable securities portfolio.

           The following table shows the fair value of the Company’s marketable securities that have unrealized losses and that are deemed to be only temporarily impaired, aggregated by investment category and length of time that the individual securities have been in a continuous unrealized loss position, at December 31, 2011 and 2010. The debt securities listed at December 31, 2011, excluding mortgage-backed securities, mature at various dates through December 2014. The mortgage-backed securities listed at December 31, 2011 mature at various dates through April 2018.

      Less than 12 Months 12 Months or Greater Total
            Unrealized      Unrealized       Unrealized
      At December 31, 2011   Fair Value Loss Fair Value Loss Fair Value      Loss
      Unrestricted
             U.S. government obligations $ 103,529 $ (81 ) $ 103,529 $ (81 )
             U.S. government guaranteed  
                    collateralized mortgage
                    obligations 623 (1 ) 623 (1 )
             Municipal bonds 4,603 (1 ) 4,603 (1 )
             Equity security 3,019 (1,025 ) 3,019 (1,025 )
             Mortgage-backed securities $ 116 $ (152 ) 116 (152 )
      $ 111,774 $ (1,108 ) $ 116 $ (152 ) $ 111,890 $ (1,260 )
       
      At December 31, 2010  
      Unrestricted  
             U.S. government obligations $ 340,444 $ (1,731 )       $ 340,444 $ (1,731 )
             U.S. government guaranteed    
                    corporate bonds   19,005   (45 ) 19,005     (45 )
             Equity security 3,612 (433 )       3,612 (433 )
             Mortgage-backed securities     $ 1,128 $ (141 ) 1,128 (141 )
      363,061   (2,209 ) 1,128 (141 ) 364,189 (2,350 )
       
      Restricted
             U.S. government obligations 6,154 (18 ) 6,154 (18 )
      6,154 (18 ) 6,154 (18 )
       
      $ 369,215 $ (2,227 ) $ 1,128 $ (141 ) $ 370,343 $ (2,368 )

           Realized gains and losses are included as a component of investment income. For the years ended December 31, 2011, 2010, and 2009, total realized gains and losses on sales of marketable securities were not material. In computing realized gains and losses, the Company computes the cost of its investments on a specific identification basis. Such cost includes the direct costs to acquire the security, adjusted for the amortization of any discount or premium.

      F-22


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The Company’s assets that are measured at fair value on a recurring basis, at December 31, 2011 and 2010, were as follows:

      Fair Value Measurements at Reporting Date Using
      Quoted Prices
      in Active
      Markets for Significant
      Identical Significant Other Unobservable
      Assets Observable Inputs Inputs
            Fair Value       (Level 1)       (Level 2)       (Level 3)
      At December 31, 2011  
      Unrestricted
      Available-for-sale marketable
             securities
             U.S. government obligations $ 284,819 $ 284,819  
             U.S. government guaranteed  
                    corporate bonds 15,316     15,316
             U.S. government guaranteed
                    collateralized mortgage    
                    obligations 622 622
             Municipal bonds   15,326 15,326
             Mortgage-backed securities 115     115
             Equity security 3,019 $ 3,019
      319,217 3,019 316,198
       
      Restricted
      Available-for-sale marketable
             securities
             U.S. government obligations 5,940 5,940
       
      $ 325,157 $ 3,019 $ 322,138
       
      At December 31, 2010  
      Unrestricted
      Available-for-sale marketable
             securities
             U.S. government obligations $ 434,367 $ 434,367
             U.S. government guaranteed
                   corporate bonds 64,008 64,008
             U.S. government guaranteed
                    collateralized mortgage
                    obligations 2,131 2,131
             Municipal bonds 1,603 1,603
             Mortgage-backed securities 1,128 1,128
             Equity security 3,612 $ 3,612
      506,849 3,612 503,237
       
      Restricted
      Available-for-sale marketable
             securities
             U.S. government obligations 7,039 7,039
       
      $ 513,888 $ 3,612 $ 510,276

      F-23


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Marketable securities included in Level 2 were valued using a market approach utilizing prices and other relevant information, such as interest rates, yield curves, prepayment speeds, loss severities, credit risks, and default rates, generated by market transactions involving identical or comparable assets. The Company considers market liquidity in determining the fair value for these securities. During the year ended December 31, 2010, deterioration in the credit quality of a marketable security subjected the Company to the risk of not being able to recover the carrying value of these securities. As a result, the Company recognized a $0.1 million impairment charge related to its Level 2 marketable securities in 2010, which the Company considered to be other-than-temporarily impaired. The Company did not record any charges for other-than-temporary impairment of its Level 2 marketable securities in 2011 and 2009.

           The Company held one Level 3 marketable security, which had a fair value of $0 at December 31, 2011 and 2010. This Level 3 security was valued using information provided by the Company’s investment advisors and other sources, including quoted bid prices which took into consideration the securities’ lack of liquidity. In 2009, the Company recorded a charge of $0.1 million for other-than-temporary impairment of this Level 3 marketable security; therefore, as of December 31, 2009, the fair value of this security had been written down to zero. There were no purchases, sales, or maturities of Level 3 marketable securities and no unrealized gains or losses related to Level 3 marketable securities for the years ended December 31, 2011 and 2010. There were no transfers of marketable securities between Levels 1, 2, or 3 classifications during the years ended December 31, 2011 and 2010.

      7. Inventory

           Inventories as of December 31, 2011 and December 31, 2010 consist of the following:

            2011       2010
      Raw materials $ 1,608 $ 592
      Work in process     10,806     699
      Finished goods 1,142 132
      $ 13,556 $ 1,423

           At December 31, 2011, $3.5 million of inventories were included in prepaid expenses and other current assets and $10.1 million of inventories were included in other assets. At December 31, 2010, inventories were included in prepaid expenses and other current assets.

           In 2011, cost of goods sold included inventory write-downs of $0.5 million. In 2010, there were no inventory write-downs included in cost of goods sold.

      8. Property, Plant, and Equipment

           Property, plant, and equipment as of December 31, 2011 and 2010 consist of the following:

      2011 2010
      Land       $ 2,117       $ 2,117  
      Building and improvements   322,753   242,035
      Leasehold improvements 4,479   4,063
      Construction-in-progress 10,880 70,356
      Laboratory and other equipment   156,397 137,951
      Furniture, computer and office equipment, and other 29,468   22,235
      526,094 478,757
      Less, accumulated depreciation and amortization (158,139 ) (131,307 )
      $ 367,955 $ 347,450

           Depreciation and amortization expense on property, plant, and equipment amounted to $31.1 million, $19.7 million, and $14.2 million for the years ended December 31, 2011, 2010, and 2009, respectively. Effective in the first quarter of 2010, the estimated useful lives of certain capitalized laboratory and other equipment, which is a component of property, plant, and equipment, were extended. The effect of this change in estimate was to lower depreciation expense by $4.0 million and to lower the Company’s net loss per share by $0.05 for the year ended December 31, 2010.

      F-24


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Included in property, plant, and equipment at December 31, 2011 and December 31 2010 was $3.6 million and $2.8 million, respectively, of leased equipment under capital leases, and related accumulated amortization was $0.5 million and $0.1 million at December 31, 2011 and December 31, 2010, respectively.

           Property, plant, and equipment at both December 31, 2011 and 2010 includes $86.2 million of costs incurred by the Company’s landlord to construct new laboratory and office facilities in Tarrytown, New York in connection with the Company’s December 2006 lease, as amended, of these facilities. See Note 12a.

           The Company capitalized interest costs of $6.4 million in 2010. The Company did not capitalize any interest costs in 2011.

      9. Accounts Payable and Accrued Expenses

           Accounts payable and accrued expenses as of December 31, 2011 and 2010 consist of the following:

            2011       2010
      Accounts payable   $ 27,736 $ 15,589
      Accrued payroll and related costs 42,835   12,025
      Accrued clinical trial expense 9,850   9,727
      Accrued property, plant, and equipment costs   1,070 7,622
      Other accrued expenses and liabilities 14,134 6,441
      Payable to Bayer HealthCare 2,254
      $ 95,625 $ 53,658

      10. Deferred Revenue

           Deferred revenue as of December 31, 2011 and 2010 consists of the following:

            2011       2010
      Current portion:
             Received from Sanofi (see Note 3a) $ 20,011 $ 19,506
             Received from Bayer HealthCare (see Note 3b) 7,907   9,884
             Received for technology license agreements (see Note 4)     23,572   25,008
             Other 150 325
      $ 51,640 $ 54,723
       
      Long-term portion:
             Received from Sanofi (see Note 3a) $ 86,017 $ 97,081
             Received from Bayer HealthCare (see Note 3b) 34,456 37,067
             Received for technology license agreements (see Note 4) 128,137 151,708
      $ 248,610 $ 285,856

      11. Convertible Debt

           In October 2011, the Company issued $400.0 million aggregate principal amount of 1.875% convertible senior notes (the “Notes”) in a private placement. The net proceeds from the Notes offering were $391.1 million after deducting the initial purchaser’s discount and issuance costs.

      F-25


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The Notes will pay interest semi-annually on April 1 and October 1, beginning April 1, 2012, and will mature on October 1, 2016 unless earlier converted or repurchased. The Notes will be convertible, subject to certain conditions, into cash, shares of the Company’s Common Stock, or a combination of cash and shares of Common Stock, at the Company's option. The initial conversion rate for the Notes will be 11.9021 shares of Common Stock (subject to adjustment in certain circumstances) per $1,000 principal amount of the Notes, or a total of approximately 4,760,840 shares upon conversion, which is equal to an initial conversion price of approximately $84.02 per share. A holder of the Notes may surrender their Notes at their option any time prior to the close of business on the business day immediately preceding July 1, 2016, only under the following circumstances: (i) during any calendar quarter commencing after the calendar quarter ending on December 31, 2011 (and only during such calendar quarter), if the last reported sale price of the Company’s Common Stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day; (ii) during the five business day period after any ten consecutive trading day period (the “measurement period”) in which the trading price, as defined, of the Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s Common Stock and the conversion rate on each such trading day; (iii) if the Company elects to issue to all or substantially all holders of its Common Stock any rights, options or warrants (other than pursuant to a rights plan) entitling them for a period of not more than 60 calendar days after the record date for such issuance, to subscribe for or purchase shares of the Company’s Common Stock, at a price per share less than the average of the last reported sales prices of the Company’s Common Stock for the ten consecutive day period ending on, and including, the trading day immediately preceding the declaration date for such issuance; (iv) upon specified distributions to the Company’s shareholders; or (v) upon the occurrence of specified corporate transactions, such as a fundamental change (i.e., a change in control), or the Company’s Common Stock ceasing to be listed on at least one U.S. national securities exchange. On or after July 1, 2016, holders may convert their Notes at the conversion rate at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date irrespective of the foregoing conditions. In the event that a fundamental change, as defined in the indenture under which the Notes have been issued, occurs prior to maturity of the Notes, the initial conversion rate may be increased to include additional shares upon conversion, or holders can require the Company to purchase from them all or a portion of their Notes for 100% of the principal value plus any accrued and unpaid interest.

           The Company has reserved sufficient shares of its Common Stock to satisfy the conversion requirements related to the Notes. The Company may not redeem the Notes prior to their maturity date.

           In accordance with accounting guidance for debt with conversion and other options, the Company accounted for the liability and equity components of the Notes separately. The estimated fair value of the liability component at the date of issuance was $271.1 million, and was computed based on the fair value of similar debt instruments that do not include a conversion feature. The equity component of $120.9 million was recognized as a debt discount and represents the difference between the $392.0 million of gross proceeds from the issuance of the Notes and the $271.1 million estimated fair value of the liability component at the date of issuance. The debt discount is amortized over the expected life of a similar liability without the equity component. The Company determined this expected life to be equal to the term of the Notes, resulting in an amortization period ending October 1, 2016. The effective interest rate used to amortize the debt discount is approximately 10.2%, which was based on the Company’s estimated non-convertible borrowing rate as of the date the Notes were issued.

           Issuance costs of $0.9 million related to the issuance of the Notes were allocated to the liability and equity components in proportion to the allocation of the proceeds and accounted for as capitalized debt issuance costs and equity issuance costs, respectively.

           The net carrying amount of the liability component of the Notes as of December 31, 2011 consists of the following:

            2011
      Total convertible senior notes – par $ 400,000
      Unamortized discount     (124,981 )
      $ 275,019

           Total interest expense associated with the Notes consisted of the following for the year ended December 31, 2011:

            2011
      Contractual coupon interest rate       $ 1,455
      Amortization of discount and note issuance costs     3,944
      $ 5,399

      F-26


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           As of December 31, 2011, the "if converted value" did not exceed the principal amount of the Notes since the closing sales price of the Company’s Common Stock was less than the initial conversion price of the Notes. The fair value of the outstanding Notes was estimated to be $375.5 million as of December 31, 2011, and was determined based on quoted market rates.

           In connection with the offering of the Notes, the Company entered into convertible note hedge (“call option”) and warrant transactions with multiple counterparties, including an affiliate of the initial purchaser. The convertible note hedge transactions cover, subject to customary anti-dilution adjustments, the number of shares of the Company's Common Stock that initially underlie the Notes, and are intended to reduce the potential dilutive impact of the conversion feature of the Notes. The convertible note hedge will terminate upon the earlier of the maturity date of the Notes or the first day the Notes are no longer outstanding. The Company paid $117.5 million for the convertible note hedge, which was recorded as a reduction to additional paid-in capital.

           The warrant transactions have an initial strike price of approximately $103.41 per share, and may be settled in cash or shares of the Company’s Common Stock, at the Company’s option. The warrant transactions will have a dilutive effect to the extent that the market price per share of the Company's Common Stock exceeds the applicable strike price of the warrants. Proceeds received from the warrant transactions totaled $93.8 million and were recorded as additional paid-in capital. The warrants expire at various dates during 2017.

           The convertible note hedge and warrants are both considered indexed to the Company’s Common Stock and classified as equity; therefore, the convertible note hedge and warrants are not accounted for as derivative instruments. The Company has reserved sufficient shares of its Common Stock to satisfy the potential settlement of the warrants.

      12. Commitments and Contingencies

      a. Leases

           Descriptions of Lease Agreements

           The Company leases laboratory and office facilities in Tarrytown, New York, under a December 2006 lease agreement, as amended (the “Tarrytown Lease”). The facilities leased by the Company under the Tarrytown Lease include (i) space in previously existing buildings, (ii) newly constructed space in two new buildings (“Buildings A and B”) that was completed in the third quarter of 2009 and, (iii) under a December 2009 amendment to the Tarrytown Lease, additional newly constructed space in a third new building (“Building C”) that was completed in the first quarter of 2011. The Tarrytown Lease will expire in June 2024 and contains three renewal options to extend the term of the lease by five years each, escalations at 2.5% per annum, and early termination options for various portions of the space exclusive of the newly constructed space in Buildings A and B. The Tarrytown Lease provides for monthly payments over its term and additional charges for utilities, taxes, and operating expenses. Certain premises under the Tarrytown Lease are accounted for as operating leases. However, for Buildings A, B, and C that the Company is leasing, the Company is deemed, in substance, to be the owner of the landlord’s buildings in accordance with the application of FASB authoritative guidance, and the landlord’s costs of constructing these new facilities are required to be capitalized on the Company’s books as a non-cash transaction, offset by a corresponding lease obligation on the Company’s balance sheet.

           In connection with the Tarrytown Lease, the Company issued a letter of credit in the amount of $3.4 million and collateralized the letter of credit with cash and marketable debt securities totaling $3.6 million at both December 31, 2011 and 2010. Such collateral has been classified as restricted cash and marketable securities.

           In October 2008, the Company entered into a sublease with Sanofi U.S. for office space in Bridgewater, New Jersey. The lease commenced in January 2009 and expired in July 2011. In July 2011, the Company entered into an operating lease for office space in Liberty Corner, New Jersey, which expires in January 2017.

           The Company also leases certain equipment under operating and capital leases which expire at various times through 2014.

      F-27


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Commitments under Operating Leases

           The estimated future minimum noncancelable lease commitments under operating leases were as follows:

      December 31,         Facilities       Equipment       Total
      2012 $ 6,072 $ 1,188 $ 7,260
      2013 7,304 258 7,562
      2014 7,428 35 7,463
      2015 7,583 7,583
      2016 7,738 7,738
      Thereafter 59,631 59,631
      $ 95,756 $ 1,481 $ 97,237

           Rent expense under operating leases was:
       
      Year Ending December 31,         Facilities       Equipment       Total
      2011 $ 7,191 $ 599 $ 7,790
      2010   7,301     335     7,636
      2009   7,722 395 8,117

           In addition to its rent expense under operating leases, and payments under facility lease obligations (see below), for various facilities, the Company paid rental charges for utilities, real estate taxes, and operating expenses of $9.3 million, $10.3 million, and $8.4 million for the years ended December 31, 2011, 2010, and 2009, respectively.

           Commitments under Capital Leases

           In 2011 and 2010, the Company entered into capital leases in connection with acquisitions of new equipment. The lease obligations are collateralized with marketable debt securities totaling $3.3 million and $3.5 at December 31, 2011 and 2010, respectively; such collateral has been classified as restricted cash and marketable securities at December 31, 2011 and 2010.

           The estimated future minimum noncancelable lease commitments under capital leases were as follows:

      December 31,         Equipment
      2012 $ 1,394
      2013   1,254
      2014 130  
      Total minimum lease payments   2,778
      Less: amount representing interest (272 )
      $ 2,506

           At the end of the lease term, the Company is required to purchase the leased equipment for a nominal amount defined in the lease agreement. At December 31, 2011 and 2010, capital lease obligations totaled $2.5 million and $2.8 million, respectively, and were included in other liabilities.

           Facility Lease Obligations

           As described above, in connection with the application of FASB authoritative guidance to the Company’s lease of office and laboratory facilities in Buildings A, B, and C, the Company capitalized the landlord’s costs of constructing the new facilities and recognized a corresponding facility lease obligation. The Company also recognized, as additional facility lease obligation, reimbursements from the Company’s landlord for tenant improvement costs that the Company incurred since, under FASB authoritative guidance, such payments that the Company receives from its landlord are deemed to be a financing obligation. Monthly lease payments on these facilities are allocated between the land element of the lease (which is accounted for as an operating lease) and the facility lease obligation, based on the estimated relative fair values of the land and buildings.

           As of December 31, 2010, the Company had capitalized the landlord’s costs of constructing Buildings A and B, which totaled $58.4 million, and of constructing Building C, which totaled $27.8 million. Reimbursements from the Company’s landlord for Buildings A and B tenant improvement costs totaled $56.9 million and were received by the Company during 2010 and 2009. Reimbursements for Building C tenant improvement costs totaled $14.2 million and were received by the Company during 2010. With respect to Buildings A and B, monthly lease payments commenced in August 2009, the buildings were placed in service by the Company in September 2009, and the imputed interest rate applicable to the Company’s facility lease obligation is approximately 11%. With respect to Building C, monthly lease payments commenced in January 2011, the building was placed in service by the Company in February 2011, and the imputed interest rate applicable to the Company’s facility lease obligation is approximately 9%.

      F-28


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           In 2011, the Company recognized $15.6 million of interest expense in connection with the Buildings A and B and the Building C facility lease obligations. In 2010 and 2009, the Company recognized $9.1 million and $2.3 million, respectively, of interest expense in connection with the Buildings A and B facility lease obligation. At December 31, 2011 and 2010, the Buildings A and B facility lease obligation balance was $113.0 million and $113.7 million, respectively, and the Building C facility lease obligation balance was $47.5 million and $46.4 million, respectively.

           The estimated future minimum noncancelable commitments under these facility lease obligations, as of December 31, 2011, were as follows:

      December 31,   Buildings A and B Building C Total
      2012       $ 12,847       $ 2,825       $ 15,672
      2013 13,092   4,370 17,462
      2014     13,343   4,490 17,833
      2015 13,600 4,614 18,214
      2016 13,864 4,740   18,604
      Thereafter 113,040 39,899 152,939
      $ 179,786 $ 60,938 $ 240,724

      b. Research Collaboration and Licensing Agreements

           As part of the Company's research and development efforts, the Company enters into research collaboration and licensing agreements with related and unrelated companies, scientific collaborators, universities, and consultants. These agreements contain varying terms and provisions which include fees and milestones to be paid by the Company, services to be provided, and ownership rights to certain proprietary technology developed under the agreements. Some of the agreements contain provisions which require the Company to pay royalties, as defined, at rates that range from 0.25% to 16.5%, in the event the Company sells or licenses any proprietary products developed under the respective agreements.

           In December 2011, the Company and Genentech, Inc., a member of the Roche Group, entered into a Non-Exclusive License and Partial Settlement Agreement (the “Genentech Agreement”) relating to ophthalmic sales of EYLEA® in the United States. Pursuant to the Genentech Agreement, the Company received a non-exclusive license to certain patents relating to VEGF receptor proteins, known as the Davis-Smyth patents, and other technology patents. The Davis-Smyth patents are the subject of patent litigation between the Company and Genentech now pending in the United States District Court, Southern District of New York. Patent litigation is continuing with respect to matters not covered by the Genentech Agreement (see Note 18).

           Under the terms of the Genentech Agreement, the Company agreed to make payments to Genentech based on U.S. sales of EYLEA® commencing upon FDA approval of EYLEA® in November 2011 through May 7, 2016. The Company will be required to make a one-time, non-refundable $60 million payment upon cumulative U.S. sales of EYLEA® reaching $400 million. In addition, the Company agreed to pay royalties of 4.75% on cumulative U.S. sales of EYLEA® between $400 million and $3 billion and 5.5% on any cumulative U.S sales of EYLEA® over $3 billion. As the Company records net product sales of EYLEA®, the Company is recognizing expense in connection with the Genentech Agreement using a blended mid-single digit royalty rate that reflects both the $60 million payment and the royalties payable on cumulative sales and that is based upon the Company’s estimate of cumulative EYLEA® sales through May 7, 2016.

           The Company recognizes royalty expense based on net product sales of EYLEA® and ARCALYST® under various licensing agreements, including, for EYLEA®, the Genentech Agreement described above. For the years ended December 31, 2011, 2010, and 2009, royalties on net product sales totaled $3.2 million, $1.7 million, and $1.5 million, respectively, and are included in cost of goods sold.

      F-29


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           In July 2008, the Company and Cellectis S.A. (“Cellectis”) entered into an Amended and Restated Non-Exclusive License Agreement (the “Cellectis Agreement”). The Cellectis Agreement resolved a dispute between the parties related to the interpretation of a license agreement entered into by the parties in December 2003 pursuant to which the Company licensed certain patents and patent applications from Cellectis. Pursuant to the Cellectis Agreement, in July 2008, the Company made a non-refundable $12.5 million payment to Cellectis (the “Cellectis Payment”) and agreed to pay Cellectis a low single-digit royalty based on revenue received by the Company from any future licenses or sales of the Company’s VelociGene® or VelocImmune® products and services. No royalties are payable to Cellectis with respect to the Company’s VelocImmune® license agreements with AstraZeneca and Astellas or the Company’s antibody collaboration with Sanofi. Moreover, no royalties are payable to Cellectis on any revenue from commercial sales of antibodies from the Company’s VelocImmune® technology.

           The Company began amortizing the Cellectis Payment in the second quarter of 2008 in proportion to past and future anticipated revenues under the Company’s license agreements with AstraZeneca and Astellas and the Discovery and Preclinical Development Agreement under the Company’s antibody collaboration with Sanofi (as amended in November 2009). In 2011, 2010, and 2009, the Company recognized $1.0 million, $0.9 million, and $2.3 million, respectively, of expense in connection with the Cellectis Payment. At December 31, 2011 and 2010, the unamortized balance of the Cellectis Payment, which was included in other assets, was $5.7 million and $6.6 million, respectively. The Company estimates that it will recognize expense of $1.0 million in each of 2012 and 2013, and $0.9 million in each of 2014, 2015, and 2016, in connection with the Cellectis Payment.

      13. Stockholders’ Equity

           The Company's Restated Certificate of Incorporation provides for the issuance of up to 40 million shares of Class A Stock, par value $0.001 per share, and 160 million shares of Common Stock, par value $0.001 per share. Shares of Class A Stock are convertible, at any time, at the option of the holder into shares of Common Stock on a share-for-share basis. Holders of Class A Stock have rights and privileges identical to Common Stockholders except that each share of Class A is entitled to ten votes per share, while each share of Common Stock is entitled to one vote per share. Class A Stock may only be transferred to specified Permitted Transferees, as defined. Under the Company’s Restated Certificate of Incorporation, the Company’s board of directors is authorized to issue up to 30 million shares of preferred stock, in series, with rights, privileges, and qualifications of each series determined by the board of directors.

           In September 2003, Sanofi purchased 2,799,552 newly issued, unregistered shares of the Company’s Common Stock for $45.0 million. See Note 3.

           In December 2007, Sanofi purchased 12 million newly issued, unregistered shares of the Company’s Common Stock for an aggregate cash price of $312.0 million. As a condition to the closing of this transaction, Sanofi entered into an investor agreement with the Company, which was amended in November 2009. Under the amended investor agreement, Sanofi has three demand rights to require the Company to use all reasonable efforts to conduct a registered underwritten public offering with respect to shares of the Company’s Common Stock beneficially owned by Sanofi immediately after the closing of the transaction. Until the later of the fifth anniversaries of the expiration or earlier termination of the License and Collaboration Agreement, as amended in 2009, under the Company’s antibody collaboration with Sanofi (see Note 3) and the Company’s collaboration agreement with Sanofi for the development and commercialization of ZALTRAP® (see Note 3), Sanofi will be bound by certain “standstill” provisions. These provisions include an agreement not to acquire more than a specified percentage of the outstanding shares of the Company’s Class A Stock and Common Stock. The percentage increased from 25% to 30% as of December 20, 2011. Under the amended investor agreement, Sanofi has also agreed not to dispose of any shares of the Company’s Common Stock that were beneficially owned by Sanofi immediately after the closing of the transaction until December 20, 2017, subject to certain limited exceptions. Following December 20, 2017, Sanofi will be permitted to sell shares of the Company’s Common Stock (i) in a registered underwritten public offering undertaken pursuant to the demand registration rights granted to Sanofi and described above, subject to the underwriter's broad distribution of securities sold, (ii) pursuant to Rule 144 under the Securities Act and transactions exempt from registration under the Securities Act, subject to a volume limitation of one million shares of the Company’s Common Stock every three months and a prohibition on selling to beneficial owners, or persons that would become beneficial owners as a result of such sale, of 5% or more of the outstanding shares of the Company’s Common Stock, and (iii) into an issuer tender offer, or a tender offer by a third party that is recommended or not opposed by the Company’s board of directors. Sanofi has agreed to vote, and cause its affiliates to vote, all shares of the Company’s voting securities they are entitled to vote, at Sanofi's election, either as recommended by the Company’s board of directors or proportionally with the votes cast by the Company’s other shareholders, except with respect to certain change of control transactions, liquidation or dissolution, stock issuances equal to or exceeding 10% of the then outstanding shares or voting rights of the Company’s Class A Stock and Common Stock, and new equity compensation plans or amendments if not materially consistent with the Company’s historical equity compensation practices. The rights and restrictions under the investor agreement are subject to termination upon the occurrence of certain events.

      F-30


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           In October 2010, the Company completed an underwritten public offering of 6,325,000 shares of Common Stock and received net proceeds of $174.8 million. Sanofi purchased 1,017,401 shares of Common Stock in this offering.

           In October 2011, the Company completed a private placement of $400.0 million aggregate principal amount of Notes, which are convertible into shares of the Company’s Common Stock. In accordance with accounting guidance for debt with conversion and other options, the Company accounted for the liability and equity components of the Notes separately. The equity component of the Notes was $120.6 million, net of issuance costs. In connection with the offering of the Notes, the Company entered into convertible note hedge and warrant transactions. The Company paid $117.5 million for the convertible note hedge, which was recorded as a reduction to additional paid-in capital. The warrant transactions have an initial strike price of approximately $103.41 per share, and may be settled in cash or shares of the Company’s Common Stock, at the Company’s option. Proceeds received from the warrant transactions totaled $93.8 million and were recorded as additional paid-in capital. The warrants expire at various dates during 2017. See Note 11.

      14. Long-Term Incentive Plans

           During 2000, the Company established the Regeneron Pharmaceuticals, Inc. 2000 Long-Term Incentive Plan which, as amended and restated (the “2000 Incentive Plan”), provides for the issuance of up to 41,307,016 shares of Common Stock in respect of awards. Employees of the Company, including officers, and nonemployees, including consultants and nonemployee members of the Company’s board of directors, (collectively, “Participants”) may receive awards as determined by a committee of independent directors (“Committee”). The awards that may be made under the 2000 Incentive Plan include: (a) Incentive Stock Options (“ISOs”) and Nonqualified Stock Options, (b) shares of Restricted Stock, (c) shares of Phantom Stock, (d) Stock Bonuses, and (e) Other Awards.

           Stock Option awards grant Participants the right to purchase shares of Common Stock at prices determined by the Committee; however, in the case of an ISO, the option exercise price will not be less than the fair market value of a share of Common Stock on the date the Option is granted. Options vest over a period of time determined by the Committee, generally on a pro rata basis over a three to five year period. The Committee also determines the expiration date of each Option; however, no ISO is exercisable more than ten years after the date of grant. The maximum term of options that have been awarded under the 2000 Incentive Plan is ten years.

           Restricted Stock awards grant Participants shares of restricted Common Stock or allow Participants to purchase such shares at a price determined by the Committee. Such shares are nontransferable for a period determined by the Committee (“vesting period”). Should employment terminate, as defined by the 2000 Incentive Plan, the ownership of the Restricted Stock, which has not vested, will be transferred to the Company, except under defined circumstances with Committee approval, in consideration of amounts, if any, paid by the Participant to acquire such shares. In addition, if the Company requires a return of the Restricted Shares, it also has the right to require a return of all dividends paid on such shares.

           Phantom Stock awards provide the Participant the right to receive, within 30 days of the date on which the share vests, an amount, in cash and/or shares of the Company’s Common Stock as determined by the Committee, equal to the sum of the fair market value of a share of Common Stock on the date such share of Phantom Stock vests and the aggregate amount of cash dividends paid with respect to a share of Common Stock during the period from the grant date of the share of Phantom Stock to the date on which the share vests. Stock Bonus awards are bonuses payable in shares of Common Stock which are granted at the discretion of the Committee.

      F-31


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           Other Awards are other forms of awards which are valued based on the Company’s Common Stock. Subject to the provisions of the 2000 Incentive Plan, the terms and provisions of such Other Awards are determined solely on the authority of the Committee.

           The 2000 Incentive Plan contains provisions that allow for the Committee to provide for the immediate vesting of awards upon a change in control of the Company, as defined in the plan.

           As of December 31, 2011, there were 10,244,318 shares available for future grants under the 2000 Incentive Plan.

      a. Stock Options

           Transactions involving stock option awards during 2011 under the 2000 Incentive Plan is summarized in the table below.

      Weighted-
      Average
      Remaining
      Weighted- Contractual Intrinsic
      Number of Average Term Value
      Stock Options:       Shares       Exercise Price       (in years)       (in thousands)
      Outstanding at December 31, 2010 23,362,248 $ 19.93
      2011:      Granted 4,286,640 $ 51.96
      Forfeited (247,898 ) $ 28.11
      Expired (551,456 ) $ 13.31
      Exercised (4,523,173 )   $ 18.73
      Outstanding at December 31, 2011   22,326,361 $ 26.40   6.90   $ 663,376
       
      Vested and expected to vest at December 31, 2011 21,755,141 $ 26.04 6.84 $ 653,990
       
      Exercisable at December 31, 2011 11,963,345 $ 18.27 5.27 $ 451,478

           The Company satisfies stock option exercises with newly issued shares of the Company’s Common Stock. The total intrinsic value of stock options exercised during 2011, 2010, and 2009 was $49.2 million, $21.4 million, and $13.2 million, respectively. The intrinsic value represents the amount by which the market price of the underlying stock exceeds the exercise price of an option.

           The Company grants stock options with exercise prices that are equal to or greater than the average market price of the Company’s Common Stock on the date of grant (“Market Price”). The table below summarizes the weighted-average exercise prices and weighted-average grant-date fair values of options issued during the years ended December 31, 2011, 2010, and 2009. The fair value of each option granted under the 2000 Incentive Plan during 2011, 2010, and 2009 was estimated on the date of grant using the Black-Scholes option-pricing model.

      Weighted- Weighted-
      Number of Average Exercise Average Fair
            Options Granted       Price       Value
      2011:    
             Exercise price equal to Market Price 4,286,640 $ 51.96 $ 23.82
       
      2010:
             Exercise price equal to Market Price   4,319,856   $ 29.43   $ 13.36
       
      2009:
             Exercise price equal to Market Price 3,490,560 $ 20.69 $ 10.89

      F-32


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           For the years ended December 31, 2011, 2010, and 2009, the Company recognized $39.2 million, $29.4 million, and $27.4 million, respectively, of non-cash stock-based compensation expense related to non-performance based stock option awards. As of December 31, 2011, there was $93.6 million of stock-based compensation cost related to outstanding non-performance based stock options, net of estimated forfeitures, which had not yet been recognized. The Company expects to recognize this compensation cost over a weighted-average period of 1.9 years.

           In addition, there were 2,195,429 performance-based options which were outstanding and unvested as of December 31, 2011 of which, subject to the optionee satisfying certain service conditions, 203,429 options that were issued in 2005 would vest upon achieving certain defined sales targets for the Company’s products and 1,992,000 options that were issued in 2011, 2010, and 2009 would vest upon achieving certain development milestones for the Company’s product candidates. In light of the Company’s receipt of marketing approval for EYLEA® for the treatment of wet AMD in November 2011, and the status of the Company’s development programs at December 31, 2011, the Company estimates that all of the remaining performance-based options issued in 2005, 2009, and 2010 will vest and approximately 50% of the performance-based options issued in 2011 will vest.

           For the years ended December 31, 2011 and 2010, the Company recognized $11.7 million and $8.1 million, respectively, of non-cash stock-based compensation expense related to these performance options. As of December 31, 2011 there was $17.4 million of stock-based compensation cost which had not yet been recognized related to the performance–based options that the Company currently estimates will vest. The Company expects to recognize this compensation cost over a weighted-average period of 2.5 years. In addition, potential compensation cost of $10.2 million related to the performance options issued in 2011, whose performance conditions (based on current facts and circumstances) are not currently considered by the Company to be probable of attainment, will begin to be recognized only if and when the Company estimates that it is probable that these options will vest. The Company’s estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods. Changes in these estimates may materially affect the amount of stock-based compensation recognized in future periods related to performance-based options.

      Fair value Assumptions:

           The following table summarizes the weighted average values of the assumptions used in computing the fair value of option grants during 2011, 2010, and 2009.

            2011       2010       2009
      Expected volatility   48%   47% 54%
      Expected lives from grant date         6.1 years         5.6 years         5.9 years
      Expected dividend yield 0% 0% 0%
      Risk-free interest rate 1.31% 2.11% 2.87%

           Expected volatility has been estimated based on actual movements in the Company’s stock price over the most recent historical periods equivalent to the options’ expected lives. Expected lives are principally based on the Company’s historical exercise experience with previously issued employee and board of directors’ option grants. The expected dividend yield is zero as the Company has never paid dividends and does not currently anticipate paying any in the foreseeable future. The risk-free interest rates are based on quoted U.S. Treasury rates for securities with maturities approximating the options’ expected lives.

      b. Restricted Stock

           A summary of the Company’s activity related to Restricted Stock awards for the year ended December 31, 2011 is summarized below:

      Weighted-
      Average
            Number of       Grant Date Fair
      Restricted Stock: Shares Value
      Outstanding at December 31, 2010 845,000 $ 25.37
      2011:      Granted   16,500   $ 58.59
      Released         (110,001 ) $ 30.63
      Outstanding at December 31, 2011 751,499 $ 25.33

      F-33


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The Company recognized non-cash stock-based compensation expense from Restricted Stock awards of $5.7 million, $2.4 million, and $2.2 million in 2011, 2010, and 2009, respectively. As of December 31, 2011, there were 751,499 unvested shares of Restricted Stock outstanding and $9.8 million of stock-based compensation cost related to these unvested shares which had not yet been recognized. The Company expects to recognize this compensation cost over a weighted-average period of 1.4 years.

      15. Executive Stock Purchase Plan

           In 1989, the Company adopted an Executive Stock Purchase Plan (the “Plan”) under which 1,027,500 shares of Class A Stock were reserved for restricted stock awards. The Plan provides for the compensation committee of the board of directors to award employees, directors, consultants, and other individuals (“Plan participants”) who render service to the Company the right to purchase Class A Stock at a price set by the compensation committee. The Plan provides for the vesting of shares as determined by the compensation committee and, should the Company's relationship with a Plan participant terminate before all shares are vested, unvested shares will be repurchased by the Company at a price per share equal to the original amount paid by the Plan participant. During 1989 and 1990, a total of 983,254 shares were issued, all of which vested as of December 31, 1999. As of December 31, 2011, there were 44,246 shares available for future grants under the Plan.

      16. Employee Savings Plan

           In 1993, the Company adopted the provisions of the Regeneron Pharmaceuticals, Inc. 401(k) Savings Plan (the “Savings Plan”). The terms of the Savings Plan provide for employees who have met defined service requirements to participate in the Savings Plan by electing to contribute to the Savings Plan a percentage of their compensation to be set aside to pay their future retirement benefits, as defined. The Savings Plan, as amended and restated, provides for the Company to make discretionary contributions (“Contribution”), as defined. The Company recognized $4.1 million, $3.2 million, and $2.6 million of Contribution expense in 2011, 2010, and 2009, respectively. At December 31, 2011 and 2010, accrued Contribution expense totaled $3.6 million and $2.9 million, respectively. During the first quarter of 2012 and 2011, the Company contributed 63,937 and 91,761 shares, respectively, of Common Stock to the Savings Plan in satisfaction of these obligations.

      17. Income Taxes

           For the year ended December 31, 2011, the Company incurred a net loss for tax purposes and recognized a full valuation allowance against deferred taxes. In 2011, the Company recognized a $1.1 million income tax benefit, consisting of (i) $0.7 million related to tax legislation that allowed the Company to claim a refund for a portion of its unused pre-2006 research tax credits and (ii) $0.4 million in connection with the net tax effect of the change in the Company’s unrealized gain (loss) on “available for sale” marketable securities, which is included in other comprehensive income (loss).

           For the year ended December 31, 2010, the Company incurred a net loss for tax purposes and recognized a full valuation allowance against deferred taxes. No provision or benefit for income taxes was recognized by the Company in 2010.

           For the year ended December 31, 2009, the Company incurred a net loss for tax purposes and recognized a full valuation allowance against deferred taxes. In 2009, the Company recognized a $4.1 million income tax benefit, consisting of (i) $2.7 million resulting from tax legislation that allowed the Company to claim a refund of U.S. federal alternative minimum tax (“AMT”) that the Company paid in connection with its 2007 U.S. federal income tax return, (ii) $0.7 million resulting from tax legislation that allowed the Company to claim a refund for a portion of its unused pre-2006 research tax credits on its 2009 U.S. federal income tax return, and (iii) $0.7 million in connection with the net tax effect of the Company’s unrealized gain on “available-for-sale” marketable securities, which is included in other comprehensive income in 2009.

      F-34


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The tax effect of temporary differences, net operating loss carry-forwards, and research and experimental and other tax credit carry-forwards as of December 31, 2011 and 2010 is as follows:

            2011       2010
      Deferred tax assets:
             Net operating loss carry-forward $ 282,480 $ 243,893
             Fixed assets 14,847 13,600  
             Deferred revenue 120,490 70,443
             Deferred compensation 47,092 39,120
             Research and experimental and other tax credit carry-forwards 67,734 45,588
             Capitalized research and development costs 31,371 38,865
             Other 15,956 10,863
        579,790 462,372  
      Deferred tax liabilities:
             Convertible senior notes (1,428 )
       
      Net deferred tax assets   578,542
      Valuation allowance (578,542 )   (462,372 )
      -- --

           The Company’s valuation allowance increased by $116.2 million in 2011, due primarily to increases in the Company’s net operating loss carry-forward and tax credit carry-forwards and the full recognition of the $165.0 million up-front payment received from Astellas in 2010 as taxable income in 2011. The Company’s valuation allowance increased by $63.0 million in 2010, due primarily to increases in the net operating loss carry-forward and tax credit carry-forwards.

           The Company is primarily subject to U.S. federal and New York State income taxes. The difference between the Company’s effective income tax rate and the U.S federal statutory rate of 35% is primarily attributable to an increase in the deferred tax valuation allowance. In 2011 and early 2012, U.S. federal tax authorities concluded examinations of the Company’s 2007, 2008, and 2009 federal income tax returns. The Company’s 2010 federal income tax return is currently being examined by the U.S. federal tax authorities. In addition, tax years subsequent to 2007 remain open to examination by New York State tax authorities.

           As of December 31, 2011 and 2010, the Company had no accruals for interest or penalties related to income tax matters.

           As of December 31, 2011, the Company had available for tax purposes unused net operating loss carry-forwards of $800.2 million which will expire in various years from 2018 to 2031 and included $96.2 million of net operating loss carry-forwards related to exercises of Nonqualified Stock Options and disqualifying dispositions of Incentive Stock Options, the tax benefit from which, if realized, will be credited to additional paid-in capital. The Company's research and experimental and other tax credit carry-forwards expire in various years from 2012 to 2031. Under the Internal Revenue Code and similar state provisions, substantial changes in the Company’s ownership have resulted in an annual limitation on the amount of net operating loss and tax credit carry-forwards that can be utilized in future years to offset future taxable income. This annual limitation may result in the expiration of net operating losses and tax credit carry-forwards before utilization.

           The following table summarizes the gross amounts of unrecognized tax benefits at the beginning and end of 2011 and 2010:

            2011       2010
      Balance as of January 1 $ 12,819 $ -
      Gross increases related to current year tax positions 2,192   3,550
      Gross increases related to prior year tax positions 9,269
      Gross decreases due to settlements     (9,415 )  
      Balance as of December 31 $ 5,596 $ 12,819

      F-35


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           In 2011, the gross decrease in unrecognized tax benefits related to prior year tax positions was primarily due to the conclusion of examinations of the Company’s 2007, 2008, and 2009 federal income tax returns by U.S. federal tax authorities. In 2010, the gross increases in unrecognized tax benefits related to prior year tax positions was primarily due to the Company’s calculations of certain pre-2010 tax credits. Due to the amounts of the Company’s net operating loss carry-forward and tax credit carry-forwards, the Company has not accrued interest or penalties related to these unrecognized tax benefits. In addition, unrecognized tax benefits at December 31, 2011 and 2010, if recognized, would not affect the Company’s effective tax rate since the adjustments to deferred tax assets would be fully offset by adjustments to the Company’s valuation allowance. For the year ended December 31, 2009, income tax positions that were deemed uncertain under the recognition thresholds and measurement attributes prescribed in FASB authoritative guidance were not material.

      18. Legal Matters

           From time to time, the Company is a party to legal proceedings in the course of the Company’s business. The Company does not expect any such current ordinary course legal proceedings to have a material adverse effect on the Company’s business or financial condition. Costs associated with the Company’s involvement in legal proceedings are expensed as incurred.

      Genentech Patent Litigation

           The Company is aware of issued patents and pending patent applications owned by Genentech that claim certain chimeric VEGF receptors. The Company does not believe that ZALTRAP® or EYLEA® infringe any valid claim in these patents or patent applications. The Company is involved in five patent litigations with Genentech, two in the United States and three in Europe. In November 2010, the Company commenced a lawsuit against Genentech in the U.S. District Court for the Southern District of New York (the “Court”), seeking a declaratory judgment that no activities relating to the Company’s VEGF Trap infringe any valid claim of certain Genentech patents referred to as the Davis-Smyth patents (the “First Davis-Smyth Case”). Genentech answered the complaint and asserted counterclaims that the Company’s prior or planned activities relating to VEGF Trap have infringed or will infringe claims of four of the five Davis-Smyth patents and requested a judgment against the Company for damages, including for willful infringement, and other relief as the Court deems appropriate.

           On December 31, 2011, the Company entered into a Non-Exclusive License and Partial Settlement Agreement with Genentech that covers making, using, and selling EYLEA® in the United States for the prevention and treatment of human eye diseases and disorders in the United States. Under the Genentech Agreement, the Company received a non-exclusive license to the Davis-Smyth patents, and certain other technology patents owned or co-owned by Genentech. The Genentech Agreement does not cover any non-U.S. patent rights or non-U.S. patent disputes, and does not cover any use of aflibercept other than for prevention and treatment of human eye diseases and disorders in the United States. The First Davis-Smyth Case is continuing with respect to matters not covered by the Genentech Agreement. The Genentech Agreement provides for the Company to make payments to Genentech based on U.S. sales of EYLEA® through May 7, 2016, the date the Davis-Smyth patents expire. The Company will make a lump-sum payment of $60 million once cumulative U.S. sales of EYLEA® reach $400 million. The Company will also pay royalties of 4.75% on cumulative U.S. sales of EYLEA® between $400 million and $3 billion and 5.5% on any cumulative U.S. sales of EYLEA® over $3 billion. As a result of the Genentech Agreement, on January 17, 2012 Genentech filed a second amended answer and counterclaim in the First Davis-Smyth Case, in which it amended its counterclaims alleging infringement of four of the five Davis-Smyth patents. On December 23, 2011, Genentech initiated a related case in the Court against Regeneron and Sanofi alleging infringement of four of the five Davis-Smyth Patents by activities relating to VEGF Trap (but excluding EYLEA®) (the “Second Davis-Smyth Case”). As in the First Davis-Smyth Case, in the new complaint Genentech requests a judgment against the Company for damages, including for willful infringement, and other relief as the Court deems appropriate.

           The Company believes Genentech's claims in the First Davis Smyth Case and the Second Davis Smyth Case are without merit and intend to continue to defend against all of Genentech’s remaining claims vigorously. As this litigation is at an early stage, at this time the Company is not able to predict the probability of the outcome or an estimate of loss, if any, related to these matters.

           The Company has initiated patent-related actions against Genentech in Germany, the United Kingdom, and Italy, and may initiate other actions in other countries outside the United States, which could have similar or other adverse outcomes that would materially harm its business and which, irrespective of the outcomes, may also entail significant costs and expenses.

      F-36


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

      19. Net Loss Per Share Data

           The Company’s basic net loss per share amounts have been computed by dividing net loss by the weighted average number of Common and Class A shares outstanding. Net loss per share is presented on a combined basis, inclusive of Common Stock and Class A Stock outstanding, as each class of stock has equivalent economic rights. In 2011, 2010, and 2009, the Company reported net losses; therefore, no common stock equivalents were included in the computation of diluted net loss per share since such inclusion would have been antidilutive. The calculations of basic and diluted net loss per share are as follows:

      December 31,
            2011       2010       2009
      Net loss (Numerator)   $ (221,760 ) $ (104,468 ) $ (67,830 )
       
      Weighted-average shares, in thousands  
             (Denominator) 90,610 82,926   79,782
         
      Basic and diluted net loss per share $ (2.45 ) $ (1.26 ) $ (0.85 )

           Shares issuable upon the exercise of options and warrants, vesting of restricted stock awards, and conversion of convertible senior notes, which have been excluded from the diluted per share amounts because their effect would have been antidilutive, include the following:

      December 31,
            2011       2010       2009
      Options:
             Weighted average number, in thousands   20,942   21,428   20,040
             Weighted average exercise price   $ 21.21 $ 18.80 $ 17.66
       
      Restricted Stock:
             Weighted average number, in thousands 846 526 500
       
      Convertible Senior Notes:
             Weighted average number, in thousands 939
       
      Warrants:
             Weighted average number, in thousands 939

      20. Statement of Cash Flows

           Supplemental disclosure of noncash investing and financing activities:

           Included in accounts payable and accrued expenses at December 31, 2011, 2010, and 2009 were $6.2 million, $10.7 million, and $9.8 million of accrued capital expenditures, respectively.

           Pursuant to the application of FASB authoritative guidance to the Company’s lease of office and laboratory facilities in Tarrytown, New York (see Note 12a), the Company recognized a facility lease obligation of $0.2 million and $31.7 million during 2010 and 2009, respectively, in connection with capitalizing, on the Company’s books, the landlord’s costs of constructing new facilities that the Company has leased. The Company did not recognize any such facility lease obligations during 2011.

           Included in facility lease obligations and property, plant, and equipment at December 31, 2010 was $3.7 million of capitalized and deferred interest for the year ended December 31, 2010, as the related facilities being leased by the Company were under construction and lease payments on these facilities did not commence until January 2011. For the years ended December 31, 2011 and 2009, the Company did not capitalize any interest.

      F-37


      REGENERON PHARMACEUTICALS, INC.
      NOTES TO FINANCIAL STATEMENTS (Continued)
      (Unless otherwise noted, dollars in thousands, except per share data)

           The Company incurred capital lease obligations of $0.7 and $2.9 million during 2011 and 2010 in connection with acquisitions of new equipment.

           Included in marketable securities at December 31, 2011, 2010, and 2009 were $0.7 million, $1.4 million, and $0.6 million of accrued interest income, respectively.

      21. Unaudited Quarterly Results

           Summarized quarterly financial data for the years ended December 31, 2011 and 2010 are set forth in the following tables.

      First Quarter Second Quarter Third Quarter Fourth Quarter
            Ended       Ended       Ended       Ended
      March 31, 2011 June 30, 2011 September 30, 2011 December 31, 2011
      (Unaudited)
      Revenues $               112,204 $               107,810 $                     102,833 $                     122,977
      Net loss (43,447 ) (62,505 ) (62,365 )   (53,443 )
      Net loss per share, basic  
             and diluted $ (0.49 ) $ (0.69 ) $ (0.68 ) $ (0.58 )
       
      First Quarter Second Quarter Third Quarter Fourth Quarter
      Ended Ended Ended Ended
      March 31, 2010 June 30, 2010 September 30, 2010 December 31, 2010
      (Unaudited)
      Revenues $ 103,534 $ 115,886   $ 105,979 $ 133,675
      Net loss (30,522 )     (25,474 ) (33,875 ) (14,597 )
      Net loss per share, basic    
             and diluted $ (0.38 ) $ (0.31 ) $ (0.41 ) $ (0.17 )

      F-38

             EX-10.1.9 2 exhibit10-1_9.htm FORM OF OPTION AGREEMENT AND RELATED NOTICE OF GRANT

      Exhibit 10.1.9

       
        Regeneron Pharmaceuticals, Inc.
      ID: [                    ]
      Notice of Grant of Stock Options 777 Old Saw Mill River Road
      and Option Agreement Tarrytown, New York 10591
       
       
      Option
      [OPTIONEE NAME] Number:                [             ]
      [OPTIONEE ADDRESS] Plan: 04
      ID [ ]
       

      Effective <date> (the Grant Date) you have been granted a Non-Qualified Stock Option to buy [     ] shares of Regeneron Pharmaceuticals, Inc. (the Company) stock at [$     ] per share.

      The total option price of the shares granted is [$     ].

      Shares in each period will become fully vested on the date shown.

      [Shares       Vest Type       Full Vest       Expiration Date
      [10 years from Grant
      ** On Vest Date [__/__/__]** Date]
      [10 years from Grant
      ** On Vest Date [__/__/__]** Date]
      [10 years from Grant
      ** On Vest Date [__/__/__]** Date]
                   
       
       

      You and the Company agree that these options are granted under and governed by the terms and conditions of the Company’s Second Amended and Restated 2000 Long-Term Incentive Plan and the enclosed Option Agreement, both of which are attached and made a part of this document.

       
      ____________________
       
      **  

      Options for non-employee directors will vest in approximately equal annual 33-1/3% installments. Full Vest Dates will occur on the first, second, and third anniversaries of the Grant Date.

           
      ***  

      Date to be 10 years from the Grant Date.



      REGENERON PHARMACEUTICALS, INC.

      Non-Qualified Stock Option

      OPTION AGREEMENT
      PURSUANT TO THE REGENERON PHARMACEUTICALS, INC.
      SECOND AMENDED AND RESTATED 2000 LONG-TERM INCENTIVE PLAN
      (Non-Employee Director Grant)

                THIS AGREEMENT, made as of the date on the Notice of Grant of Stock Options, by and between Regeneron Pharmaceuticals, Inc., a New York corporation (the "Company"), and the individual named on the Notice of Grant of Stock Options (the "Grantee");

                WHEREAS, the Grantee is a non-employee member of the board of directors of the Company (the "Board") and the Company desires to afford the Grantee the opportunity to acquire or enlarge the Grantee's stock ownership in the Company so that the Grantee may have a direct proprietary interest in the Company's success; and

                WHEREAS, the Committee administering the Company's Second Amended and Restated 2000 Long-Term Incentive Plan (as amended from time to time, the "Plan") has granted (as of the effective date of grant specified in the Notice of Grant of Stock Options) to the Grantee a Stock Option to purchase the number of shares of the Company's Common Stock ($.001 par value) (the "Common Stock") as set forth in the Notice of Grant of Stock Options.

                NOW, THEREFORE, in consideration of the covenants and agreements herein contained, the parties agree as follows:

           1. Grant of Award. Pursuant to Section 7 of the Plan, the Company grants to the Grantee, subject to the terms and conditions of the Plan and subject further to the terms and conditions set forth here, the option to purchase from the Company all or any part of an aggregate of shares of Common Stock at the purchase price per share (the "Option") as shown on the Notice of Grant of Stock Options. No part of the Option granted hereby is intended to qualify as an Incentive Stock Option under Section 422 of the Internal Revenue Code of 1986, as amended (the "Code").

           2. Vesting; Exercise. (a) The Option is exercisable in installments as provided on the Notice of Grant of Stock Options. To the extent that the Option has become exercisable with respect to the number of shares of Common Stock as provided on the Notice of Grant of Stock Options and subject to the terms and conditions of the Plan, including without limitation, Section 7(c)(2), the Option may thereafter be exercised by the Grantee, in whole or in part, at any time or from time to time prior to the expiration of the Option in accordance with the requirements set forth in Section 7(c)(3) of the Plan, including, without limitation, the filing of such written form of exercise notice as may be provided by the Company, and in accordance with applicable tax and other laws. In addition to the methods of payment described in Section 7(c)(3) of the Plan, the Grantee shall be eligible to pay for shares of Common Stock purchased upon the exercise of the Option by directing the Company to withhold shares of Common Stock that would otherwise be issued pursuant to the Option exercise having a Fair Market Value (as measured on the date of exercise) equal to the Option exercise price. The Grantee acknowledges that it is the Grantee's responsibility to satisfy any federal, state and local tax requirements related to the exercise of the Option.

           (b) The Notice of Grant of Stock Options indicates each date upon which the Grantee shall be entitled to exercise the Option with respect to the number of shares of Common Stock granted as indicated provided that (except as set forth below with respect to Retirement) the Grantee has not incurred a termination of service as a member of the Board prior to such date. There shall be no proportionate or partial vesting in the periods between the Full Vest Dates specified in the Notice of Grant of Stock Options and all vesting shall occur only on the Full Vest Dates. Except as otherwise provided below or in the Notice of Grant of Stock Options or as may be otherwise determined by the Committee in accordance with Section 7(e) of the Plan, no vesting shall occur after such date as the Grantee ceases to be on the Board and all unvested Options shall be forfeited at such time. Notwithstanding the preceding sentence, upon the Grantee’s Retirement from service on the Board, the Option shall continue to vest in installments as provided on the Notice of Grant of Stock Options as if the Grantee had remained in service on the Board. For purposes of this Agreement, "Retirement" shall mean a voluntary termination of service on the Board (including by not standing for re-election) by the Grantee at a time when the Grantee meets both of the following criteria: the Grantee has served as a member of the Board for a minimum of three (3) years, and the combination of the Grantee’s age and total years of service as a member of the Board equals a minimum of 80.

           (c) Notwithstanding anything herein or in the Notice of Grant of Stock Options to the contrary, the Option shall be fully vested on the date of a Change in Control. If the application of the provision in the foregoing sentence, similar provisions in other stock option or restricted stock grants, and other payments and benefits payable to the Grantee in connection with a Change in Control (collectively, the “Company Payments”) would result in the Grantee being subject to the excise tax payable under Internal Revenue Code Section 4999 (the “Excise Tax”), the amount of any Company Payments shall be automatically reduced to an amount one dollar less than an amount that would subject the Grantee to the Excise Tax; provided, however, that the reduction shall occur only if the reduced Company Payments received by the Grantee (after taking into account further reductions for applicable federal, state and local income, social security and other taxes) would be greater than the unreduced Company Payments to be received by the Grantee minus (i) the Excise Tax payable with respect to such Company Payments and (ii) all applicable federal, state and local income, social security and other taxes on such Company Payments. If the Company Payments are to be reduced in accordance with the foregoing, the Company Payments shall be reduced as mutually agreed between the Company and the Grantee or, in the event the parties cannot agree, in the following order (1) acceleration of vesting of any option where the exercise price exceeds the fair market value of the underlying shares at the time the acceleration would otherwise occur, (2) any lump sum severance based on a multiple of base salary or bonus, (3) any other cash amounts payable to the Grantee, (4) any benefits valued as parachute payments, and (5) acceleration of vesting of any equity not covered by (1) above.

      2


           3. Option Term. Except as otherwise provided in the next sentence or in the Plan, the Option shall expire on the tenth anniversary of the grant of the Option as shown on the Notice of Grant of Stock Options. In the event of termination of service as a member of the Board of the Company, except as may be otherwise determined by the Committee in accordance with Section 7(e) of the Plan, the vested portion of the Option shall expire on the earlier of (i) the tenth anniversary of this grant, or (ii)(A) subject to (D) below, three months after such termination if such termination is for any reason other than death, Retirement, or long-term disability, (B) the tenth anniversary of this grant if such termination is due to the Grantee's Retirement, (C) one year after the termination if such termination is due to the Grantee's death or long-term disability or (D) one year after such termination if such termination is at any time within two years after the occurrence of a Change in Control.

           4. Restrictions on Transfer of Option. The Option granted hereby shall not be transferable other than by will or by the laws of descent and distribution. During the lifetime of the Grantee, this Option shall be exercisable only by the Grantee. In addition, except as otherwise provided in this Agreement, the Option shall not be assigned, negotiated, pledged or hypothecated in any way (whether by operation of law or otherwise), and the Option shall not be subject to execution, attachment or similar process. Upon any other attempt to transfer, assign, negotiate, pledge or hypothecate the Option, or in the event of any levy upon the option by reason of any execution, attachment, or similar process contrary to the provisions hereof, the Option shall immediately become null and void. Notwithstanding the foregoing provisions of this Section 4, subject to the approval of the Committee in its sole and absolute discretion and to any conditions that the Committee may prescribe, the Grantee may, upon providing written notice to the Company, elect to transfer the Option to members of his or her immediate family, including, but not limited to, children, grandchildren and spouse or to trusts for the benefit of such immediate family members or to partnerships in which such family members are the only partners; provided, however, that no such transfer may be made in exchange for consideration.

           5. Rights of a Stockholder. The Grantee shall have no rights as a stockholder with respect to any shares of Common Stock subject to this Option prior to the date of issuance to the Grantee of a certificate or certificates for such shares. No adjustment shall be made for dividends in cash or other property, distributions, or other rights with respect to such shares for which the record date is prior to the date upon which the Grantee shall become the holder of record therefor.

           6. Compliance with Law and Regulations. This award and any obligation of the Company hereunder shall be subject to all applicable federal, state and local laws, rules and regulations and to such approvals by any government or regulatory agency as may be required. The Company shall be under no obligation to effect the registration pursuant to federal securities laws of any interests in the Plan or any shares of Common Stock to be issued hereunder or to effect similar compliance under any state laws. The Company shall not be obligated to cause to be issued or delivered any certificates evidencing shares of Common Stock pursuant to this Agreement unless and until the Company is advised by its counsel that the issuance and delivery of such certificates is in compliance with all applicable laws, regulations of governmental authority and the requirements of any securities exchange on which shares of Common Stock are traded. The Committee may require, as a condition of the issuance and delivery of certificates evidencing shares of Common Stock pursuant to the terms hereof, that the recipient of such shares make such agreements and representations, and that such certificates bear such legends, as the Committee, in its sole discretion, deems necessary or desirable. Except to the extent preempted by any applicable federal law, this Agreement shall be construed and administered in accordance with the laws of the State of New York without reference to its principles of conflicts of law.

           7. Grantee Bound by Plan. The Grantee acknowledges receipt of a copy of the Plan and agrees to be bound by all the terms and provisions thereof. The Plan is incorporated herein by reference, and any capitalized term used but not defined herein shall have the same meaning as in the Plan. To the extent that this Agreement is silent with respect to, or in any way inconsistent with, the terms of the Plan, the provisions of the Plan shall govern and this Agreement shall be deemed to be modified accordingly.

           8. Notices. Any notice or communication given hereunder shall be in writing and shall be deemed given when delivered in person, or by United States mail, at the following addresses: (i) if to the Company, to: Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, Attention: Secretary, and (ii) if to the Grantee, to: the Grantee at Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, or, if the Grantee has terminated service, to the last address for the Grantee indicated in the records of the Company, or such other address as the relevant party shall specify at any time hereafter in accordance with this Section 8.

      3

             EX-10.26 3 exhibit10-26.htm NON-EXCLUSIVE LICENSE AND PARTIAL SETTLEMENT AGREEMENT WITH GENENTECH, INC.

      Exhibit 10.26

      Portions of this Exhibit Have Been
      Omitted and Separately Filed
      with the Securities And Exchange
      Commission with a Request For
      Confidential Treatment

      NON-EXCLUSIVE LICENSE AND PARTIAL SETTLEMENT AGREEMENT

           This Non-Exclusive License and Partial Settlement Agreement (“Agreement”) is entered into as of the Effective Date by and between Genentech, Inc. (“Genentech”), a Delaware corporation having its principal place of business at 1 DNA Way, South San Francisco, California 94080 and Regeneron Pharmaceuticals, Inc. (“Licensee”), a New York corporation having its principal place of business at 777 Old Saw Mill River Road, Tarrytown, NY 10591.

      WHEREAS:

            A.      

      Genentech and Licensee are parties to a patent litigation now pending in the United States District Court, Southern District of New York, captioned Regeneron Pharmaceuticals, Inc. vs. Genentech, Inc. (Civil Action No. 11-CV-01156-VB) (the “Pending U.S. Litigation”);

       
      B.

      In general, Genentech claims in the Pending U.S. Litigation that certain of Licensee’s activities with respect to the biopharmaceutical product known as aflibercept infringe and/or will infringe certain United States patents owned by Genentech, and Licensee claims that none of its activities with respect to aflibercept infringe any valid claim of such patents; and

       
      C.

      Genentech and Licensee now are willing to settle some of the matters in dispute in the Pending U.S. Litigation, by means of Genentech’s granting to Licensee certain non-exclusive patent licenses desired by Licensee, and Licensee’s paying to Genentech certain monetary consideration for the grant of such rights, all on the specific terms and conditions set forth herein.

            NOW, THEREFORE, in consideration of the promises and mutual covenants recited herein, the Parties agree as follows:

      Page 1


      Article I

      DEFINITIONS

           The following words and phrases shall have meanings set forth below solely for purposes of this Agreement:

           1.01. “Affiliate” shall mean any Person that, on or after the Effective Date, controls, is controlled by, or is under common control with, a Party. For purposes of this definition only, “controlled” and “control” shall mean (i) owning, directly or indirectly, at least fifty percent (50%) of the outstanding voting securities or other ownership interest of a Person, or (ii) possessing, directly or indirectly, the power to manage, direct, or cause the direction of the management and policies of a Person or the power to elect or appoint fifty percent (50%) or more of the members of the governing body of the Person. A Person shall be an Affiliate only during such period of time that such Person meets the definition set forth in this Section 1.01. With respect to Genentech, the term “Affiliate” shall not include Chugai Pharmaceutical Co., Ltd. (“Chugai”) unless and until Genentech provides written notice to Licensee specifying Chugai as an Affiliate of Genentech.

           1.02. “Calendar Quarter” shall mean each three month period commencing January 1, April 1, July 1 and October 1 of each calendar year.

           1.03. “Designee” shall mean any Person (other than an Affiliate of Licensee) that is employed by or otherwise under written contract with Licensee to make, use, sell, offer for sale, promote, distribute, or market Licensed Product in the Field in the Territory on behalf of, or in collaboration or partnership with, Licensee; provided however, the term “Designee” shall not apply to any such Person to which Licensed Product is sold by Licensee solely for resale by such Person to Third Parties in the Field in the Territory, where such Person (i) does not pay any consideration to Licensee or any Affiliate of Licensee in connection with its resale of Licensed Product, and (ii) has no significant contractual obligations to Licensee or any Affiliate of Licensee with regard to marketing or promotion of the Licensed Product.

           1.04. “Effective Date” shall mean December 31, 2011.

           1.05. “Encumbered Patent” shall mean any U.S. patent or U.S. patent application, other than those within the Excluded Patents, that is owned or co-owned by Genentech as of the Effective Date, and with respect to which Genentech has entered into a written agreement prior to the Effective Date that grants one or more Third Parties a license, co-license, co-ownership, control, right to enforce, or other right in regards to such patent or patent application, as a consequence of which Genentech is contractually precluded, as of the Effective Date, from granting to Licensee a license under such patent or patent application, or under a U.S. patent that issues from or claims priority to such patent application, of the scope set forth in Section 2.01, without breaching such written agreement or owing a royalty or other financial obligation to one or more of such Third Parties.

           1.06. “Europe” shall mean the member states of the European Union together with the member states of the European Economic Area and Switzerland.

      Page 2


            1.07. “Excluded Patents” shall mean (i) the U.S. patents listed on Exhibit A hereto; (ii) any U.S. patent issuing at any time from any patent application to which any patent listed on Exhibit A claims priority; (iii) any U.S. patent issuing at any time from a divisional, continuation, or continuation-in-part of any patent application to which any patent listed on Exhibit A claims priority; (iv) all reissues, reexaminations, and extensions of any of the foregoing (i), (ii), and (iii); and (v) all non-U.S. patents and non-U.S. patent applications that are owned or co-owned by Genentech prior to or after the Effective Date, and all extensions thereof (for example, any Supplementary Protection Certificate).

            1.08. “Field” shall mean and be limited to the prevention or treatment of eye diseases and eye disorders in a human through the administration of Licensed Product to the eye, (including, but not limited to, the prevention or treatment of age-related macular degeneration, central retinal vein occlusion, diabetic macular edema, and/or myopic choroidal neovascularization in a human). The Parties acknowledge and agree, for the sake of clarity, that “Field” does not mean, and therefore excludes, the use of Licensed Product for any other purpose, including prevention or treatment of any other diseases or disorders other than eye diseases and eye disorders in a human. By way of example only, and without limitation, “Field” excludes any use of Licensed Product for the prevention or treatment of any form of breast cancer, colorectal cancer, lung cancer, ovarian cancer, or prostate cancer in a human.

            1.09. “First Commercial Sale” shall mean the first sale in the Territory of Licensed Product by Licensee or any of its Affiliates or Designees to a Third Party for use in the Field. That sale shall be deemed to have occurred on the date of the first invoice to the Third Party for the Licensed Product (which date may be prior to the Effective Date).

            1.10. “Genentech Technology Patents” shall mean all U.S. patents (whether issued prior to or after the Effective Date), other than the Licensed Patents, Excluded Patents, and Encumbered Patents, that (i) are owned or co-owned by Genentech as of the Effective Date or (ii) are issued after the Effective Date and claim priority to a patent application owned or co-owned by Genentech as of the Effective Date; and that, in each of cases (i) and (ii), would be infringed by any activity licensed under Section 2.01 but for the license granted under Section 2.02.

            1.11. “Gross Sales” shall have the meaning given in Section 1.15.

            1.12. “Legal Proceeding” shall mean any legal or administrative proceeding in any country, including, but not limited to, the Pending U.S. Litigation and any legal or administrative proceeding in Europe, now or in the future, involving [**************].

            1.13. “Licensed Patents” shall mean (i) U.S. Patent Nos. 5,952,199; 6,100,071; 6,383,486; 6,897,294; and 7,771,721; (ii) any U.S. patent issuing at any time from any patent application to which any of the foregoing patents claim priority; (iii) any U.S. patent issuing at any time from a divisional, continuation, or continuation-in-part of any patent application to which any of the foregoing patents claims priority; and (iv) all reissues, reexaminations, and extensions of any of the foregoing (i), (ii), and (iii). Under no circumstance shall a Licensed Patent be deemed to be within the definition of Excluded Patents. The Parties acknowledge and agree, for the sake of clarity, that the definition of Licensed Patents set forth in this Section 1.13 includes any U.S. patent issuing from any patent application, or any divisional, continuation, or continuation-in-part of any patent application, that is in the chain of applications through which any of the U.S. patents listed in clause (i) claims priority.

      Page 3


           1.14. “Licensed Product” shall mean aflibercept, which is being sold in the Field in the Territory under the trade name Eylea™ as of the Effective Date, and any pharmaceutical formulation containing aflibercept that is intended for use in the Field in the Territory.

           1.15. “Net Sales” shall mean:

                1) The gross amounts invoiced for sales of all Licensed Product, commencing with the First Commercial Sale, sold in the Territory by Licensee, its Affiliates and Designees to Third Parties for use in the Field (such invoiced amounts referred to hereinafter as “Gross Sales”), less the following deductions from Gross Sales which are actually incurred:

            (i)      

      credits or allowances granted for billing errors or for damaged, outdated, returned, rejected or recalled Licensed Product;

       
      (ii)

      uncollectible amounts on previously sold Licensed Product and retroactive price reductions;

       
      (iii)

      reasonable trade, cash and quantity discounts or rebates;

       
      (iv)

      taxes, duties and any other governmental charges or levies imposed upon or measured by the manufacture, use, or sale of a Licensed Product, as adjusted by any rebates or refunds;

       
      (v)

      chargebacks and rebates, including those granted to managed health care organizations, wholesalers, buying groups, retailers or to federal, state, local and other governments, their agencies and purchasers and reimbursers;

       
      (vi)

      freight, insurance, data, distribution-related fees, and other charges or fees directly related to the handling or distribution of Licensed Product or services provided in connection with the handling or distribution of Licensed Product (to the extent not paid by a Third Party customer), subject, however, to the limitation that only fifty percent (50%) of any charges and fees associated with any credit card transactions may be included in the deductions; and

       
      (vii)

      nursing fees, and inventory management fees, discounts or credits; and credits and allowances made for wastage replacement, indigent patients, patients unable to satisfy co-pay obligations and similar programs;

      All of the foregoing elements of Net Sales calculations shall be determined and recorded in accordance with U.S. Generally Accepted Accounting Principles, consistently applied. Where actual data for a particular deduction is not reasonably available at the time that a royalty payment is due under this Agreement with respect to relevant Gross Sales, Licensee shall make a reasonable estimate of that deduction for purposes of calculating Net Sales due for a particular Calendar Quarter. Licensee will subsequently make any required adjustment with respect to that deduction in the royalty payment owed for the Calendar Quarter in which actual data for a particular deduction does reasonably become available. In the case of actual data for a particular deduction that is not reasonably available until after the Royalty Term, Licensee’s royalty payments made during the Royalty Term shall be adjusted by a subsequent payment to Genentech or refund to Licensee (as the case may be) as required based on such actual data, provided, however, that (i) Licensee shall report such actual data to Genentech as soon as it reasonably becomes available to Licensee, and (ii) any such refund to Licensee shall not in any event exceed five million U.S. dollars ($5,000,000).

      Page 4


                2) In the event a Licensed Product is sold in combination with one or more other active ingredients that are not the subject of this Agreement (as used in this definition of Net Sales, a “Combination”), then the gross amount invoiced for that Licensed Product shall be calculated by multiplying the gross amount invoiced for such Combination by the fraction A/(A+B), where “A” is the gross amount invoiced for the Licensed Product sold separately and “B” is the gross amount invoiced for the other active ingredient(s) sold separately.

      In the event that the other active ingredient(s) is not sold separately, then the gross amount invoiced for that Licensed Product shall be calculated by multiplying the gross amount invoiced for the Combination by the fraction A/C, where “A” is the gross invoice amount for the Licensed Product, if sold separately, and “C” is the gross invoice amount for the Combination.

      In the event that no such separate sales are made, Net Sales for royalty determination shall be determined by the Parties in good faith.

           1.16. “Party” shall mean either Genentech or Licensee, and when used in the plural shall mean both Genentech and Licensee.

           1.17. “Person” shall mean an individual, trust, corporation, partnership, joint venture, limited liability company, association, unincorporated organization or other legal or governmental entity.

           1.18. “Royalty Term” shall mean the period commencing on the date of the First Commercial Sale and ending on May 7, 2016.

           1.19. “Term of this Agreement” shall have the meaning given in Section 7.01.

           1.20. “Territory” shall mean the United States of America only, including its territories and possessions.

           1.21. “Third Party” shall mean any Person other than Genentech or Licensee or any of their respective Affiliates and Designees.

           1.22. “U.S.” and “United States” shall mean the United States of America, including its territories and possessions.

      Page 5


      Article II

      GRANTS

           2.01. License to Licensed Patents. Subject to the terms and conditions of this Agreement, Genentech hereby grants to Licensee and Licensee hereby accepts a non-exclusive license under the Licensed Patents for the Term of this Agreement to:

            (i)       make and have made Licensed Product in the Territory solely for use or sale in the Field in the Territory, and to export Licensed Product that is initially made in bulk or other non-finished form in the Territory solely for the purpose of converting such Licensed Product to filled and/or finished form outside the Territory for reimportation into the Territory pursuant to Section 2.01(ii);
       
      (ii) reimport Licensed Product into the Territory that initially is made in bulk or other non-finished form in the Territory pursuant to the preceding subsection 2.01(i) and subsequently converted to filled and/or finished form outside the Territory, which reimported Licensed Product is solely for use or sale in the Field in the Territory;
       
      (iii) import Licensed Product into the Territory that is made on or after October 29, 2012 outside the Territory for export to the Territory, which imported Licensed Product is solely for use or sale in the Field in the Territory; and
       
      (iv) use, sell, offer for sale, and have sold Licensed Product made or had made pursuant to the preceding subsection 2.01(i), or reimported pursuant to the preceding subsection 2.01(ii), or imported pursuant to the preceding subsection 2.01(iii), in each case solely in the Field in the Territory.

           2.02. License to Genentech Technology Patents. Subject to the terms and conditions of this Agreement, Genentech hereby grants to Licensee and Licensee hereby accepts a non-exclusive license under the Genentech Technology Patents for the Term of this Agreement solely to practice the license granted to Licensee in Section 2.01.

      Page 6


           2.03. Covenant Not To Sue For Activities Prior to Effective Date. Genentech, on behalf of itself and its predecessors, successors, assigns, and Affiliates, agrees and covenants not to sue Licensee, its Affiliates or Designees for infringement of any of the Licensed Patents or Genentech Technology Patents based on any activity that occurred prior to the Effective Date that would be licensed under Section 2.01 had such activity occurred on or after the Effective Date; provided, however, that this covenant does not release Licensee, its Affiliates and Designees from any obligation under this Agreement, including, but not limited to, the obligation to pay the sales milestone and royalties and to maintain records and make reports under and in accordance with Articles III and IV with respect to all Net Sales of Licensed Product sold during the Royalty Term. The Parties acknowledge and agree, for the sake of clarity, that (i) the covenant in this Section 2.03 is given only with respect to the Licensed Patents and Genentech Technology Patents, and not any other patents, and (ii) nothing contained in this Agreement is intended or shall be deemed to prevent or limit either Party from seeking, in connection with any Legal Proceeding to the extent permitted by governing laws and rules, discovery from the other Party and its Affiliates and Designees relating to any activity that occurred prior to the Effective Date.

           2.04. Right of Licensee to Grant Sublicenses. Licensee shall have the right to grant sublicenses to its Affiliates and Designees under the licenses granted to Licensee in Sections 2.01 and 2.02; provided, however, that Licensee may not grant to any of its Designees a sublicense to have Licensed Product made for such Designee by a Third Party. Licensee shall always be responsible for the payment of royalties on Net Sales of Licensed Product sold during the Royalty Term by any of its Affiliates or Designees and for the performance by such Affiliates and Designees of obligations delegated to them by Licensee pursuant to this Agreement, irrespective of whether such Affiliate or Designee has formally been granted a sublicense by Licensee under this Section 2.04. No Affiliate or Designee of Licensee shall have the right to grant any further sublicenses to any Licensed Patents and/or Genentech Technology Patents, except that any Affiliate of Licensee may grant a sublicense to have Licensed Product made for such Affiliate.

           2.05. License Scope Limitations. Licensee acknowledges and agrees that the licenses granted to it in this Article II are limited in scope and, by way of example only and without limitation, do not confer on Licensee or its Affiliates or Designees any license (express or implied) or any other rights (i) under any Excluded Patent, including, but not limited to, [**************]; (ii) under any Encumbered Patent; (iii) to promote, distribute, market, sell, offer for sale, or have sold any Licensed Product outside the U.S. for any purpose; (iv) to make or have made Licensed Product (in any form) in the U.S. for sale or offer for sale in any other country; (v) to make or have made Licensed Product (in any form) in the U.S. for export to any other country, except to the extent expressly permitted under Section 2.01(i); (vi) to make or have made Licensed Product (in any form) outside the U.S. for sale or offer for sale outside the U.S.; or (vii) to make, have made, use, promote, distribute, market, sell, offer for sale, or have sold any Licensed Product for any use outside the Field. Licensee further acknowledges and agrees that (a) nothing in Article II is intended or shall be deemed to grant, whether by implication, estoppel, or otherwise, any right or license under any non-U.S. patent or any extension thereof, including but not limited to [**************], and (b) any activities outside the U.S. involving or relating to Licensed Product continue to be subject to, and are conducted at risk of Genentech’s asserting at any time, all claims of patent infringement under non-U.S. patents and/or claims for violation of other non-U.S. legal rights, notwithstanding the licenses under the Licensed Patents and Genentech Technology Patents that are granted in Section 2.01 and Section 2.02 and the covenant that is granted in Section 2.03.

      Page 7


           2.06. Disputed Activities. The Parties acknowledge and agree, for the avoidance of doubt, that Licensee shall not be in breach of this Agreement by performing any activities, or inducing or encouraging others to perform any activities, that Genentech contends are outside the scope of the licenses granted to Licensee pursuant to Sections 2.01 and 2.02 of this Agreement and/or the covenant granted to Licensee pursuant to Section 2.03; provided, however, that Genentech shall be entitled to seek any other relief that may be available at law and equity to redress such activities, including, but not limited to, filing an action against Licensee and/or such others for infringement of any patents.

           2.07. Acknowledgement, Licensee acknowledges that U.S. patents are publicly available documents and consequently Licensee had the ability prior to the Effective Date to search for and identify those U.S. patents owned or co-owned by Genentech for which it believed a license was necessary or desirable to make, use, or sell Licensed Product in the Field in the Territory. Licensee further acknowledges that it could have sought from Genentech royalty-bearing licenses with respect to only one or several individual patents within the Licensed Patents and/or the Genentech Technology Patents prior to entering into this Agreement, but that for reasons of convenience, business certainty, and other considerations, Licensee agreed to enter into this Agreement and obtain the licenses herein with respect to all patents within the Licensed Patents and Genentech Technology Patents.

      Article III

      MILESTONE AND ROYALTIES OWED

           3.01. Sales Milestone. Within thirty (30) days following the date when total cumulative Net Sales of Licensed Product reach four hundred million U.S. dollars ($400,000,000), Licensee shall make a one-time, non-refundable, non-creditable payment of sixty million U.S. dollars ($60,000,000) to Genentech.

      Page 8


           3.02. Royalties. Licensee shall pay to Genentech the following royalties as a percentage of Net Sales of Licensed Product sold during the Royalty Term:         

            (i)       4.75% on total cumulative Net Sales of Licensed Product between four hundred million U.S. dollars ($400,000,000) and three billion U.S. dollars ($3,000,000,000); and
       
      (ii) 5.50% on total cumulative Net Sales of Licensed Product in excess of three billion U.S. dollars ($3,000,000,000).

      Royalties shall be paid within sixty (60) days after the end of each full or partial Calendar Quarter during the Royalty Term in which sales subject to royalties occur. For the purpose of calculating royalties under this Section 3.02, the sale of a unit of Licensed Product shall be deemed to occur on the date of the first invoice to a Third Party for the Licensed Product. Royalties owed under this Section 3.02 are in addition to the sales milestone owed under Section 3.01. The Parties acknowledge and agree, for the sake of clarity, that no royalties shall be owed on any Licensed Product that is sold after the last day of the Royalty Term (even if such Licensed Product was made during the Royalty Term).

           3.03. Sales To or Between Licensee, Affiliates, and Designees. No royalties shall be paid upon sales of Licensed Product to or between any of Licensee, its Affiliates and Designees for further sale; provided, however, that in such cases royalties shall be paid based on the first sale of each unit of Licensed Product by Licensee, or any of its Affiliates or Designees, to a Third Party in an arm’s length transaction.

           3.04. No Other Consideration. Without the prior written consent of Genentech, Licensee and its Affiliates and Designees shall not solicit or accept any consideration for the sale of Licensed Product other than as will be accurately reflected in Net Sales; provided, however, that the supply or other disposition of Licensed Product, without charge, in the Field in the Territory (i) as samples, (ii) as replacement for damaged or otherwise unusable Licensed Product (provided that such replacement is not with respect to damaged or otherwise unusable Licensed Product for which a deduction from Net Sales has or will be taken under Section 1.15); (iii) for use in clinical studies conducted in the Territory to obtain U.S. regulatory approval(s) or for post-marketing surveillance purposes in the U.S. (also referred to as Phase IV clinical trials); or (iv) for use in any tests or studies reasonably necessary to comply with any applicable U.S. law or U.S. regulation, or any request by a U.S. regulatory or U.S. governmental authority, in each of cases (i), (ii), (iii), and (iv) in an amount that is commercially reasonable, shall not be included in the computation of Net Sales.

      Page 9


      Article IV

      RECORDS, REPORTS AND PAYMENTS

           4.01. Records Retention. Licensee and its Affiliates shall keep true, complete, and accurate records of all sales of all Licensed Product in the Field in the Territory in sufficient detail to permit Genentech to confirm the accuracy of Licensee’s Net Sales calculations and royalty calculations, including for sales by a Designee. At Genentech’s request and expense, Licensee shall permit not more than once in a twelve (12) month period an independent certified public accountant appointed by Genentech and approved by Licensee (such approval not to be unreasonably withheld or delayed) to examine at a mutually agreeable location in New York, NY or another city as to which the Parties may mutually agree, upon reasonable notice and at reasonable times, such records to the extent necessary for Genentech to confirm the accuracy of Licensee’s Net Sales calculations (including the details of all deductions taken from Gross Sales to arrive at Net Sales) and royalty calculations. Licensee shall be responsible for providing the appointed accountant access at such location to such records that in the ordinary course of business are in the possession, custody, or control of Licensee and its Affiliates. In addition, Licensee shall (a) require its Designees to keep and maintain true, complete, and accurate records of all Net Sales and the calculation of royalties due on such Net Sales for at least three (3) years from the Calendar Quarter in which such Net Sales are made, ensure compliance with such obligation by its Designees, and require quarterly written reports to Licensee of all Net Sales and all deductions therefrom, and (b) use commercially reasonable efforts to cause its Designees to make available for inspection by the appointed accountant, at a mutually convenient location in the United States, true, complete, and accurate records of Designee’s sales of all Licensed Product in the Field in the Territory in sufficient detail to permit Genentech to confirm the accuracy of Licensee’s Net Sales calculations and royalty calculations based on such Designee’s sales. The appointed accountant shall enter into a confidentiality agreement with Licensee upon terms comparable to those in Section 8.13, which confidentiality agreement shall continue to apply to any information provided to such accountant for the examination unless and until such information (i) becomes generally available to the public other than through any breach of the confidentiality agreement by such accountant or (ii) becomes known to such accountant other than from or through a Person having an obligation to Licensee not to disclose such information. Such examination of the records of Licensee, its Affiliates and Designees shall be limited to a period of time no more than three (3) years immediately preceding the request for examination. The report of any such examination shall be made simultaneously to Genentech and Licensee and shall include a statement of the amount, if any, by which Licensee has underpaid or overpaid its royalties, and a description of the nature and basis of the underpayment or overpayment. In the event of an underpayment of royalties, Licensee shall promptly pay the deficiency plus interest pursuant to Section 4.05 to Genentech; and if royalties to Genentech were underpaid by more than five (5) percent, then Licensee shall additionally reimburse Genentech for its reasonable costs incurred in examining such records.

      Page 10


           4.02. Reports. Within sixty (60) days after the end of each full or partial Calendar Quarter during the Royalty Term, Licensee shall furnish to Genentech a written report of all sales of all Licensed Product during such Calendar Quarter. Such report shall separately state with respect to such sales (i) the total Gross Sales, (ii) the Net Sales, and (iii) for all Net Sales subject to royalties pursuant to Section 3.02, the amount of royalties owed. Genentech shall maintain this report as confidential pursuant to Section 8.13.

           4.03. Payments. The sales milestone (Section 3.01), royalties (Section 3.02), and any other amounts owed by Licensee to Genentech under this Agreement shall be paid in U.S. dollars and, unless otherwise agreed to by Genentech in writing, shall be made by wire transfer of immediately available funds to such bank account as Genentech may from time to time designate in writing. All payments shall be free and clear of any taxes, duties, levies, fees or charges.

           4.04. Finality. Except in the event of Genentech’s material breach of Section 2.01, 2.02, and/or 2.03, as established in an arbitration proceeding conducted pursuant to Section 8.10, Licensee hereby releases and forever waives any right to challenge or dispute any amounts paid or owed on Licensed Product pursuant to the terms and conditions of this Agreement after the Effective Date, except to the extent the Parties have a disagreement with respect to the calculation of Net Sales or the timing of the royalty payments owed on Net Sales of Licensed Product.

           4.05. Interest. Any payment not made when due shall bear interest, calculated from the date such payment was due, at the annual rate of one percent (1%) over the prime rate of interest as reported in the Wall Street Journal.

      Article V

      REPRESENTATIONS AND WARRANTIES; COVENANTS

           5.01. Each Party represents and warrants that it has been represented by independent legal counsel of its own choosing in connection with this Agreement, and that it had adequate opportunity to consult with such counsel prior to the execution of this Agreement.

           5.02. Genentech represents and warrants that, as of the Effective Date, it is the owner of the Licensed Patents, and that it has the right to grant the licenses set forth in Article II.

           5.03. Genentech represents that, to the best of its knowledge as of the Effective Date, it did not within the six months preceding the Effective Date assign to any of its Affiliates or any Third Party ownership of, or grant to any of its Affiliates or any Third Party an exclusive license under, any U.S. patent that (i) would be infringed by Licensee’s practice of the license granted to it in Section 2.01, and (ii) but for such assignment or exclusive license, would have been within the definition of Genentech Technology Patents as of the Effective Date. As used in this paragraph, “knowledge” means actual knowledge following reasonable inquiry within Genentech’s Legal Department based on whatever facts Genentech has regarding, for example, the structure, composition, formulation, and manufacture of the Licensed Product.

      Page 11


           5.04. Genentech represents that, to the best of its knowledge as of the Effective Date, Licensee’s practice of the license granted to it in Section 2.01 would not infringe any U.S. patent within the Encumbered Patents issued and existing as of the Effective Date. As used in this paragraph, “knowledge” means actual knowledge following reasonable inquiry within Genentech’s Legal Department based on whatever facts Genentech has regarding, for example, the structure, composition, formulation, and manufacture of the Licensed Product.

           5.05. Licensee represents and warrants that it has obtained (or will obtain) the agreement of its Affiliates, Designees, and any Person to whom Licensee discloses any of the terms of this Agreement under and in accordance with Section 8.13(iii), to be bound by Sections 8.08 and 8.15. Genentech represents and warrants that it will obtain the agreement of any Third Party to which Genentech discloses any of the terms of this Agreement under and in accordance with Section 8.13(iv) to be bound by Section 8.15.

           5.06. Except in the event of Genentech’s material breach of Section 2.01, 2.02, and/or 2.03, as established in an arbitration proceeding conducted pursuant to Section 8.10, Licensee covenants that during the Term of this Agreement it will not fail or refuse to pay to Genentech the sales milestone (Section 3.01) and royalties (Section 3.02) owed with respect to Licensed Product pursuant to the terms and conditions of this Agreement.

           5.07. Nothing in this Agreement is or shall be construed as:

            (i)      

      A warranty or representation by Genentech as to the scope of any claim or patent or patent application within the Licensed Patents or the Genentech Technology Patents;

       
      (ii)

      A warranty or representation by Genentech that anything made, used, offered for sale, sold, or otherwise disposed of under any license granted in this Agreement is or will be free from infringement of any patent rights or other intellectual property right of any Third Party;

       
      (iii)

      A grant by Genentech, whether by implication, estoppel, or otherwise, of any right or license under any non-U.S. patent or any extension thereof, including but not limited to [**************];

      Page 12


            (iv)      

      A grant by Genentech, whether by implication, estoppel, or otherwise, of any licenses other than those expressly granted under Article II; or

       
      (v)

      An obligation on the part of Genentech to bring or prosecute actions or suits against any Third Party for infringement of any of the Licensed Patents or the Genentech Technology Patents.

           5.08. EXCEPT AS OTHERWISE SET FORTH IN THIS AGREEMENT, NO PARTY MAKES ANY REPRESENTATIONS OR WARRANTIES, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND EACH PARTY SPECIFICALLY DISCLAIMS ANY EXPRESS OR IMPLIED REPRESENTATION OR WARRANTY WHATSOEVER. THE PARTIES SPECIFICALLY DISCLAIM ANY EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR PATENTABILITY, VALIDITY, OR ENFORCEABILITY OF THE LICENSED PATENTS OR THE GENENTECH TECHNOLOGY PATENTS.

      Article VI

      INDEMNIFICATION

           6.01. Indemnification by Licensee. Licensee shall indemnify, defend and hold harmless Genentech, its Affiliates, and each of their respective directors, officers, employees and agents from and against any and all liabilities, claims, demands, expenses (including, without limitation, reasonable attorneys’ and professional fees and other costs of litigation), losses or causes of action (each, a “Liability”) arising out of or relating to a claim by a Third Party in any way based on (i) the possession, manufacture, use, sale or other disposition of Licensed Product, whether based on breach of warranty, negligence, product liability or otherwise, or (ii) the exercise of any right granted to Licensee or its Affiliates or Designees pursuant to this Agreement, except to the extent, in each case (i) and (ii), that such Liability is caused by the negligence or willful misconduct of Genentech as determined by a court or other tribunal having jurisdiction. Upon receiving notice of any such Liability from or with respect to any Third Party, Genentech shall promptly inform Licensee of such notice of Liability and permit Licensee to handle and control the defense (including litigation and settlement) of such Liability, at Licensee’s sole expense, provided, however, that Licensee shall not settle any such Liability without the prior written consent of Genentech (which consent shall not be unreasonably withheld or delayed).

      Page 13


           6.02. Indemnification for Breach of Warranty. Any Party that breaches any warranty set forth in Article V shall indemnify, defend and hold harmless the other Party and its Affiliates, and each of their respective directors, officers, employees and agents, from and against any and all liabilities, claims, demands, expenses (including, without limitation, reasonable attorneys’ and professional fees and other costs of litigation), losses or causes of action arising out of or relating to any such breach of warranty.

      Article VII

      TERM AND TERMINATION

           7.01. Term. This Agreement will commence on the Effective Date and remain in full force and effect until the expiration of the last patent within the Licensed Patents and the Genentech Technology Patents (“Term of this Agreement”). Subject to the fulfillment by Licensee and its Affiliates and Designees of all the terms and conditions of this Agreement including, but not limited to, the payment of all amounts owed under Article III, following the Royalty Term the licenses under Sections 2.01 and 2.02 and any sublicense(s) granted in accordance with Section 2.04 shall become fully paid-up and royalty free for the remainder of the Term of this Agreement.

           7.02. Breach of Article III. Genentech is materially relying on Licensee’s agreement to comply fully and in all respects with Article III. Accordingly, Genentech and Licensee agree that if Licensee fails to comply with any section of Article III in any respect, Genentech shall notify Licensee in writing of such failure to comply and Licensee shall have thirty (30) days to cure the failure to comply (“the Licensee Cure Period”). If Licensee fails to cure the non-compliance by the end of the Licensee Cure Period, Genentech shall be entitled to seek all relief available at law and equity in an arbitration proceeding conducted pursuant to Section 8.10. If the arbitration award includes an order terminating this Agreement on account of Licensee’s failure to comply with Article III, Genentech shall be entitled to file in a U.S. district court or other tribunal of competent jurisdiction a patent infringement lawsuit against Licensee, its Affiliates and/or Designees with respect to the Licensed Patents, Genentech Technology Patents, and/or any other patents.

           7.03. Breach of Article II. Licensee is materially relying on Genentech’s agreement to grant the licenses and covenant not to sue provided for in Article II. Accordingly, Genentech and Licensee agree that if Genentech commits a material breach of Article II by revoking or terminating any of the licenses and/or covenant provided for therein, Licensee shall notify Genentech in writing of such material breach and Genentech shall have thirty (30) days to cure that material breach (“the Genentech Cure Period”). If Genentech fails to cure the material breach by the end of the Genentech Cure Period, Licensee shall be entitled to seek all relief available at law and equity in an arbitration proceeding conducted pursuant to Section 8.10.

      Page 14


      Article VIII

      MISCELLANEOUS PROVISIONS

           8.01. No Other License. No license other than those expressly set forth in Article II is or shall be deemed to have been granted under this Agreement whether by implication, estoppel or otherwise.

           8.02. Relationship of the Parties. Nothing in this Agreement is intended or shall be deemed to constitute or give rise to a partnership, agency, distributorship, employer-employee, joint venture, or fiduciary relationship between the Parties. No Party shall incur any debts or make any commitments for the other.

           8.03. Patent Prosecution and Enforcement. Genentech shall be solely responsible, at its sole discretion and expense, for the prosecution, defense, and maintenance of the Licensed Patents and Genentech Technology Patents (including whether to undertake such activities), and for enforcing the same against actual or suspected Third Party infringers (including whether to undertake such activities).

           8.04. Assignment. Neither Party shall assign any of its rights or obligations hereunder except: (i) as incident to the merger, consolidation, reorganization or acquisition of stock or assets affecting substantially all of the assets or voting control of the assigning Party; (ii) to any Person to which it transfers all or substantially all of its assets related to the Licensed Product; (iii) to an Affiliate if the assigning Party remains liable and responsible for the performance and observance of all of the Affiliate’s duties and obligations hereunder; or (iv) with the prior written consent of the other Party (which consent shall not be unreasonably withheld). A Party making an assignment shall promptly give written notice thereof to the other Party. This Agreement shall be binding upon the successors and permitted assigns of the Parties, and the name of a Party appearing herein shall be deemed to include the names of such Party’s successor’s and permitted assigns to the extent necessary to carry out the intent of this Agreement. Any assignment not in accordance with this Section 8.04 shall be void.

           8.05. Trade Names and Trademarks. Except as otherwise provided herein, no right, expressed or implied, is granted by this Agreement to use in any manner the name “Genentech” or any other trade name or trademark of Genentech in connection with the performance of this Agreement. Except as otherwise provided herein, no right, expressed or implied, is granted by this Agreement to use in any manner the name “Regeneron” or any other trade name or trademark of Licensee in connection with the performance of this Agreement.

           8.06. Entire Agreement. This Agreement constitutes and contains the entire understanding and agreement of the Parties with respect to the subject matter hereof and cancels and supersedes any and all prior negotiations, correspondence, understandings and agreements, whether verbal or written, between the Parties with respect to subject matter hereof. No waiver, modification, or amendment of any provision of this Agreement shall be valid or effective unless made in writing and signed by a duly authorized representative of each of the Parties.

      Page 15


           8.07. No Effect on Other Agreements. Nothing in this Agreement is intended or shall be deemed to amend, alter, modify, or have any effect whatsoever on any of the terms and conditions of any other written agreement between the Parties entered into prior to the Effective Date that pertains to subject matter different from the subject matter of this Agreement. Nothing in this Agreement shall be used to construe or interpret any other written agreement between the Parties. By way of example only, and without limitation, nothing in this Agreement is intended or shall be deemed to amend, alter, modify, or have any effect on (i) that certain Confidentiality Agreement that was entered into by and between the Parties with respect to the settlement discussions that preceded this Agreement, and (ii) [**************].

           8.08. No Effect Outside the Territory. Nothing contained in this Agreement is intended or shall be deemed to have any effect whatsoever on any legal or administrative proceedings outside the Territory, now or in the future, between Genentech, on the one hand, and Licensee, its Affiliates, Designees, and/or any Third Party on the other hand, relating to Licensed Product. By way of example only, and without limitation, nothing contained in this Agreement has any effect whatsoever on legal or administrative proceedings in Europe, now or in the future, involving [**************].

           8.09. Waiver of Breach or Default. The waiver by a Party of any breach of or default under any of the provisions of this Agreement or the failure of a Party to enforce any of the provisions of this Agreement or to exercise any right hereunder shall not constitute or be construed as a waiver of any other breach or default or as a waiver of any such rights or provisions hereunder.

      Page 16


           8.10. Dispute Resolution. Except as otherwise expressly provided in this Agreement, any dispute, controversy, or claim arising out of or in connection with or relating to this Agreement or the breach or alleged breach thereof (including any dispute regarding arbitrability), but not including any dispute, controversy, or claim concerning the patentability, validity, enforceability, or infringement of any patent, shall be finally and exclusively decided by binding arbitration under the then-current Commercial Arbitration Rules of the American Arbitration Association (“AAA”). If the arbitration is demanded by Genentech, the arbitration shall be held in New York, New York. If the arbitration is demanded by Licensee, the arbitration shall be held in San Francisco, California. The Parties shall choose, by mutual agreement, one (1) neutral arbitrator within thirty (30) days of receipt of the notice of the intent to arbitrate. If no arbitrator is appointed within that time or any extension thereof to which the Parties may mutually agree, the AAA shall make the appointment of the arbitrator within thirty (30) days of such failure, which arbitrator shall have substantial prior experience arbitrating patent licensing disputes. The Parties shall have the right to conduct discovery as provided for in the Federal Rules of Civil Procedure. All discovery shall be completed within two (2) months following the appointment of the arbitrator. The arbitrator’s decision and award in the arbitration shall be in writing setting forth the basis therefor and shall be rendered within six (6) months following the appointment of the arbitrator. The award rendered by the arbitrator shall include costs of the arbitration, reasonable attorneys’ fees, and reasonable costs for experts and other witnesses, and judgment on the award may be entered in any court having jurisdiction. To the extent permitted by law, the arbitration proceeding and arbitrator’s decision shall be confidential and the arbitrator shall issue appropriate protective orders to safeguard each Party’s confidential information. Nothing in this Agreement shall be deemed as preventing either Party from seeking temporary injunctive relief (or any other provisional remedy) from any court having jurisdiction over the Parties and the subject matter of the dispute but only to the extent necessary to protect such Party’s name, confidential information, or other similar proprietary rights, or to prevent any imminent irreparable harm. Each Party hereby consents to the jurisdiction and venue of the courts in the State of California and the State of New York for purposes of entering judgment on the arbitration award.

           8.11. Choice of Law. The validity, performance, construction, and effect of this Agreement and any arbitration conducted under Section 8.10 shall be governed by and interpreted in accordance with the laws of the State of New York without regard to conflict of laws principles.

           8.12. Notices. Any notice, request, consent, or other document required or permitted to be given under this Agreement or otherwise relating to this Agreement shall be in writing and shall be deemed to have been sufficiently given if delivered in person, or sent by overnight courier or registered mail to the Party to whom it is directed at its address shown below or such other address as such Party shall have last given by notice to the other Party. Any such notice, request, delivery, approval or consent shall be deemed received on the date of hand delivery (provided that such date is a business day, otherwise it shall be deemed received on the next business day), or one (1) business day after dispatch by overnight courier, or five (5) business days after dispatch by registered mail.

      If to Licensee, addressed to:
      Regeneron Pharmaceuticals, Inc.
      777 Old Saw Mill River Road
      Tarrytown, NY 10591
      Attn: General Counsel

      Page 17


      If to Genentech, addressed to:
      Genentech, Inc.
      1 DNA Way
      South San Francisco, CA 94080
      Attn: Corporate Secretary

           8.13. Confidentiality. Each Party agrees not to disclose any of the terms of this Agreement or any of the information contained in reports pursuant to Section 4.02 of this Agreement to any Person without the prior written consent of the other Party; provided, however, that each Party shall be free to disclose any such terms or information (i) to the extent that the Party is required to make such disclosure pursuant to any court order or subpoena, provided that the Party required to make such disclosure shall promptly notify the other Party and allow the other Party a reasonable opportunity to seek a protective order or injunctive relief from the obligation to make such disclosure; (ii) that in the opinion of such Party’s legal counsel is required to be disclosed by the securities laws or regulations of any jurisdiction or the rules or regulations of any relevant stock exchange, or by any other governmental law or regulation or by any order of a government agency, provided that to the extent possible under the circumstances the Party intending to make such disclosure shall provide prior notice thereof to the other Party and, in addition, shall request confidential treatment for any part of such disclosure for which such treatment may reasonably be expected to be granted; (iii) to its Affiliates, Designees, accountants, attorneys and other professional advisors, provided that such Persons are obligated to keep such terms or information confidential to the same extent as said Party and agree to be bound by Section 8.15; and [**************]. Each Party may disclose the terms of this Section 8.13, 8.15, and 8.16 (but no other terms of this Agreement) for the sole and exclusive purpose of seeking from any Person to whom a Party intends to make a disclosure under and in accordance with clause (iii) or (iv) that Person’s acceptance of the conditions of disclosure set forth in such clause. Licensee represents that, in the opinion of its counsel, the public disclosure of the financial terms of this Agreement is required by the securities laws and/or regulations of the United States as applied to Licensee. The confidentiality terms of this Section 8.13 shall survive any expiration of this Agreement or the Licensed Patents or the Genentech Technology Patents.

           8.14. Publicity. Neither Party shall issue any press release or other publicity material or make any public representation that refers to the existence of this Agreement without the prior written consent of the other Party (which consent shall not be unreasonably withheld or delayed). Notwithstanding the generality of the foregoing, either Party may issue a press release that contains, or may otherwise disclose, any or all of the information set forth in Exhibit B. In addition, either Party may disclose that (i) this Agreement conveys no license or other rights under any non-U.S. patents or other non-U.S. legal rights, (ii) this Agreement conveys no license or other rights with respect to any diseases or disorders other than eye diseases and eye disorders in a human, and (iii) this Agreement shall have no effect upon any patent litigation or other patent dispute outside of the United States. The text set forth in Exhibit B is for reference in connection with this Section 8.14 only and shall not control or affect in any way the meaning or construction of any other provisions of this Agreement. This Section 8.14 and any announcement or disclosure permitted under this Section 8.14 shall in no way limit the provisions of Sections 8.15 and 8.16.

      Page 18


           8.15. Prohibited Use and Discovery of Agreement in Legal Proceedings. This Agreement is the result of settlement and compromise. Except as expressly set forth in Section 8.16, no Party, or any of its Affiliates or Designees, or any other Person to which either Party discloses any of the terms of this Agreement under and in accordance with Section 8.13(iii) or 8.13(iv), shall seek to obtain through discovery, attempt to admit into evidence, or attempt to reference or use for any purpose, this Agreement or any of its terms in any Legal Proceeding, regardless of whether the Parties or any of their respective Affiliates or Designees or such other Persons are litigants in such Legal Proceeding, and regardless of the subject matter of such Legal Proceeding. Without in any way limiting the generality of the foregoing, except as expressly permitted under Section 8.16: No Party, or any of its Affiliates or Designees, or any other Person to which either Party discloses any of the terms of this Agreement under and in accordance with Section 8.13(iii) or 8.13(iv), shall reference or use this Agreement, or any facts relating to the terms or existence of this Agreement, in any Legal Proceeding for purposes of any statement, analysis, expert opinion, or argument relating to patent infringement, patent validity, liability, damages (including reasonable royalty and lost profits measures of damages), willful infringement, enhanced or augmented damages, or attorneys’ fees and costs. In addition, no Party, or any of its Affiliates or Designees, or any other Person to which either Party discloses any of the terms of this Agreement under and in accordance with Section 8.13(iii) or 8.13(iv), shall attempt to admit into evidence or make reference to in any Legal Proceeding the fact that Licensee, its Affiliates and/or Designees are able to perform the activities licensed under Article II with the permission of Genentech, or without interference or objection by Genentech, or the like.

           8.16. Limited Permitted Use of Agreement in Legal Proceedings. Notwithstanding anything set forth in Section 8.15, the Parties may use or rely upon this Agreement in a Legal Proceeding (i) to the limited extent necessary for the sole and exclusive purpose of enforcing this Agreement (including, for example, (a) proving or disproving a defense of license to any claim of patent infringement; (b) proving or disproving the right to add, prosecute, or defend against claims, counterclaims, allegations, or parties with respect to activities that are not licensed under Article II; or (c) in support of a motion in limine, a request for an injunction, or any similar motion or request to a court or other tribunal, to prevent or limit any reference to or use of this Agreement), or (ii) in response to this Agreement’s being admitted into evidence, or referenced or used, by any Third Party in any Legal Proceeding. In addition, notwithstanding anything set forth in Section 8.15, the Parties may disclose to the judge (but not the jury) in the Pending U.S. Litigation or any related U.S. litigation the existence of this Agreement and the Parties’ respective views regarding whether and to what extent the terms of this Agreement affect any substantive or procedural issues in such legal proceedings, so long as the disclosure is not made for any purpose prohibited by the third sentence of Section 8.15.

      Page 19


           8.17. No Admissions or Concessions. Nothing contained in this Agreement, nor any milestone or royalty payment made by Licensee pursuant to this Agreement, is intended or shall be deemed to be, or offered in any Legal Proceeding as evidence of, any admission or concession (i) by Licensee that any Licensed Patent, Genentech Technology Patent, Encumbered Patent, Excluded Patent or any other patent owned or co-owned by Genentech is valid, enforceable, and/or infringed by Licensee or any of its Affiliates or Designees, or (ii) by Genentech, that it is willing or able to grant licenses under the Licensed Patents and/or Genentech Technology Patents, or as to what is or may be reasonable consideration for a license under the Licensed Patents, Genentech Technology Patents, and/or any other patent owned or co-owned by Genentech.

           8.18. Effect of Agreement on Pending U.S. Litigation. Nothing contained in this Agreement shall preclude or otherwise have any effect on Licensee’s ability in the Pending U.S. Litigation or the lawsuit referenced in the last sentence of Section 8.19, to the extent permitted by governing laws and rules, to (i) challenge the validity or enforceability of any patent; (ii) take any position with respect to the scope or interpretation of any patent or any claim of any patent; or (iii) seek to establish that Licensee (and its Affiliates and Designees) do not infringe any patent or to defend against any claim that Licensee (and its Affiliates and Designees) infringe any patent, in each of cases (i), (ii), and (iii) including, but not limited to, any Licensed Patent, Genentech Technology Patent, Excluded Patent, or Encumbered Patent. Nothing contained in this Agreement shall preclude or otherwise have any effect on Genentech’s ability, to the extent permitted by governing laws and rules, to amend its pleadings in the Pending U.S. Litigation at any time to add claims, counterclaims, allegations, or parties with respect to activities that are not licensed under Article II.

           8.19. Effect of Agreement on Any Future Litigation. Nothing contained in this Agreement shall preclude or otherwise have any effect on Licensee’s ability, to the extent permitted by governing laws and rules, (i) to commence a new legal or administrative proceeding in any venue at any time challenging the validity, enforceability, or infringement of any patent (a) to which a license has not been granted to Licensee under Article II (including, but not limited to, the Excluded Patents and the Encumbered Patents) or (b) in connection with activities outside the scope of the licenses granted to Licensee under Article II; or (ii) to defend against any new legal or administrative proceeding commenced by Genentech against Licensee in any venue at any time by challenging the validity, enforceability or infringement of any patent asserted by Genentech against Licensee in that proceeding. Nothing contained in this Agreement shall preclude or otherwise have any effect on Genentech’s ability, to the extent permitted by governing laws and rules, to commence at any time a new action for infringement of (a) any Licensed Patent, but only in the United States District Court for the Southern District of New York, White Plains Division, with respect to activities that are not licensed under Section 2.01; or (b) any other patent (including, but not limited to, the Excluded Patents and the Encumbered Patents), in any venue, with respect to activities outside the scope of the licenses granted to Licensee under Article II. Nothing contained in this Agreement shall preclude or otherwise have any effect on Genentech’s maintaining and prosecuting, to the extent permitted by governing laws and rules, the infringement action it filed in the United States District Court for the Southern District of New York, captioned Genentech, Inc. vs. Regeneron Pharmaceuticals, Inc., Sanofi-Aventis U.S. LLC, et al. (Civil Action No. 11-CV-09463).

      Page 20


           8.20. Amendment of Pleadings in Pending U.S. Litigation. Not later than fifteen (15) business days after the Effective Date, Genentech shall file an unopposed motion in the form attached hereto as Exhibit C seeking leave to file the Second Amended Answer and Counterclaims in the form attached hereto as Exhibit D. The Parties acknowledge and agree, for the avoidance of doubt, that the Second Amended Answer and Counterclaims is intended to withdraw allegations that are inconsistent with the license and release granted pursuant to this Agreement. To the extent that the Second Amended Answer and Counterclaims includes any allegations that are inconsistent with the license and release granted pursuant to this Agreement, the terms of this Agreement shall control. Nothing contained in the Second Amended Answer and Counterclaims shall be used to construe any term or condition of this Agreement.

           8.21. Construction. Both Parties have been represented and advised by legal counsel in connection with the negotiation, drafting, and execution of this Agreement, and both Parties, through their respective counsel, have participated in the drafting of this Agreement and accordingly that this Agreement shall not be deemed to have been drafted by one Party or the other and will be construed accordingly.

           8.22. Counterparts. This Agreement may be executed simultaneously in one or more counterparts (including in the form of a PDF or other electronic document), each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

      Page 21


           IN WITNESS WHEREOF, Genentech and Licensee have caused this Agreement to be executed by their duly authorized representatives.

           
      GENENTECH, INC. REGENERON PHARMACEUTICALS, INC.
       
       
      By:    /s/ Leonard Schleifer By:    /s/ Frederick C. Kentz III
       
       
      Title:    President & CEO Title:    Sr. Vice President
         
       
      Date:    December 31, 2011 Date:    December 31, 2011

      Page 22


      Exhibit A

      Excluded Patents
       

      [**************]

       

       

       

       

       

       

      Page 23


      Exhibit B

      Regeneron Announces Settlement of Patent Litigation with Genentech for U.S. Ophthalmic Sales of EYLEA™ (aflibercept) Injection

      Tarrytown, NY, [date] -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) announced today that the Company has entered into a non-exclusive license and partial settlement agreement (Agreement) with Genentech, Inc. relating to U.S. ophthalmic sales of EYLEA™ (aflibercept) Injection.

      Regeneron received a non-exclusive license to certain patents relating to VEGF receptor proteins, known as the Davis-Smyth patents, and other technology patents. The Davis-Smyth patents are the subject of patent litigation between Regeneron and Genentech now pending in the United States District Court, Southern District of New York. Patent litigation is continuing with respect to matters not covered by the Agreement.

      Under the terms of the Agreement, Regeneron will make payments to Genentech based on U.S. sales of EYLEA through May 7, 2016. Regeneron will pay $60 million upon cumulative U.S. sales of EYLEA reaching $400 million. Regeneron will also pay royalties of 4.75% on cumulative U.S sales of EYLEA between $400 million and $3 billion and 5.5% on any cumulative U.S sales of EYLEA over $3 billion.

      About Regeneron Pharmaceuticals
      Regeneron is a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron markets two products, ARCALYST® (rilonacept) Injection For Subcutaneous Use and EYLEA™ (aflibercept) Injection. Regeneron also has completed several Phase 3 studies and is conducting an additional Phase 3 clinical trial for the product candidate ZALTRAP® (aflibercept) Concentrate for Intravenous Infusion. Additional therapeutic candidates developed from proprietary Regeneron technologies for creating fully human monoclonal antibodies are in earlier stage development programs in rheumatoid arthritis and other inflammatory conditions, pain, cholesterol reduction, allergic and immune conditions, and cancer. Additional information about Regeneron and recent news releases are available on the Regeneron web site at www.regeneron.com.

      Page 24


      Regeneron Forward Looking Statement
      This news release includes forward-looking statements that involve risks and uncertainties relating to future events and the future performance of Regeneron, and actual events or results may differ materially from these forward-looking statements. These statements concern, and these risks and uncertainties include, among others, the nature, timing, and possible success and therapeutic applications of EYLEA and Regeneron’s product candidates and research and clinical programs now underway or planned, the likelihood and timing of possible regulatory approval and commercial launch of Regeneron’s late-stage product candidates, determinations by regulatory and administrative governmental authorities which may delay or restrict Regeneron’s ability to continue to develop or commercialize EYLEA and other products and drug candidates, competing drugs that may be superior to EYLEA and Regeneron’s products and drug candidates, uncertainty of market acceptance of EYLEA and Regeneron’s products and drug candidates, the possibility of EYLEA sales meeting or exceeding any of the cumulative U.S. sales targets triggering payments to Genentech described in this news release, the possibility of EYLEA sales meeting or exceeding any of the cumulative U.S. sales targets triggering payments to Genentech described in this news release, unanticipated expenses, the availability and cost of capital, the costs of developing, producing, and selling products, the potential for any license or collaboration agreement, including Regeneron’s agreements with Sanofi and Bayer HealthCare, to be canceled or terminated without any product success, and risks associated with third party intellectual property and pending or future litigation relating thereto. A more complete description of these and other material risks can be found in Regeneron's filings with the United States Securities and Exchange Commission, including its Form 10-K for the year ended December 31, 2010 and Form 10-Q for the quarter ended September 30, 2011. Regeneron does not undertake any obligation to update publicly any forward-looking statement, whether as a result of new information, future events, or otherwise, unless required by law.

      Your Investor Relations Contact at Regeneron:
      Michael Aberman, M.D. Tel. +1 (914) 345-7799
      E-Mail: michael.aberman@regeneron.com

      Your Media Contact at Regeneron:
      Peter Dworkin, Tel. +1 (914) 345-7640
      E-Mail: peter.dworkin@regeneron.com

      Page 25


      Exhibit C

      UNITED STATES DISTRICT COURT
      SOUTHERN DISTRICT OF NEW YORK

      REGENERON PHARMACEUTICALS, INC.,      
      Plaintiff,
      v.
      GENENTECH, INC., Civil Action No. 11-CV-01156 (VB)
      Defendant. ECF Case
      GENENTECH, INC.,
      Counter-Plaintiff,
      v.

      REGENERON PHARMACEUTICALS, INC.,
      Counter-Defendant.

      GENENTECH’S UNOPPOSED MOTION FOR
      LEAVE TO AMEND ITS COUNTERCLAIMS

           Genentech, Inc. (“Genentech”) files this unopposed motion for leave to amend its counterclaims in response to the Complaint filed by Plaintiff Regeneron Pharmaceuticals, Inc. (“Regeneron”) to clarify the nature of Genentech’s allegations against Regeneron. See Exhibit 1. Regeneron does not oppose this motion.

           Rule 15(a) provides that a Court’s permission to amend a pleading “shall be freely given when justice so requires.” Fed. R. Civ. P. 15(a); see also Foman v. Davis, 371 U.S. 178, 182 (1962) (“[T]his mandate is to be heeded. . . . [T]he leave sought should, as the rules require, be ‘freely given.’”). In the Second Circuit, the rule is “to allow a party to amend its pleadings in the absence of a showing by the nonmovant of prejudice or bad faith.” Block v. First Blood Assocs., 988 F.2d 344, 350 (2d Cir. 1993).

      Page 26


           There is no prejudice or bad faith here. Genentech’s motion to amend is timely filed within the period allowed by this Court’s Scheduling Order. D.I. 33 (providing that the deadline for amendment of pleadings is May 10, 2012). This case is still in an early stage of proceedings, and the parties have yet to exchange infringement contentions and invalidity contentions, which are due in February 2012 and March 2012, respectively.

           Accordingly, this Court should grant Genentech leave to amend its counterclaims.

      Dated: January __, 2012

      PAUL, WEISS, RIFKIND, WHARTON &
      GARRISON LLP
       
      By:         /s/ Kenneth A Gallo
      Kenneth A. Gallo
      2001 K Street NW
      Washington, DC 20006
      Tel: (202) 223-7300
      Fax: (202) 223-7420
      Email: kgallo@paulweiss.com
       
      John E. Nathan
      Eric Alan Stone
      1285 Avenue of the Americas
      New York, NY 10019
      Tel: (212) 373-3000
      Fax: (212) 757-3990
      Email: jnathan@paulweiss.com
      Email: estone@paulweiss.com

      Page 27


            BAKER BOTTS LLP
      Jennifer Gordon
        Scott Familant
      30 Rockefeller Center
      New York, NY 10112
      Tel: (212) 408-2500
      Fax: (212) 408-2501
      Email: jennifer.gordon@bakerbotts.com
      Email: scott.familant@bakerbotts.com
      Attorneys for Defendant and Counter-Plaintiff
      Genentech, Inc.

      Page 28


      Exhibit D

      UNITED STATES DISTRICT COURT
      SOUTHERN DISTRICT OF NEW YORK

      REGENERON PHARMACEUTICALS, INC.,      
      Plaintiff, Civil Action No. 11-CV-01156 (VB)
      v. ECF Case
      GENENTECH, INC., Jury Demand
      Defendant.

      SECOND AMENDED ANSWER AND COUNTERCLAIM

           Genentech, Inc. (“Genentech”) files this second amended answer and counterclaim in response to the Complaint filed by Plaintiff Regeneron Pharmaceuticals, Inc. (“Regeneron”).

      “NATURE OF THIS ACTION”

           1. Genentech admits that Regeneron purports to have brought this action under 28 U.S.C. §§ 1331, 2201, and 2202, and 35 U.S.C. § 100 et seq. In all other respects, Genentech denies the allegations in Paragraph 1 of the Complaint.

           2. Genentech admits that Regeneron purports to seek a declaration in this action relating to U.S. Patent Nos. 5,952,199; 6,100,071; 6,383,486; 6,897,294; and 7,771,721. In all other respects, Genentech denies the allegations in Paragraph 2 of the Complaint.

      “THE PARTIES”

           3. Genentech admits that Regeneron purports to be a corporation organized and existing under the laws of the State of New York with its principal place of business at 777 Old Saw Mill River Road, Tarrytown, New York. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the remaining allegations in Paragraph 3 of the Complaint and on that basis denies them.

      Page 29


           4. Genentech denies that Regeneron scientists discovered a novel pharmaceutical referred to in the Complaint as VEGF Trap. Genentech admits that the VEGF Trap is in clinical development for ophthalmologic and oncology indications. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the remaining allegations in Paragraph 4 of the Complaint and on that basis denies them.

           5. Genentech admits the allegations in Paragraph 5 of the Complaint.

           6. Genentech admits that it has been and currently is licensed to do business in the State of New York, and that it has and currently does business in the State of New York. Genentech admits that it has sold and continues to offer for sale and sells products in the State of New York and within this judicial district. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the remaining allegations in Paragraph 6 of the Complaint and on that basis denies them.

      “JURISDICTION AND VENUE”

           7. This paragraph states a legal conclusion to which no response is required. To the extent a response is required, Genentech admits the allegations in Paragraph 7 of the Complaint.

      Page 30


           8. This paragraph states a legal conclusion to which no response is required. To the extent a response is required, Genentech admits that venue is proper under 28 U.S.C. §§ 1391(b) & (c) because Genentech admits that this Court had personal jurisdiction over Genentech for the purposes of this action at the time the action was commenced.

      “INTRA-DISTRICT ASSIGNMENT”

           9. Genentech admits that Regeneron resides in Westchester County. Genentech denies the remaining allegations in Paragraph 9 of the Complaint.

      Page 31


      “BACKGROUND”

      “DEVELOPMENT OF THE VEGF TRAP”

           10. Genentech admits that Regeneron purports to have filed in 2007 a Phase III clinical trial for the use of VEGF Trap in the treatment of neovascular wet age-related macular degeneration, that Phase III studies may be used to develop data to support a Biologics License Application for the United States Food and Drug Administration, and that a Biologics License Application is necessary to secure approval to market a drug in commerce in the United States. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the remaining allegations in Paragraph 10 of the Complaint and on that basis denies them.

           11. Genentech admits that on November 22, 2010, Regeneron issued a press release regarding the results of purported Phase III studies for VEGF Trap relating to wet age-related macular degeneration.

           12. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the allegations in Paragraph 12 of the Complaint and on that basis denies them.

           13. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the allegations in Paragraph 13 of the Complaint and on that basis denies them.

           14. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the allegations in Paragraph 14 of the Complaint and on that basis denies them.

      Page 32


           15. Genentech lacks knowledge and information sufficient to form a belief as to the truthfulness of the allegations in Paragraph 15 of the Complaint and on that basis denies them.

      “GENENTECH’S DAVIS-SMYTH PATENTS”

           16. Genentech admits the allegations in Paragraph 16 of the Complaint.

           17. Genentech admits that Regeneron’s publicly-available filings with the United States Securities and Exchange Commission contain the statements reflected in Paragraph 17 of the Complaint.

           18. Genentech admits that it maintains that VEGF Trap infringes one or more of the Davis-Smyth patents. Genentech also admits that: after Regeneron filed a declaratory judgment complaint against Genentech on November 19, 2010, relating to non-infringement of the Davis-Smyth patents, Regeneron, by letter dated December 22, 2010, asked Genentech for a covenant not to sue regarding those patents; and Genentech subsequently responded that because of Regeneron’s complaint, any discussions must involve the parties’ attorneys, and invited Regeneron to contact Genentech’s general counsel for further discussion. Genentech also admits that Arthur Levinson referred to Regeneron’s discussion in Regeneron’s own SEC filings of the Davis-Smyth patents when responding to questions by investors. Genentech denies the remaining allegations of Paragraph 18 of the Complaint.

           19. Genentech denies the allegations in Paragraph 19 as of the date this Complaint was filed.

      Page 33


      “CLAIM FOR RELIEF”

      “(Declaratory Judgment of Non-Infringement and/or Invalidity of the Genentech Davis-Smyth Patents)”

           20. Genentech incorporates by reference its answers to the allegations of paragraphs 1 through 19.

           21. Genentech admits that Regeneron seeks a judicial declaration that no acts by any entity related to the VEGF Trap do or will directly infringe or infringe under the doctrine of equivalents, or contribute to or induce the infringement of, any valid claim of U.S. Patent Nos. 5,952,199, 6,100,071, 6,383,486, 6,897,294, and 7,771,721, but denies that Regeneron is entitled to such a judicial declaration. Genentech denies the remaining allegations of Paragraph 21 of the Complaint.

      “PRAYER FOR RELIEF”

           Genentech denies that Regeneron is entitled to the relief requested or any other relief.

      AFFIRMATIVE DEFENSES

      FIRST AFFIRMATIVE DEFENSE
      (Failure to State a Claim)

           22. Regeneron’s claims are barred, in whole or in part, as Regeneron has not stated a claim upon which relief can be granted.

      RIGHT TO ASSERT ADDITIONAL DEFENSES

           23. Genentech reserves the right to assert and pursue additional defenses.

      DEMAND FOR A JURY TRIAL ON ALL DEFENSES

           24. Genentech demands trial by jury on all defenses and issues triable by jury.

      Page 34


      SECOND AMENDED COUNTERCLAIM

           For its counterclaim against Regeneron, Counter-Plaintiff Genentech alleges as follows:

      PARTIES

           25. Counter-Plaintiff Genentech, Inc. is a corporation organized under the laws of Delaware, with its principal place of business in South San Francisco, California. Genentech is registered to do business and is doing business in the State of New York.

           26. Counter-Defendant Regeneron, Inc. is a corporation organized under the laws of the State of New York and lists its principal place of business as 777 Old Saw Mill River Road, Tarrytown, New York.

      JURISDICTION AND VENUE

           27. This action arises under the patent laws of the United States of America, 35 U.S.C. § 1 et seq., and jurisdiction is therefore properly based on Title 35 of the United States Code, § 271, and Title 28 of the United States Code, § 1338(a).

           28. This Court has personal jurisdiction over Regeneron by virtue of, inter alia, its residing in the State of New York.

           29. Venue is proper in this District pursuant to Title 28, United States Code, §§ 1391(c) and 1400(b).

      THE DAVIS-SMYTH PATENTS

           30. U.S. Patent No. 5,952,199, titled Chimeric Receptors as Inhibitors of Vascular Endothelial Growth Factor Activity, And Processes for Their Production, was issued by the U.S. Patent and Trademark Office on September 14, 1999. The inventors on the patent are Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, and Napoleone Ferrara, all of whom are or were Genentech employees.

      Page 35


           31. U.S. Patent No. 6,100,071, titled Receptors as Novel Inhibitors of Vascular Endothelial Growth Factor Activity And Processes for Their Production, was issued by the U.S. Patent and Trademark Office on August 8, 2000. The inventors on the patent are Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, and Napoleone Ferrara, all of whom are or were Genentech employees.

           32. U.S. Patent No. 6,383,486, titled Inhibitors of Vascular Endothelial Growth Factor Activity, Their Uses And Processes for Their Production, was issued by the U.S. Patent and Trademark Office on May 7, 2002. The inventors on the patent are Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, and Napoleone Ferrara, all of whom are or were Genentech employees.

           33. U.S. Patent No. 6,897,294, titled Inhibitors of Vascular Endothelial Growth Factor Activity, Their Uses And Processes for Their Production, was issued by the U.S. Patent and Trademark Office on May 24, 2005. The inventors on the patent are Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, and Napoleone Ferrara, all of whom are or were Genentech employees.

           34. U.S. Patent No. 7,771,721, titled Methods for Using Chimeric Vascular Endothelial Growth Factor Receptor Proteins, was issued by the U.S. Patent and Trademark Office on August 10, 2010. The inventors on the patent are Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, and Napoleone Ferrara, all of whom are or were Genentech employees.

      Page 36


           35. The 5,952,199, 6,100,071, 6,383,486, 6,897,294, and 7,771,721 patents will be referred to herein as the “Davis-Smyth patents.”

           36. Genentech owns all rights, title, and interest in and to the Davis-Smyth patents.

           37. On information and belief, Regeneron has known about the ’199, ’071 and/or ’486 patents at least since March 3, 2005 and has known about the ’294 and ’721 patents at least since they issued on May 24, 2005 and August 10, 2010, respectively.

      VEGF Trap-Eye

           38. On information and belief, Regeneron’s VEGF Trap-Eye product is a protein, the amino acid sequence of which is in part derived from the human VEGF Receptor 1 (“VEGFR1” or “FLT-1”), the human VEGF Receptor 2 (“VEGFR2” or “KDR”), and human immunoglobulin G1.

           39. On information and belief, Regeneron’s VEGF Trap-Eye product was and is designed to bind VEGF and, in turn, treat disease states characterized by undesirable angiogenesis and/or neovascularization.

           40. Regeneron has filed a BLA with the FDA, seeking approval to market VEGF Trap-Eye in the U.S. for use in treating wet age-related macular degeneration.

           41. On information and belief, Regeneron: a) has made, used, offered for sale, and/or sold; b) is making, using, offering for sale, and/or selling; and/or c) is preparing to make, use, offer for sale, and/or sell VEGF Trap-Eye in the United States, including within this judicial district, for purposes of export, use, and/or sale in other countries.

      Page 37


           42. On information and belief, Regeneron has taken concrete and substantial steps to prepare for commercial manufacturing, marketing, and selling of VEGF Trap-Eye throughout the United States, including within this judicial district, for purposes of export, use, and/or sale of VEGF Trap-Eye in other countries.

           43. On information and belief, Regeneron is manufacturing VEGF Trap-Eye in the United States for purposes of export, use, and/or sale in other countries.

      COUNT I
      (Infringement of the ’071 patent)

           44. Genentech incorporates the allegations in Paragraphs 25-43 as if fully set forth herein.

           45. By virtue of Regeneron engaging in the following past, present and/or prospective activities:

                a) having made, used, offered for sale, and/or sold VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

      Page 38


                b) making, using, offering for sale, and/or selling VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

                c) preparing to make, use, offer for sale, and/or sell VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States), Regeneron has infringed, is infringing and/or will infringe—directly, and/or by contributing to others’ infringement of and/or by inducing others to infringe—one or more claims of the ’071 patent, either literally and/or under the doctrine of equivalents.

           46. Regeneron’s past, ongoing, and/or future infringement has damaged, is damaging, and/or will damage Genentech, which is entitled to recover from Regeneron the damages resulting from Regeneron’s wrongful acts in an amount to be determined at trial, but no less than a reasonable royalty.

           47. Regeneron’s infringement has been, is, and/or will be willful, justifying an award to Genentech of increased damages under 35 U.S.C. § 284 and attorney’s fees and costs incurred in prosecuting this action under 35 U.S.C. § 285.

      Page 39


           48. Regeneron’s infringing activities have caused, are causing, and/or will cause Genentech to suffer irreparable harm for which there is no adequate remedy at law. This harm will continue unless and until Counter-Defendant’s infringement is enjoined by this Court.

      COUNT II
      (Infringement of the ’486 patent)

           49. Genentech incorporates the allegations in Paragraphs 25-48 as if fully set forth herein.

           50. By virtue of Regeneron engaging in the following past, present and/or prospective activities:

                a) having made, used, offered for sale, and/or sold VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

                b) making, using, offering for sale, and/or selling VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

      Page 40


                c) preparing to make, use, offer for sale, and/or sell VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States), Regeneron has infringed, is infringing and/or will infringe—directly, and/or by contributing to others’ infringement of and/or by inducing others to infringe—one or more claims of the ’486 patent, either literally and/or under the doctrine of equivalents.

           51. Regeneron’s past, ongoing, and/or future infringement has damaged, is damaging, and/or will damage Genentech, which is entitled to recover from Regeneron the damages resulting from Regeneron’s wrongful acts in an amount to be determined at trial, but no less than a reasonable royalty.

           52. Regeneron’s infringement has been, is, and/or will be willful, justifying an award to Genentech of increased damages under 35 U.S.C. § 284 and attorney’s fees and costs incurred in prosecuting this action under 35 U.S.C. § 285.

           53. Regeneron’s infringing activities have caused, are causing, and/or will cause Genentech to suffer irreparable harm for which there is no adequate remedy at law. This harm will continue unless and until Counter-Defendant’s infringement is enjoined by this Court.

      Page 41


      COUNT III
      (Infringement of the ’294 patent)

           54. Genentech incorporates the allegations in Paragraphs 25-53 as if fully set forth herein.

           55. By virtue of Regeneron engaging in the following past, present and/or prospective activities:

                a) having made, used, offered for sale, and/or sold VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

                b) making, using, offering for sale, and/or selling VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

                c) preparing to make, use, offer for sale, and/or sell VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States), Regeneron has infringed, is infringing and/or will infringe—directly, and/or by contributing to others’ infringement of and/or by inducing others to infringe—one or more claims of the ’294 patent, either literally and/or under the doctrine of equivalents.

      Page 42


           56. Regeneron’s past, ongoing, and/or future infringement has damaged, is damaging, and/or will damage Genentech, which is entitled to recover from Regeneron the damages resulting from Regeneron’s wrongful acts in an amount to be determined at trial, but no less than a reasonable royalty.

           57. Regeneron’s infringement has been, is, and/or will be willful, justifying an award to Genentech of increased damages under 35 U.S.C. § 284 and attorney’s fees and costs incurred in prosecuting this action under 35 U.S.C. § 285.

           58. Regeneron’s infringing activities have caused, are causing, and/or will cause Genentech to suffer irreparable harm for which there is no adequate remedy at law. This harm will continue unless and until Counter-Defendant’s infringement is enjoined by this Court.

      COUNT IV
      (Infringement of the ’721 patent)

           59. Genentech incorporates the allegations in Paragraphs 25-58 as if fully set forth herein.

           60. By virtue of Regeneron engaging in the following past, present and/or prospective activities:

      Page 43


                a) having made, used, offered for sale, and/or sold VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

                b) making, using, offering for sale, and/or selling VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States);

                c) preparing to make, use, offer for sale, and/or sell VEGF Trap-Eye in the United States for export to; and/or use, offer for sale, and/or sale in other countries (except where that exportation, use, offer for sale, and/or sale is solely for purposes of converting bulk and/or other unfinished VEGF Trap-Eye into a filled and/or finished form for re-importation into the United States for use, offer for sale, and/or sale in the United States for prevention or treatment of eye diseases and eye disorders in a human in the United States), Regeneron has infringed, is infringing and/or will infringe—directly, and/or by contributing to others’ infringement of and/or by inducing others to infringe—one or more claims of the ’721 patent, either literally and/or under the doctrine of equivalents.

      Page 44


           61. Regeneron’s past, ongoing, and/or future infringement has damaged, is damaging, and/or will damage Genentech, which is entitled to recover from Regeneron the damages resulting from Regeneron’s wrongful acts in an amount to be determined at trial, but no less than a reasonable royalty.

           62. Regeneron’s infringement has been, is, and/or will be willful, justifying an award to Genentech of increased damages under 35 U.S.C. § 284 and attorney’s fees and costs incurred in prosecuting this action under 35 U.S.C. § 285.

           63. Regeneron’s infringing activities have caused, are causing, and/or will cause Genentech to suffer irreparable harm for which there is no adequate remedy at law. This harm will continue unless and until Counter-Defendant’s infringement is enjoined by this Court.

      Page 45


      PRAYER FOR RELIEF

           WHEREFORE, Genentech requests that judgment be entered in its favor against Regeneron:

           1. Finding that Regeneron by virtue of the activities alleged above in each Count: a) has directly infringed and/or will directly infringe; b) has actively induced and/or will actively induce others to infringe, and/or c) has engaged and/or will engage in acts that contribute to others infringing one or more claims of the ’071, ’486, ’294, and ’721 patents;

           2. Finding that Regeneron’s infringement of the ’071, ’486, ’294, and ’721 patents, by virtue of the activities alleged above in each Count, was and/or is willful and deliberate;

           3. If appropriate, taking into account the interests of patients, enjoining Regeneron and its officers, agents, servants, employees, parents, subsidiaries, affiliates, successors, assignees, licensees, and attorneys, and all persons acting in concert or participation with them, from infringing the ’071, ’486, ’294, and ’721 patents directly, by contributory infringement, and/or by actively inducing infringement, via the activities alleged above in each Count;

           4. Ordering Regeneron to account for and pay to Genentech any and all damages caused by the infringement of one or more claims of the ’071, ’486, ’294, and ’721 patents, via the activities alleged above in each Count;

           5. Ordering Regeneron to pay increased damages, up to treble damages to Genentech because of the willful nature of Regeneron’s infringement of one or more claims of the ’071, ’486, ’294, and ’721 patents, via the activities alleged above in each Count;

           6. Ordering that this case be declared an exceptional case under 35 U.S.C. § 285 and that Genentech be awarded its attorney’s fees incurred in this action;

      Page 46


           7. Ordering an award of Genentech’s costs and expenses for this action, pre- and post-judgment interest on any money damages award, and any other charges to the maximum extent permitted;

           8. Ordering such future relief as the Court deems just and proper under the circumstances.

      Page 47


      JURY TRIAL DEMAND

           Genentech demands a trial by jury of all issues so triable.

      Dated: January ___, 2012
      PAUL, WEISS, RIFKIND, WHARTON &
      GARRISON LLP
        
            By:  /s/ Kenneth A Gallo  
      Kenneth A. Gallo
      2001 K Street NW
      Washington, DC 20006
      Tel: (202) 223-7300
      Fax: (202) 223-7420
      Email: kgallo@paulweiss.com
        
      John E. Nathan
      Eric Alan Stone
      1285 Avenue of the Americas
      New York, NY 10019
      Tel: (212) 373-3000
      Fax: (212) 757-3990
      Email: jnathan@paulweiss.com
      Email: estone@paulweiss.com
       
      BAKER BOTTS LLP
      Jennifer Gordon
      Scott Familant
      30 Rockefeller Center
      New York, NY 10112
      Tel: (212) 408-2500
      Fax: (212) 408-2501
      Email: jennifer.gordon@bakerbotts.com
      Email: scott.familant@bakerbotts.com
        
      Attorneys for Defendant and Counter-Plaintiff
      Genentech, Inc.

      Page 48

             EX-23.1 4 exhibit23-1.htm CONSENT OF PRICEWATERHOUSECOOPERS LLP

      Exhibit 23.1

      CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

      We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 333-61132, 333-97375, 333-119257, 333-151941, 333-169569, and 333-174863) and on Form S-3 (No. 333-169786) of Regeneron Pharmaceuticals, Inc., of our report dated February 21, 2012 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in this Form 10-K.

      /s/ PricewaterhouseCoopers LLP

      New York, New York
      February 21, 2012

      EX-31.1 5 exhibit31-1.htm CERTIFICATION OF CEO PURSUANT TO RULE 13A-14(A)

      Exhibit 31.1

      Certification of CEO Pursuant to
      Rule 13a-14(a) under the Securities Exchange Act
      of 1934, as Adopted Pursuant to
      Section 302 of the Sarbanes-Oxley Act of 2002

      I, Leonard S. Schleifer, certify that:

      1.       I have reviewed this annual report on Form 10-K of Regeneron Pharmaceuticals, Inc.;
       
      2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
       
      3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
       
      4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
       
              a)       Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
       
        b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
       
        c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
       
        d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting: and
       
      5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
       
        a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
       
        b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
       

      Date: February 21, 2012 By:   /s/ LEONARD S. SCHLEIFER  
            Leonard S. Schleifer, M.D., Ph.D.
            President and Chief Executive Officer

      EX-31.2 6 exhibit31-2.htm CERTIFICATION OF CFO PURSUANT TO RULE 13A-14(A)

      Exhibit 31.2

      Certification of CFO Pursuant to
      Rule 13a-14(a) under the Securities Exchange Act
      of 1934, as Adopted Pursuant to
      Section 302 of the Sarbanes-Oxley Act of 2002

      I, Murray A. Goldberg, certify that:

      1.       I have reviewed this annual report on Form 10-K of Regeneron Pharmaceuticals, Inc.;
       
      2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
       
      3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
       
      4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
       
              a)       Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
       
        b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
       
        c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
       
        d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting: and
       
      5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
       
        a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
       
        b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
       

      Date: February 21, 2012 By:   /s/ MURRAY A. GOLDBERG  
            Murray A. Goldberg
            Senior Vice President, Finance & Administration,
            Chief Financial Officer, Treasurer, and Assistant
            Secretary

      EX-32 7 exhibit32.htm CERTIFICATION OF CEO AND CFO PURSUANT TO 18 U.S.C. SECTION 1350

      Exhibit 32

      Certification of CEO and CFO Pursuant to
      18 U.S.C. Section 1350,
      As Adopted Pursuant to
      Section 906 of the Sarbanes-Oxley Act of 2002

      In connection with the Annual Report of Regeneron Pharmaceuticals, Inc. (the "Company") on Form 10-K for the year ended December 31, 2011 as filed with the Securities and Exchange Commission on the date hereof (the "Report"), Leonard S. Schleifer, M.D., Ph.D., as Chief Executive Officer of the Company, and Murray A. Goldberg, as Chief Financial Officer of the Company, each hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to the best of his knowledge, that:

            (1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

            (2) The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company.

      /s/ LEONARD S. SCHLEIFER  
      Leonard S. Schleifer, M.D., Ph.D.
      Chief Executive Officer
      February 21, 2012
       
       
      /s/ MURRAY A. GOLDBERG
      Murray A. Goldberg
      Chief Financial Officer
      February 21, 2012

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width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">164</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">87</font></font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">___</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(77)</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" colspan="2" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(77)</font></font></div></td></tr><tr><td valign="top" width="31%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">315,926</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">316,198</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">508</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(236)</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" colspan="2" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">272</font></font></div></td></tr><tr><td valign="top" width="31%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%" colspan="2"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="31%" 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MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">10</font></div></td></tr><tr><td valign="top" width="31%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%" colspan="2"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="31%" align="left"><div style="TEXT-INDENT: 0pt; 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inline">522</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(33)</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%" colspan="2" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">489</font></font></div></td></tr><tr><td valign="top" width="31%"><div style="TEXT-INDENT: 0pt; DISPLAY: block">&#160;</div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Maturities after one year through five 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inline">$(141)</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">1,128</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(141)</font></font></div></td></tr><tr><td valign="top" width="26%"><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"></font>&#160;</div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">363,061</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(2,209)</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 10.05pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">1,128</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; 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style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="26%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Restricted</font></div></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="26%"><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160;&#160;&#160;&#160;U.S. government obligations</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">6,154</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(18)</font></font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 10.05pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">____</font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 8.35pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">____</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">6,154</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(18)</font></font></div></td></tr><tr><td valign="top" width="26%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">6,154</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(18)</font></font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 10.05pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">____</font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 8.35pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">____</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">6,154</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(18)</font></font></div></td></tr><tr><td valign="top" width="26%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="26%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$369,215</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$(2,227)</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 10.05pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$1,128</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 8.35pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: 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MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Quoted Prices in Active Markets for Identical Assets</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">(Level 1)</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="bottom" width="16%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Significant Other Observable Inputs</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">(Level 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DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$111,890</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$(1,260)</font></font></div></td></tr><tr><td valign="top" width="26%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="26%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; 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FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="26%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Unrestricted</font></div></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td></tr><tr><td valign="top" width="26%"><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">U.S. government obligations</font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$340,444</font></div></td><td valign="top" width="10%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 9.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; 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FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">c. Product Revenue</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="MARGIN-LEFT: 18pt"></font>Product sales consist of U.S. sales of the Company&#8217;s two marketed products, EYLEA<font style="DISPLAY: inline; FONT-FAMILY: Symbol, serif; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">&#210;</font> and ARCALYST<font style="DISPLAY: inline; FONT-FAMILY: Symbol, serif; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">&#210;</font>.&#160;&#160;Revenue from product sales is recognized when persuasive evidence of an arrangement exists, title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, the Company has no further performance obligations, and returns can be reasonably estimated.&#160;&#160;The Company&#8217;s written contracts with its customers stipulate product is shipped freight on board destination (FOB destination).&#160;&#160;The Company records revenue from product sales upon delivery to its customers.</font></div><div style="TEXT-INDENT: 0pt; 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FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Regeneron Pharmaceuticals, Inc. 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DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The following table summarizes the weighted average values of the assumptions used in computing the fair value of option grants during 2011, 2010, and 2009.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"></font><br />&#160;</div><div><table cellspacing="0" cellpadding="0" width="100%"><tr><td valign="top" width="26%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="15%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 27pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">2011</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="15%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 27pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">2010</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="15%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 27pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">2009</font></font></div></td></tr><tr><td valign="top" width="26%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Expected volatility</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">48%</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">47%</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">54%</font></div></td></tr><tr><td valign="top" width="26%" align="left"><div style="TEXT-INDENT: -9pt; DISPLAY: block; MARGIN-LEFT: 27pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Expected lives from grant date</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; 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DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2.11%</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 18pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2.87%</font></div></td></tr></table></div> <div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The estimated future minimum noncancelable lease commitments under operating leases were as follows:</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div><table cellspacing="0" cellpadding="0" width="100%"><tr><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="29%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; 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DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2015</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,583</font></div></td><td valign="top" width="12%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,583</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2016</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,738</font></div></td><td valign="top" width="12%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,738</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Thereafter</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">59,631</font></font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 23pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">___</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">59,631</font></font></div></td></tr><tr><td valign="top" width="29%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; 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FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">106</font></font></div></td></tr><tr><td valign="top" width="31%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block">&#160;</div><div style="TEXT-INDENT: -9pt; DISPLAY: block; MARGIN-LEFT: 9pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Maturities after one year through five years</font></div></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="10%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="11%" colspan="2"><font style="DISPLAY: inline; 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DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">4,370</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">17,462</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2014</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">13,343</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">4,490</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">17,833</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2015</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">13,600</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; 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MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">39,899</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">152,939</font></font></div></td></tr><tr><td valign="top" width="29%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$179,786</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$60,938</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$240,724</font></font></div></td></tr></table></div> <div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Accounts payable and accrued expenses as of December 31, 2011 and 2010 consist of the following:</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div><table cellspacing="0" cellpadding="0" width="100%"><tr><td valign="top" width="46%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="15%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">2011</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="16%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">2010</font></font></div></td></tr><tr><td valign="top" width="46%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Accounts payable</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$27,736</font></div></td><td valign="top" width="16%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$15,589</font></div></td></tr><tr><td valign="top" width="46%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Accrued payroll and related costs</font></div></td><td valign="top" width="15%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 21.6pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">42,835</font></div></td><td valign="top" width="16%" align="right"><div style="TEXT-INDENT: 0pt; 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FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">2.&#160;&#160;</font></div></td><td><div style="TEXT-INDENT: 0pt; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Summary of Significant Accounting Policies</font></div></td></tr></table></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Cash and Cash Equivalents</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">For purposes of the statement of cash flows and the balance sheet, the Company considers all highly liquid debt instruments with a maturity of three months or less when purchased to be cash equivalents.&#160;&#160;The carrying amount reported in the balance sheet for cash and cash equivalents approximates its fair value.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"></font><br />&#160;</div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Marketable Securities</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The Company has an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification.&#160;&#160;The Company has invested its excess cash primarily in direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities.&#160;&#160;The Company considers its marketable securities to be &#8220;available-for-sale,&#8221; as defined by authoritative guidance issued by the Financial Accounting Standards Board (&#8220;FASB&#8221;).&#160;&#160;These assets are carried at fair value and the unrealized gains and losses are included in accumulated other comprehensive income (loss) as a separate component of stockholders&#8217; equity.&#160;&#160;If the decline in the value of a marketable security in the Company&#8217;s investment portfolio is deemed to be other-than-temporary, the Company writes down the security to its current fair value and recognizes a loss as a charge against income.&#160;&#160;As described under &#8220;Use of Estimates&#8221; below, the Company reviews its portfolio of marketable securities, using both quantitative and qualitative factors, to determine if declines in fair value below cost are other-than-temporary.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; 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otherwise, such costs are expensed as research and development.&#160;&#160;The Company periodically analyzes its inventory levels to identify inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, and writes-down such inventories as appropriate. 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DISPLAY: block"><br /></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="MARGIN-LEFT: 72pt"></font>Building and improvements&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;10-40 years</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="MARGIN-LEFT: 72pt"></font>Laboratory and other equipment&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;3-10 years</font></div><div style="TEXT-INDENT: 0pt; 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performance conditions to be probable of attainment.&#160;&#160;The Company&#8217;s estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The Company uses the Black-Scholes model to compute the estimated fair value of stock option awards.&#160;&#160;Using this model, fair value is calculated based on assumptions with respect to (i) expected volatility of the Company&#8217;s Common Stock price, (ii) the periods of time over which employees and members of the board of directors are expected to hold their options prior to exercise (expected lives), (iii) expected dividend yield on the Common Stock, and (iv) risk-free interest rates.&#160;&#160;Stock-based compensation expense also includes an estimate, which is made at the time of grant, of the number of awards that are expected to be forfeited.&#160;&#160;This estimate is revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.</font></div><div style="TEXT-INDENT: 0pt; 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DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The Company also leases certain equipment under operating and capital leases which expire at various times through 2014.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"></font><br />&#160;</div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Commitments under Operating Leases</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; 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DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">Equipment</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="12%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="DISPLAY: inline">Total</font></font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2012</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$6,072</font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 23pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$1,188</font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$7,260</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2013</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,304</font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 23pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">258</font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,562</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2014</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,428</font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 23pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">35</font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,463</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2015</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,583</font></div></td><td valign="top" width="12%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,583</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2016</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,738</font></div></td><td valign="top" width="12%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,738</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Thereafter</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">59,631</font></font></div></td><td valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 23pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">___</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">59,631</font></font></div></td></tr><tr><td valign="top" width="29%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$95,756</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 23pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$1,481</font></font></div></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="12%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$97,237</font></font></div></td></tr></table></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Rent expense under operating leases was:</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div><table cellspacing="0" cellpadding="0" width="100%"><tr><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="29%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">Year Ending December 31,</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">Facilities</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">&#160;&#160;&#160;&#160;&#160;<font style="DISPLAY: inline">Equipment</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="11%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">Total</font></font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2011</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$7,191</font></div></td><td valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 18.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$599</font></div></td><td valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 18.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$7,790</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2010</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,301</font></div></td><td valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 18.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">335</font></div></td><td valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 18.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,636</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2009</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">7,722</font></div></td><td valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 18.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">395</font></div></td><td valign="top" width="11%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 18.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">8,117</font></div></td></tr></table></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">In addition to its rent expense under operating leases, and payments under facility lease obligations (see below), for various facilities, the Company paid rental charges for utilities, real estate taxes, and operating expenses of $9.3 million, $10.3 million, and $8.4 million for the years ended December 31, 2011, 2010, and 2009, respectively.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Commitments under Capital Leases</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">In 2011 and 2010, the Company entered into capital leases in connection with acquisitions of new equipment.&#160;&#160;The lease obligations are collateralized with marketable debt securities totaling $3.3 million and $3.5 at December 31, 2011 and 2010, respectively; such collateral has been classified as restricted cash and marketable securities at December 31, 2011 and 2010.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The estimated future minimum noncancelable lease commitments under capital leases were as follows:</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div><table cellspacing="0" cellpadding="0" width="100%"><tr><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="29%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">December 31,</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">Equipment</font></font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2012</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">$1,394</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2013</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">1,254</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2014</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">130</font></font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 14pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Total minimum lease payments</font></div></td><td valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">2,778</font></div></td></tr><tr><td valign="top" width="29%" align="left"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Less: amount representing interest</font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">(272)</font></font></div></td></tr><tr><td valign="top" width="29%"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">&#160; </font></td><td style="BORDER-BOTTOM: black 4px double" valign="top" width="14%" align="right"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 27.5pt" align="right"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline">$2,506</font></font></div></td></tr></table></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">At the end of the lease term, the Company is required to purchase the leased equipment for a nominal amount defined in the lease agreement.&#160;&#160;At December 31, 2011 and 2010, capital lease obligations totaled $2.5 million and $2.8 million, respectively, and were included in other liabilities.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Facility Lease Obligations</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">As described above, in connection with the application of FASB authoritative guidance to the Company&#8217;s lease of office and laboratory facilities in Buildings A, B, and C, the Company capitalized the landlord&#8217;s costs of constructing the new facilities and recognized a corresponding facility lease obligation.&#160;&#160;The Company also recognized, as additional facility lease obligation, reimbursements from the Company&#8217;s landlord for tenant improvement costs that the Company incurred since, under FASB authoritative guidance, such payments that the Company receives from its landlord are deemed to be a financing obligation.&#160;&#160;Monthly lease payments on these facilities are allocated between the land element of the lease (which is accounted for as an operating lease) and the facility lease obligation, based on the estimated relative fair values of the land and buildings.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">As of December 31, 2010, the Company had capitalized the landlord&#8217;s costs of constructing Buildings A and B, which totaled $58.4 million, and of constructing Building C, which totaled $27.8 million.&#160;&#160;Reimbursements from the Company&#8217;s landlord for Buildings A and B tenant improvement costs totaled $56.9 million and were received by the Company during 2010 and 2009.&#160;&#160;Reimbursements for Building C tenant improvement costs totaled $14.2 million and were received by the Company during 2010.&#160;&#160;With respect to Buildings A and B, monthly lease payments commenced in August 2009, the buildings were placed in service by the Company in September 2009, and the imputed interest rate applicable to the Company&#8217;s facility lease obligation is approximately 11%.&#160;&#160;With respect to Building C, monthly lease payments commenced in January 2011, the building was placed in service by the Company in February 2011, and the imputed interest rate applicable to the Company&#8217;s facility lease obligation is approximately 9%.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">In 2011, the Company recognized $15.6 million of interest expense in connection with the Buildings A and B and the Building C facility lease obligations.&#160;&#160;In 2010 and 2009, the Company recognized $9.1 million and $2.3 million, respectively, of interest expense in connection with the Buildings A and B facility lease obligation.&#160;&#160;At December 31, 2011 and 2010, the Buildings A and B facility lease obligation balance was $113.0 million and $113.7 million, respectively, and the Building C facility lease obligation balance was $47.5 million and $46.4 million, respectively.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 18pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The estimated future minimum noncancelable commitments under these facility lease obligations, as of December 31, 2011, were as follows:</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div><table cellspacing="0" cellpadding="0" width="100%"><tr><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="29%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">December 31,</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="15%"><div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold"><font style="DISPLAY: inline">Buildings A and B</font></font></div></td><td style="BORDER-BOTTOM: black 2px solid" valign="top" width="14%"><div style="TEXT-INDENT: 0pt; 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Two Years Thereafter Operating Leases, Future Minimum Payments, Due Thereafter Rent expense under operating leases [Abstract] Unused net operating loss carry-forwards Net operating loss carry-forwards, expiration dates Loss from operations Operating Income (Loss) Total revenues Revenues Revenues Revenues [Abstract] Option Indexed to Issuer's Equity, Type [Axis] Option Indexed to Issuer's Equity [Line Items] Option Indexed to Issuer's Equity [Table] Change in net unrealized gain (loss) on marketable securities, net of tax effect Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Change in net unrealized gain on marketable securities, tax effect Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Tax Other income (expense) Pending or Threatened Litigation [Member] Genentech Patent-Related Matters [Member] Preferred stock, shares authorized (in shares) Preferred stock, authorized (in shares) Preferred stock, issued (in shares) Preferred stock, outstanding (in shares) Preferred stock, par value (in dollars per share) Net proceeds in connection with issuance of Common Stock Proceeds in connection with issuance of warrants Proceeds received from the Warrant Sales or maturities of marketable securities Product Concentration Risk [Member] Property, plant and equipment, gross Property, plant, and equipment, at cost, net of accumulated depreciation and amortization Property, plant and equipment, net Property, Plant, and Equipment [Abstract] Property, Plant, and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Purchases of marketable securities Payments to Acquire Marketable Securities Purchases of restricted marketable securities Payments to Acquire Restricted Investments Accounts Receivable - Trade Unrecognized tax benefits [Roll forward] Accounts receivable from Sanofi Amounts receivable from collaboration agreements Payments in connection with capital lease obligation Repayments of Long-term Capital Lease Obligations Collaboration and Contract Research Agreements Research, Development, and Computer Software Disclosure [Text Block] Collaboration development revenue Total incurred expenses associated with agreements Research and Development Expenses Research [Member] Research and Experimental and Other [Member] Accumulated deficit Retained Earnings (Accumulated Deficit) Contract research and other Contract research revenue Technology licensing Technology licensing revenue recognized Investment Income Revenue Recognition, Collaboration Revenue Revenue Recognition Revenue Recognition, Product Revenue Revenue Recognition, Technology Licensing Royalty expense Net product sales Net product sales Product Revenue [Abstract] Product Revenue [Abstract] Inventory Inventory Disclosure [Text Block] Net Carrying Amount of the Liability Component of Convertible Notes Deferred Revenue Deferred Revenue, by Arrangement, Disclosure [Table Text Block] Property, Plant, and Equipment Selling, general, and admistrative Service Life [Member] Granted (in shares) Granted, weighted-average grant date fair value (in dollars per share) Outstanding, beginning of period (in shares) Outstanding, end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Outstanding, beginning of period, weighted-average grant date fair value (in dollars per share) Outstanding, end of period, weighted-average grant date fair value (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Unrecognized stock-based compensation cost, net of estimated forfeitures Weighted average period for recognition of total unrecognized compensation expense (in years) Released (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Released, weighted-average grant date fair value (in dollars per share) Number of shares of Common Stock reserved for future issuance (in shares) Number of shares available for future grants (in shares) Total intrinsic value of stock options exercised Exercised, weighted-average exercise price (in dollars per share) Expired (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Expired, weighted-average exercise price (in dollars per share) Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Forfeited, weighted-average exercise price (in dollars per share) Granted (in shares) Number of Options Granted (in shares) Granted, weighted-average exercise price (in dollars per share) Weighted-Average Exercise Price (in dollars per share) Weighted-Average Fair Value (in dollars per share) Outstanding, end of period, intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Outstanding, beginning of period (in shares) Outstanding, end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Outstanding, beginning of period, weighted-average exercise price (in dollars per share) Outstanding, end of period, weighted-average exercise price (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Exercisable, end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Exercisable, end of period, weighted-average exercise price (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Exercisable, end of period, weighted-average remaining contractual term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Expected dividend yield (in hundredths) Expected lives from grant date (in years) Expected volatility (in hundredths) Risk-free interest rate (in hundredths) Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Award Type and Plan Name [Axis] Share-based Compensation Arrangements by Share-based Payment Award, Award Type and Plan Name [Domain] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] STATEMENTS OF CASH FLOWS [Abstract] STATEMENTS OF STOCKHOLDERS' EQUITY [Abstract] Stock-based Compensation Stockholders' equity Stockholders' Equity Attributable to Parent [Abstract] Stockholders Equity Stockholders' Equity Note Disclosure [Text Block] Strike price of the warrant transaction (in dollars per share) Exercise price (in dollars per share) Number of shares called by warrants (in shares) Unrecognized Tax Benefits Summary of Income Tax Contingencies [Table Text Block] Supplemental disclosure of cash flow information Supplier Concentration Risk [Member] Tax Credit Carryforward, Name [Domain] Tax credit carry-forwards, expiration dates Tax Credit Carryforward [Axis] Tax Credit Carryforward [Line Items] Tax Credit Carryforward [Table] Cash paid for income taxes Income tax expense paid Total current assets Assets, Current Current assets Assets, Current [Abstract] Research and Development Expenses [Abstract] Municipal Bonds [Member] U S Government Obligations [Member] U.S. Government Obligations [Member] Balance, as of January 1 Balance, as of December 31 Unrecognized Tax Benefits Gross increases related to current year tax positions Gross increases related to prior year tax positions Deferred Tax Asset [Domain] Valuation Allowance by Deferred Tax Asset [Axis] Valuation Allowance [Line Items] Valuation Allowance [Table] Common Stock [Member] Leased Equipment Under Capital Leases [Member] Construction-in-Progress [Member] Property, Plant, and Equipment Property, Plant and Equipment Disclosure [Text Block] Property, Plant and Equipment, Type [Domain] Useful life, maximum (in years) Useful life, minimum (in years) Building and Building Improvements [Member] Building and Improvements [Member] Research and development Call Option [Member] Schedule of Available-for-sale Securities [Table] Major Types of Debt and Equity Securities [Domain] Amortized Cost Basis - Maturities within one year Amortized Cost Basis - Maturities after one year through five years Amortized Cost Basis - Maturities after five years through ten years Available-for-sale Securities, Debt Maturities, after Five Through Ten Years, Amortized Cost Basis Amortized Cost Basis - Total Available-for-sale Securities, Debt Maturities, Amortized Cost Basis Fair Value - Maturities within one year Fair Value - Maturities after one year through five years Fair Value - Maturities after five years through ten years Available-for-sale Securities, Debt Maturities, after Five Through Ten Years, Fair Value Debt Maturities, Amortized Cost Basis [Abstract] Debt Maturities, Fair Value [Abstract] Continuous Unrealized Loss Position, Fair Vaue [Abstract] Fair Value - Less than 12 Months Fair Value - 12 Months or Greater Fair Value - Total Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value Continuous Unrealized Loss Position, Aggregate Losses [Abstract] Available-for-sale marketable securities Fair Value - Total Available-for-sale Securities, Debt Securities Fair value of equity securities Total assets Assets Other long term liabilities Other Liabilities, Noncurrent Concentration Risk by Benchmark [Axis] Concentration Risk Benchmark [Domain] Sales Revenue, Product Line [Member] Concentration risk, additional characteristic Income Tax Authority [Domain] Common Stock, conversion features Long-Term Incentive Plans Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Statement [Table] Antidilutive Securities, Name [Domain] ASSETS Assets [Abstract] Statement [Line Items] Fair Value, Assets Measured on a Recurring Basis Class of Warrant or Right [Table] Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Strike price (in dollars per share) Common stock allowed to purchase (in shares) Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Line Items] Fair Value, Inputs, Level 1 [Member] Fair Value Measurements at Reporting Date Using Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] Fair Value, Inputs, Level 2 [Member] Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member] Fair Value, Inputs, Level 3 [Member] Fair Value Measurements at Reporting Date Using Significant Unobservable Inputs (Level 3) [Member] Capital lease obligations Capital Lease Obligations Incurred Capital leases [Abstract] Operating leases [Abstract] Stockholders Equity [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Unaudited Quarterly Results Quarterly Financial Information [Text Block] Future maturities [Abstract] Class of Warrant or Right [Line Items] Class of Stock [Domain] Statement of Cash Flows Cash Flow, Supplemental Disclosures [Text Block] Option Indexed to Issuer's Equity, Type [Domain] Internal Revenue Service (IRS) [Member] U.S. Federal [Member] Class A Stock [Member] Deferred tax assets: Increase (decrease) in stockholders' equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] (Decrease) increase in deferred revenue Deferred revenue Deferred revenue Deferred Revenue Other assets Other Assets, Noncurrent Weighted average number, in thousands (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, by Antidilutive Securities [Axis] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Net Loss Per Share Data [Abstract] Antidilutive Securities Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Per Share Data Commitments and Contingencies Commitments Disclosure [Text Block] Deferred net product sales recognized as revenue Net loss before income tax benefit Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Schedule of Available-for-sale Securities, Major Types of Debt and Equity Securities [Axis] Schedule of Available-for-sale Securities [Line Items] Class of Stock [Axis] Current portion: Long-term portion: Schedule of Property, Plant and Equipment [Table] Common Stock, par value (in dollars per share) Property, Plant and Equipment by Type [Axis] Property, Plant and Equipment [Line Items] Common Stock, voting rights Total stockholders' equity Balance Balance Stockholders' Equity Attributable to Parent Income tax (benefit) expense Income tax benefit Capitalized and deferred interest Total interest expense [Abstract] Preferred stock Description of leasing arrangement Statement, Equity Components [Axis] Additional Paid-in Capital [Member] Accumulated Deficit [Member] Accumulated Other Comprehensive Income (Loss) [Member] Equity Component [Domain] Sanofi collaboration revenue Issuance of Common Stock in a public offering, net of issuance costs Net proceeds from issuance of Common Stock Issuance of restricted Common Stock under Long-Term Incentive Plan Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Conversion of Class A Stock to Common Stock Stock Issued During Period, Value, Conversion of Convertible Securities Issuance of Common Stock in a public offering, net of issuance costs (in shares) Issuance of Common Stock in a public offering (in shares) Number of shares issued (in shares) Issuance of restricted Common Stock under Long-Term Incentive Plan (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Conversion of Class A Stock to Common Stock (in shares) Stock Issued During Period, Shares, Conversion of Convertible Securities Comprehensive Income (Loss) Stockholders' Equity, Policy [Policy Text Block] U S Government Guaranteed Collateralized Mortgage Obligations [Member] U.S. Government Guaranteed Collateralized Mortgage Obligations [Member] Mortgage-Backed Securities [Member] Comprehensive Loss [Member] Expenses Total expenses Costs and Expenses Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Stock options activity [Roll forward] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Stock options activity, additional disclosures [Abstract] Restricted stock activity [Roll forward] Restricted stock activity, additional disclosures [Abstract] Other-than-temporary impairment charge Vested and expected to vest, end of period, weighted-average exercise price (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Vested and expected to vest, end of period, intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Vested and expected to vest, end of period, weighted-average remaining contractual term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Vested and expected to vest, end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Total available-for-sale marketable securities Available-for-sale Securities, Fair Value Disclosure Weighted-average values of assumptions used in computing fair value of option grants [Abstract] Convertible notes Fair value of the outstanding Notes Net Loss Per Share Data Earnings Per Share [Text Block] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Research and Development Arrangement, Contract to Perform for Others by Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Arrangement, Contract to Perform for Others [Line Items] Depreciation and amortization expense Class of Stock [Line Items] Schedule of Stock by Class [Table] Commitments and contingencies (Note 12) Marketable Securities Marketable Securities [Text Block] Restricted cash and marketable securities Restricted Cash and Investments, Noncurrent Adjustments to reconcile net loss to net cash provided by (used in) operating activities Adjustments to reconcile net loss to net cash (used in) provided by operating activities Total adjustments Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities Convertible Debt [Abstract] Convertible Debt [Abstract] Long-term Debt, Type [Axis] Organization and Business Nature of Operations [Text Block] Accounts payable and accrued expenses Accounts payable and accrued expenses Accounts Payable and Accrued Liabilities, Current Accounts payable Expenses under the collaboration payable to collaborating party Accrued payroll and related costs Accrued interest payable related to convertible notes Accrued interest expense related to Convertible Notes Other accrued expenses and liabilities Accounts payable and accrued expenses [Abstract] Long-term Debt, Type [Domain] Accrued contribution expense to 401(k) Savings Plan Accrued 401(k) Savings Plan contribution expense Stock-based compensation charges Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Payment in connection with purchase of convertible note hedges Payments for Hedge, Financing Activities Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Contractual coupon interest rate Capitalized interest costs Fair Value, Measurement Frequency [Domain] Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value, Measurements, Recurring [Member] Measured on a Recurring Basis [Member] Amount of milestone payment received Unrealized Gains - Total Available-for-sale Securities, Gross Unrealized Gains Accounts Payable and Accrued Expenses [Abstract] Organization and Business [Abstract] Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution (in shares) Common Stock contributed to the Savings Plan (in shares, thousands) Common Stock contributed to 401(k) Savings Plan (in shares) Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution Stock Issued During Period, Value, Employee Benefit Plan Balance (in shares) Balance (in shares) Shares, Outstanding Accounts Payable and Accrued Expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Fair Value, Hierarchy [Axis] Fair Value by Measurement Frequency [Axis] Future Maturities Relating to Convertible Notes Rent Expense Under Operating Leases Commitments Under Operating Leases Commitments Under Capital Leases Deferred Tax Assets Fair Value and Unrealized Losses of Marketable Securities Accounts Payable and Accrued Expenses Commitments and Contingencies [Abstract] Legal Matters Legal Matters and Contingencies [Text Block] Income Taxes [Abstract] Fair Value Measurements [Abstract] Inventory [Abstract] Rent expense Cost basis of equity securities Summarized Quarterly Financial Data Transactions Involving Stock Option Awards Weighted-Average Values of Assumptions Used in Computing Fair Value of Option Grants Unaudited Quarterly Results [Abstract] Letter of credit amount outstanding in connection with lease Long-Term Incentive Plans [Abstract] Use of Estimates Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Table] Schedule of Capital Leased Asssets [Table] Capital Leased Assets [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Summary of Significant Accounting Policies [Abstract] Collaboration and Contract Research Agreements [Abstract] Unrealized (Losses) - Total Available-for-sale Securities, Gross Unrealized Losses Accounts receivable - other Other Receivables, Net, Current Income Tax Authority [Axis] Basic and diluted net loss per share [Abstract] Net loss per share, basic and diluted (in dollars per share) Basic and diluted net loss per share (in dollars per share) Net loss per share, basic and diluted (in dollars per share) Vesting period, minimum (in years) Vesting period, maximum (in years) Basic and Diluted Net Loss Per Share Unrealized Gains (Losses), Net [Abstract] Unrealized Net - Total Available-for-sale Securities, Gross Unrealized Gain (Loss) Schedule of Operating Leased Assets [Table] Operating Leased Assets [Line Items] Outstanding, end of period, weighted-average remaining contractual term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Exercisable, end of period, intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Unrealized Loss - Less than 12 Months Available-for-sale Securities, Continuous Unrealized Loss Position, Less than 12 Months, Aggregate Losses Unrealized Loss - 12 Months or Greater Available-for-sale Securities, Continuous Unrealized Loss Position, 12 Months or Longer, Aggregate Losses Unrealized Loss - Total Available-for-sale Securities, Continuous Unrealized Loss Position, Aggregate Losses Activity Related to Restricted Stock Awards Marketable Securities, Based on Contractual Maturity Dates Equity component of convertible senior notes, net of issuance costs Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt Carrying amount of Equity Component Total interest recorded for the period Effective interest rate used to amortize the discount on the liability component (in hundredths) Initial conversion price (in dollars per share) Conversion price (in dollars per share) Impaired securities [Abstract] Amendment Flag Current Fiscal Year End Date Document Period End Date Entity [Text Block] Entity [Domain] Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Registrant Name Entity Central Index Key Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus Legal Entity [Axis] Document Type Deferred Revenue From Related Party Current The current portion of deferred revenue from related parties as of balance sheet date. Deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized, and is expected to be recognized in the next twelve months. Generally, an entity records deferred revenue when it receives consideration before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP. Deferred revenue from Sanofi, current portion Facility Lease Obligations, Current Represents the current portion of a lease liability. In connection with the application of FASB authoritative guidance to the Company's lease of additional new facilities, the Company is deemed, in substance, to be the owner of the landlord's building; therefore, costs of constructing the facilities were capitalized, offset by a corresponding lease obligation. Facility lease obligations, current portion Deferred Revenue From Related Party Noncurrent The noncurrent portion of deferred revenue from related parties amount as of balance sheet date. Deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized, and is not expected to be recognized in the next twelve months. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP. Deferred revenue from Sanofi Other Collaboration Revenue Revenue realized from sales and other transactions (excluding transactions that are eliminated in consolidated or combined financial statements related to our collaboration agreements) during the period. Other collaboration revenue Weighted Average Shares Outstanding Basic And Diluted The average number of shares or units issued and outstanding that are used in calculating basic and diluted EPS. Weighted average shares outstanding, basic and diluted (in shares) Weighted-average shares, in thousands (Denominator) (in shares) Change In Accounting Estimate Deferred Revenue Lower Net Loss Per Share Represents the financial effect of the change in accounting estimate for deferred net product sales revenue. Change in accounting estimate, deferred revenue - lower net loss per share (in dollars per share) Sales Revenue Product Line Excluding Deferred Sales Recognized Product revenue recognized during the period, after deducting returns, allowances and discounts. Does not include previously deferred net product sales revenue recognized during the period. Net product sales, excluding deferred sales recognized as revenue Antidilutive Securities Excluded From Computation Of Earnings Per Share Weighted Average Exercise Price The weighted average price of the antidilutive securities at which grantees can acquire the shares reserved for issuance under the stock option plan. Weighted average exercise price (in dollars per share) Accrued Capital Expenditures Carrying value as of the balance sheet date of obligations incurred and payable for purchases of fixed assets. Included in accounts payable and accrued expenses. Accrued capital expenditures Facility Lease Obligations Incurred The increase during the period in facility lease obligations in connection with capitalizing, on the Company's books, the landlord's costs of constructing new facilities that the Company has leased. Facility lease obligation Employee Exercises Of Stock Options Receivable Carrying amount as of the balance sheet date of amounts due to the Company in connection with employee exercises of stock options. Employee exercises of stock options, due to the Company Available For Sale Securities Debt Maturities Within One Year Unrealized Gains Losses Net This item represents the net unrealized gains and losses of debt securities which are expected to mature within one year of the balance sheet date and are categorized neither as held-to-maturity nor trading securities. Unrealized Net - Maturities within one year Available For Sale Securities Debt Maturities Within One Year Gross Unrealized Loss This item represents the gross unrealized loss of debt securities which are expected to mature within one year of the balance sheet date and which are categorized neither as held-to-maturity nor trading securities. Unrealized (Losses) - Maturities within one year Available For Sale Securities Debt Maturities Within One Year Gross Unrealized Gains This item represents the gross unrealized gains of debt securities which are expected to mature within one year of the balance sheet date and which are categorized neither as held-to-maturity nor trading securities. Unrealized Gains - Maturities within one year Available For Sale Securities Debt Maturities After One Through Five Years Gross Unrealized Gains This item represents the gross unrealized gains of debt securities which are expected to mature after one year and through five years of the balance sheet date and which are categorized neither as held-to-maturity nor trading securities. Unrealized Gains - Maturities after one year through five years Available For Sale Securities Debt Maturities After Five Through Ten Years Gross Unrealized Gains This item represents the gross unrealized gains of debt securities which are expected to mature after five years and through ten years of the balance sheet date and which are categorized neither as held-to-maturity nor trading securities. Unrealized Gains - Maturities after five years through ten years Available For Sale Securities Debt Maturities After One Through Five Years Gross Unrealized Loss This item represents the gross unrealized loss of debt securities which are expected to mature after one year and through five years of the balance sheet date and which are categorized neither as held-to-maturity nor trading securities. Unrealized (Losses) - Maturities after one year through five years Available For Sale Securities Debt Maturities After Five Through Ten Years Gross Unrealized Loss This item represents the gross unrealized loss of debt securities which are expected to mature after five years and through ten years of the balance sheet date and which are categorized neither as held-to-maturity nor trading securities. Unrealized (Losses) - Maturities after five years through ten years Available For Sale Securities Debt Maturities After One Through Five Years Unrealized Gains Losses Net This item represents the net unrealized gains and losses of debt securities which are expected to mature after one year through five years of the balance sheet date and are categorized neither as held-to-maturity nor trading securities. Unrealized Net - Maturities after one year through five years Available For Sale Securities Debt Maturities After Five Through Ten Years Unrealized Gains Losses Net This item represents the net unrealized gains and losses of debt securities which are expected to mature after five years through ten years of the balance sheet date and are categorized neither as held-to-maturity nor trading securities. Unrealized Net - Maturities after five years through ten years Number Of Marketable Securities Held Disclosure of the number of marketable securities held as of the reporting date. Number of marketable securities held Accrued Clinical Trial Expense Current Carrying value as of the balance sheet date of obligations incurred (and for which invoices have not been received) in connection with clinical trials. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued clinical trial expense Accrued Property Plant And Equipment Expenditures Current Carrying value as of the balance sheet date of obligations incurred (and for which invoices have not been received) in connection with expenditures on property, plant and equipment. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued property, plant, and equipment costs Accounts Payable To Healthcare Company Current Carrying value as of the balance sheet date of amounts due to Bayer HealthCare under a collaboration agreement with the Company. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Payable to Bayer HealthCare Schedule of Inventory, Current and Noncurrent [Table Text Block] Tabular disclosure of the carrying amount as of the balance sheet date of merchandise, goods, commodities, or supplies held for future sale or to be used in manufacturing, servicing or production process. Tabular disclosure includes inventories not expected to be converted to cash, sold or exchanged within the normal operating cycle. Inventories Inventory Current and Noncurrent Carrying amount (lower of cost or market) as of the balance sheet date of gross inventories. Also includes inventory balances not expected to be converted to cash, sold or exchanged within one year. Total inventories Maximum amount of substantive milestone payments that may be received relating to marketing approvals The maximum amount of substantive milestone payments the Company may receive under the collaboration agreement related to receipt of specified marketing approvals. Maximum amount of substantive milestone payments that may be received relating to marketing approvals Maximum amount of milestone payments that may be received relating to marketing approvals Maximum Amount Of Substantive Milestone Payments That May Be Received In U S Or European Union The maximum amount of substantive milestone payments the Company may receive under the collaboration agreement related to receipt of specified marketing approvals in the U.S. or the European Union. Maximum amount of substantive milestone payments that may be received relating to marketing approvals in the U.S. or European Union Maximum amount of milestone payments that may be received relating to marketing approvals in the U.S. or European Union Maximum Number Of Product Candidates For Which Substantive Milestone Payments May Be Received In U S Or European Union The maximum number of product candidates for which substantive milestone payments may be received under the collaboration agreement related to specified marketing approvals in the U.S. or European Union. Maximum number of product candidates for which substantive milestone payments may be received relating to marketing approvals in the U.S. or European Union Maximum number of product candidates for which milestone payments may be received relating to marketing approvals in the U.S. or European Union Maximum amount of substantive milestone payments that may be received in Japan The maximum amount of substantive milestone payments the Company may receive under the collaboration agreement related to receipt of specified marketing approvals in Japan. Maximum amount of substantive milestone payments that may be received relating to marketing approvals in Japan Maximum amount of milestone payments that may be received relating to marketing approvals in Japan Maximum number of product candidates for which substantive milestone payments may be received in Japan The maximum number of product candidates for which substantive milestone payments may be received under the collaboration agreement related to specified marketing approvals in Japan. Maximum number of product candidates for which substantive milestone payments may be received relating to marketing approvals in Japan Maximum number of product candidates for which milestone payments may be received relating to marketing approvals in Japan Substantive Milestone Payment To Company Under Certain Defined Circumstances The amount of the substantive milestone payment to be made by the collaborating company to the entity, under certain defined circumstances. Amount of the substantive milestone payment to be made by the collaborating company to the entity, under certain defined circumstances Adjustments To Additional Paid In Capital Cost Of Bond Hedge And Warrants Net Adjustment to additional paid in capital from the cost of the convertible note hedge and warrant transactions, net. Cost of bond hedge and warrant transactions, net Cost of bond hedge and warrant transactions, net Cost of call spread options, net Technology Licensing Agreements [Abstract] Technology Licensing Agreements [Text Block] The entire disclosure pertaining to the terms of agreements to allow other parties to utilize the Company's technology, under a licensing arrangement. Technology Licensing Agreements Executive Stock Purchase Plan [Abstract] Executive Stock Purchase Plan [Text Block] The entire disclosure pertaining to the Executive Stock Purchase Plan, including a description of the plan and share activity under the plan. Executive Stock Purchase Plan Employee Savings Plan [Text Block] The entire disclosure pertaining to the entity's defined contribution plan, the 401(k) Savings Plan. Employee Savings Plan Facility lease obligations noncurrent Represents the noncurrent portion of a lease liability. In connection with the application of FASB authoritative guidance to the Company's lease of additional new facilities, the Company is deemed, in substance, to be the owner of the landlord's building; therefore, costs of constructing the facilities were capitalized, offset by a corresponding lease obligation. Facility lease obligations Proceeds from facility lease obligations The cash inflow from proceeds received from lessor related to the construction of facilities associated with a building lease. Proceeds in connection with facility lease obligation Payments in connection with facility lease obligations The cash outflow for payments made to lessor related to a building lease. Payments in connection with facility lease obligation Proceeds from Convertible Debt Net of Issuance Costs Net proceeds from the issuance of convertible notes, after deducting the initial purchaser's discount and payments made to third parties related to offering expenses. Proceeds in connection with issuance of convertible notes, net of debt issuance costs Net proceeds from offering, net of discount and issuance costs Estimated useful lives of property, plant, and equipment [Table Text Block] Tabular disclosure of the estimated useful lives of property, plant, and equipment. Estimated Useful Lives of Property, Plant, and Equipment Percentage of start-up costs of total contract value, minimum The typical minimum percentage of start-up costs to total contract value. Percentage of start-up costs of total contract value, minimum (in hundredths) Percentage of start-up costs of total contract value, maximum The typical maximum percentage of start-up costs to total contract value. Percentage of start-up costs of total contract value, maximum (in hundredths) Milestone Method of Revenue Recognition [Policy Text Block] Disclosure of accounting policy for recognizing revenue under the milestone method. The disclosure may encompass the factors taken into consideration in determining whether a payment is deemed to be a substantive performance milestone, as well as the treatment of payments for achieving milestones which are not considered substantive. Milestone Method of Revenue Recognition Maximum Amount Of Substantive Milestone Payments That May Be Received In Major Market Countries Outside The U S The maximum amount of substantive milestone payments the Company may receive under the collaboration agreement relating to marketing approvals in major market countries outside the U.S. Maximum amount of substantive milestone payments that may be received relating to marketing approvals in major market countries outside the U.S. Maximum amount of milestone payments that may be received related to marketing approvals in major market countries outside the U.S. Non-exclusive license agreement term The term (in years) of the non-exclusive license agreement. Non-exclusive license agreement term (in years) Number of annual payments not received due to cancellation of obligation The number of annual payments not paid to the Company due to the termination of the licensing agreement. Advance payment received due to amended licensing agreement The amount of up-front payment made to the Company under the terms of the amended licensing agreement with Astellas Pharma Inc. Advance payment received due to amended licensing agreement with Astellas Pharma Inc Number of days of advance written notice to terminate agreement The number of days the licensee must provide advance written notice in order to terminate the licensing agreement. Number of days of advance written notice to terminate agreement (in days) Annual, non-refundable licensing payment received The amount of non-refundable payment made annually to the Company under the terms of the licensing agreement. Annual, non-refundable licensing payment received Recognition period for advance payment The revenue recognition period (in years) of the up-front payment the Company received under the terms of the amended licensing agreement. This payment was deferred upon receipt and will be recognized as revenue ratably, beginning in mid-2011. Recognition period for advance payment (in years) Period over which annual payment is recognized as revenue The ensuing period (in months) over which each annual payment is ratably recognized as revenue. Period over which annual payment is recognized as revenue (in months) U S Government Obligations Fair Value Disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents Available-for-sale Securities which consist of investments in U.S. government obligations neither classified as trading or held-to-maturity securities. U.S. government obligations U S Government Guaranteed Corporate Bonds Fair Value Disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents Available-for-sale Securities which consist of investments in U.S. government guaranteed corporate bonds neither classified as trading or held-to-maturity securities. U.S. government guaranteed corporate bonds U S Government Guaranteed Collateralized Mortgage Obligations Fair Value Disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents Available-for-sale Securities which consist of investments in U.S. government guaranteed collateralized mortgage obligations neither classified as trading or held-to-maturity securities. U.S. government guaranteed collateralized mortgage obligations Municipal bonds fair value disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents Available-for-sale Securities which consist of investments in municipal bonds neither classified as trading or held-to-maturity securities. Municipal bonds Mortgage-backed securities fair value disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents Available-for-sale Securities which consist of investments in mortgage-backed securities neither classified as trading or held-to-maturity securities. Mortgage-backed securities Equity security fair value disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents Available-for-sale Securities which consist of investments in equity securities neither classified as trading or held-to-maturity securities. Equity security Deferred revenue - other, noncurrent The noncurrent portion of other deferred revenue as of balance sheet date. Deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized, and is not expected to be recognized in the next twelve months. Does not include deferred revenue from Sanofi, noncurrent portion. Deferred revenue - other Deferred revenue - other, current The carrying amount of other consideration received or receivable as of the balance sheet date on potential earnings that were not recognized as revenue, and which are expected to be recognized as revenuech within one year or the normal operating cycle, if longer. Does not include deferred revenue from Sanofi, current portion. Deferred revenue - other, current portion Change in accounting estimate, decrease in depreciation expense The decrease to depreciation expense effected by a change in accounting estimate. Change in accounting estimate, decrease in net loss per share The decrease in net loss per share effected by a change in accounting estimate. Change in accounting estimate, decrease in net loss per share (in dollars per share) Debt Instrument Option period The option period (in days) granted to the initial purchaser to purchase a specified additional aggregate principal amount of notes. Option period (in days) Debt Instrument Additional principal amount that may be purchased during option period The additional aggregate principal amount of notes that may be purchased by the initial purchaser during the option period. Additional principal amount that may be purchased during option period Debt instrument convertible Increment of principal amount of conversion The increment of principal amount of conversion on which the initial conversion rate is based. Increment of principal amount of conversion Debt instrument Conversion premium above the closing price common stock The conversion premium above the closing price of the Company's shares of common stock. Conversion premium above the closing price of the Company's shares of common stock (in hundredths) Closing price of common stock The closing price of the Company's shares of common stock. Closing price of common stock (in dollars per share) Debt instrument Percentage of principal value that holders can require Company to repurchase The percentage of the principal value that the holders can require the Company to purchase in the event of a "fundamental change". Percentage of principal value that holders can require the Company to repurchase (in hundredths) Percentage of strike price above the closing sale price of common stock The percentage of the strike price of the warrant transaction above the closing sale price of the Company's common stock. Percentage of strike price above the closing sale price of common stock (in dollars per share) Net proceeds if the initial purchaser exercises its option to purchase additional notes in full The approximate net proceeds from the issuance of convertible debt if the initial purchaser exercises its option to purchase additional notes in full. Percentage of outstanding shares of common stock related to prohibition on selling to beneficial owners The percentage of outstanding shares of Common Stock related to the prohibition on selling to beneficial owners, or persons that would become beneficial owners as a result of such sale, following December 20, 2017, under the amended investor agreement. Percentage of outstanding shares of Common Stock related to prohibition on selling to beneficial owners (in hundredths) Number of demand rights under the amended investor agreement The number of demand rights, under the amended investor agreement with Sanofi, to require the Company to use all reasonable efforts to conduct a registered underwritten public offering with respect to share of the Company's Common Stock beneficially owned by Sanofi immediately after the closing of the transaction. Number of new buildings leased The number of newly constructed buildings leased by the Company. For these new buildings, the Company is deemed, in substance, to be the owner of the landlord's buildings in accordance with the application of FASB authoritative guidance, and the landlord's costs of constructing these new facilities are required to be capitalized on the Company's books as a non-cash transaction, offset by a corresponding lease obligation on the Company's balance sheet. Cash and marketable debt securities collateral The carrying amount of cash and marketable debt securities serving as collateral for the letter of credit amount outstanding in connection with the operating lease. Rental charges for utilities, real estate taxes, and operating expense The total amount of rental charges for utilities, real estate taxes, and operating expense for the period. Imputed interest rate applicable to facility lease obligation The imputed interest rate applicable to the facility lease obligation. Imputed interest rate applicable to the facility lease obligation (in hundredths) Facility lease obligation Represents the current and noncurrent portion of a lease liability. In connection with the application of FASB authoritative guidance to the Company's lease of additional facilities, the Company is deemed, in substance, to be the owner of the landlord's building; therefore, costs of constructing the facilities were capitalized, offset by a corresponding lease obligation. Royalty rate maximum The maximum royalty rate to be paid by the Company under the agreement. Royalty rate, maximum (in hundredths) Royalty rate minimum The minimum royalty rate to be paid by the Company under the agreement. Royalty rate, minimum (in hundredths) Termination notice minimum The minimum period of written notice (in days) to terminate certain agreements under which the Company is required to pay fees. Termination notice, minimum (in days) Termination notice, maximum The maximum period of written notice (in days) to terminate certain agreements under which the Company is required to pay fees. Termination notice, maximum (in days) Non-refundable advance payment made under license agreement Non-refundable advance payment made by the Company upon resolution of a dispute between the parties related to the interpretation of a license agreement. Amortization of advance payment Recognized amortization expense in connection with the non-refundable advance payment made under the license agreement. Unamortized balance of advance payment The unamortized balance of the advance payment made under the license agreement. Facility Leases, Future Minimum Payments Due [Abstract] Commitments under facility leases [Abstract] Facility Leases, Future Minimum Payments Due, current Contractually required payments related to facility lease obligations, due within one year from the balance sheet date. 2012 Facility Leases, Future Minimum Payments Due, due in two years Contractually required payments related to facility lease obligations, due within the second year from the balance sheet date. 2013 Facility Leases, Future Minimum Payments Due, due in three years Contractually required payments related to facility lease obligations, due within the third year from the balance sheet date. 2014 Facility Leases, Future Minimum Payments Due, due in four years Contractually required payments related to facility lease obligations, due within the fourth year from the balance sheet date. 2015 Facility Leases, Future Minimum Payments Due, due in five years Contractually required payments related to facility lease obligations, due within the fifth year from the balance sheet date. 2016 Facility Leases, Future Minimum Payments Due, due thereafter Contractually required payments related to facility lease obligations, due after the fifth year from the balance sheet date. Thereafter Facility Leases, Future Minimum Payments Due The total contractually required payments related to facility lease obligations. Total Commitments Under Facility lease Obligations [Table Text Block] Tabular disclosure of the commitments required in the aggregate and for each of the five succeeding fiscal years under facility lease obligations having noncancelable lease terms. Commitments Under Facility Lease Obligations Marketable debt securities collateral The carrying amount of marketable debt securities serving as collateral for the capital lease obligations. Facility lease obligations [Abstract] Reimbursements recognized as additional facility lease obligation Reimbursements from the Company's landlord for tenant improvement costs recognized as additional facility lease obligation. Interest expense in connection with facility lease obligation Interest expense recognized during the period in connection with facility lease obligation. Facility lease obligation, including reimbursements The facility lease obligation balance as of the reporting date. Facility lease obligation Research collaboration and licensing agreements [Abstract] Future amortization expense of advance payment [Abstract] Future Expense Of Advance Payment Year One The amount of expense in connection with the advance payment under the license agreement that is expected to be recognized during year one of the five succeeding fiscal years. 2012 Future Expense Of Advance Payment Year Two The amount of expense in connection with the advance payment under the license agreement, expected to be recognized during year two of the five succeeding fiscal years. 2013 Future Expense Of Advance Payment Year Three The amount of expense in connection with the advance payment under the license agreement, expected to be recognized during year three of the five succeeding fiscal years. 2014 Future Expense Of Advance Payment Year Four The amount of expense in connection with the advance payment under the license agreement, expected to be recognized during year four of the five succeeding fiscal years. 2015 Future Expense Of Advance Payment Year Five The amount of expense in connection with the advance payment under the license agreement, expected to be recognized during year five of the five succeeding fiscal years. 2016 Description of period of 'standstill' provisions A description of the period of time over which certain 'standstill' provisions are in effect, under the amended investor agreement with the Company. Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions The maximum percentage of outstanding shares of the Company's Class A Stock and Common Stock that may be acquired under the 'standstill' provisions, in effect after the specified date. Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions (in hundredths) Volume limitation of sales of Common Stock The volume limitation of sales of the Company's Common Stock, every three months, following December 20, 2017, under the amended investor agreement. Volume limitation of sales of Common Stock (in shares) Percentage Of Outstanding Shares Or Voting Rights Under Amended Investor Agreement The percentage of the then outstanding shares or voting rights of the Company's Class A Stock and Common Stock, which if a stock issuance equals or exceeds such amount, Sanofi has not contractually agreed to vote, and cause its affiliates to vote, either as recommended by the Company's board of directors or proportionally with the votes cast by the Company's other shareholders. Percentage of outstanding shares or voting rights under the amended investor agreement (in hundredths) Number of newly issued, unregistered shares of Common Stock purchased The number of unregistered shares issued of the Company's Common Stock purchased in connection with the Sanofi collaboration agreement. Number of newly issued, unregistered shares of Common Stock purchased (in shares) Cash price of newly issued, unregistered shares of Common Stock purchased The cash price of the unregistered shares issued of the Company's Common Stock purchased in connection with the Sanofi collaboration agreement. Deferred Tax Assets Deferred Expense Capitalized Research And Development Costs The tax effect as of the balance sheet date of the amount of the estimated future tax deductions attributable to research and development costs capitalized for tax purposes, which can only be realized if sufficient taxable income is generated in future periods to enable the deduction to be taken. Capitalized research and development costs Deferred Tax Assets, Property, Plant and Equipment The tax effect as of the balance sheet date of the amount of the estimated future tax deductions attributable to property, plant and equipment which can only be realized if sufficient taxable income is generated in future periods to enable the deduction to be taken. Fixed assets Net Operating Loss Carry-forwards, Exercises of Nonqualified Stock Options and Disqualifying Dispositions of Incentive Stock Options The amount of net operating loss carryforwards, before tax effects, available to reduce future taxable income under enacted tax laws attributable to exercises of Nonqualified Stock Options and disqualifying dispositions of Incentive Stock Options. Net operating loss carry-forwards related to exercises of Nonqualified Stock Options and disqualifying dispositions of Incentive Stock Options Income Tax Expense Benefit Resulting from Provision in Housing Assistance Tax Act of 2008 The amount of the current income tax expense or benefit and the deferred income tax expense or benefit attributable to a provision in Housing Assistance Tax Act of 2008 that allowed the Company to claim a refund for a portion of its unused pre-2006 research tax credits on its 2008 U.S. federal income tax return. Income tax expense (benefit) resulting from provision in Housing Assistance Tax Act of 2008 Income Tax Expense Benefit Resulting from Provision in Worker, Homeownership, and Business Assistance Act of 2009 The amount of the current income tax expense or benefit and the deferred income tax expense or benefit attributable to a provision in the Worker, Homeownership, and Business Assistance Act of 2009 that allows the Company to claim a refund of U.S. federal alternative minimum tax (AMT) that the Company paid in connection with its 2007 U.S. federal income tax return. Income tax expense (benefit) resulting from provision in Worker, Homeownership, and Business Assistance Act of 2009 Income Tax Expense Benefit Resulting from Provision in American Recovery and Reinvestment Act of 2009 The amount of the current income tax expense or benefit and the deferred income tax expense or benefit attributable to a provision in the American Recovery and Reinvestment Act of 2009 that allows the Company to claim a refund for a portion of its unused pre-2006 research tax credits on its 2009 U.S. federal income tax return. Income tax expense (benefit) resulting from provision in American Recovery and Reinvestment Act of 2009 Research And Development Costs Capitalized Amount of research and development costs capitalized during the period for tax purposes only, which are amortized over future periods. Capitalized research and development costs Capitalized Research and Development Costs, Amortization Period The amortization period for research and development costs capitalized for tax purposes only. Capitalized research and development costs, amortization period (in years) Share Based Compensation Arrangement By Share Based Payment Award Options Nonvested Number The number of non-vested stock (or unit) options, as of the balance sheet date. Number of unvested options (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Expected To Vest Upon Achieving Sales Targets The number of non-vested stock (or unit) options that are expected to vest upon achieving certain defined sales targets for the Company's products, subject to the optionee satisfying certain service conditions. Number of options expected to vest upon achieving sales targets (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Expected to Vest Upon Achieving Development Milestones The number of non-vested stock (or unit) options that would vest upon achieving certain development milestones for the Company's product candidates, subject to the optionee satisfying certain service conditions. Number of options that would vest upon achieving certain development milestones (in shares) Employee Service Share Based Compensation Nonvested Options Potential Compensation Cost As of the balance sheet date, the aggregate unrecognized potential compensation cost, which will begin to be recognized only if, and when, the Company estimates that it is probable that these options will vest. Potential compensation cost to be recognized if vesting is probable Share Based Compensation Arrangement By Share Based Payment Award Period From Vesting Date Awards May Be Received The period (in days) from the vesting date during which the Participant has the right to receive, an amount, in cash and/or shares of the Company's Common Stock as determined by the Committee, equal to the sum of the fair market value of a share of Common Stock on the date such share of Phantom Stock vests and the aggregate amount of cash dividends paid with respect to a share of Common Stock during the period from the grant date of the share of Phantom Stock to the date on which the share vests. Period within vesting date that awards may be received (in days) Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted-Average Exercise Prices and Weighted Average Grant Date Fair Value [Table Text Block] Tabular disclosure of the weighted-average exercise prices and weighted-average grant-date fair value of equity options or other equity instruments granted during the year. Weighted-Average Exercise Prices and Weighted-Average Grant-Date Fair Values of Options Issued Share Based Compensation Arrangement By Share Based Payment Award Award Expiration The term (in years) when the equity-based award expires as specified in the award agreement. Maximum term of awards (in years) Exercise price equal to Market Price [Abstract] Estimated percentage of options issued that will vest The estimated percentage of options issued that will vest, since the Company considers these options' performance conditions to be probable of attainment. Estimated percentage of options issued that will vest (in hundredths) Amount of non-refundable payment received for collaboration agreement The amount of non-refundable payment received in relation to the collaboration agreement. May be an up-front payment, termination payment, and/or payment made in connection to an amendment to the agreement. Royalty based on percentage of annual sales in Japan The royalty percentage on annual sales in Japan that the Company is entitled to receive, subject to certain potential adjustments. Royalty based on percentage of annual sales in Japan (in hundredths) Percentage of development expenses to be reimbursed due to profitability of collaboration agreement The percentage of development expenses to be reimbursed if the collaboration become profitable. Percentage of development expenses to be reimbursed due to profitability of agreement (in hundredths) Number of years of first commercial sale under the collaboration agreement The number of years of the first commercial sale under the collaboration agreement. If the first commercial sale in Intraocular Delivery predates this period, then the Company will begin reimbursing development expenses in accordance with a formula until the first commercial sale under the collaboration occurs. Number of years of first commercial sale of the product (in years) Reimbursement of development expenses in accordance with formula until first commercial sale The maximum amount of development expenses to be reimbursed in accordance with a formula until the first commercial sale under the collaboration, if the first commercial sale in Intraocular Delivery predates the first commercial sale by two years. Excess Share of profit not required to to be applied to reimburse development cost The excess percentage of profits from collaboration not required to be used to reimburse development cost in any calendar quarter. Excess share of profit not required to to be applied to reimburse development cost (in hundredths) Amount of funding of agreed-upon cost incurred to expand manufacturing capacity The amount of funding of agreed-upon costs incurred by the Company to expand its manufacturing capacity. Starting specified levels of annual sales at which sales milestone payments may be received The starting specified levels of total annual sales outside the United States at which the Company may be eligible to receive sales milestone payments. Minimum amount of research funding The minimum amount of funding provided for research under the grant. Period of funding The period (in years) of the grant. Period of funding (in years) Additional funding to optimize certain existing technology The amount of funding provided to optimize certain existing technology, subject to compliance with its terms and annual funding approvals. Development expenses incurred to date The amount of development expenses incurred by both companies under the collaboration agreement, to date. Minimum advance notice required to terminate collaboration agreement The minimum advance notice required of the collaborating party to terminate the agreement without cause. Increase decrease in collaboration revenue recognized based on shortened extended performance period The increase (decrease) in collaboration revenue recognized due to the shortening or extending of the related performance period in connection with the payments received. Increase (decrease) in collaboration revenue recognized based on shortened (extended) performance period Amount of research funded from inception, to date The amount of research funded from inception of the collaboration, to date. Annual funding maximum of research activities per amended agreement The maximum annual amount of funding for research activities through 2017 per the amended agreement. Annual funding maximum of research activities through 2017 per amended agreement Adjusted maximum amount of annual funding per amended agreement The adjusted maximum amount of annual funding per the amended agreement, commencing in 2014, if over the prior two years certain specified criteria were not satisfied. Amount of research funded during the period The amount of research funded during the period, under the amended agreement. Balance between amount funded and annual funding maximum The balance between the amount of research funded during the period and the annual funding maximum, under the amended agreement. Option to extend The period (in years) available to the collaborating party to extend the agreement. Option to extend (in years) Number of therapeutic antibodies currently under development The number of therapeutic antibodies currently being co-developed under the agreement. Percentage of Trial Costs borne by collaborating party The percentage of subsequent Shared Phase 3 Trial costs borne by the collaborating party upon receipt of the first positive Phase 3 trial results for a co-developed drug candidate. Percentage of Shared Phase 3 Trial Costs borne by collaborating party (in hundredths) Percentage of Trial Costs borne by entity The percentage of subsequent Shared Phase 3 Trial costs borne by the Company upon receipt of the first positive Phase 3 trial results for a co-developed drug candidate. Percentage of Shared Phase 3 Trial Costs borne by entity (in hundredths) Percentage of trial costs to be reimbursed due to profitability of agreement The percentage of Shared Phase 3 trial costs to be reimbursed due to profitability of agreement. Percentage of Shared Phase 3 Trial Costs to be reimbursed due to profitability of agreement Starting share of profits outside the United States, based on sales, for collaborating party On a sliding scale, this element represents the starting share of profits outside the United States, based on sales, for the collaborating party. Starting share of profits outside the United States, based on sales, for collaborating party (in hundredths) Starting share of profits outside the United States, based on sales, for Company On a sliding scale, this element represents the starting share of profits outside the United States, based on sales, for the Company. Starting share of profits outside the United States, based on sales, for Company (in hundredths) Ending share of profits outside the United States, based on sales, for collaborating party On a sliding scale, this element represents the ending share of profits outside the United States, based on sales, for the collaborating party. Ending share of profits outside the United States, based on sales, for collaborating party (in hundredths) Ending share of profits outside the United States, based on sales, for Company On a sliding scale, this element represents the ending share of profits outside the United States, based on sales, for the Company. Ending share of profits outside the United States, based on sales, for Company (in hundredths) Share of losses outside the United States, for collaborating party This element represents the share of losses outside the United States for the collaborating party. Share of losses outside the United States, for collaborating party (in hundredths) Share of losses outside the United States, for Company This element represents the share of losses outside the United States for the Company. Share of losses outside the United States, for Company (in hundredths) Period of notice to opt-out of further development and/or commercialization The period of notice (in months) for either party under the agreement to opt-out of further development and/or commercialization of each antibody product which enters development. Period of notice to opt-out of further development and/or commercialization (in months) Period of notice to opt-out of further development upon entering of joint development product The notice period (in days) that the Company must give to exercise its option to opt-out of further development with respect to each antibody product which enters development. Period of notice to opt-out of further development upon entering of joint development product (in days) Minimum payments expected to be received under the agreement The minimum amount of payments expected to be received under the agreement. Amount of Milestone payments earned The amount of milestone payments earned during the period. Amount of milestone payments earned Maximum amount of sales milestone payments if total sales achieve specific levels The maximum amount of sales milestone payments the Company is eligible to receive when and if total annual sales outside the United States achieve certain specified levels. Development expenses that were shared equally The amount of development expenses incurred by both companies, under a global development plan, that were shared equally. Development expenses for which the Company was solely responsible The amount of development expenses for which the Company was solely responsible. Additional research and development expenses obligated to reimburse The amount of additional research and development expenses the Company was obligated to reimburse to the collaborating party. Milestone payment receivable The amount of milestone payment receivable from the collaborating party. Conditions for commencement of sales milestone payments A description of the conditions for which sales milestone payments will commence. Amount of funding to expand manufacturing capacity that has been received or is receivable The amount of funding to expand manufacturing capacity that has been received or is receivable. Number of substantive milestone payments earned The number of substantive milestone payments earned during the period. Future payment to be made under terms of amended licensing agreement The amount of future payment to be made to the Company in June 2018 under the terms of the amended licensing agreement, unless the license agreement is terminated prior to that date. Future payment to be made to the Company under the terms of the amended licensing agreement Finished goods held at Distributors/Special Pharmacies The amount of the finished goods balance as of the reporting date held at Distributors/Special Pharmacies. Finished goods held at Distributors/SPs Depreciation And Amortization Less Amounts Capitalized The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets, less the amount of expense capitalized in inventory. Depreciation and amortization Debt Instrument Convertible Fair Value Of Liability Component The estimated fair value of the liability component of convertible debt as of the date of issuance. Estimated fair value of the Liability Component Net Cost Of Convertible Note Hedge And Warrant Transactions The cost of the convertible note hedge net of the proceeds received from the sale of the warrant transaction. Net cost of the convertible note hedge and warrant transactions Stock Issued During Period Value Stock Options Exercised Net Of Shares Tendered Value of stock issued during the period as a result of the exercise of stock options, net of shares tendered. Issuance of Common Stock in connection with exercise of stock options, net of shares tendered Stock Issued During Period Shares Stock Options Exercised Net Of Shares Tendered Number of share options (or share units) exercised during the current period, net of shares tendered. Issuance of Common Stock in connection with exercise of stock options, net of shares tendered (in shares) Amount of payment to be made upon reaching minimum sales target The amount of payment to be made by the Company upon cumulative U.S. sales of EYLEA reaching a minimum sales target, under the terms of the non-exclusive license agreement. Cumulative Sales Range Minimum The minimum amount of cumulative U.S. sales of EYLEA which would require the Company to make payments. Cumulative sales range, minimum Royalty Payment Percentage Of Cumulative Sales Within Range Royalty payment percentage to be made on cumulative U.S. sales of EYLEA within the cumulative sales range, under the terms of the non-exclusive license agreement. Royalty payment percentage of cumulative sales within cumulative sales range (in hundredths) Cumulative Sales Range Maximum The maximum amount of cumulative U.S. sales of EYLEA within the range, which will require the Company to make royalty payments of 4.75%. Cumulative sales range, maximum Royalty Payment Percentage Of Cumulative Sales Over Range Percentage of royalty payment to be made on cumulative U.S. sales of EYLEA over the cumulative sales range, under the terms of the non-exclusive license agreement. Royalty payment percentage of cumulative sales over range (in hundredths) Maximum amount of milestone payments that may be received if certain sales are achieved The maximum amount of milestone payments that may be received commencing only if and after aggregate annual sales outside the U.S. exceed $1.0 billion on a rolling 12-month basis. Number Of Options That Vested Upon Attainment Of Performance Conditions The number of options that vested during the period upon attainment of performance conditions. Number of options that vested upon attainment of performance conditions (in shares) Non-cash stock-based compensation expense recognized for options vested upon attainment of performance conditions The amount of non-cash stock-based compensation expense recognized for options that vested during the period upon attainment of performance conditions. Net deferred tax assets liabilities gross For entities that net deferred tax assets and tax liabilities, represents the unclassified net amount of deferred tax assets and liabilities as of the balance sheet date, PRIOR to deducting any valuation allowance, which results from applying the applicable enacted tax rate to net temporary differences and carryforwards pertaining to assets or liabilities. Net deferred tax assets Net carrying amount of the liability component [Abstract] Interest Expense Associated with Convertible Notes [Table Text Block] Tabular disclosure of the components of interest expense associated with Convertible notes, including the contractual coupon interest rate and amortization of discount and note issuance costs. Interest Expense Associated with Convertible Notes Furniture, Computer and Office Equipment, and Other [Member] Long lived, depreciable assets not directly used in the production process for inventories or facilities. New Laboratory and Office Facilities [Member] Construction of new laboratory and office facilities in Tarrytown, New York in connection with the Company's December 2006 lease, as amended, of these new facilities. Collaboration Agreement with Bayer HealthCare LLC [Member] Collaboration agreement with Bayer HealthCare LLC. Grant from National Institutes of Health [Member] Information pertaining to a grant awarded by the National Institutes of Health (NIH) as part of the NIH's Knockout Mouse Project. Collaboration Agreement with Sanofi [Member] Collaboration agreement with Sanofi. Aflibercept Agreement [Member] In September 2003, the Company entered into a collaboration agreement (the Aflibercept Agreement) with Aventis Pharmaceuticals Inc. (predecessor to Sanofi), to jointly develop and commercialize aflibercept. ZALTRAP Agreement [Memeber] Antibody Collaboration [Member] In November 2007, the Company entered into a global, strategic collaboration (the Antibody Collaboration) with Sanofi to discover, develop, and commercialize fully human monoclonal antibodies. VelociGene Agreement [Member] In August 2008, the Company entered into a separate agreement with Sanofi to use Regeneron's proprietary VelociGene technology platform to supply Sanofi with genetically modified mammalian models of gene function and disease (the VelociGene Agreement). Research and Development Arrangement, Contract to Perform for Others by Product [Axis] Significant terms of research and development arrangements accounted for as a contract to perform research and development for others, by product. Research and Development Arrangement, Contract to Perform for Others, By Product [Domain] Listing of significant agreements under research and development arrangements, by product, accounted for as a contract to perform research and development for others. Other Deferred Revenue Agreements [Member] Other category of deferred revenue agreements not otherwise specified in the taxonomy. License Agreement with Astellas Pharma Inc [Member] License Agreement with Astellas Pharma Inc. [Member] Category of deferred revenue by arrangement wherein certain rights are granted to Astellas Pharma Inc. under a license agreement to exploit the Company's technology, under which fees received are taken into income as revenue recognition criteria are met. License Agreement with AstraZeneca UK Limited [Member] Category of deferred revenue by arrangement wherein certain rights are granted to AstraZeneca UK Limited under a license agreement to exploit the Company's technology, under which fees received are taken into income as revenue recognition criteria are met. EYLEA Net Product Sales [Member] Revenue during the period derived from a specified product line (EYLEA), after deducting applicable provisions for discounts, returns, rebates, chargebacks, distribution fees, and other sales-related deductions. Gross Product Revenue [Member] Gross product revenue during the period when it serves as a benchmark in a concentration of risk calculation. Total Revenue [Member] Total revenue during the period when it serves as a benchmark in a concentration of risk calculation. U S Government Guaranteed Corporate Bonds [Member] U.S. Government Guaranteed Corporate Bonds [Member] This category includes investments in debt securities issued by corporations that are guaranteed by the U.S. Government. Unrestricted [Member] Investments whose use is not restricted in whole or in part, by contractual agreements or regulatory requirements. Restricted [Member] Investments whose use is restricted in whole or in part, generally by contractual agreements or regulatory requirements. Classification of Investment [Axis] This element represents the general categories of investments, which may be classified as Unrestricted or Restricted. Classification of Investment [Domain] Provides general categories of investments for which information is required or determined to be disclosed. Warrant Transactions [Member] Warrant transactions entered into in connection with the offering of the convertible senior notes. Tarrytown Lease [Member] A lease agreement, as amended, under which the Company leases laboratory and office facilities in Tarrytown, New York. Name of Lease [Axis] The name of the lease for which pertinent information is disclosed. Name of Lease [Domain] The name of the lease for which pertinent information is disclosed. Facilities Buildings A and B [Member] Buildings A and B [Member] Facility lease obligations pertaining to office and laboratory facilities in Buildings A and B in Tarrytown, New York. Facilities Building C [Member] Building C [Member] Facility lease obligations pertaining to office and laboratory facilities in Building C in Tarrytown, New York. Schedule of Facility Leases [Table] Facility Lease Obligations [Axis] Facility lease obligations, by facility. Facility Lease Obligations, Name [Domain] The name of the facilities leased under facility lease obligations. Schedule of Facility Leases [Line Items] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Agreements with Royalty Provisions [Member] Certain research collaboration and licensing agreements that contain provisions which require the Company to pay royalties, as defined, in the event the Company sells or licenses any proprietary products developed under agreement. Agreements with Fee Provisions [Member] Certain research collaboration and licensing agreements under which the Company is required to pay fees. Licensing Agreements Which Require Royalty Payments Based on ARCALYST Net Product Sales [Member] Various licensing agreements which require royalty payments based on ARCALYST net product sales. Cellectis Agreement [Member] An Amended and Restated Non-Exclusive License Agreement entered into with Cellectis S.A. License Agreement With Genentech [Member] A non-exclusive license agreement with Genentech which requires the Company to make certain payments if certain sales targets are exceeded during the term of the agreement. Research Collaboration and Licensing Arrangements [Table] Research Collaboration and Licensing Agreements [Axis] The research collaboration and licensing agreements entered into. Research Collaboration and Licensing Agreements [Domain] Research collaboration and licensing agreements, by name. Research Collaboration and Licensing Arrangements [Line Items] Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Sanofi [Member] Information related to Sanofi. Phantom Stock [Member] Phantom Stock awards provide the Participant the right to receive an amount, in cash and/or shares of the Company's Common Stock as determined by the Committee, equal to the sum of the fair market value of a share of Common Stock on the date such share of Phantom Stock vests and the aggregate amount of cash dividends paid with respect to a share of Common Stock during the period from the grant date of the share of Phantom Stock to the date on which the share vests. Non-Performance Based Stock Options [Member] A stock option whose vesting is not contingent upon performance achievements. Performance-Based Stock Options [Member] A stock option which would vest upon satisfying service conditions, achieving certain defined sales targets of the Company's products or certain development milestones for the Company's product candidates. Incentive Plan 1990 [Member] 1990 Incentive Plan [Member] An equity-based long-term incentive plan established by the Company during 1990, by which employees and nonemployees received awards as determined by a committee of independent directors. Under the provisions of the 1990 Incentive Plan, there will be no future awards from the plan. Awards under the 1990 Incentive Plan consisted of Incentive Stock Options and Nonqualified Stock Options which generally vested on a pro rata basis over a three or five year period and had a term of ten years. Long-Term Incentive Plan 2000 [Member] 2000 Incentive Plan [Member] An equity-based long-term incentive plan established by the Company during 2000, through which employees and nonemployees may receive awards as determined by a committee of independent directors. The awards that may be made under the 2000 Incentive Plan include: (a) Incentive Stock Options (ISOs) and Nonqualified Stock Options, (b) shares of Restricted Stock, (c) shares of Phantom Stock, (d) Stock Bonuses, and (e) Other Awards. Executive Stock Purchase Plan [Member] An Executive Stock Purchase Plan adopted in 1989 which provides for the compensation committee of the board of directors to award employees, directors, consultants, and other individuals who render service to the Company the right to purchase Class A Stock at a price set by the compensation committee. Net Operating Loss Carryforward and Tax Credit Carryforwards [Member] The deferred tax asset for the net operating loss carryforward and tax credit carryforwards. Net Operating Loss Carryforward [Member] The deferred tax asset for the net operating loss carryforward. U S Federal and New York State [Member] U.S. Federal and New York State [Member] The designated tax department of the United States of America government and New York State government entitled to levy and collect income taxes from the entity. Document And Entity Information [Abstract] Entities [Table] Entity Information [Line Items] Restricted Common Stock tendered upon vesting in connection with employee tax obligations Adjustments Related To Tax Withholding For Share Based Compensation Restricted Common Stock tendered upon vesting in connection with employee tax obligations (in shares) Shares Paid For Tax Withholding For Share Based Compensation Adjustment To Additional Paid In Capital Cost Of The Convertible Note Hedge Adjustment to additional paid in capital from the cost of the convertible note hedge. Purchase of convertible note hedges Adjustments To Additiona lPaid In Capita lWarrant Issued Issuance of warrants in connection with issuance of convertible senior notes Other Noncash Income Expense Other non-cash charges and expenses, net Increase Decrease In Restricted Cash And Investments (Increase) decrease in restricted cash and marketable securities Percentage Of Prompt Pay Discount The Compay Accrues The percentage of the prompt pay discount that the Company accrues that is based on the gross amount of the product invoice, at the time of sale. Government Rebate and Chargeback Accruals The Company's government rebate and chargeback accruals, which was based on a percentage of gross sales. Distribution-Related Fees Accruals The Company's accrual for distribution-related fees, which was based on a percentage of gross sales. Shared Pre-Launch Commercialization Expenses With Collaborator Shared product pre-launch commercialization expenses under the collaboration agreement. Arcalyst Net Product Sales Member ARCALYST Net Product Sales [Member] Costs incurred by the landlord to construct new laboratory and office facilities Costs incurred by the landlord to construct new laboratory and office facilities which are included in PP and E Purchase of convertible note hedges Adjustments to additonal paid in capital from the cost of the convertible note hedge. Gross proceeds from the issuance of the Notes Gross proceeds from the issuance of the Notes. Debtinstrumentissuanceatpercentofpar The percentage of par value at which the debt instrument is issued Percentage of par value at which the debt instrument is issued Unrecognized Tax Benefits Decreases Resulting From Settlements With Taxing Authorities Gross decreases due to settlements and lapse of statute of limitations Company-incurred expenses associated with Sanofi collaborations Total Company-incurred expenses associated with Sanofi collaborations, which include reimbursable and non-reimbursable amounts and an allocable portion of general and administrative costs. Inventory write down Inventory write down Number of shares of Common Stock purchased (in shares) Total number of shares of the Company's Common Stock held by Sanofi, principally in connection with the companies' ZALTRAP and antibody collaborations. Total number of newly issued unregistered shares of common stock purchased (in shares) Substantive milestone payment to the Company Substantive milstone payment from Sanofi to the Company under certain defined circumstances, upon exercising its option to license rights to particular candidates. Substantive milestone payment to be received if option to license rights is exercised Payable to Bayer HealthCare Carrying value as of the balance sheet date of amounts due to Bayer HealthCare under a collaboration agreement with the Company. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Issuance costs Represents the amount of debt issuance costs, a portion of which was capitalized and a portion of which represented an adjustment to APIC. 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      Income Taxes (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Income Taxes [Abstract]  
      Deferred Tax Assets
      The tax effect of temporary differences, net operating loss carry-forwards, and research and experimental and other tax credit carry-forwards as of December 31, 2011 and 2010 is as follows:



       
                   2011
                   2010
           Deferred tax assets:
      		   
       
      Net operating loss carry-forward
      $282,480
      $243,893
       
      Fixed assets
      14,847
      13,600
       
      Deferred revenue
      120,490
      70,443
       
      Deferred compensation
      47,092
      39,120
       
      Research and experimental and other tax credit carry-forwards
      67,734
      45,588
       
      Capitalized research and development costs
      31,371
      38,865
       
      Other
      15,956
      10,863
       
      579,790
      462,372
           Deferred tax liabilities:
      		 
       
       
      Convertible senior notes
       (1,428)
      		 
           
           Net deferred tax assets:
      578,542
      		 
           Valuation allowance
       (578,542)
      (462,372)
         
                   --
                   --
      Unrecognized Tax Benefits
      The following table summarizes the gross amounts of unrecognized tax benefits at the beginning and end of 2011 and 2010:
         
      2011
      2010
      Balance as of January 1
      		 
      $12,819
      $         -
      Gross increases related to current year tax positions
      		 
      2,192
      3,550
      Gross increases related to prior year tax positions
      		   
      9,269
      Gross decreases due to settlements
      		 
      (9,415)
      _____
      Balance as of December 31
      		 
      $5,596
      $12,819
      XML 16 R54.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Commitments and Contingencies, Research Collaboration and Licensing Agreements (Details) (USD $)
      In Millions, unless otherwise specified
      		 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended
      Dec. 31, 2011
      Agreements with Royalty Provisions [Member]
      Percent
      Dec. 31, 2010
      Agreements with Royalty Provisions [Member]
      Dec. 31, 2009
      Agreements with Royalty Provisions [Member]
      Jul. 31, 2008
      Cellectis Agreement [Member]
      Dec. 31, 2011
      Cellectis Agreement [Member]
      Dec. 31, 2010
      Cellectis Agreement [Member]
      Dec. 31, 2009
      Cellectis Agreement [Member]
      Dec. 31, 2011
      License Agreement With Genentech [Member]
      Percent
      Research collaboration and licensing agreements [Abstract]                
      Royalty rate, minimum (in hundredths) 0.25%              
      Royalty rate, maximum (in hundredths) 16.50%              
      Royalty expense $ 3.2 $ 1.7 $ 1.5          
      Non-refundable advance payment made under license agreement       12.5        
      Amortization of advance payment         1.0 0.9 2.3  
      Unamortized balance of advance payment         5.7 6.6    
      Future amortization expense of advance payment [Abstract]                
      2012         1.0      
      2013         1.0      
      2014         0.9      
      2015         0.9      
      2016         0.9      
      Amount of payment to be made upon reaching minimum sales target               60
      Cumulative sales range, minimum               400
      Royalty payment percentage of cumulative sales within cumulative sales range (in hundredths)               4.75%
      Cumulative sales range, maximum               $ 3,000
      Royalty payment percentage of cumulative sales over range (in hundredths)               5.50%
      XML 17 R48.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Inventory (Details) (USD $)
      		 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Inventory [Abstract]    
      Raw materials $ 1,608,000 $ 592,000
      Work in process 10,806,000 699,000
      Finished goods 1,142,000 132,000
      Total inventories 13,556,000 1,423,000
      Inventories included in prepaid expenses and other current assets 3,500,000  
      Inventories included in other assets 10,100,000  
      Inventory write down $ 500,000  
      XML 18 R55.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Stockholders Equity (Details) (USD $)
      		 1 Months Ended 12 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended
      Oct. 31, 2011
      Oct. 31, 2010
      Dec. 31, 2011
      PerShare
      Dec. 31, 2010
      PerShare
      Dec. 31, 2009
      Oct. 31, 2011
      Warrant Transactions [Member]
      Oct. 31, 2011
      Call Option [Member]
      Oct. 31, 2011
      Convertible Senior Notes [Member]
      Oct. 31, 2010
      Sanofi [Member]
      Nov. 30, 2009
      Sanofi [Member]
      Percent
      Dec. 31, 2007
      Sanofi [Member]
      Jan. 31, 2003
      Sanofi [Member]
      Dec. 31, 2011
      Sanofi [Member]
      Percent
      Dec. 31, 2011
      Class A Stock [Member]
      PerShare
      Dec. 31, 2010
      Class A Stock [Member]
      PerShare
      Class of Stock [Line Items]                              
      Common Stock, shares authorized for issuance (in shares)     160,000,000 160,000,000                   40,000,000 40,000,000
      Common Stock, par value (in dollars per share)     0.001 0.001                   0.001 0.001
      Common Stock, conversion features                           share-for-share basis  
      Common Stock, voting rights     one vote per share                     ten votes per share  
      Preferred stock, authorized (in shares)     30,000,000 30,000,000                      
      Number of newly issued, unregistered shares of Common Stock purchased (in shares)                 1,017,401   12,000,000 2,799,552      
      Cash price of newly issued, unregistered shares of Common Stock purchased                     $ 312,000,000 $ 45,000,000      
      Description of period of 'standstill' provisions                   Until the later of the fifth anniversaries of the expiration or earlier termination of the License and Collaboration Agreement          
      Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions (in hundredths)                   25.00%     30.00%    
      Percentage of outstanding shares of Common Stock related to prohibition on selling to beneficial owners (in hundredths)                   5.00%          
      Percentage of outstanding shares or voting rights under the amended investor agreement (in hundredths)                   10.00%          
      Issuance of Common Stock in a public offering (in shares)   6,325,000                          
      Net proceeds from issuance of Common Stock       174,828,000                      
      Debt Instrument [Line Items]                              
      Principal amount               400,000,000              
      Equity component of convertible senior notes, net of issuance costs 120,623,000                            
      Option Indexed to Issuer's Equity [Line Items]                              
      Purchase of convertible note hedges             117,500,000                
      Class of Warrant or Right [Line Items]                              
      Strike price of the warrant transaction (in dollars per share)           $ 103.41                  
      Proceeds received from the Warrant     $ 93,800,000 $ 0 $ 0                    
      XML 19 R46.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Marketable Securities (Details) (USD $)
      Dec. 31, 2011
      Dec. 31, 2010
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months $ 111,774,000 $ 369,215,000
      Fair Value - 12 Months or Greater 116,000 1,128,000
      Fair Value - Total 111,890,000 370,343,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months (1,108,000) (2,227,000)
      Unrealized Loss - 12 Months or Greater (152,000) (141,000)
      Unrealized Loss - Total (1,260,000) (2,368,000)
      Equity Securities [Member]
      		    
      Schedule of Available-for-sale Securities [Line Items]    
      Fair value of equity securities 3,000,000 3,600,000
      Cost basis of equity securities 4,000,000 4,000,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized (Losses) - Total (1,000,000) (400,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months 3,019,000 3,612,000
      Fair Value - Total 3,019,000 3,612,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months (1,025,000) (433,000)
      Unrealized Loss - Total (1,025,000) (433,000)
      Debt Securities [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Total 321,845,000 511,625,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Total 322,138,000 510,276,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Total 529,000 586,000
      Unrealized (Losses) - Total (236,000) (1,935,000)
      Unrealized Net - Total 293,000 (1,349,000)
      Unrestricted [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year 43,225,000 136,307,000
      Amortized Cost Basis - Maturities after one year through five years 272,537,000 367,977,000
      Amortized Cost Basis - Maturities after five years through ten years 164,000 284,000
      Amortized Cost Basis - Total 315,926,000 504,568,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year 43,331,000 136,796,000
      Fair Value - Maturities after one year through five years 272,780,000 366,198,000
      Fair Value - Maturities after five years through ten years 87,000 243,000
      Fair Value - Total 316,198,000 503,237,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Maturities within one year 108,000 522,000
      Unrealized Gains - Maturities after one year through five years 400,000 64,000
      Unrealized Gains - Total 508,000 586,000
      Unrealized (Losses) - Maturities within one year (2,000) (33,000)
      Unrealized (Losses) - Maturities after one year through five years (157,000) (1,843,000)
      Unrealized (Losses) - Maturities after five years through ten years (77,000) (41,000)
      Unrealized (Losses) - Total (236,000) (1,917,000)
      Unrealized Net - Maturities within one year 106,000 489,000
      Unrealized Net - Maturities after one year through five years 243,000 (1,779,000)
      Unrealized Net - Maturities after five years through ten years (77,000) (41,000)
      Unrealized Net - Total 272,000 (1,331,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months   363,061,000
      Fair Value - 12 Months or Greater   1,128,000
      Fair Value - Total   364,189,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months   (2,209,000)
      Unrealized Loss - 12 Months or Greater   (141,000)
      Unrealized Loss - Total   (2,350,000)
      Unrestricted [Member] | U.S. Government Obligations [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year 12,025,000 83,635,000
      Amortized Cost Basis - Maturities after one year through five years 272,433,000 352,345,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year 12,067,000 83,684,000
      Fair Value - Maturities after one year through five years 272,752,000 350,683,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Maturities within one year 42,000 54,000
      Unrealized Gains - Maturities after one year through five years 400,000 64,000
      Unrealized (Losses) - Maturities within one year   (5,000)
      Unrealized (Losses) - Maturities after one year through five years (81,000) (1,726,000)
      Unrealized Net - Maturities within one year 42,000 49,000
      Unrealized Net - Maturities after one year through five years 319,000 (1,662,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months 103,529,000 340,444,000
      Fair Value - Total 103,529,000 340,444,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months (81,000) (1,731,000)
      Unrealized Loss - Total (81,000) (1,731,000)
      Unrestricted [Member] | U.S. Government Guaranteed Corporate Bonds [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year 15,263,000 48,173,000
      Amortized Cost Basis - Maturities after one year through five years   15,522,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year 15,316,000 48,531,000
      Fair Value - Maturities after one year through five years   15,477,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Maturities within one year 53,000 358,000
      Unrealized (Losses) - Maturities after one year through five years   (45,000)
      Unrealized Net - Maturities within one year 53,000 358,000
      Unrealized Net - Maturities after one year through five years   (45,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months   19,005,000
      Fair Value - 12 Months or Greater   19,005,000
      Unrestricted [Member] | U.S. Government Guaranteed Collateralized Mortgage Obligations [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year 623,000 2,027,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year 622,000 2,131,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Maturities within one year   104,000
      Unrealized (Losses) - Maturities within one year (1,000)  
      Unrealized Net - Maturities within one year (1,000) 104,000
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months 623,000  
      Fair Value - Total 623,000  
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months (1,000) (45,000)
      Unrealized Loss - Total (1,000) (45,000)
      Unrestricted [Member] | Municipal Bonds [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year 15,314,000 1,597,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year 15,326,000 1,603,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Maturities within one year 13,000 6,000
      Unrealized (Losses) - Maturities within one year (1,000)  
      Unrealized Net - Maturities within one year 12,000 6,000
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months 4,603,000  
      Fair Value - Total 4,603,000  
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months (1,000)  
      Unrealized Loss - Total (1,000)  
      Unrestricted [Member] | Mortgage-Backed Securities [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year   875,000
      Amortized Cost Basis - Maturities after one year through five years 104,000 110,000
      Amortized Cost Basis - Maturities after five years through ten years 164,000 284,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year   847,000
      Fair Value - Maturities after one year through five years 28,000 38,000
      Fair Value - Maturities after five years through ten years 87,000 243,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized (Losses) - Maturities within one year   (28,000)
      Unrealized (Losses) - Maturities after one year through five years (76,000) (72,000)
      Unrealized (Losses) - Maturities after five years through ten years (77,000) (41,000)
      Unrealized Net - Maturities within one year   (28,000)
      Unrealized Net - Maturities after one year through five years (76,000) (72,000)
      Unrealized Net - Maturities after five years through ten years (77,000) (41,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - 12 Months or Greater 116,000 1,128,000
      Fair Value - Total 116,000 1,128,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - 12 Months or Greater (152,000) (141,000)
      Unrealized Loss - Total (152,000) (141,000)
      Restricted [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Total 5,919,000 7,057,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Total 5,940,000 7,039,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Total 21,000  
      Unrealized (Losses) - Total   (18,000)
      Unrealized Net - Total 21,000 (18,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months   6,154,000
      Fair Value - Total   6,154,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months   (18,000)
      Unrealized Loss - Total   (18,000)
      Restricted [Member] | U.S. Government Obligations [Member]
      		    
      Debt Maturities, Amortized Cost Basis [Abstract]    
      Amortized Cost Basis - Maturities within one year 3,347,000 2,922,000
      Amortized Cost Basis - Maturities after one year through five years 2,572,000 4,135,000
      Debt Maturities, Fair Value [Abstract]    
      Fair Value - Maturities within one year 3,357,000 2,921,000
      Fair Value - Maturities after one year through five years 2,583,000 4,118,000
      Unrealized Gains (Losses), Net [Abstract]    
      Unrealized Gains - Maturities within one year 10,000  
      Unrealized Gains - Maturities after one year through five years 11,000  
      Unrealized (Losses) - Maturities within one year   (1,000)
      Unrealized (Losses) - Maturities after one year through five years   (17,000)
      Unrealized Net - Maturities within one year 10,000 (1,000)
      Unrealized Net - Maturities after one year through five years 11,000 (17,000)
      Continuous Unrealized Loss Position, Fair Vaue [Abstract]    
      Fair Value - Less than 12 Months   6,154,000
      Fair Value - Total   6,154,000
      Continuous Unrealized Loss Position, Aggregate Losses [Abstract]    
      Unrealized Loss - Less than 12 Months   (18,000)
      Unrealized Loss - Total   $ (18,000)
      XML 20 R33.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Property, Plant, and Equipment (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Property, Plant, and Equipment [Abstract]  
      Property, Plant, and Equipment
      Property, plant, and equipment as of December 31, 2011 and 2010 consist of the following:

       
      2011
      2010
      Land
         $2,117
         $2,117
      Building and improvements
      322,753
      242,035
      Leasehold improvements
      4,479
      4,063
      Construction-in-progress
      10,880
      70,356
      Laboratory and other equipment
      156,397
      137,951
      Furniture, computer and office equipment, and other
      29,468
      22,235
       
      526,094
      478,757
      Less, accumulated depreciation and amortization
      (158,139)
      (131,307)
       
      $367,955
      $347,450
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      Executive Stock Purchase Plan (Details) (Executive Stock Purchase Plan [Member])
      		 24 Months Ended
      Dec. 31, 1990
      Dec. 31, 2011
      Dec. 31, 1989
      Executive Stock Purchase Plan [Member]
      		      
      Employee Stock Ownership Plan (ESOP) Disclosures [Line Items]      
      Number of shares of Class A Stock reserved for restricted stock awards (in shares)     1,027,500
      Number of shares issued (in shares) 983,254    
      Number of shares available for future grants under the Plan (in shares)   44,246  
      XML 23 R25.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Legal Matters
      		 12 Months Ended
      Dec. 31, 2011
      Legal Matters [Abstract]  
      Legal Matters
      18.  
      Legal Matters

      From time to time, the Company is a party to legal proceedings in the course of the Company’s business.  The Company does not expect any such current ordinary course legal proceedings to have a material adverse effect on the Company’s business or financial condition.  Costs associated with the Company’s involvement in legal proceedings are expensed as incurred.

      Genentech Patent Litigation

      The Company is aware of issued patents and pending patent applications owned by Genentech that claim certain chimeric VEGF receptors.  The Company does not believe that ZALTRAP® or EYLEAÒ infringe any valid claim in these patents or patent applications.  The Company is involved in five patent litigations with Genentech, two in the United States and three in Europe.  In November 2010, the Company commenced a lawsuit against Genentech in the U.S. District Court for the Southern District of New York (the “Court”), seeking a declaratory judgment that no activities relating to the Company’s VEGF Trap infringe any valid claim of certain Genentech patents referred to as the Davis-Smyth patents (the “First Davis-Smyth Case”).   Genentech answered the complaint and asserted counterclaims that the Company’s prior or planned activities relating to VEGF Trap have infringed or will infringe claims of four of the five Davis-Smyth patents and requested a judgment against the Company for damages, including for willful infringement, and other relief as the Court deems appropriate.    
       

       
      On December 31, 2011, the Company entered into a Non-Exclusive License and Partial Settlement Agreement with Genentech that covers making, using, and selling EYLEAÒ in the United States for the prevention and treatment of human eye diseases and disorders in the United States.  Under the Genentech Agreement, the Company received a non-exclusive license to the Davis-Smyth patents, and certain other technology patents owned or co-owned by Genentech.  The Genentech Agreement does not cover any non-U.S. patent rights or non-U.S. patent disputes, and does not cover any use of aflibercept other than for prevention and treatment of human eye diseases and disorders in the United States.  The First Davis-Smyth Case is continuing with respect to matters not covered by the Genentech Agreement.  The Genentech Agreement provides for the Company to make payments to Genentech based on U.S. sales of EYLEAÒ through May 7, 2016, the date the Davis-Smyth patents expire.  The Company will make a lump-sum payment of $60 million once cumulative U.S. sales of EYLEAÒ reach $400 million.  The Company will also pay royalties of 4.75% on cumulative U.S. sales of EYLEAÒ between $400 million and $3 billion and 5.5% on any cumulative U.S. sales of EYLEAÒ over $3 billion.  As a result of the Genentech Agreement, on January 17, 2012 Genentech filed a second amended answer and counterclaim in the First Davis-Smyth Case, in which it amended its counterclaims alleging infringement of four of the five Davis-Smyth patents.  On December 23, 2011, Genentech initiated a related case in the Court against Regeneron and Sanofi alleging infringement of four of the five Davis-Smyth Patents by activities relating to VEGF Trap (but excluding EYLEAÒ) (the “Second Davis-Smyth Case”).  As in the First Davis-Smyth Case, in the new complaint Genentech requests a judgment against the Company for damages, including for willful infringement, and other relief as the Court deems appropriate. 
       

       
      The Company believes Genentech's claims in the First Davis Smyth Case and the Second Davis Smyth Case are without merit and intend to continue to defend against all of Genentech’s remaining claims vigorously.  As this litigation is at an early stage, at this time the Company is not able to predict the probability of the outcome or an estimate of loss, if any, related to these matters.
       

      The Company has initiated patent-related actions against Genentech in Germany, the United Kingdom, and Italy, and may initiate other actions in other countries outside the United States, which could have similar or other adverse outcomes that would materially harm its business and which, irrespective of the outcomes, may also entail significant costs and expenses.
      XML 24 R50.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Accounts Payable and Accrued Expenses (Details) (USD $)
      In Thousands, unless otherwise specified
      Dec. 31, 2011
      Dec. 31, 2010
      Accounts payable and accrued expenses [Abstract]    
      Accounts payable $ 27,736 $ 15,589
      Accrued payroll and related costs 42,835 12,025
      Accrued clinical trial expense 9,850 9,727
      Accrued property, plant, and equipment costs 1,070 7,622
      Other accrued expenses and liabilities 14,134 6,441
      Payable to Bayer HealthCare 0 2,254
      Accounts payable and accrued expenses $ 95,625 $ 53,658
      XML 25 R42.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Summary of Significant Accounting Policies (Details) (USD $)
      In Millions, unless otherwise specified
      		 12 Months Ended
      Dec. 31, 2011
      Percent
      Summary of Significant Accounting Policies [Abstract]  
      Percentage Of Prompt Pay Discount The Compay Accrues 100.00%
      Government Rebate and Chargeback Accruals $ 0.6
      Distribution-Related Fees Accruals $ 1.5
      Research and Development Expenses [Abstract]  
      Percentage of start-up costs of total contract value, minimum (in hundredths) 10.00%
      Percentage of start-up costs of total contract value, maximum (in hundredths) 20.00%
      Building and Improvements [Member]
      		  
      Property, Plant and Equipment [Line Items]  
      Useful life, minimum (in years) 10
      Useful life, maximum (in years) 40
      Laboratory and Other Equipment [Member]
      		  
      Property, Plant and Equipment [Line Items]  
      Useful life, minimum (in years) 3
      Useful life, maximum (in years) 10
      Furniture and Fixtures [Member]
      		  
      Property, Plant and Equipment [Line Items]  
      Useful life, maximum (in years) 5
      XML 26 R37.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Commitments and Contingencies (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Commitments and Contingencies [Abstract]  
      Commitments Under Operating Leases
      The estimated future minimum noncancelable lease commitments under operating leases were as follows:

      December 31,
      Facilities
      Equipment
                 Total
      2012
      $6,072
      $1,188
      $7,260
      2013
      7,304
      258
      7,562
      2014
      7,428
      35
      7,463
      2015
      7,583
      		 
      7,583
      2016
      7,738
      		 
      7,738
      Thereafter
      59,631
      ___
      59,631
       
      $95,756
      $1,481
      $97,237
      Rent Expense Under Operating Leases
      Rent expense under operating leases was:

      Year Ending December 31,
      Facilities
           Equipment
      Total
      2011
      $7,191
      $599
      $7,790
      2010
      7,301
      335
      7,636
      2009
      7,722
      395
      8,117
      Commitments Under Capital Leases
      The estimated future minimum noncancelable lease commitments under capital leases were as follows:

      December 31,
      Equipment
      2012
      $1,394
      2013
      1,254
      2014
      130
      Total minimum lease payments
      2,778
      Less: amount representing interest
      (272)
       
      $2,506
      Commitments Under Facility Lease Obligations
      The estimated future minimum noncancelable commitments under these facility lease obligations, as of December 31, 2011, were as follows:

      December 31,
      Buildings A and B
      Building C
      Total
      2012
      $12,847
      $2,825
      $15,672
      2013
      13,092
      4,370
      17,462
      2014
      13,343
      4,490
      17,833
      2015
      13,600
      4,614
      18,214
      2016
      13,864
      4,740
      18,604
      Thereafter
      113,040
      39,899
      152,939
       
      $179,786
      $60,938
      $240,724
      XML 27 R52.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Convertible Debt (Details) (USD $)
      		 12 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Oct. 31, 2011
      Call Option [Member]
      Oct. 31, 2011
      Warrant Transactions [Member]
      Oct. 17, 2011
      Convertible Senior Notes [Member]
      Integer
      Decimal
      Percent
      Dec. 31, 2011
      Convertible Senior Notes [Member]
      Oct. 31, 2011
      Convertible Senior Notes [Member]
      Debt Instrument [Line Items]                
      Principal amount               $ 400,000,000
      Interest rate, stated percentage (in hundredths)           1.875%    
      Net proceeds from offering, net of discount and issuance costs 391,107,000 0 0          
      Initial conversion rate           11.9021    
      Increment of principal amount of conversion           1,000    
      Total shares upon conversion (in shares)           4,760,840    
      Initial conversion price (in dollars per share)           $ 84.02    
      Terms of conversion feature           A holder of the Notes may surrender their Notes at their option any time prior to the close of business on the business day immediately preceding July 1, 2016, only under the following circumstances: (i) during any calendar quarter commencing after the calendar quarter ending on December 31, 2011 (and only during such calendar quarter), if the last reported sale price of the Company's Common Stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day; (ii) during the five business day period after any ten consecutive trading day period (the "measurement period") in which the trading price, as defined, of the Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company's Common Stock and the conversion rate on each such trading day; (iii) if the Company elects to issue to all or substantially all holders of its Common Stock any right, options or warrants (other than pursuant to a rights plan) entitling them for a period of not more than 60 calendar days after the record date for such issuance, to subscribe for or purchase shares of the Company's Common Stock, at a price per share less than the average of the last reported sales prices of the Company's Common Stock for the ten consecutive day period ending on, and including, the trading day immediately preceding the declaration date for such issuance; (iv) upon specified distributions to the Company's shareholders; or (v) upon the occurrence of specified corporate transactions, such as a fundamental change (i.e., a change in control), or the Company's Common Stock ceasing to be listed on at least one U.S. national securities exchange. On or after July 1, 2016, holders may convert their Notes at the conversion rate at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date irrespective of the foregoing conditions.    
      Percentage of principal value that holders can require the Company to repurchase (in hundredths)           100.00%    
      Estimated fair value of the Liability Component           271,100,000    
      Carrying amount of Equity Component           120,900,000    
      Effective interest rate used to amortize the discount on the liability component (in hundredths)           10.20%    
      Net carrying amount of the liability component [Abstract]                
      Total convertible senior notes - par             400,000,000  
      Unamortized discount             124,981,000  
      Net carrying amount of the liability component             275,019,000  
      Total interest expense [Abstract]                
      Contractual coupon interest rate             1,455,000  
      Amortization of discount and note issuance costs             3,944,000  
      Total interest expense             5,399,000  
      Fair value of the outstanding Notes 375,500,000              
      Gross proceeds from the issuance of the Notes           392,000,000    
      Issuance costs           900,000    
      Class of Warrant or Right [Line Items]                
      Strike price of the warrant transaction (in dollars per share)         $ 103.41      
      Proceeds received from the Warrant 93,800,000 0 0          
      Option Indexed to Issuer's Equity [Line Items]                
      Purchase of convertible note hedges       $ 117,500,000        
      XML 28 R61.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Net Loss Per Share Data (Details) (USD $)
      In Thousands, except Per Share data, unless otherwise specified
      		 3 Months Ended 12 Months Ended
      Dec. 31, 2011
      Sep. 30, 2011
      Jun. 30, 2011
      Mar. 31, 2011
      Dec. 31, 2010
      Sep. 30, 2010
      Jun. 30, 2010
      Mar. 31, 2010
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Basic and diluted net loss per share [Abstract]                      
      Net loss (Numerator) $ (53,443) $ (62,365) $ (62,505) $ (43,447) $ (14,597) $ (33,875) $ (25,474) $ (30,522) $ (221,760) $ (104,468) $ (67,830)
      Weighted-average shares, in thousands (Denominator) (in shares)                 90,610 82,926 79,782
      Basic and diluted net loss per share (in dollars per share) $ (0.58) $ (0.68) $ (0.69) $ (0.49) $ (0.17) $ (0.41) $ (0.31) $ (0.38) $ (2.45) $ (1.26) $ (0.85)
      Options [Member]
      		                      
      Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                      
      Weighted average number, in thousands (in shares)                 20,942 21,428 20,040
      Weighted average exercise price (in dollars per share)                 $ 21.21 $ 18.80 $ 17.66
      Restricted Stock [Member]
      		                      
      Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                      
      Weighted average number, in thousands (in shares)                 846 526 500
      Convertible Senior Notes [Member]
      		                      
      Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                      
      Weighted average number, in thousands (in shares)                 939    
      Warrants [Member]
      		                      
      Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]                      
      Weighted average number, in thousands (in shares)                 939    
      XML 29 R47.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Marketable Securities, Fair Value (Details) (USD $)
      		 12 Months Ended 12 Months Ended
      Dec. 31, 2011
      Fair Value Measurements at Reporting Date Using Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
      Dec. 31, 2010
      Fair Value Measurements at Reporting Date Using Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
      Dec. 31, 2010
      Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member]
      Dec. 31, 2011
      Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member]
      Dec. 31, 2009
      Fair Value Measurements at Reporting Date Using Significant Unobservable Inputs (Level 3) [Member]
      Dec. 31, 2011
      Fair Value Measurements at Reporting Date Using Significant Unobservable Inputs (Level 3) [Member]
      Integer
      Dec. 31, 2010
      Fair Value Measurements at Reporting Date Using Significant Unobservable Inputs (Level 3) [Member]
      Integer
      Dec. 31, 2011
      Unrestricted [Member]
      Dec. 31, 2010
      Unrestricted [Member]
      Dec. 31, 2011
      Unrestricted [Member]
      Fair Value Measurements at Reporting Date Using Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
      Dec. 31, 2010
      Unrestricted [Member]
      Fair Value Measurements at Reporting Date Using Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
      Dec. 31, 2011
      Unrestricted [Member]
      Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member]
      Dec. 31, 2010
      Unrestricted [Member]
      Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member]
      Dec. 31, 2011
      Restricted [Member]
      Dec. 31, 2010
      Restricted [Member]
      Dec. 31, 2011
      Restricted [Member]
      Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member]
      Dec. 31, 2010
      Restricted [Member]
      Fair Value Measurements at Reporting Date Using Significant Other Observable Inputs (Level 2) [Member]
      Dec. 31, 2011
      Measured on a Recurring Basis [Member]
      Dec. 31, 2010
      Measured on a Recurring Basis [Member]
      Available-for-sale marketable securities                                      
      U.S. government obligations               $ 284,819,000 $ 434,367,000     $ 284,819,000 $ 434,367,000 $ 5,940,000 $ 7,039,000 $ 5,940,000 $ 7,039,000    
      U.S. government guaranteed corporate bonds               15,316,000 64,008,000     15,316,000 64,008,000            
      U.S. government guaranteed collateralized mortgage obligations               622,000 2,131,000     622,000 2,131,000            
      Municipal bonds               15,326,000 1,603,000     15,326,000 1,603,000            
      Mortgage-backed securities               115,000 1,128,000     115,000 1,128,000            
      Equity security               3,019,000 3,612,000 3,019,000 3,612,000                
      Total available-for-sale marketable securities 3,019,000 3,612,000 510,276,000 322,138,000   0 0 319,217,000 506,849,000 3,019,000 3,612,000 316,198,000 503,237,000         325,157,000 513,888,000
      Impaired securities [Abstract]                                      
      Number of marketable securities held           1 1                        
      Other-than-temporary impairment charge     $ 100,000   $ 100,000                            
      XML 30 R9.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Summary of Significant Accounting Policies
      		 12 Months Ended
      Dec. 31, 2011
      Summary of Significant Accounting Policies [Abstract]  
      Summary of Significant Accounting Policies
      2.  
      Summary of Significant Accounting Policies

      Cash and Cash Equivalents

      For purposes of the statement of cash flows and the balance sheet, the Company considers all highly liquid debt instruments with a maturity of three months or less when purchased to be cash equivalents.  The carrying amount reported in the balance sheet for cash and cash equivalents approximates its fair value.

       
      Marketable Securities

      The Company has an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification.  The Company has invested its excess cash primarily in direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities.  The Company considers its marketable securities to be “available-for-sale,” as defined by authoritative guidance issued by the Financial Accounting Standards Board (“FASB”).  These assets are carried at fair value and the unrealized gains and losses are included in accumulated other comprehensive income (loss) as a separate component of stockholders’ equity.  If the decline in the value of a marketable security in the Company’s investment portfolio is deemed to be other-than-temporary, the Company writes down the security to its current fair value and recognizes a loss as a charge against income.  As described under “Use of Estimates” below, the Company reviews its portfolio of marketable securities, using both quantitative and qualitative factors, to determine if declines in fair value below cost are other-than-temporary.

      Accounts Receivable - Trade

      The Company’s trade accounts receivable represents amounts due from its distributors and specialty pharmacies (collectively, the Company’s “customers”), which are all located in the United States.  The Company monitors the financial performance and credit worthiness of its large customers so that it can properly assess and respond to changes in their credit profile.  The Company provides reserves against trade receivables for estimated losses that may result from a customer’s inability to pay.  Amounts determined to be uncollectible are written-off against the reserve.  As of December 31, 2011 and 2010, there were no reserves against trade accounts receivable.  In addition, during the years ended December 31, 2011, 2010 and 2009, no trade accounts receivable were written-off.

      Inventory

      Inventories are stated at the lower of cost or estimated realizable value.  The Company determines the cost of inventory using the first-in, first-out, or FIFO, method.  The Company capitalizes inventory costs associated with the Company’s products prior to regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized; otherwise, such costs are expensed as research and development.  The Company periodically analyzes its inventory levels to identify inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, and writes-down such inventories as appropriate. In addition, the Company’s products are subject to strict quality control and monitoring which the Company performs throughout the manufacturing process.  If certain batches or units of product no longer meet quality specifications or become obsolete due to expiration, the Company records a charge to cost of goods sold to write down such unmarketable inventory to its estimated realizable value.

      Property, Plant, and Equipment

      Property, plant, and equipment are stated at cost, net of accumulated depreciation.  Depreciation is provided on a straight-line basis over the estimated useful lives of the assets.  Expenditures for maintenance and repairs which do not materially extend the useful lives of the assets are charged to expense as incurred.  The cost and accumulated depreciation or amortization of assets retired or sold are removed from the respective accounts, and any gain or loss is recognized in operations.  The estimated useful lives of property, plant, and equipment are as follows:

      Building and improvements                                                                           10-40 years
      Laboratory and other equipment                                                                           3-10 years
      Furniture and fixtures                                                                           5 years

      Leasehold improvements are amortized over the shorter of the estimated useful lives of the assets or the lease term, without assuming renewal features, if any, are exercised.  Costs of construction of certain long-lived assets include capitalized interest which is amortized over the estimated useful life of the related asset.

      Accounting for the Impairment of Long-Lived Assets

      The Company periodically assesses the recoverability of long-lived assets, such as property, plant, and equipment, and evaluates such assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable.  Asset impairment is determined to exist if estimated future undiscounted cash flows are less than the carrying amount.  For all periods presented, no impairment losses were recorded.

      Patents

      As a result of the Company’s research and development efforts, the Company obtains and applies for patents to protect proprietary technology and inventions.  All costs associated with patents for product candidates under development are expensed as incurred. Patent costs related to commercial products are capitalized and amortized over the shorter of their estimated useful life or the remaining patent term.  To date, the Company has no capitalized patent costs.

      Operating Leases

      On certain of its operating lease agreements, the Company may receive rent holidays and other incentives.  The Company recognizes operating lease costs on a straight-line basis without regard to deferred payment terms, such as rent holidays, that defer the commencement date of required payments.  In addition, lease incentives that the Company receives are treated as a reduction of rent expense over the term of the related agreements.

      Revenue Recognition

      a. Collaboration Revenue

      The Company earns collaboration revenue in connection with collaboration agreements to develop and commercialize product candidates and utilize the Company’s technology platforms.  The terms of these agreements typically include non-refundable up-front licensing payments, research progress (milestone) payments, and payments for development activities.  Non-refundable up-front license payments, where continuing involvement is required of the Company, are deferred and recognized over the related performance period.  The Company estimates its performance period based on the specific terms of each agreement, and adjusts the performance periods, if appropriate, based on the applicable facts and circumstances.   Although the Company did not enter into, or materially modify, any collaboration arrangements with multiple-deliverables during the year ended December 31, 2011, any future arrangements with multiple deliverables will be divided into separate units of accounting if the deliverables in the arrangement meet certain criteria, including whether the delivered item or items has value to the collaborator on a standalone basis. Payments which are based on achieving a specific performance milestone, involving a degree of risk, are recognized as revenue when the milestone is achieved and the related payment is due and non-refundable, provided there is no future service obligation associated with that milestone.  Substantive performance milestones typically consist of significant achievements in the development life-cycle of the related product candidate, such as completion of clinical trials, filing for approval with regulatory agencies, and receipt of approvals by regulatory agencies.  In determining whether a payment is deemed to be a substantive performance milestone, the Company takes into consideration (i) the enhancement in value to the related development product candidate, (ii) the Company’s performance and relative level of effort required to achieve the milestone, (iii) whether the milestone relates solely to past performance, and (iv) whether the milestone payment is considered reasonable relative to all of the deliverables and payment terms.  Payments for achieving milestones which are not considered substantive are deferred and recognized over the related performance period.

      The Company enters into collaboration agreements that include varying arrangements regarding which parties perform and bear the costs of research and development activities.  The Company may share the costs of research and development activities with a collaborator, such as in the Company’s EYLEAÒ collaboration with Bayer HealthCare LLC, or the Company may be reimbursed for all or a significant portion of the costs of the Company’s research and development activities, such as in the Company’s ZALTRAP® (aflibercept) and antibody collaborations with Sanofi.  The Company records its internal and third-party development costs associated with these collaborations as research and development expenses.  When the Company is entitled to reimbursement of all or a portion of the research and development expenses that it incurs under a collaboration, the Company records those reimbursable amounts as collaboration revenue proportionately as the Company recognizes its expenses.  If the collaboration is a cost-sharing arrangement in which both the Company and its collaborator perform development work and share costs, in periods when the Company’s collaborator incurs development expenses that benefit the collaboration and Regeneron, the Company also recognizes, as additional research and development expense, the portion of the collaborator’s development expenses that the Company is obligated to reimburse.  In certain cases, the Company may also share the costs of pre-launch commercialization activities with its collaborators.  The Company records its share of these costs as a reduction of collaboration revenue.

      In connection with non-refundable licensing payments, the Company’s performance period estimates are principally based on projections of the scope, progress, and results of its research and development activities.  Due to the variability in the scope of activities and length of time necessary to develop a drug product, changes to development plans as programs progress, and uncertainty in the ultimate requirements to obtain governmental approval for commercialization, revisions to performance period estimates are likely to occur periodically, and could result in material changes to the amount of revenue recognized each year in the future.  In addition, estimated performance periods may change if development programs encounter delays, or the Company and its collaborators decide to expand or contract the clinical plans for a drug candidate in various disease indications.  Also, if a collaborator terminates an agreement in accordance with the terms of the agreement, the Company would recognize any unamortized remainder of an up-front or previously deferred payment at the time of the termination.

      b. VelocImmune® Technology Licensing

      The Company enters into non-exclusive license agreements with third parties that allow the third party to utilize the Company’s VelocImmune® technology in its internal research programs.  The terms of these agreements include up-front payments and entitle the Company to receive royalties on any future sales of products discovered by the third party using the Company’s VelocImmune® technology.  Up-front payments under these agreements, where continuing involvement is required of the Company, are deferred and recognized ratably over their respective license periods.

      c. Product Revenue

      Product sales consist of U.S. sales of the Company’s two marketed products, EYLEAÒ and ARCALYSTÒ.  Revenue from product sales is recognized when persuasive evidence of an arrangement exists, title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, the Company has no further performance obligations, and returns can be reasonably estimated.  The Company’s written contracts with its customers stipulate product is shipped freight on board destination (FOB destination).  The Company records revenue from product sales upon delivery to its customers.

      The Company sells EYLEAÒ in the United States to three distributors and several specialty pharmacies.  The Company sells ARCALYSTÒ in the United States to two specialty pharmacies.  Under these distribution models, the distributors and specialty pharmacies generally take physical delivery of product.  For EYLEAÒ, the distributors and specialty pharmacies generally sell the product directly to healthcare providers; whereas for ARCALYSTÒ, the specialty pharmacies sell the product directly to patients.

      Revenue from product sales are recorded net of applicable provisions for prompt pay discounts, rebates and chargebacks under governmental programs (including Medicaid), product returns, distribution-related fees, and other sales-related deductions.  Calculating these provisions involves estimates and judgments.  The Company reviews its estimates of rebates, chargebacks, and other applicable provisions each period and records any necessary adjustments in the current period’s net product sales.

      Prompt Pay Discounts: No prompt pay discounts are currently offered to the Company’s customers on sales of EYLEAÒ.  In connection with sales of ARCALYSTÒ, the Company offers discounts to its customers for prompt payments.  The Company estimates these discounts based on customer terms and historical experience, and expects that its customers will always take advantage of this discount.  Therefore, the Company accrues 100% of the prompt pay discount that is based on the gross amount of each ARCALYSTÒ invoice, at the time of sale.

      The Company’s accrual for prompt pay discounts was not material at December 31, 2011 and 2010.

      Government Rebates and Chargebacks:  The Company estimates reductions to product sales for Medicaid and Veterans’ Administration (VA) programs, and for certain other qualifying federal and state government programs.  Based upon the Company’s contracts with government agencies, statutorily-defined discounts applicable to government-funded programs, historical experience, and, in the case of EYLEAÒ, estimated payer mix based on third-party market research data, the Company estimates and records an allowance for rebates and chargebacks.  The Company’s liability for Medicaid rebates consists of estimates for claims that a state will make for a current quarter, claims for prior quarters that have been estimated for which an invoice has not been received, and invoices received for claims from prior quarters that have not been paid.  The Company’s reserves related to discounted pricing offered to VA,  Public Health Services (PHS), and other institutions (collectively, “qualified healthcare providers”) represent the Company’s estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices the Company charges to its customers (i.e., distributors and specialty pharmacies).  The Company’s customers charge the Company for the difference between what they pay for the products and the ultimate selling price to the qualified healthcare providers.  The Company’s reserve for this discounted pricing is based on expected sales to qualified healthcare providers and the chargebacks that customers have already claimed.

      The Company’s government rebate and chargeback accruals were $0.6 million at December 31, 2011, which was based on a percentage of gross sales.  Government rebate and chargeback accruals were not material at December 31, 2010.

      Product Returns:  Consistent with industry practice, the Company offers its customers a limited right to return product purchased directly from the Company, which is principally based upon the product’s expiration date.  The Company will accept returns for three months prior to and up to six months after the product expiration date.  Product returned is generally not resalable given the nature of the Company’s products and method of administration.  The Company develops estimates for product returns based upon historical experience, inventory levels in the distribution channel, and other relevant factors.

      The Company has developed estimates for EYLEAÒ product returns, based on several factors, including (i) the Company’s historical experience to date, and the Company’s expectation, that its customers will not stock significant supplies of EYLEAÒ due to contractual limitations and other mitigating circumstances, (ii) historical industry information regarding product return rates for similar specialty products, and (iii) the shelf life of the product.  Estimates for ARCALYSTÒ product returns have been developed based primarily on historical returns experience; to date, actual ARCALYSTÒ product returns have been negligible.  The Company monitors product supply levels in the distribution channel, as well as sales by its customers of EYLEAÒ to healthcare providers and ARCALYSTÒ to patients using product-specific data provided by its customers.  If necessary, the Company’s estimates of product returns may be adjusted in the future based on actual returns experience, known or expected changes in the marketplace, or other factors.

      The Company’s product returns accruals were not material at December 31, 2011 and 2010.

      Distribution-Related Fees:  The Company has written contracts with its customers that include terms for distribution-related fees.  The Company estimates and records distribution and related fees due to its customers based on a percentage of gross sales.  The Company’s accrual for distribution-related fees was $1.5 million at December 31, 2011.   The Company’s accrual for distribution-related fees at December 31, 2010 was not material.

       
      Investment Income

      Interest income, which is included in investment income, is recognized as earned.

      Research and Development Expenses

      Research and development expenses include costs directly attributable to the conduct of research and development programs, including the cost of salaries, payroll taxes, employee benefits, materials, supplies, depreciation on and maintenance of research equipment, costs related to research collaboration and licensing agreements, the cost of services provided by outside contractors, including services related to the Company’s clinical trials, clinical trial expenses, the full cost of manufacturing drug for use in research, preclinical development, and clinical trials, amounts that the Company is obligated to reimburse to collaborators for research and development expenses that they incur, and the allocable portions of facility costs, such as rent, utilities, insurance, repairs and maintenance, depreciation, and general support services.  All costs associated with research and development are expensed.

      Clinical trial costs are a significant component of research and development expenses and include costs associated with third-party contractors.  The Company outsources a substantial portion of its clinical trial activities, utilizing external entities such as contract research organizations (“CROs”), independent clinical investigators, and other third-party service providers to assist the Company with the execution of its clinical studies.  For each clinical trial that the Company conducts, certain clinical trial costs are expensed immediately, while others are expensed over time based on the expected total number of patients in the trial, the rate at which patients enter the trial, and/or the period over which clinical investigators or CROs are expected to provide services.

      Clinical activities which relate principally to clinical sites and other administrative functions to manage the Company’s clinical trials are performed primarily by CROs.  CROs typically perform most of the start-up activities for the Company’s trials, including document preparation, site identification, screening and preparation, pre-study visits, training, and program management.  On a budgeted basis, these start-up costs are typically 10% to 20% of the total contract value.  On an actual basis, this percentage range can be significantly wider, as many of the Company’s contracts with CROs are either expanded or reduced in scope compared to the original budget, while start-up costs for the particular trial may not change materially.  These start-up costs usually occur within a few months after the contract has been executed and are event driven in nature. The remaining activities and related costs, such as patient monitoring and administration, generally occur ratably throughout the life of the individual contract or study. In the event of early termination of a clinical trial, the Company accrues and recognizes expenses in an amount based on its estimate of the remaining non-cancelable obligations associated with the winding down of the clinical trial and/or penalties.

      For clinical study sites, where payments are made periodically on a per-patient basis to the institutions performing the clinical study, the Company accrues expense on an estimated cost-per-patient basis, based on subject enrollment and activity in each quarter.  The amount of clinical study expense recognized in a quarter may vary from period to period based on the duration and progress of the study, the activities to be performed by the sites each quarter, the required level of patient enrollment, the rate at which patients actually enroll in and drop-out of the clinical study, and the number of sites involved in the study.  Clinical trials that bear the greatest risk of change in estimates are typically those that have a significant number of sites, require a large number of patients, have complex patient screening requirements, and span multiple years.  During the course of a trial, the Company adjusts its rate of clinical expense recognition if actual results differ from the Company’s estimates.  The Company’s estimates and assumptions for clinical expense recognition could differ significantly from its actual results, which could cause material increases or decreases in research and development expenses in future periods when the actual results become known.

       
      Stock-based Compensation

      The Company recognizes stock-based compensation expense for grants of stock option awards and restricted stock under the Company’s Long-Term Incentive Plan to employees and non-employee members of the Company’s board of directors based on the grant-date fair value of those awards.  The grant-date fair value of an award is generally recognized as compensation expense over the award’s requisite service period.  In addition, the Company has granted performance-based stock option awards which vest based upon the optionee satisfying certain performance and service conditions as defined in the agreements.  Potential compensation cost, measured on the grant date, related to these performance options will be recognized only if, and when, the Company estimates that these options will vest, which is based on whether the Company consider the options’ performance conditions to be probable of attainment.  The Company’s estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods.

      The Company uses the Black-Scholes model to compute the estimated fair value of stock option awards.  Using this model, fair value is calculated based on assumptions with respect to (i) expected volatility of the Company’s Common Stock price, (ii) the periods of time over which employees and members of the board of directors are expected to hold their options prior to exercise (expected lives), (iii) expected dividend yield on the Common Stock, and (iv) risk-free interest rates.  Stock-based compensation expense also includes an estimate, which is made at the time of grant, of the number of awards that are expected to be forfeited.  This estimate is revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.

      Income Taxes

      The Company recognizes deferred tax liabilities and assets for the expected future tax consequences of events that have been included in the financial statements or tax returns.  Under this method, deferred tax liabilities and assets are determined on the basis of the difference between the tax basis of assets and liabilities and their respective financial reporting amounts (“temporary differences”) at enacted tax rates in effect for the years in which the differences are expected to reverse.  A valuation allowance is established for deferred tax assets for which it is more likely than not that some portion or all of the deferred tax assets will not be realized.

      Uncertain tax positions are accounted for in accordance with FASB authoritative guidance, which prescribes a comprehensive model for the manner in which a company should recognize, measure, present, and disclose in its financial statements all material uncertain tax positions that the company has taken or expects to take on a tax return.  Those positions, for which management's assessment is that there is more than a 50% probability of sustaining the position upon challenge by a taxing authority based upon its technical merits, are subjected to certain measurement criteria.

      The Company’s policy is to recognize interest and penalties related to income tax matters in income tax expense.

      Comprehensive Income (Loss)

      Comprehensive income (loss) of the Company includes net income (loss) adjusted for the change in net unrealized gain or loss on marketable securities, net of any tax effect.  Comprehensive income (loss) for the years ended December 31, 2011, 2010, and 2009 have been included in the Statements of Stockholders’ Equity.

      Concentration of Credit Risk

      Financial instruments which potentially subject the Company to concentrations of credit risk consist of cash, cash equivalents, marketable securities (see Note 6), and accounts receivable.

      Per Share Data

      Net income (loss) per share, basic and diluted, is computed on the basis of the net income (loss) for the period divided by the weighted average number of shares of Common Stock and Class A Stock outstanding during the period.  Basic net income (loss) per share excludes restricted stock awards until vested.  Diluted net income per share is based upon the weighted average number of shares of Common Stock and Class A Stock outstanding, and of common stock equivalents outstanding when dilutive.  Common stock equivalents include: (i) outstanding stock options and restricted stock awards under the Company’s Long-Term Incentive Plans, which are included under the “treasury stock method” when dilutive, (ii) Common Stock to be issued upon the assumed conversion of the Company’s convertible senior notes, which are included under the “if-converted method” when dilutive, and (iii) Common Stock to be issued upon the exercise of outstanding warrants, which are included under the “treasury stock method” when dilutive.  The computation of diluted net loss per share for the years ended December 31, 2011, 2010, and 2009 does not include common stock equivalents, since such inclusion would be antidilutive.




      Risks and Uncertainties

      Developing and commercializing new medicines entails significant risk and expense.  Before revenues from the commercialization of the Company’s current or future product candidates can be realized, the Company (or its collaborators) must overcome a number of hurdles which include successfully completing research and development and obtaining regulatory approval from the FDA and regulatory authorities in other countries.  In addition, the biotechnology and pharmaceutical industries are rapidly evolving and highly competitive, and new developments may render the Company’s products and technologies uncompetitive or obsolete.  The Company may be subject to legal claims by third parties seeking to enforce patents to limit or prohibit the Company from marketing or selling its products.  The Company is also dependent upon the services of its employees, consultants, collaborators, and certain third-party suppliers, including single-source unaffiliated third-party suppliers of certain raw materials and equipment.  Regeneron, as licensee, licenses certain technologies that are important to the Company’s business which impose various obligations on the Company.  If Regeneron fails to comply with these requirements, licensors may have the right to terminate the Company’s licenses.

      The Company has generally incurred net losses and negative cash flows from operations since its inception.  The Company received regulatory approval from the FDA for ARCALYST® for the treatment of CAPS in February 2008 and EYLEAÒ for the treatment of wet AMD in November 2011; however, the Company has not generated significant sales or profits to date from these two drug products.  Revenues to date have principally been limited to (i) up-front, license, milestone, and reimbursement payments from the Company’s collaborators and other entities related to the Company’s development activities and technology platforms, (ii) ARCALYST® and EYLEAÒ product sales, (iii) payments for past contract manufacturing activities, and (iv) investment income.  Collaboration revenue in 2011 was earned from Sanofi and Bayer HealthCare under collaboration agreements (see Note 3 for the terms of these agreements).  These collaboration agreements contain early termination provisions that are exercisable by Sanofi or Bayer HealthCare, as applicable.

      Use of Estimates

      The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes.  Actual results could differ from those estimates.  Estimates which could have a significant impact on the Company’s financial statements include:

      ·  
      Product rebates, chargebacks, and returns in connection with the recognition of product sales revenue.
      ·  
      Periods over which payments, including non-refundable up-front, license, and milestone payments, are recognized as revenue in connection with collaboration and other agreements to develop and commercialize product candidates and utilize the Company’s technology platforms.
      ·  
      Periods over which certain clinical trial costs, including costs for clinical activities performed by contract research organizations, are recognized as research and development expenses.
      ·  
      In connection with the recognition of expense, using a blended royalty rate, related to the Company’s non-exclusive license with Genentech, Inc., the Company’s estimate of cumulative EYLEAÒ sales through May 7, 2016 (see Note 12b).
      ·  
      In connection with stock option awards, (i) the fair value of stock options on their date of grant using the Black-Scholes option-pricing model, based on assumptions with respect to (a) expected volatility of the Company’s Common Stock price, (b) the periods of time for which employees and members of the Company’s board of directors are expected to hold their options prior to exercise (expected lives), (c) expected dividend yield on the Company’s Common Stock, and (d) risk-free interest rates, which are based on quoted U.S. Treasury rates for securities with maturities approximating the options’ expected lives; (ii) the number of stock option awards that are expected to be forfeited; and (iii) with respect to performance-based stock option awards, if and when the options’ performance conditions are considered to be probable of attainment.
      ·  
      The Company’s determination of whether marketable securities are other-than-temporarily impaired.  The Company conducts a review of its portfolio of marketable securities, using both quantitative and qualitative factors, to determine, for securities whose current fair value is less than their cost, whether the decline in fair value below cost is other-than-temporary.  In making this determination, the Company considers factors such as the length of time and the extent to which fair value has been less than cost, financial condition and near-term prospects of the issuer, recommendations of investment advisors, and forecasts of economic, market, or industry trends.  This review process also includes an evaluation of the Company’s ability and intent to hold individual securities until they mature or their full value can be recovered.  This review is subjective and requires a high degree of judgment.
      ·  
      Useful lives of property, plant, and equipment.
      ·  
      Inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, which is written-down, as appropriate.  In addition, capitalization of inventory costs associated with the Company’s products prior to regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized.
      ·  
      The extent to which deferred tax assets and liabilities are offset by a valuation allowance.

      In addition, the Company’s share of EYLEAÒ development expenses incurred by Bayer HealthCare, including the Company’s share of Bayer HealthCare’s estimated EYLEAÒ development expenses for the most recent fiscal quarter, are included in research and development expenses.  The Bayer HealthCare estimate for the most recent fiscal quarter is adjusted in the subsequent quarter to reflect actual expenses for the quarter.  Also, the Company’s share of ZALTRAP® pre-launch commercialization expenses incurred by Sanofi, including the Company’s share of Sanofi’s estimated ZALTRAP® pre-launch commercialization expenses for the most recent fiscal quarter, are included as a reduction of Sanofi collaboration revenue.  The Sanofi estimate for the most recent fiscal quarter is adjusted in the subsequent quarter to reflect actual expenses for the quarter.

      Impact of Recently Issued Accounting Standards

      Multiple-deliverable revenue arrangements

       
      During the first quarter of 2011 the Company adopted amended authoritative guidance issued by the FASB on multiple-deliverable revenue arrangements.  The amended guidance provides greater ability to separate and allocate consideration to be received in a multiple-deliverable revenue arrangement by requiring the use of estimated selling prices to allocate the consideration, thereby eliminating the use of the residual method of allocation.  The amended guidance also requires expanded qualitative and quantitative disclosures surrounding multiple-deliverable revenue arrangements.  The Company is applying this amended guidance prospectively for new or materially modified arrangements, of which there were none during the year ended December 31, 2011; therefore, the adoption of this guidance did not have an impact on the Company’s financial statements.

      Milestone method of revenue recognition

      During the first quarter of 2011, the Company adopted amended authoritative guidance issued by the FASB codifying the milestone method of revenue recognition as an acceptable revenue recognition model when a milestone is deemed to be substantive.  The Company earns substantive performance milestone payments in connection with its collaboration agreements to develop and commercialize product candidates with Sanofi and Bayer HealthCare.  Descriptions of these collaboration agreements, including various financial terms and conditions, are provided in Note 3.  Since the Company has historically accounted for milestones under the milestone method, the adoption of this guidance did not have a material impact on the Company’s financial statements.

      Fees paid to the federal government by pharmaceutical manufacturers

      In December 2010, the FASB provided authoritative guidance on how pharmaceutical manufacturers should recognize and classify in their income statement annual fees mandated by the Patient Protection and Affordable Care Act as amended by the Health Care and Education Reconciliation Act.  This guidance became effective for calendar years beginning after December 31, 2010.  The adoption of this guidance did not have an impact on the Company’s financial statements for the year ended December 31, 2011, since (i) ARCALYST® for the treatment of CAPS, has been approved as an orphan drug and orphan drugs are not subject to this annual fee and (ii) since EYLEAÒ received regulatory approval from the FDA, and was launched, in November 2011.

      Presentation of comprehensive income

      In June 2011, the FASB amended its authoritative guidance on the presentation of comprehensive income.  Under the amendment, an entity will have the option to present the total of comprehensive income, the components of net income, and the components of other comprehensive income either in a single continuous statement of comprehensive income or in two separate but consecutive statements.  This amendment, therefore, eliminates the currently available option to present the components of other comprehensive income as part of the statement of changes in stockholders' equity. The amendment does not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income.  The Company will adopt this amended guidance for the fiscal year beginning January 1, 2012.  As this guidance relates to presentation only, the adoption of this guidance will not have any other effect on the Company's financial statements.

      Reclassifications

      Certain reclassifications have been made to prior period amounts to conform with the current period’s presentation.
      XML 31 R62.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Statement of Cash Flows (Details) (USD $)
      In Millions, unless otherwise specified
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]      
      Accrued capital expenditures $ 6.2 $ 10.7 $ 9.8
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      Collaboration and Contract Research Agreements (Details) (USD $)
      		 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Dec. 31, 2011
      Collaboration Agreement with Sanofi [Member]
      Integer
      Dec. 31, 2010
      Collaboration Agreement with Sanofi [Member]
      Dec. 31, 2009
      Collaboration Agreement with Sanofi [Member]
      Jan. 31, 2006
      Collaboration Agreement with Sanofi [Member]
      ZALTRAP Agreement [Memeber]
      Jan. 31, 2005
      Collaboration Agreement with Sanofi [Member]
      ZALTRAP Agreement [Memeber]
      Jan. 31, 2003
      Collaboration Agreement with Sanofi [Member]
      ZALTRAP Agreement [Memeber]
      Dec. 31, 2011
      Collaboration Agreement with Sanofi [Member]
      ZALTRAP Agreement [Memeber]
      Percent
      Dec. 31, 2010
      Collaboration Agreement with Sanofi [Member]
      ZALTRAP Agreement [Memeber]
      Dec. 31, 2009
      Collaboration Agreement with Sanofi [Member]
      ZALTRAP Agreement [Memeber]
      Dec. 31, 2007
      Collaboration Agreement with Sanofi [Member]
      Antibody Collaboration [Member]
      Nov. 30, 2007
      Collaboration Agreement with Sanofi [Member]
      Antibody Collaboration [Member]
      Dec. 31, 2011
      Collaboration Agreement with Sanofi [Member]
      Antibody Collaboration [Member]
      Percent
      Integer
      Dec. 31, 2010
      Collaboration Agreement with Sanofi [Member]
      Antibody Collaboration [Member]
      Dec. 31, 2009
      Collaboration Agreement with Sanofi [Member]
      Antibody Collaboration [Member]
      Nov. 30, 2009
      Collaboration Agreement with Sanofi [Member]
      Antibody Collaboration [Member]
      Dec. 31, 2011
      Collaboration Agreement with Sanofi [Member]
      VelociGene Agreement [Member]
      Jan. 31, 2011
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Dec. 31, 2010
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Jul. 31, 2009
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Aug. 31, 2007
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Oct. 31, 2006
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Dec. 31, 2010
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Integer
      Dec. 31, 2011
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Percent
      Dec. 31, 2010
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Dec. 31, 2009
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      Sep. 30, 2006
      Grant from National Institutes of Health [Member]
      Dec. 31, 2011
      Grant from National Institutes of Health [Member]
      Dec. 31, 2010
      Grant from National Institutes of Health [Member]
      Dec. 31, 2009
      Grant from National Institutes of Health [Member]
      Research and Development Arrangement, Contract to Perform for Others [Line Items]                                                                
      Total number of newly issued unregistered shares of common stock purchased (in shares)       15,816,953                                                        
      Collaboration development revenue                   $ 17,500,000 $ 26,400,000 $ 36,500,000     $ 309,100,000 $ 284,900,000 $ 210,700,000                 $ 43,100,000 $ 75,400,000 $ 67,300,000        
      Amount of non-refundable payment received for collaboration agreement             25,000,000 25,000,000 80,000,000         85,000,000                   75,000,000                
      Number of newly issued, unregistered shares of Common Stock purchased (in shares)                 2,799,552       12,000,000                                      
      Cash price of newly issued, unregistered shares of Common Stock purchased                 45,000,000       312,000,000                                      
      Royalty based on percentage of annual sales in Japan (in hundredths)                   35.00%                                            
      Maximum amount of milestone payments that may be received relating to marketing approvals       400,000,000                                                        
      Maximum amount of milestone payments that may be received if certain sales are achieved                             250,000,000                                  
      Maximum amount of milestone payments that may be received relating to marketing approvals in the U.S. or European Union       360,000,000                                                        
      Maximum number of product candidates for which milestone payments may be received relating to marketing approvals in the U.S. or European Union       8                                                        
      Maximum amount of milestone payments that may be received relating to marketing approvals in Japan       40,000,000                                                        
      Maximum number of product candidates for which milestone payments may be received relating to marketing approvals in Japan       5                                                        
      Percentage of development expenses to be reimbursed due to profitability of agreement (in hundredths)                   50.00%         50.00%                     50.00%            
      Development expenses incurred to date       763,400,000                     582,300,000                     370,900,000            
      Number of years of first commercial sale of the product (in years)                   2Y                                            
      Reimbursement of development expenses in accordance with formula until first commercial sale                   7,500,000                                            
      Minimum advance notice required to terminate collaboration agreement                   12M         3M                     six months or twelve months            
      Increase (decrease) in collaboration revenue recognized based on shortened (extended) performance period                             (5,300,000)                                  
      Amounts receivable from collaboration agreements 74,781,000 79,603,000                 3,900,000       78,500,000 75,700,000                   4,500,000            
      Deferred revenue                   22,900,000 32,600,000       83,100,000 84,000,000         47,000,000       47,000,000 42,400,000 47,000,000          
      Annual funding maximum of research activities through 2017 per amended agreement                                   160,000,000                            
      Adjusted maximum amount of annual funding per amended agreement                                 120,000,000                              
      Amount of research funded during the period                               137,700,000                                
      Balance between amount funded and annual funding maximum                               22,300,000                                
      Option to extend (in years)                             3Y                                  
      Substantive milestone payment to be received if option to license rights is exercised                             10,000,000                                  
      Number of therapeutic antibodies currently under development                             7                                  
      Percentage of Shared Phase 3 Trial Costs borne by collaborating party (in hundredths)                             80.00%                                  
      Percentage of Shared Phase 3 Trial Costs borne by entity (in hundredths)                             20.00%                                  
      Percentage of Shared Phase 3 Trial Costs to be reimbursed due to profitability of agreement                             30.00%                                  
      Excess share of profit not required to to be applied to reimburse development cost (in hundredths)                             10.00%                                  
      Starting share of profits outside the United States, based on sales, for collaborating party (in hundredths)                             65.00%                                  
      Starting share of profits outside the United States, based on sales, for Company (in hundredths)                             35.00%                                  
      Ending share of profits outside the United States, based on sales, for collaborating party (in hundredths)                             55.00%                                  
      Ending share of profits outside the United States, based on sales, for Company (in hundredths)                             45.00%                                  
      Share of losses outside the United States, for collaborating party (in hundredths)                             55.00%                                  
      Share of losses outside the United States, for Company (in hundredths)                             45.00%                                  
      Conditions for commencement of sales milestone payments                             only if and after aggregate annual sales outside the United States exceed $1.0 billion on a rolling 12-month basis                                  
      Amount of funding of agreed-upon cost incurred to expand manufacturing capacity                             30,000,000                                  
      Amount of funding to expand manufacturing capacity that has been received or is receivable                             28,200,000                                  
      Period of notice to opt-out of further development and/or commercialization (in months)                             12M                                  
      Period of notice to opt-out of further development upon entering of joint development product (in days)                             30D                                  
      Minimum payments expected to be received under the agreement                                     21,500,000                          
      Amount of milestone payment received                                       10,000,000 10,000,000 20,000,000 20,000,000                  
      Number of substantive milestone payments earned                                                 2              
      Amount of milestone payments earned                                                 20,000,000              
      Maximum amount of milestone payments that may be received related to marketing approvals in major market countries outside the U.S.                                                   50,000,000            
      Maximum amount of sales milestone payments if total sales achieve specific levels                                                   135,000,000            
      Starting specified levels of annual sales at which sales milestone payments may be received                                                   200,000,000            
      Additional research and development expenses obligated to reimburse                                                   47,800,000 48,900,000 37,700,000        
      Expenses under the collaboration payable to collaborating party                   3,700,000                                            
      Minimum amount of research funding                                                         25,300,000      
      Period of funding (in years)                                                         5Y      
      Additional funding to optimize certain existing technology                                                         1,500,000      
      Contract research revenue 6,599,000 6,945,000 6,434,000                                                     3,600,000 4,600,000 5,500,000
      Shared Pre-Launch Commercialization Expenses With Collaborator                   9,300,000                                            
      Company-incurred expenses associated with Sanofi collaborations       381,200,000 282,400,000 209,400,000                                                    
      Payable to Bayer HealthCare                                         $ 2,300,000       $ 2,300,000   $ 2,300,000          
      XML 34 R29.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Summary of Significant Accounting Policies (Policies)
      		 12 Months Ended
      Dec. 31, 2011
      Summary of Significant Accounting Policies [Abstract]  
      Cash and Cash Equivalents
      Cash and Cash Equivalents

      For purposes of the statement of cash flows and the balance sheet, the Company considers all highly liquid debt instruments with a maturity of three months or less when purchased to be cash equivalents.  The carrying amount reported in the balance sheet for cash and cash equivalents approximates its fair value.
      Marketable Securities
      Marketable Securities

      The Company has an investment policy that includes guidelines on acceptable investment securities, minimum credit quality, maturity parameters, and concentration and diversification.  The Company has invested its excess cash primarily in direct obligations of the U.S. government and its agencies, other debt securities guaranteed by the U.S. government, and money market funds that invest in U.S. government securities.  The Company considers its marketable securities to be "available-for-sale," as defined by authoritative guidance issued by the Financial Accounting Standards Board ("FASB").  These assets are carried at fair value and the unrealized gains and losses are included in accumulated other comprehensive income (loss) as a separate component of stockholders' equity.  If the decline in the value of a marketable security in the Company's investment portfolio is deemed to be other-than-temporary, the Company writes down the security to its current fair value and recognizes a loss as a charge against income.  As described under "Use of Estimates" below, the Company reviews its portfolio of marketable securities, using both quantitative and qualitative factors, to determine if declines in fair value below cost are other-than-temporary.
      Accounts Receivable - Trade
      Accounts Receivable - Trade

      The Company’s trade accounts receivable represents amounts due from its distributors and specialty pharmacies (collectively, the Company’s “customers”), which are all located in the United States.  The Company monitors the financial performance and credit worthiness of its large customers so that it can properly assess and respond to changes in their credit profile.  The Company provides reserves against trade receivables for estimated losses that may result from a customer’s inability to pay.  Amounts determined to be uncollectible are written-off against the reserve.  As of December 31, 2011 and 2010, there were no reserves against trade accounts receivable.  In addition, during the years ended December 31, 2011, 2010 and 2009, no trade accounts receivable were written-off.
      Inventory
      Inventory

      Inventories are stated at the lower of cost or estimated realizable value.  The Company determines the cost of inventory using the first-in, first-out, or FIFO, method.  The Company capitalizes inventory costs associated with the Company's products prior to regulatory approval when, based on management's judgment, future commercialization is considered probable and the future economic benefit is expected to be realized; otherwise, such costs are expensed as research and development.  The Company periodically analyzes its inventory levels to identify inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, and writes-down such inventories as appropriate. In addition, the Company's products are subject to strict quality control and monitoring which the Company performs throughout the manufacturing process.  If certain batches or units of product no longer meet quality specifications or become obsolete due to expiration, the Company records a charge to cost of goods sold to write down such unmarketable inventory to its estimated realizable value.
      Property, Plant, and Equipment
      Property, Plant, and Equipment

      Property, plant, and equipment are stated at cost, net of accumulated depreciation.  Depreciation is provided on a straight-line basis over the estimated useful lives of the assets.  Expenditures for maintenance and repairs which do not materially extend the useful lives of the assets are charged to expense as incurred.  The cost and accumulated depreciation or amortization of assets retired or sold are removed from the respective accounts, and any gain or loss is recognized in operations.  The estimated useful lives of property, plant, and equipment are as follows:

      Building and improvements                                                                           10-40 years
      Laboratory and other equipment                                                                           3-10 years
      Furniture and fixtures                                                                           5 years

      Leasehold improvements are amortized over the shorter of the estimated useful lives of the assets or the lease term, without assuming renewal features, if any, are exercised.  Costs of construction of certain long-lived assets include capitalized interest which is amortized over the estimated useful life of the related asset.
      Accounting for the Impairment of Long-Lived Assets
      Accounting for the Impairment of Long-Lived Assets

      The Company periodically assesses the recoverability of long-lived assets, such as property, plant, and equipment, and evaluates such assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable.  Asset impairment is determined to exist if estimated future undiscounted cash flows are less than the carrying amount.  For all periods presented, no impairment losses were recorded.
      Patents
      Patents

      As a result of the Company's research and development efforts, the Company obtains and applies for patents to protect proprietary technology and inventions.  All costs associated with patents for product candidates under development are expensed as incurred. Patent costs related to commercial products are capitalized and amortized over the shorter of their estimated useful life or the remaining patent term.  To date, the Company has no capitalized patent costs.
      Operating Leases
      Operating Leases

      On certain of its operating lease agreements, the Company may receive rent holidays and other incentives.  The Company recognizes operating lease costs on a straight-line basis without regard to deferred payment terms, such as rent holidays, that defer the commencement date of required payments.  In addition, lease incentives that the Company receives are treated as a reduction of rent expense over the term of the related agreements.
      Revenue Recognition, Collaboration Revenue
      a. Collaboration Revenue

      The Company earns collaboration revenue in connection with collaboration agreements to develop and commercialize product candidates and utilize the Company’s technology platforms.  The terms of these agreements typically include non-refundable up-front licensing payments, research progress (milestone) payments, and payments for development activities.  Non-refundable up-front license payments, where continuing involvement is required of the Company, are deferred and recognized over the related performance period.  The Company estimates its performance period based on the specific terms of each agreement, and adjusts the performance periods, if appropriate, based on the applicable facts and circumstances.   Although the Company did not enter into, or materially modify, any collaboration arrangements with multiple-deliverables during the year ended December 31, 2011, any future arrangements with multiple deliverables will be divided into separate units of accounting if the deliverables in the arrangement meet certain criteria, including whether the delivered item or items has value to the collaborator on a standalone basis. Payments which are based on achieving a specific performance milestone, involving a degree of risk, are recognized as revenue when the milestone is achieved and the related payment is due and non-refundable, provided there is no future service obligation associated with that milestone.  Substantive performance milestones typically consist of significant achievements in the development life-cycle of the related product candidate, such as completion of clinical trials, filing for approval with regulatory agencies, and receipt of approvals by regulatory agencies.  In determining whether a payment is deemed to be a substantive performance milestone, the Company takes into consideration (i) the enhancement in value to the related development product candidate, (ii) the Company’s performance and relative level of effort required to achieve the milestone, (iii) whether the milestone relates solely to past performance, and (iv) whether the milestone payment is considered reasonable relative to all of the deliverables and payment terms.  Payments for achieving milestones which are not considered substantive are deferred and recognized over the related performance period.

      The Company enters into collaboration agreements that include varying arrangements regarding which parties perform and bear the costs of research and development activities.  The Company may share the costs of research and development activities with a collaborator, such as in the Company’s EYLEAÒ collaboration with Bayer HealthCare LLC, or the Company may be reimbursed for all or a significant portion of the costs of the Company’s research and development activities, such as in the Company’s ZALTRAP® (aflibercept) and antibody collaborations with Sanofi.  The Company records its internal and third-party development costs associated with these collaborations as research and development expenses.  When the Company is entitled to reimbursement of all or a portion of the research and development expenses that it incurs under a collaboration, the Company records those reimbursable amounts as collaboration revenue proportionately as the Company recognizes its expenses.  If the collaboration is a cost-sharing arrangement in which both the Company and its collaborator perform development work and share costs, in periods when the Company’s collaborator incurs development expenses that benefit the collaboration and Regeneron, the Company also recognizes, as additional research and development expense, the portion of the collaborator’s development expenses that the Company is obligated to reimburse.  In certain cases, the Company may also share the costs of pre-launch commercialization activities with its collaborators.  The Company records its share of these costs as a reduction of collaboration revenue.

      In connection with non-refundable licensing payments, the Company’s performance period estimates are principally based on projections of the scope, progress, and results of its research and development activities.  Due to the variability in the scope of activities and length of time necessary to develop a drug product, changes to development plans as programs progress, and uncertainty in the ultimate requirements to obtain governmental approval for commercialization, revisions to performance period estimates are likely to occur periodically, and could result in material changes to the amount of revenue recognized each year in the future.  In addition, estimated performance periods may change if development programs encounter delays, or the Company and its collaborators decide to expand or contract the clinical plans for a drug candidate in various disease indications.  Also, if a collaborator terminates an agreement in accordance with the terms of the agreement, the Company would recognize any unamortized remainder of an up-front or previously deferred payment at the time of the termination.
      Revenue Recognition, Technology Licensing
      b. VelocImmune® Technology Licensing

      The Company enters into non-exclusive license agreements with third parties that allow the third party to utilize the Company’s VelocImmune® technology in its internal research programs.  The terms of these agreements include up-front payments and entitle the Company to receive royalties on any future sales of products discovered by the third party using the Company’s VelocImmune® technology.  Up-front payments under these agreements, where continuing involvement is required of the Company, are deferred and recognized ratably over their respective license periods.
      Revenue Recognition, Product Revenue
      c. Product Revenue

      Product sales consist of U.S. sales of the Company’s two marketed products, EYLEAÒ and ARCALYSTÒ.  Revenue from product sales is recognized when persuasive evidence of an arrangement exists, title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, the Company has no further performance obligations, and returns can be reasonably estimated.  The Company’s written contracts with its customers stipulate product is shipped freight on board destination (FOB destination).  The Company records revenue from product sales upon delivery to its customers.

      The Company sells EYLEAÒ in the United States to three distributors and several specialty pharmacies.  The Company sells ARCALYSTÒ in the United States to two specialty pharmacies.  Under these distribution models, the distributors and specialty pharmacies generally take physical delivery of product.  For EYLEAÒ, the distributors and specialty pharmacies generally sell the product directly to healthcare providers; whereas for ARCALYSTÒ, the specialty pharmacies sell the product directly to patients.

      Revenue from product sales are recorded net of applicable provisions for prompt pay discounts, rebates and chargebacks under governmental programs (including Medicaid), product returns, distribution-related fees, and other sales-related deductions.  Calculating these provisions involves estimates and judgments.  The Company reviews its estimates of rebates, chargebacks, and other applicable provisions each period and records any necessary adjustments in the current period’s net product sales.

      Prompt Pay Discounts: No prompt pay discounts are currently offered to the Company’s customers on sales of EYLEAÒ.  In connection with sales of ARCALYSTÒ, the Company offers discounts to its customers for prompt payments.  The Company estimates these discounts based on customer terms and historical experience, and expects that its customers will always take advantage of this discount.  Therefore, the Company accrues 100% of the prompt pay discount that is based on the gross amount of each ARCALYSTÒ invoice, at the time of sale.

      The Company’s accrual for prompt pay discounts was not material at December 31, 2011 and 2010.

      Government Rebates and Chargebacks:  The Company estimates reductions to product sales for Medicaid and Veterans’ Administration (VA) programs, and for certain other qualifying federal and state government programs.  Based upon the Company’s contracts with government agencies, statutorily-defined discounts applicable to government-funded programs, historical experience, and, in the case of EYLEAÒ, estimated payer mix based on third-party market research data, the Company estimates and records an allowance for rebates and chargebacks.  The Company’s liability for Medicaid rebates consists of estimates for claims that a state will make for a current quarter, claims for prior quarters that have been estimated for which an invoice has not been received, and invoices received for claims from prior quarters that have not been paid.  The Company’s reserves related to discounted pricing offered to VA,  Public Health Services (PHS), and other institutions (collectively, “qualified healthcare providers”) represent the Company’s estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices the Company charges to its customers (i.e., distributors and specialty pharmacies).  The Company’s customers charge the Company for the difference between what they pay for the products and the ultimate selling price to the qualified healthcare providers.  The Company’s reserve for this discounted pricing is based on expected sales to qualified healthcare providers and the chargebacks that customers have already claimed.

      The Company’s government rebate and chargeback accruals were $0.6 million at December 31, 2011, which was based on a percentage of gross sales.  Government rebate and chargeback accruals were not material at December 31, 2010.

      Product Returns:  Consistent with industry practice, the Company offers its customers a limited right to return product purchased directly from the Company, which is principally based upon the product’s expiration date.  The Company will accept returns for three months prior to and up to six months after the product expiration date.  Product returned is generally not resalable given the nature of the Company’s products and method of administration.  The Company develops estimates for product returns based upon historical experience, inventory levels in the distribution channel, and other relevant factors.

      The Company has developed estimates for EYLEAÒ product returns, based on several factors, including (i) the Company’s historical experience to date, and the Company’s expectation, that its customers will not stock significant supplies of EYLEAÒ due to contractual limitations and other mitigating circumstances, (ii) historical industry information regarding product return rates for similar specialty products, and (iii) the shelf life of the product.  Estimates for ARCALYSTÒ product returns have been developed based primarily on historical returns experience; to date, actual ARCALYSTÒ product returns have been negligible.  The Company monitors product supply levels in the distribution channel, as well as sales by its customers of EYLEAÒ to healthcare providers and ARCALYSTÒ to patients using product-specific data provided by its customers.  If necessary, the Company’s estimates of product returns may be adjusted in the future based on actual returns experience, known or expected changes in the marketplace, or other factors.

      The Company’s product returns accruals were not material at December 31, 2011 and 2010.

      Distribution-Related Fees:  The Company has written contracts with its customers that include terms for distribution-related fees.  The Company estimates and records distribution and related fees due to its customers based on a percentage of gross sales.  The Company’s accrual for distribution-related fees was $1.5 million at December 31, 2011.   The Company’s accrual for distribution-related fees at December 31, 2010 was not material.
      Investment Income
      Investment Income

      Interest income, which is included in investment income, is recognized as earned.
      Research and Development Expenses
      Research and Development Expenses

      Research and development expenses include costs directly attributable to the conduct of research and development programs, including the cost of salaries, payroll taxes, employee benefits, materials, supplies, depreciation on and maintenance of research equipment, costs related to research collaboration and licensing agreements, the cost of services provided by outside contractors, including services related to the Company's clinical trials, clinical trial expenses, the full cost of manufacturing drug for use in research, preclinical development, and clinical trials, amounts that the Company is obligated to reimburse to collaborators for research and development expenses that they incur, and the allocable portions of facility costs, such as rent, utilities, insurance, repairs and maintenance, depreciation, and general support services.  All costs associated with research and development are expensed.

      Clinical trial costs are a significant component of research and development expenses and include costs associated with third-party contractors.  The Company outsources a substantial portion of its clinical trial activities, utilizing external entities such as contract research organizations ("CROs"), independent clinical investigators, and other third-party service providers to assist the Company with the execution of its clinical studies.  For each clinical trial that the Company conducts, certain clinical trial costs are expensed immediately, while others are expensed over time based on the expected total number of patients in the trial, the rate at which patients enter the trial, and/or the period over which clinical investigators or CROs are expected to provide services.

      Clinical activities which relate principally to clinical sites and other administrative functions to manage the Company's clinical trials are performed primarily by CROs.  CROs typically perform most of the start-up activities for the Company's trials, including document preparation, site identification, screening and preparation, pre-study visits, training, and program management.  On a budgeted basis, these start-up costs are typically 10% to 20% of the total contract value.  On an actual basis, this percentage range can be significantly wider, as many of the Company's contracts with CROs are either expanded or reduced in scope compared to the original budget, while start-up costs for the particular trial may not change materially.  These start-up costs usually occur within a few months after the contract has been executed and are event driven in nature. The remaining activities and related costs, such as patient monitoring and administration, generally occur ratably throughout the life of the individual contract or study. In the event of early termination of a clinical trial, the Company accrues and recognizes expenses in an amount based on its estimate of the remaining non-cancelable obligations associated with the winding down of the clinical trial and/or penalties.

      For clinical study sites, where payments are made periodically on a per-patient basis to the institutions performing the clinical study, the Company accrues expense on an estimated cost-per-patient basis, based on subject enrollment and activity in each quarter.  The amount of clinical study expense recognized in a quarter may vary from period to period based on the duration and progress of the study, the activities to be performed by the sites each quarter, the required level of patient enrollment, the rate at which patients actually enroll in and drop-out of the clinical study, and the number of sites involved in the study.  Clinical trials that bear the greatest risk of change in estimates are typically those that have a significant number of sites, require a large number of patients, have complex patient screening requirements, and span multiple years.  During the course of a trial, the Company adjusts its rate of clinical expense recognition if actual results differ from the Company's estimates.  The Company's estimates and assumptions for clinical expense recognition could differ significantly from its actual results, which could cause material increases or decreases in research and development expenses in future periods when the actual results become known
      Stock-based Compensation
      Stock-based Compensation

      The Company recognizes stock-based compensation expense for grants of stock option awards and restricted stock under the Company's Long-Term Incentive Plan to employees and non-employee members of the Company's board of directors based on the grant-date fair value of those awards.  The grant-date fair value of an award is generally recognized as compensation expense over the award's requisite service period.  In addition, the Company has granted performance-based stock option awards which vest based upon the optionee satisfying certain performance and service conditions as defined in the agreements.  Potential compensation cost, measured on the grant date, related to these performance options will be recognized only if, and when, the Company estimates that these options will vest, which is based on whether the Company consider the options' performance conditions to be probable of attainment.  The Company's estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods.

      The Company uses the Black-Scholes model to compute the estimated fair value of stock option awards.  Using this model, fair value is calculated based on assumptions with respect to (i) expected volatility of the Company's Common Stock price, (ii) the periods of time over which employees and members of the board of directors are expected to hold their options prior to exercise (expected lives), (iii) expected dividend yield on the Common Stock, and (iv) risk-free interest rates.  Stock-based compensation expense also includes an estimate, which is made at the time of grant, of the number of awards that are expected to be forfeited.  This estimate is revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.
      Income Taxes
      Income Taxes

      The Company recognizes deferred tax liabilities and assets for the expected future tax consequences of events that have been included in the financial statements or tax returns.  Under this method, deferred tax liabilities and assets are determined on the basis of the difference between the tax basis of assets and liabilities and their respective financial reporting amounts ("temporary differences") at enacted tax rates in effect for the years in which the differences are expected to reverse.  A valuation allowance is established for deferred tax assets for which it is more likely than not that some portion or all of the deferred tax assets will not be realized.
      Uncertain tax positions are accounted for in accordance with FASB authoritative guidance, which prescribes a comprehensive model for the manner in which a company should recognize, measure, present, and disclose in its financial statements all material uncertain tax positions that the company has taken or expects to take on a tax return.  Those positions, for which management's assessment is that there is more than a 50% probability of sustaining the position upon challenge by a taxing authority based upon its technical merits, are subjected to certain measurement criteria.

      The Company's policy is to recognize interest and penalties related to income tax matters in income tax expense.
      Comprehensive Income (Loss)
      Comprehensive Income (Loss)

      Comprehensive income (loss) of the Company includes net income (loss) adjusted for the change in net unrealized gain or loss on marketable securities, net of any tax effect.  Comprehensive income (loss) for the years ended December 31, 2011, 2010, and 2009 have been included in the Statements of Stockholders' Equity.
      Per Share Data
      Per Share Data

      Net income (loss) per share, basic and diluted, is computed on the basis of the net income (loss) for the period divided by the weighted average number of shares of Common Stock and Class A Stock outstanding during the period.  Basic net income (loss) per share excludes restricted stock awards until vested.  Diluted net income per share is based upon the weighted average number of shares of Common Stock and Class A Stock outstanding, and of common stock equivalents outstanding when dilutive.  Common stock equivalents include: (i) outstanding stock options and restricted stock awards under the Company's Long-Term Incentive Plans, which are included under the "treasury stock method" when dilutive, (ii) Common Stock to be issued upon the assumed conversion of the Company's convertible senior notes, which are included under the "if-converted method" when dilutive, and (iii) Common Stock to be issued upon the exercise of outstanding warrants, which are included under the "treasury stock method" when dilutive.  The computation of diluted net loss per share for the years ended December 31, 2011, 2010, and 2009 does not include common stock equivalents, since such inclusion would be antidilutive.
      Use of Estimates
      Use of Estimates

      The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes.  Actual results could differ from those estimates.  Estimates which could have a significant impact on the Company’s financial statements include:

      ·  
      Product rebates, chargebacks, and returns in connection with the recognition of product sales revenue.
      ·  
      Periods over which payments, including non-refundable up-front, license, and milestone payments, are recognized as revenue in connection with collaboration and other agreements to develop and commercialize product candidates and utilize the Company’s technology platforms.
      ·  
      Periods over which certain clinical trial costs, including costs for clinical activities performed by contract research organizations, are recognized as research and development expenses.
      ·  
      In connection with the recognition of expense, using a blended royalty rate, related to the Company’s non-exclusive license with Genentech, Inc., the Company’s estimate of cumulative EYLEAÒ sales through May 7, 2016 (see Note 12b).
      ·  
      In connection with stock option awards, (i) the fair value of stock options on their date of grant using the Black-Scholes option-pricing model, based on assumptions with respect to (a) expected volatility of the Company’s Common Stock price, (b) the periods of time for which employees and members of the Company’s board of directors are expected to hold their options prior to exercise (expected lives), (c) expected dividend yield on the Company’s Common Stock, and (d) risk-free interest rates, which are based on quoted U.S. Treasury rates for securities with maturities approximating the options’ expected lives; (ii) the number of stock option awards that are expected to be forfeited; and (iii) with respect to performance-based stock option awards, if and when the options’ performance conditions are considered to be probable of attainment.
      ·  
      The Company’s determination of whether marketable securities are other-than-temporarily impaired.  The Company conducts a review of its portfolio of marketable securities, using both quantitative and qualitative factors, to determine, for securities whose current fair value is less than their cost, whether the decline in fair value below cost is other-than-temporary.  In making this determination, the Company considers factors such as the length of time and the extent to which fair value has been less than cost, financial condition and near-term prospects of the issuer, recommendations of investment advisors, and forecasts of economic, market, or industry trends.  This review process also includes an evaluation of the Company’s ability and intent to hold individual securities until they mature or their full value can be recovered.  This review is subjective and requires a high degree of judgment.
      ·  
      Useful lives of property, plant, and equipment.
      ·  
      Inventory that may expire prior to expected sale or has a cost basis in excess of its estimated realizable value, which is written-down, as appropriate.  In addition, capitalization of inventory costs associated with the Company’s products prior to regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized.
      ·  
      The extent to which deferred tax assets and liabilities are offset by a valuation allowance.

      In addition, the Company’s share of EYLEAÒ development expenses incurred by Bayer HealthCare, including the Company’s share of Bayer HealthCare’s estimated EYLEAÒ development expenses for the most recent fiscal quarter, are included in research and development expenses.  The Bayer HealthCare estimate for the most recent fiscal quarter is adjusted in the subsequent quarter to reflect actual expenses for the quarter.  Also, the Company’s share of ZALTRAP® pre-launch commercialization expenses incurred by Sanofi, including the Company’s share of Sanofi’s estimated ZALTRAP® pre-launch commercialization expenses for the most recent fiscal quarter, are included as a reduction of Sanofi collaboration revenue.  The Sanofi estimate for the most recent fiscal quarter is adjusted in the subsequent quarter to reflect actual expenses for the quarter.
      XML 35 R28.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Unaudited Quarterly Results
      		 12 Months Ended
      Dec. 31, 2011
      Unaudited Quarterly Results [Abstract]  
      Unaudited Quarterly Results
      21.  
      Unaudited Quarterly Results

      Summarized quarterly financial data for the years ended December 31, 2011 and 2010 are set forth in the following tables.

       
      First Quarter
      Ended
      March 31, 2011
      Second Quarter Ended
      June 30, 2011
      Third Quarter Ended
      September 30, 2011
      Fourth Quarter
      Ended
      December 31, 2011
       
      (Unaudited)
      Revenues
       $112,204
      $107,810
      $102,833
      $122,977
      Net loss
       (43,447)
         (62,505)
         (62,365)
         (53,443)
      Net loss per share, basic and diluted:
       
          $(0.49)
       
         $(0.69)
       
         $(0.68)
       
        $(0.58)


       
      First Quarter
      Ended
      March 31, 2010
      Second Quarter Ended
      June 30, 2010
      Third Quarter Ended
      September 30, 2010
      Fourth Quarter
      Ended
      December 31, 2010
       
      (Unaudited)
      Revenues
       $103,534
      $115,886
      $105,979
      $133,675
      Net loss
       (30,522)
         (25,474)
         (33,875)
         (14,597)
      Net loss per share, basic and diluted:
       
          $(0.38)
       
         $(0.31)
       
         $(0.41)
       
        $(0.17)
      XML 36 R56.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Long-Term Incentive Plans (Details) (USD $)
      		 1 Months Ended 12 Months Ended
      Dec. 31, 2005
      Percent
      Dec. 31, 2011
      Integer
      Percent
      Dec. 31, 2010
      Percent
      Dec. 31, 2009
      Percent
      2000 Incentive Plan [Member]
      		        
      Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
      Number of shares of Common Stock reserved for future issuance (in shares)   41,307,016    
      Number of shares available for future grants (in shares)   10,244,318    
      Stock Options [Member]
      		        
      Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
      Maximum term of awards (in years)   10Y    
      Stock options activity [Roll forward]        
      Outstanding, beginning of period (in shares)   23,362,248    
      Granted (in shares)   4,286,640 4,319,856 3,490,560
      Forfeited (in shares)   (247,898)    
      Expired (in shares)   (551,456)    
      Exercised (in shares)   (4,523,173)    
      Vested and expected to vest, end of period (in shares)   21,755,141    
      Exercisable, end of period (in shares)   11,963,345    
      Outstanding, end of period (in shares)   22,326,361 23,362,248  
      Stock options activity, additional disclosures [Abstract]        
      Outstanding, beginning of period, weighted-average exercise price (in dollars per share)   $ 19.93    
      Granted, weighted-average exercise price (in dollars per share)   $ 51.96 $ 29.43 20.69
      Forfeited, weighted-average exercise price (in dollars per share)   $ 28.11    
      Expired, weighted-average exercise price (in dollars per share)   $ 13.31    
      Exercised, weighted-average exercise price (in dollars per share)   $ 18.73    
      Outstanding, end of period, weighted-average exercise price (in dollars per share)   $ 26.40 $ 19.93  
      Vested and expected to vest, end of period, weighted-average exercise price (in dollars per share)   $ 26.04    
      Exercisable, end of period, weighted-average exercise price (in dollars per share)   $ 18.27    
      Outstanding, end of period, weighted-average remaining contractual term (in years)   6.90    
      Vested and expected to vest, end of period, weighted-average remaining contractual term (in years)   6.84    
      Exercisable, end of period, weighted-average remaining contractual term (in years)   5.27    
      Outstanding, end of period, intrinsic value   $ 663,376,000    
      Vested and expected to vest, end of period, intrinsic value   653,990,000    
      Exercisable, end of period, intrinsic value   451,478,000    
      Total intrinsic value of stock options exercised   49,200,000 21,400,000 13,200,000
      Exercise price equal to Market Price [Abstract]        
      Number of Options Granted (in shares)   4,286,640 4,319,856 3,490,560
      Weighted-Average Exercise Price (in dollars per share)   $ 51.96 $ 29.43 20.69
      Weighted-Average Fair Value (in dollars per share)   $ 23.82 $ 13.36 10.89
      Weighted-average values of assumptions used in computing fair value of option grants [Abstract]        
      Expected volatility (in hundredths)   48.00% 47.00% 54.00%
      Expected lives from grant date (in years)   6.1 5.6 5.9
      Expected dividend yield (in hundredths)   0.00% 0.00% 0.00%
      Risk-free interest rate (in hundredths)   1.31% 2.11% 2.87%
      Phantom Stock [Member]
      		        
      Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
      Period within vesting date that awards may be received (in days)   30D    
      Non-Performance Based Stock Options [Member]
      		        
      Share-based compensation, aggregate disclosures [Abstract]        
      Non-cash stock-based compensation expense   39,200,000 29,400,000 27,400,000
      Unrecognized stock-based compensation cost, net of estimated forfeitures   93,600,000    
      Weighted average period for recognition of total unrecognized compensation expense (in years)   1.9    
      Performance-Based Stock Options [Member]
      		        
      Share-based compensation, aggregate disclosures [Abstract]        
      Non-cash stock-based compensation expense   11,700,000 8,100,000  
      Unrecognized stock-based compensation cost, net of estimated forfeitures   17,400,000    
      Weighted average period for recognition of total unrecognized compensation expense (in years)   2.5    
      Number of unvested options (in shares)   2,195,429    
      Number of options expected to vest upon achieving sales targets (in shares)   203,429    
      Number of options that would vest upon achieving certain development milestones (in shares)   1,992,000    
      Estimated percentage of options issued that will vest (in hundredths) 100.00% 50.00% 100.00% 100.00%
      Potential compensation cost to be recognized if vesting is probable   10,200,000    
      Restricted Stock [Member]
      		        
      Share-based compensation, aggregate disclosures [Abstract]        
      Non-cash stock-based compensation expense   5,700,000 2,400,000 2,200,000
      Unrecognized stock-based compensation cost, net of estimated forfeitures   $ 9,800,000    
      Weighted average period for recognition of total unrecognized compensation expense (in years)   1.4    
      Number of unvested options (in shares)   751,499    
      Restricted stock activity [Roll forward]        
      Outstanding, beginning of period (in shares)   845,000    
      Granted (in shares)   16,500    
      Released (in shares)   (110,001)    
      Outstanding, end of period (in shares)   751,499 845,000  
      Restricted stock activity, additional disclosures [Abstract]        
      Outstanding, beginning of period, weighted-average grant date fair value (in dollars per share)   $ 25.37    
      Granted, weighted-average grant date fair value (in dollars per share)   $ 58.59    
      Released, weighted-average grant date fair value (in dollars per share)   $ 30.63    
      Outstanding, end of period, weighted-average grant date fair value (in dollars per share)   $ 25.33 $ 25.37  
      XML 37 R44.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Technology Licensing Agreements (Details) (USD $)
      		 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended
      Aug. 31, 2010
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Feb. 28, 2011
      License Agreement with AstraZeneca UK Limited [Member]
      Integer
      Feb. 28, 2007
      License Agreement with AstraZeneca UK Limited [Member]
      Dec. 31, 2011
      License Agreement with AstraZeneca UK Limited [Member]
      Dec. 31, 2010
      License Agreement with AstraZeneca UK Limited [Member]
      Dec. 31, 2009
      License Agreement with AstraZeneca UK Limited [Member]
      Dec. 31, 2008
      License Agreement with AstraZeneca UK Limited [Member]
      Dec. 31, 2007
      License Agreement with AstraZeneca UK Limited [Member]
      Aug. 31, 2010
      License Agreement with Astellas Pharma Inc [Member]
      Mar. 31, 2007
      License Agreement with Astellas Pharma Inc [Member]
      Dec. 31, 2011
      License Agreement with Astellas Pharma Inc [Member]
      Dec. 31, 2010
      License Agreement with Astellas Pharma Inc [Member]
      Dec. 31, 2009
      License Agreement with Astellas Pharma Inc [Member]
      Dec. 31, 2008
      License Agreement with Astellas Pharma Inc [Member]
      Dec. 31, 2007
      License Agreement with Astellas Pharma Inc [Member]
      Deferred Revenue Arrangement [Line Items]                                    
      Non-exclusive license agreement term (in years)           6Y             6Y          
      Annual, non-refundable licensing payment received               $ 20,000,000 $ 20,000,000 $ 20,000,000 $ 20,000,000       $ 20,000,000 $ 20,000,000 $ 20,000,000 $ 20,000,000
      Period over which annual payment is recognized as revenue (in months)               12M 12M 12M 12M              
      Number of annual payments not received due to cancellation of obligation         2                          
      Advance payment received due to amended licensing agreement with Astellas Pharma Inc 165,000,000                                  
      Recognition period for advance payment (in years)                       7Y            
      Future payment to be made to the Company under the terms of the amended licensing agreement                             130,000,000      
      Number of days of advance written notice to terminate agreement (in days)                             90D      
      Technology licensing revenue recognized   24,858,000 40,150,000 40,013,000     2,900,000 20,000,000 20,000,000         22,000,000 20,000,000 20,000,000    
      Deferred revenue                           $ 151,700,000 $ 173,700,000      
      XML 38 R30.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Summary of Significant Accounting Policies (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Summary of Significant Accounting Policies [Abstract]  
      Estimated Useful Lives of Property, Plant, and Equipment
      The estimated useful lives of property, plant, and equipment are as follows:

      Building and improvements                                                                           10-40 years
      Laboratory and other equipment                                                                           3-10 years
      Furniture and fixtures                                                                           5 years
      XML 39 R31.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Marketable Securities (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Marketable Securities [Abstract]  
      Marketable Securities, Based on Contractual Maturity Dates
      The following tables summarize the amortized cost basis of debt securities included in marketable securities, the aggregate fair value of those securities, and gross unrealized gains and losses on those securities at December 31, 2011 and 2010.  The Company classifies its debt securities, other than mortgage-backed securities, based on their contractual maturity dates.  Maturities of mortgage-backed securities have been estimated based primarily on repayment characteristics and experience of the senior tranches that the Company holds.

       
      Amortized
        Fair
      Unrealized
      		 
      At December 31, 2011
      Cost Basis
        Value
               Gains
           (Losses)
                   Net
      Unrestricted
      		         
      Maturities within one year
      		         
      U.S. government obligations
      $12,025
      $12,067
      $42
      		 
      $42
      U.S. government guaranteed corporate bonds
      15,263
      15,316
      53
      		 
      53
      U.S. government guaranteed collateralized mortgage obligations
      623
      622
      		 
      (1)
      (1)
      Municipal bonds
      15,314
      15,326
      13
      (1)
      12
       
      43,225
      43,331
      108
      (2)
      106
       
      Maturities after one year through five years
      		         
      U.S. government obligations
      272,433
      272,752
      400
      (81)
      319
      Mortgage-backed securities
      104
      28
      ___
      (76)
      (76)
       
      272,537
      272,780
      400
      (157)
      243
       
      Maturities after five years through ten years
      		         
      Mortgage-backed securities
      164
      87
      ___
      (77)
      (77)
       
      315,926
      316,198
      508
      (236)
      272
                 
      Restricted
      		         
      Maturities within one year
      		         
      U.S. government obligations
      3,347
      3,357
      10
      		 
      10
                 
      Maturities after one year through five years
      		         
      U.S. government obligations
      2,572
      2,583
      11
      ___
      11
       
      5,919
      5,940
      21
      ___
      21
                 
       
      $321,845
      $322,138
      $529
      $(236)
      $293

       
       
       


                 
       
      Amortized
        Fair
      Unrealized
      		 
      At December 31, 2010
      Cost Basis
        Value
               Gains
           (Losses)
                   Net
                 
      Unrestricted
      		         
      Maturities within one year
      		         
        U.S. government obligations
      $83,635
      $83,684
      $54
      $(5)
      $49
      U.S. government guaranteed corporate bonds
      48,173
      48,531
      358
      		 
      358
        U.S. government guaranteed
           collateralized mortgage obligations
      2,027
      2,131
      104
      		 
      104
      Municipal bonds
      1,597
      1,603
      6
      		 
      6
        Mortgage-backed securities
      875
      847
      ___
      (28)
      (28)
       
      136,307
      136,796
      522
      (33)
      489
       
      Maturities after one year through five years
      		         
        U.S. government obligations
      352,345
      350,683
      64
      (1,726)
      (1,662)
      U.S. government guaranteed corporate bonds
      15,522
      15,477
      		 
      (45)
      (45)
        Mortgage-backed securities
      110
      38
      ___
      (72)
      (72)
       
      367,977
      366,198
      64
      (1,843)
      (1,779)
       
      Maturities after five years through ten years
      		         
        Mortgage-backed securities
      284
      243
      ___
      (41)
      (41)
       
      504,568
      503,237
      586
      (1.917)
      (1,331)
                 
      Restricted
      		         
      Maturities within one year
      		         
        U.S. government obligations
      2,922
      2,921
      		 
      (1)
      (1)
                 
      Maturities after one year through five years
      		         
        U.S. government obligations
      4,135
      4,118
      ___
      (17)
      (17)
       
      7,057
      7,039
      ___
      (18)
      (18)
                 
       
      $511,625
      $510,276
      $586
      $(1,935)
      $(1,349)
      Fair Value and Unrealized Losses of Marketable Securities
      The following table shows the fair value of the Company's marketable securities that have unrealized losses and that are deemed to be only temporarily impaired, aggregated by investment category and length of time that the individual securities have been in a continuous unrealized loss position, at December 31, 2011 and 2010.  The debt securities listed at December 31, 2011, excluding mortgage-backed securities, mature at various dates through December 2014.  The mortgage-backed securities listed at December 31, 2011 mature at various dates through April 2018.

       
       
      Less than 12 Months
       
      12 Months or Greater
       
      Total
       
      At December 31, 2011
       
      Fair Value
      Unrealized Loss
       
      Fair Value
      Unrealized Loss
       
      Fair Value
      Unrealized Loss
      Unrestricted
      		           
      U.S. government obligations
      $103,529
      $(81)
      		   
      $103,529
      $(81)
      U.S. government guaranteed
        collateralized mortgage
        obligations
      623
      (1)
      		   
      623
      (1)
      Municipal bonds
      4,603
      (1)
      		   
      4,603
      (1)
      Equity security
      3,019
      (1,025)
      		   
      3,019
      (1,025)
      Mortgage-backed securities
      _____
      ____
      $116
      $(152)
      116
      (152)
       
      $111,774
      $(1,108)
      $116
      $(152)
      $111,890
      $(1,260)
                   
                   
      At December 31, 2010
      		           
      Unrestricted
      		           
      U.S. government obligations
      $340,444
      $(1,731)
      		   
      $340,444
      $(1,731)
      U.S. government guaranteed
        corporate bonds
      19,005
      (45)
      		   
      19,005
      (45)
      Equity security
      3,612
      (433)
      		   
      3,612
      (433)
      Mortgage-backed securities
      _____
      ____
      $1,128
      $(141)
      1,128
      (141)
       
      363,061
      (2,209)
      1,128
      (141)
      364,189
      (2,350)
                   
      Restricted
      		           
          U.S. government obligations
      6,154
      (18)
      ____
      ____
      6,154
      (18)
       
      6,154
      (18)
      ____
      ____
      6,154
      (18)
                   
       
      $369,215
      $(2,227)
      $1,128
      $(141)
      $370,343
      $(2,368)
      Fair Value, Assets Measured on a Recurring Basis
      The Company's assets that are measured at fair value on a recurring basis, at December 31, 2011 and 2010, were as follows:

         
      Fair Value Measurements at Reporting Date Using
       
       
      Fair Value
      Quoted Prices in Active Markets for Identical Assets
      (Level 1)
      Significant Other Observable Inputs
      (Level 2)
      Significant Unobservable Inputs
      (Level 3)
      At December 31, 2011
      		       
      Unrestricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
      $284,819
      		 
      $284,819
      		 
      U.S. government guaranteed corporate bonds
      15,316
      		 
      15,316
      		 
      U.S. government guaranteed collateralized mortgage obligations
      622
      		 
      622
      		 
      Municipal bonds
      15,326
      		 
      15,326
      		 
      Mortgage-backed securities
      115
      		 
      115
      		 
      Equity security
      3,019
      $3,019
      _______
      		 
       
      319,217
      3,019
      316,198
      		 

               
      Restricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
          5,940
      _____
      5,940
      		 
               
       
      $325,157
      $3,019
      $322,138
      		 
               
      At December 31, 2010
      		       
      Unrestricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
      $434,367
      		 
      $434,367
      		 
      U.S. government guaranteed corporate bonds
      64,008
      		 
      64,008
      		 
      U.S. government guaranteed collateralized mortgage obligations
      2,131
      		 
      2,131
      		 
      Municipal bonds
      1,603
      		 
      1,603
      		 
      Mortgage-backed securities
      1,128
      		 
      1,128
      		 
      Equity security
      3,612
      $3,612
      _______
      		 
       
      506,849
      3,612
      503,237
      		 
               
      Restricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
          7,039
      _____
      7,039
      		 
               
       
      $513,888
      $3,612
      $510,276
      XML 40 R8.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Organization and Business
      		 12 Months Ended
      Dec. 31, 2011
      Organization and Business [Abstract]  
      Organization and Business
      1.  
      Organization and Business

      Regeneron Pharmaceuticals, Inc. (the “Company” or “Regeneron”) was incorporated in January 1988 in the State of New York.  The Company is a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions.  In 2008, the Company received marketing approval from the U.S. Food and Drug Administration (“FDA”) for the Company’s first commercial drug product, ARCALYSTÒ (rilonacept) Injection for Subcutaneous Use for the treatment of Cryopyrin-Associated Periodic Syndromes (“CAPS”).  In November 2011, the Company received marketing approval from the FDA for EYLEAÒ (aflibercept) Injection for the treatment of neovascular wet age-related macular degeneration (“wet AMD”).  The Company's facilities are primarily located in New York.  The Company’s business is subject to certain risks including, but not limited to, uncertainties relating to conducting pharmaceutical research, obtaining regulatory approvals, commercializing products, and obtaining and enforcing patents.
      XML 41 R32.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Inventory (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Inventory [Abstract]  
      Inventories
      Inventories as of December 31, 2011 and December 31, 2010 consist of the following:

       
      2011
      2010
                   Raw materials
      $1,608
      $592
                   Work in process
      10,806
      699
                   Finished goods
      1,142
      132
       
      $13,556
      $1,423
      XML 42 R40.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Net Loss Per Share Data (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Net Loss Per Share Data [Abstract]  
      Basic and Diluted Net Loss Per Share
      The calculations of basic and diluted net loss per share are as follows:

       
      December 31,
       
      2011
      2010
      2009
             
         Net loss (Numerator)
      $(221,760)
      $(104,468)
      $(67,830)
             
         Weighted-average shares, in thousands (Denominator)
       
      90,610
       
      82,926
       
      79,782
             
      Basic and diluted net loss per share
      $(2.45)
      $(1.26)
      $(0.85)
      Antidilutive Securities
      Shares issuable upon the exercise of options and warrants, vesting of restricted stock awards, and conversion of convertible senior notes, which have been excluded from the diluted per share amounts because their effect would have been antidilutive, include the following:

         
      December 31,
      		 
       
      2011
      2010
      2009
      Options:
      		     
         Weighted average number, in thousands
      20,942
      21,428
      20,040
         Weighted average exercise price
      $21.21
      $18.80
      $17.66
             
      Restricted Stock:
      		     
         Weighted average number, in thousands
      846
      526
      500
             
      Convertible Senior Notes:
      		     
          Weighted average number, in thousands
      939
      		   
             
      Warrants:
      		     
          Weighted average number, in thousands
      939
      		   
      XML 43 R53.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Commitments and Contingencies, Leases (Details) (USD $)
      		 12 Months Ended 24 Months Ended
      Dec. 31, 2011
      Percent
      Dec. 31, 2010
      Dec. 31, 2009
      Dec. 31, 2010
      Commitments under operating leases [Abstract]        
      2012 $ 7,260,000      
      2013 7,562,000      
      2014 7,463,000      
      2015 7,583,000      
      2016 7,738,000      
      Thereafter 59,631,000      
      Total 97,237,000      
      Rent expense under operating leases [Abstract]        
      Rent expense 7,790,000 7,636,000 8,117,000  
      Rental charges for utilities, real estate taxes, and operating expense 9,300,000 10,300,000 8,400,000  
      Capital leases [Abstract]        
      Marketable debt securities collateral 3,300,000 3,500,000   3,500,000
      Commitments under capital leases [Abstract]        
      Capital lease obligations 2,500,000 2,800,000   2,800,000
      Facility lease obligations [Abstract]        
      Interest expense in connection with facility lease obligation 15,600,000      
      Commitments under facility leases [Abstract]        
      2012 15,672,000      
      2013 17,462,000      
      2014 17,833,000      
      2015 18,214,000      
      2016 18,604,000      
      Thereafter 152,939,000      
      Total 240,724,000      
      Buildings A and B [Member]
      		        
      Facility lease obligations [Abstract]        
      Capitalized costs of constructing the new facility   58,400,000   58,400,000
      Reimbursements recognized as additional facility lease obligation       56,900,000
      Imputed interest rate applicable to the facility lease obligation (in hundredths) 11.00%      
      Interest expense in connection with facility lease obligation   9,100,000 2,300,000  
      Facility lease obligation 113,000,000 113,700,000   113,700,000
      Commitments under facility leases [Abstract]        
      2012 12,847,000      
      2013 13,092,000      
      2014 13,343,000      
      2015 13,600,000      
      2016 13,864,000      
      Thereafter 113,040,000      
      Total 179,786,000      
      Building C [Member]
      		        
      Facility lease obligations [Abstract]        
      Capitalized costs of constructing the new facility   27,800,000   27,800,000
      Reimbursements recognized as additional facility lease obligation   14,200,000    
      Imputed interest rate applicable to the facility lease obligation (in hundredths) 9.00%      
      Facility lease obligation 47,500,000 46,400,000   46,400,000
      Commitments under facility leases [Abstract]        
      2012 2,825,000      
      2013 4,370,000      
      2014 4,490,000      
      2015 4,614,000      
      2016 4,740,000      
      Thereafter 39,899,000      
      Total 60,938,000      
      Facilities [Member]
      		        
      Commitments under operating leases [Abstract]        
      2012 6,072,000      
      2013 7,304,000      
      2014 7,428,000      
      2015 7,583,000      
      2016 7,738,000      
      Thereafter 59,631,000      
      Total 95,756,000      
      Rent expense under operating leases [Abstract]        
      Rent expense 7,191,000 7,301,000 7,722,000  
      Equipment [Member]
      		        
      Commitments under operating leases [Abstract]        
      2012 1,188,000      
      2013 258,000      
      2014 35,000      
      Total 1,481,000      
      Rent expense under operating leases [Abstract]        
      Rent expense 599,000 335,000 395,000  
      Commitments under capital leases [Abstract]        
      2012 1,394,000      
      2013 1,254,000      
      2014 130,000      
      Total 2,778,000      
      Less: amount representing interest (272,000)      
      Total 2,506,000      
      Tarrytown Lease [Member]
      		        
      Operating leases [Abstract]        
      Number of new buildings leased 2      
      Description of leasing arrangement expire in June 2024 and contains three renewal options to extend the term of the lease by five years each, escalations at 2.5% per annum      
      Letter of credit amount outstanding in connection with lease 3,400,000 3,400,000   3,400,000
      Cash and marketable debt securities collateral $ 3,600,000 $ 3,600,000   $ 3,600,000
      XML 44 R2.htm IDEA: XBRL DOCUMENT v2.4.0.6
      BALANCE SHEETS (USD $)
      In Thousands, unless otherwise specified
      Dec. 31, 2011
      Dec. 31, 2010
      Current assets    
      Cash and cash equivalents $ 483,610 $ 112,572
      Marketable securities 43,332 136,796
      Accounts receivable from Sanofi 74,781 79,603
      Accounts receivable - trade, net 28,254 2,314
      Prepaid expenses and other current assets 22,898 26,337
      Total current assets 652,875 357,622
      Restricted cash and marketable securities 7,721 7,518
      Marketable securities 275,887 370,053
      Property, plant, and equipment, at cost, net of accumulated depreciation and amortization 367,955 347,450
      Other assets 19,145 6,789
      Total assets 1,323,583 1,089,432
      Current liabilities    
      Accounts payable and accrued expenses 95,625 53,658
      Deferred revenue from Sanofi, current portion 20,011 19,506
      Deferred revenue - other, current portion 31,629 35,217
      Facility lease obligations, current portion 1,006 675
      Total current liabilities 148,271 109,056
      Deferred revenue from Sanofi 86,017 97,081
      Deferred revenue - other 162,593 188,775
      Facility lease obligations 159,508 159,355
      Convertible senior notes 275,019 0
      Other long term liabilities 6,443 7,350
      Total liabilities 837,851 561,617
      Commitments and contingencies (Note 12)      
      Stockholders' equity    
      Preferred stock 0 0
      Common Stock 91 87
      Additional paid-in capital 1,754,824 1,575,780
      Accumulated deficit (1,267,323) (1,045,563)
      Accumulated other comprehensive loss (1,862) (2,491)
      Total stockholders' equity 485,732 527,815
      Total liabilities and stockholders' equity 1,323,583 1,089,432
      Class A Stock [Member]
      		    
      Stockholders' equity    
      Common Stock $ 2 $ 2
      XML 45 R45.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Product Revenue (Details) (USD $)
      		 3 Months Ended 12 Months Ended
      Mar. 31, 2010
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Concentration Risk [Line Items]        
      Net product sales   $ 44,686,000 $ 25,254,000 $ 18,364,000
      EYLEA Net Product Sales [Member] | Product Concentration Risk [Member]
      		        
      Concentration Risk [Line Items]        
      Net product sales   24,800,000    
      ARCALYST Net Product Sales [Member] | Product Concentration Risk [Member]
      		        
      Concentration Risk [Line Items]        
      Deferred net product sales recognized as revenue 4,800,000      
      Change in accounting estimate, deferred revenue - lower net loss per share (in dollars per share)     $ (0.06)  
      Net product sales   19,900,000 25,300,000 18,400,000
      Net product sales, excluding deferred sales recognized as revenue     $ 20,500,000  
      XML 46 R6.htm IDEA: XBRL DOCUMENT v2.4.0.6
      STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) (USD $)
      In Millions, unless otherwise specified
      		 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2009
      STATEMENTS OF STOCKHOLDERS' EQUITY [Abstract]    
      Change in net unrealized gain on marketable securities, tax effect $ 0.4 $ 0.7
      XML 47 R59.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Income Taxes (Details) (USD $)
      		 1 Months Ended 12 Months Ended
      Aug. 31, 2010
      Dec. 31, 2011
      Percent
      Dec. 31, 2010
      Dec. 31, 2009
      Income Taxes [Abstract]        
      Income tax benefit   $ (1,132,000) $ 0 $ (4,122,000)
      Income tax expense (benefit) resulting from provision in Worker, Homeownership, and Business Assistance Act of 2009       (2,700,000)
      Income tax expense (benefit) resulting from provision in American Recovery and Reinvestment Act of 2009   (700,000)   (700,000)
      Income tax expense (benefit) in connection with the net tax effect of unrealized gain on 'available for sale' marketable securities   (400,000)   (700,000)
      Deferred tax assets:        
      Net operating loss carry-forward   282,480,000 243,893,000  
      Fixed assets   14,847,000 13,600,000  
      Deferred revenue   120,490,000 70,443,000  
      Deferred compensation   47,092,000 39,120,000  
      Research and experimental and other tax credit carry-forwards   67,734,000 45,588,000  
      Capitalized research and development costs   31,371,000 38,865,000  
      Other   15,956,000 10,863,000  
      Deferred tax assets, gross   579,970,000 462,372,000  
      Deferred tax liabilities:        
      Convertible senior notes   (1,428,000)    
      Net deferred tax assets   578,542,000    
      Valuation allowance   (578,542,000) (462,372,000)  
      Deferred tax assets (liabilities), net   0 0  
      Advance payment received due to amended licensing agreement 165,000,000      
      Effective income tax reconciliation [Abstract]        
      U.S federal statutory income tax rate (in hundredths)   35.00%    
      Unrecognized tax benefits [Roll forward]        
      Balance, as of January 1   12,819,000    
      Gross increases related to current year tax positions   2,192,000 3,550,000  
      Gross increases related to prior year tax positions     9,269,000  
      Gross decreases due to settlements and lapse of statute of limitations   (9,415,000)    
      Balance, as of December 31   5,596,000 12,819,000  
      Research and Experimental and Other [Member]
      		        
      Tax Credit Carryforward [Line Items]        
      Tax credit carry-forwards, expiration dates   2012 to 2031    
      U.S. Federal and New York State [Member]
      		        
      Operating Loss Carryforwards [Line Items]        
      Unused net operating loss carry-forwards   800,200,000    
      Net operating loss carry-forwards, expiration dates   2018 to 2031    
      Net operating loss carry-forwards related to exercises of Nonqualified Stock Options and disqualifying dispositions of Incentive Stock Options   96,200,000    
      Net Operating Loss Carryforward and Tax Credit Carryforwards [Member]
      		        
      Valuation Allowance [Line Items]        
      Increase in valuation allowance   $ 116,200,000 $ 63,000,000  
      XML 48 R35.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Deferred Revenue (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Deferred Revenue [Abstract]  
      Deferred Revenue
      Deferred revenue as of December 31, 2011 and 2010 consists of the following:
       
                   2011
      		 
                   2010
      Current portion:
      		     
         Received from Sanofi (see Note 3a)
      $20,011
      		 
      $19,506
         Received from Bayer HealthCare (see Note 3b)
      7,907
      		 
      9,884
         Received for technology license agreements (see Note 4)
      23,572
      		 
      25,008
         Other
      150
      		 
      325
       
      $51,640
      		 
      $54,723
             
      Long-term portion:
      		     
         Received from Sanofi (see Note 3a)
      $86,017
      		 
      $97,081
         Received from Bayer HealthCare (see Note 3b)
      34,456
      		 
      37,067
         Received for technology license agreements (see Note 4)
      128,137
      		 
      151,708
       
      $248,610
      		 
      $285,856
      XML 49 R22.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Executive Stock Purchase Plan
      		 12 Months Ended
      Dec. 31, 2011
      Executive Stock Purchase Plan [Abstract]  
      Executive Stock Purchase Plan
      15.  
      Executive Stock Purchase Plan

      In 1989, the Company adopted an Executive Stock Purchase Plan (the “Plan”) under which 1,027,500 shares of Class A Stock were reserved for restricted stock awards.  The Plan provides for the compensation committee of the board of directors to award employees, directors, consultants, and other individuals (“Plan participants”) who render service to the Company the right to purchase Class A Stock at a price set by the compensation committee.  The Plan provides for the vesting of shares as determined by the compensation committee and, should the Company's relationship with a Plan participant terminate before all shares are vested, unvested shares will be repurchased by the Company at a price per share equal to the original amount paid by the Plan participant.  During 1989 and 1990, a total of 983,254 shares were issued, all of which vested as of December 31, 1999.  As of December 31, 2011, there were 44,246 shares available for future grants under the Plan.
      XML 50 R36.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Convertible Debt (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Convertible Debt [Abstract]  
      Net Carrying Amount of the Liability Component of Convertible Notes
      The net carrying amount of the liability component of the Notes as of December 31, 2011 consists of the following:
       
      2011
      		 
      Total convertible senior notes - par
      $400,000
      		 
      Unamortized discount
      124,981
      		 
       
      $275,019
      Interest Expense Associated with Convertible Notes
      Total interest expense associated with the Notes consisted of the following for the year ended December 31, 2011:
       
          2011
      		 
      Contractual coupon interest rate
      $1,455
      		 
      Amortization of discount and note issuance costs
      3,944
      		 
       
      $5,399
      XML 51 R24.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Income Taxes
      		 12 Months Ended
      Dec. 31, 2011
      Income Taxes [Abstract]  
      Income Taxes
      17.  
      Income Taxes

      For the year ended December 31, 2011, the Company incurred a net loss for tax purposes and recognized a full valuation allowance against deferred taxes.  In 2011, the Company recognized a $1.1 million income tax benefit, consisting of (i) $0.7 million related to tax legislation that allowed the Company to claim a refund for a portion of its unused pre-2006 research tax credits and (ii) $0.4 million in connection with the net tax effect of the change in the Company’s unrealized gain (loss) on “available for sale” marketable securities, which is included in other comprehensive income (loss).

      For the year ended December 31, 2010, the Company incurred a net loss for tax purposes and recognized a full valuation allowance against deferred taxes.  No provision or benefit for income taxes was recognized by the Company in 2010.

      For the year ended December 31, 2009, the Company incurred a net loss for tax purposes and recognized a full valuation allowance against deferred taxes.  In 2009, the Company recognized a $4.1 million income tax benefit, consisting of (i) $2.7 million resulting from tax legislation that allowed the Company to claim a refund of U.S. federal alternative minimum tax (“AMT”) that the Company paid in connection with its 2007 U.S. federal income tax return, (ii) $0.7 million resulting from tax legislation that allowed the Company to claim a refund for a portion of its unused pre-2006 research tax credits on its 2009 U.S. federal income tax return, and (iii) $0.7 million in connection with the net tax effect of the Company’s unrealized gain on “available-for-sale” marketable securities, which is included in other comprehensive income in 2009.

      The tax effect of temporary differences, net operating loss carry-forwards, and research and experimental and other tax credit carry-forwards as of December 31, 2011 and 2010 is as follows:



       
                   2011
                   2010
           Deferred tax assets:
      		   
       
      Net operating loss carry-forward
      $282,480
      $243,893
       
      Fixed assets
      14,847
      13,600
       
      Deferred revenue
      120,490
      70,443
       
      Deferred compensation
      47,092
      39,120
       
      Research and experimental and other tax credit carry-forwards
      67,734
      45,588
       
      Capitalized research and development costs
      31,371
      38,865
       
      Other
      15,956
      10,863
       
      579,790
      462,372
           Deferred tax liabilities:
      		 
       
       
      Convertible senior notes
       (1,428)
      		 
           
           Net deferred tax assets
      578,542
      		 
           Valuation allowance
       (578,542)
      (462,372)
         
                   --
                   --

      The Company’s valuation allowance increased by $116.2 million in 2011, due primarily to increases in the Company’s net operating loss carry-forward and tax credit carry-forwards and the full recognition of the $165.0 million up-front payment received from Astellas in 2010 as taxable income in 2011.  The Company’s valuation allowance increased by $63.0 million in 2010, due primarily to increases in the net operating loss carry-forward and tax credit carry-forwards.

      The Company is primarily subject to U.S. federal and New York State income taxes. The difference between the Company’s effective income tax rate and the U.S federal statutory rate of 35% is primarily attributable to an increase in the deferred tax valuation allowance.  In 2011 and early 2012, U.S. federal tax authorities concluded examinations of the Company’s 2007, 2008, and 2009 federal income tax returns.  The Company’s 2010 federal income tax return is currently being examined by the U.S. federal tax authorities.  In addition, tax years subsequent to 2007 remain open to examination by New York State tax authorities.

      As of December 31, 2011 and 2010, the Company had no accruals for interest or penalties related to income tax matters.

      As of December 31, 2011, the Company had available for tax purposes unused net operating loss carry-forwards of $800.2 million which will expire in various years from 2018 to 2031 and included $96.2 million of net operating loss carry-forwards related to exercises of Nonqualified Stock Options and disqualifying dispositions of Incentive Stock Options, the tax benefit from which, if realized, will be credited to additional paid-in capital. The Company's research and experimental and other tax credit carry-forwards expire in various years from 2012 to 2031.  Under the Internal Revenue Code and similar state provisions, substantial changes in the Company’s ownership have resulted in an annual limitation on the amount of net operating loss and tax credit carry-forwards that can be utilized in future years to offset future taxable income.  This annual limitation may result in the expiration of net operating losses and tax credit carry-forwards before utilization.

      The following table summarizes the gross amounts of unrecognized tax benefits at the beginning and end of 2011 and 2010:
         
      2011
      2010
      Balance as of January 1
      		 
      $12,819
      $         -
      Gross increases related to current year tax positions
      		 
      2,192
      3,550
      Gross increases related to prior year tax positions
      		   
      9,269
      Gross decreases due to settlements
      		 
      (9,415)
      _____
      Balance as of December 31
      		 
      $5,596
      $12,819

      In 2011, the gross decrease in unrecognized tax benefits related to prior year tax positions was primarily due to the conclusion of examinations of the Company’s 2007, 2008, and 2009 federal income tax returns by U.S. federal tax authorities.  In 2010, the gross increases in unrecognized tax benefits related to prior year tax positions was primarily due to the Company’s calculations of certain pre-2010 tax credits.  Due to the amounts of the Company’s net operating loss carry-forward and tax credit carry-forwards, the Company has not accrued interest or penalties related to these unrecognized tax benefits.  In addition, unrecognized tax benefits at December 31, 2011 and 2010, if recognized, would not affect the Company’s effective tax rate since the adjustments to deferred tax assets would be fully offset by adjustments to the Company’s valuation allowance.  For the year ended December 31, 2009, income tax positions that were deemed uncertain under the recognition thresholds and measurement attributes prescribed in FASB authoritative guidance were not material.
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      STATEMENTS OF CASH FLOWS (USD $)
      In Thousands, unless otherwise specified
      		 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Cash flows from operating activities      
      Net loss $ (221,760) $ (104,468) $ (67,830)
      Adjustments to reconcile net loss to net cash (used in) provided by operating activities      
      Depreciation and amortization 31,082 19,687 14,247
      Non-cash compensation expense 56,094 39,897 31,259
      Other non-cash charges and expenses, net 10,366 3,171 2,238
      Changes in assets and liabilities      
      Increase in Sanofi and trade accounts receivable (21,118) (17,518) (30,494)
      Increase in prepaid expenses and other assets (6,033) (7,303) (4,436)
      (Decrease) increase in deferred revenue (40,329) 158,151 (27,497)
      Increase in accounts payable, accrued expenses, and other liabilities 50,016 7,605 12,577
      Total adjustments 80,078 203,690 (2,106)
      Net cash (used in) provided by operating activities (141,682) 99,222 (69,936)
      Cash flows from investing activities      
      Purchases of marketable securities (240,391) (605,124) (199,997)
      Sales or maturities of marketable securities 426,356 273,723 295,117
      (Increase) decrease in restricted cash and marketable securities (277) (5,941) 50
      Capital expenditures (57,217) (99,689) (97,318)
      Net cash provided by (used in) investing activities 128,471 (437,031) (2,148)
      Cash flows from financing activities      
      Proceeds in connection with facility lease obligation 0 47,544 23,640
      Payments in connection with facility lease obligation (674) (924) (875)
      Payments in connection with capital lease obligation (993) (104) 0
      Proceeds in connection with issuance of convertible notes, net of debt issuance costs 391,107 0 0
      Proceeds in connection with issuance of warrants 93,800 0 0
      Payment in connection with purchase of convertible note hedges (117,500) 0 0
      Net proceeds in connection with issuance of Common Stock 18,509 196,790 8,598
      Net cash provided by financing activities 384,249 243,306 31,363
      Net increase (decrease) in cash and cash equivalents 371,038 (94,503) (40,721)
      Cash and cash equivalents at beginning of period 112,572 207,075 247,796
      Cash and cash equivalents at end of period 483,610 112,572 207,075
      Supplemental disclosure of cash flow information      
      Cash paid for interest $ 14,725 $ 12,737 $ 2,525
      XML 54 R3.htm IDEA: XBRL DOCUMENT v2.4.0.6
      BALANCE SHEETS (Parenthetical)
      Dec. 31, 2011
      PerShare
      Dec. 31, 2010
      PerShare
      Stockholders' equity    
      Preferred stock, par value (in dollars per share) 0.01 0.01
      Preferred stock, shares authorized (in shares) 30,000,000 30,000,000
      Preferred stock, issued (in shares) 0 0
      Preferred stock, outstanding (in shares) 0 0
      Common Stock, par value (in dollars per share) 0.001 0.001
      Common Stock, shares authorized (in shares) 160,000,000 160,000,000
      Common Stock, shares issued (in shares) 90,692,071 87,238,301
      Common Stock, shares outstanding (in shares) 90,692,071 87,238,301
      Class A Stock [Member]
      		    
      Stockholders' equity    
      Common Stock, par value (in dollars per share) 0.001 0.001
      Common Stock, shares authorized (in shares) 40,000,000 40,000,000
      Common Stock, shares issued (in shares) 2,109,512 2,182,036
      Common Stock, shares outstanding (in shares) 2,109,512 2,182,036
      XML 55 R17.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Deferred Revenue
      		 12 Months Ended
      Dec. 31, 2011
      Deferred Revenue [Abstract]  
      Deferred Revenue
      10.  
      Deferred Revenue

      Deferred revenue as of December 31, 2011 and 2010 consists of the following:
       
                   2011
      		 
                   2010
      Current portion:
      		     
         Received from Sanofi (see Note 3a)
      $20,011
      		 
      $19,506
         Received from Bayer HealthCare (see Note 3b)
      7,907
      		 
      9,884
         Received for technology license agreements (see Note 4)
      23,572
      		 
      25,008
         Other
      150
      		 
      325
       
      $51,640
      		 
      $54,723
             
      Long-term portion:
      		     
         Received from Sanofi (see Note 3a)
      $86,017
      		 
      $97,081
         Received from Bayer HealthCare (see Note 3b)
      34,456
      		 
      37,067
         Received for technology license agreements (see Note 4)
      128,137
      		 
      151,708
       
      $248,610
      		 
      $285,856
      XML 56 R1.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Document And Entity Information (USD $)
      		 12 Months Ended
      Dec. 31, 2011
      Feb. 10, 2012
      Jun. 30, 2011
      Entity Information [Line Items]      
      Entity Registrant Name REGENERON PHARMACEUTICALS INC    
      Entity Central Index Key 0000872589    
      Current Fiscal Year End Date --12-31    
      Entity Well-known Seasoned Issuer Yes    
      Entity Voluntary Filers No    
      Entity Current Reporting Status Yes    
      Entity Filer Category Large Accelerated Filer    
      Entity Public Float     $ 4,913,223,000
      Entity Common Stock, Shares Outstanding   91,779,465  
      Document Fiscal Year Focus 2011    
      Document Fiscal Period Focus FY    
      Document Type 10-K    
      Amendment Flag false    
      Document Period End Date Dec. 31, 2011    
      Class A Stock [Member]
      		      
      Entity Information [Line Items]      
      Entity Common Stock, Shares Outstanding   2,109,512  
      XML 57 R18.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Convertible Debt
      		 12 Months Ended
      Dec. 31, 2011
      Convertible Debt [Abstract]  
      Convertible Debt
      11.  
      Convertible Debt
       
      In October 2011, the Company issued $400.0 million aggregate principal amount of 1.875% convertible senior notes (the “Notes”) in a private placement.  The net proceeds from the Notes offering were $391.1 million after deducting the initial purchaser’s discount and issuance costs.

      The Notes will pay interest semi-annually on April 1 and October 1, beginning April 1, 2012, and will mature on October 1, 2016 unless earlier converted or repurchased.  The Notes will be convertible, subject to certain conditions, into cash, shares of the Company’s Common Stock, or a combination of cash and shares of Common Stock, at the Company's option.  The initial conversion rate for the Notes will be 11.9021 shares of Common Stock (subject to adjustment in certain circumstances) per $1,000 principal amount of the Notes, or a total of approximately 4,760,840 shares upon conversion, which is equal to an initial conversion price of approximately $84.02 per share.  A holder of the Notes may surrender their Notes at their option any time prior to the close of business on the business day immediately preceding July 1, 2016, only under the following circumstances: (i) during any calendar quarter commencing after the calendar quarter ending on December 31, 2011 (and only during such calendar quarter), if the last reported sale price of the Company’s Common Stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day; (ii) during the five business day period after any ten consecutive trading day period (the “measurement period”) in which the trading price, as defined, of the Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s Common Stock and the conversion rate on each such trading day; (iii) if the Company elects to issue to all or substantially all holders of its Common Stock any rights, options or warrants (other than pursuant to a rights plan) entitling them for a period of not more than 60 calendar days after the record date for such issuance, to subscribe for or purchase shares of the Company’s Common Stock, at a price per share less than the average of the last reported sales prices of the Company’s Common Stock for the ten consecutive day period ending on, and including, the trading day immediately preceding the declaration date for such issuance; (iv) upon specified distributions to the Company’s shareholders; or (v) upon the occurrence of specified corporate transactions, such as a fundamental change (i.e., a change in control), or the Company’s Common Stock ceasing to be listed on at least one U.S. national securities exchange. On or after July 1, 2016, holders may convert their Notes at the conversion rate at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date irrespective of the foregoing conditions. In the event that a fundamental change, as defined in the indenture under which the Notes have been issued, occurs prior to maturity of the Notes, the initial conversion rate may be increased to include additional shares upon conversion, or holders can require the Company to purchase from them all or a portion of their Notes for 100% of the principal value plus any accrued and unpaid interest.  

      The Company has reserved sufficient shares of its Common Stock to satisfy the conversion requirements related to the Notes.  The Company may not redeem the Notes prior to their maturity date.

      In accordance with accounting guidance for debt with conversion and other options, the Company accounted for the liability and equity components of the Notes separately.   The estimated fair value of the liability component at the date of issuance was $271.1 million, and was computed based on the fair value of similar debt instruments that do not include a conversion feature.  The equity component of $120.9 million was recognized as a debt discount and represents the difference between the $392.0 million of gross proceeds from the issuance of the Notes and the $271.1 million estimated fair value of the liability component at the date of issuance.  The debt discount is amortized over the expected life of a similar liability without the equity component.  The Company determined this expected life to be equal to the term of the Notes, resulting in an amortization period ending October 1, 2016.  The effective interest rate used to amortize the debt discount is approximately 10.2%, which was based on the Company’s estimated non-convertible borrowing rate as of the date the Notes were issued.

      Issuance costs of $0.9 million related to the issuance of the Notes were allocated to the liability and equity components in proportion to the allocation of the proceeds and accounted for as capitalized debt issuance costs and equity issuance costs, respectively.  

      The net carrying amount of the liability component of the Notes as of December 31, 2011 consists of the following:
       
      2011
      		 
      Total convertible senior notes – par
      $400,000
      		 
      Unamortized discount
      124,981
      		 
       
      $275,019
       
      		 
      Total interest expense associated with the Notes consisted of the following for the year ended December 31, 2011:
       
          2011
      		 
      Contractual coupon interest rate
      $1,455
      		 
      Amortization of discount and note issuance costs
      3,944
      		 
       
      $5,399
       
      		 
      As of December 31, 2011, the "if converted value" does not exceed the principal amount of the Notes since the closing sales price of the Company’s Common Stock was less than the initial conversion price of the Notes.  The fair value of the outstanding Notes was estimated to be $375.5 million as of December 31, 2011, and was determined based on quoted market rates.  

      In connection with the offering of the Notes, the Company entered into convertible note hedge (“call option”) and warrant transactions with multiple counterparties, including an affiliate of the initial purchaser.  The convertible note hedge transactions cover, subject to customary anti-dilution adjustments, the number of shares of the Company's Common Stock that initially underlie the Notes, and are intended to reduce the potential dilutive impact of the conversion feature of the Notes. The convertible note hedge will terminate upon the earlier of the maturity date of the Notes or the first day the Notes are no longer outstanding.  The Company paid $117.5 million for the convertible note hedge, which was recorded as a reduction to additional paid-in capital.

      The warrant transactions have an initial strike price of approximately $103.41 per share, and may be settled in cash or shares of the Company’s Common Stock, at the Company’s option.  The warrant transactions will have a dilutive effect to the extent that the market price per share of the Company's Common Stock exceeds the applicable strike price of the warrants.  Proceeds received from the warrant transactions totaled $93.8 million and were recorded as additional paid-in capital.  The warrants expire at various dates during 2017.

      The convertible note hedge and warrants are both considered indexed to the Company’s Common Stock and classified as equity; therefore, the convertible note hedge and warrants are not accounted for as derivative instruments.  The Company has reserved sufficient shares of its Common Stock to satisfy the potential settlement of the warrants.
      XML 58 R4.htm IDEA: XBRL DOCUMENT v2.4.0.6
      STATEMENTS OF OPERATIONS (USD $)
      In Thousands, except Per Share data, unless otherwise specified
      		 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Revenues      
      Sanofi collaboration revenue $ 326,609 $ 311,332 $ 247,140
      Other collaboration revenue 43,072 75,393 67,317
      Net product sales 44,686 25,254 18,364
      Technology licensing 24,858 40,150 40,013
      Contract research and other 6,599 6,945 6,434
      Total revenues 445,824 459,074 379,268
      Expenses      
      Research and development 529,506 489,252 398,762
      Selling, general, and admistrative 117,261 65,201 52,923
      Cost of goods sold 4,216 2,093 1,686
      Total expenses 650,983 556,546 453,371
      Loss from operations (205,159) (97,472) (74,103)
      Other income (expense)      
      Investment income 3,549 2,122 4,488
      Interest expense (21,282) (9,118) (2,337)
      Total other income (expense) (17,733) (6,996) 2,151
      Net loss before income tax benefit (222,892) (104,468) (71,952)
      Income tax benefit (1,132) 0 (4,122)
      Net loss $ (221,760) $ (104,468) $ (67,830)
      Net loss per share, basic and diluted (in dollars per share) $ (2.45) $ (1.26) $ (0.85)
      Weighted average shares outstanding, basic and diluted (in shares) 90,610 82,926 79,782
      XML 59 R12.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Product Revenue
      		 12 Months Ended
      Dec. 31, 2011
      Product Revenue [Abstract]  
      Product Revenue
      5.  
      Product Revenue

      In November 2011, the Company received marketing approval from the FDA for EYLEAÒ for the treatment of wet AMD.  In accordance with the Company’s revenue recognition policy described in Note 2, the Company recorded EYLEAÒ net product sales of $24.8 million for the year ended December 31, 2011.

      In February 2008, the Company received marketing approval from the FDA for ARCALYST® Injection for Subcutaneous Use for the treatment of CAPS.  ARCALYST® net product sales totaled $19.9 million, $25.3 million, and $18.4 million for the years ended December 31, 2011, 2010, and 2009, respectively.  The Company had limited historical return experience for ARCALYST® beginning with initial sales in 2008 through the end of 2009; therefore, ARCALYST® net product sales were deferred until the right of return no longer existed and rebates could be reasonably estimated.  Effective in the first quarter of 2010, the Company determined that it had accumulated sufficient historical data to reasonably estimate both product returns and rebates of ARCALYST®.  As a result, ARCALYST® net product sales during 2010 included $20.5 million of net product sales made during this period and $4.8 million of previously deferred net product sales.  The effect of recognizing the previously deferred ARCALYST® net product sales revenue was to lower the Company’s net loss per share by $0.06 in 2010.
      XML 60 R11.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Technology Licensing Agreements
      		 12 Months Ended
      Dec. 31, 2011
      Technology Licensing Agreements [Abstract]  
      Technology Licensing Agreements
      4.  
      Technology Licensing Agreements

      In March 2007, the Company entered into a six-year, non-exclusive license agreement with Astellas Pharma Inc. to allow Astellas to utilize the Company’s VelocImmune® technology in its internal research programs to discover human monoclonal antibodies.  Under the terms of the agreement, Astellas made a $20.0 million annual, non-refundable payment to the Company in each of 2010, 2009, 2008, and 2007.  In July 2010, the license agreement with Astellas was amended and extended through June 2023.  Under the terms of the amended agreement, Astellas made a $165.0 million up-front payment to the Company in August 2010, which was deferred upon receipt and will be recognized as revenue ratably over the seven-year period beginning in mid-2011.  In addition, Astellas will make a $130.0 million second payment to the Company in June 2018 unless the license agreement has been terminated prior to that date.  Astellas has the right to terminate the agreement at any time by providing 90 days’ advance written notice.  Under certain limited circumstances, such as a material breach of the agreement by the Company, Astellas may terminate the agreement and receive a refund of a portion of its up-front payment or, if such termination occurs after June 2018, a portion of its second payment, to the Company under the July 2010 amendment to the agreement.  The Company is entitled to receive a mid-single digit royalty on any future sales of antibody products discovered by Astellas using the Company’s VelocImmune® technology.  In connection with the Astellas license agreement, for each of the years ended December 31, 2011, 2010, and 2009, the Company recognized $22.0 million, $20.0 million, and $20.0 million of technology licensing revenue, respectively.  In addition, deferred revenue at December 31, 2011 and 2010 was $151.7 million and $173.7 million, respectively.

      In February 2007, the Company entered into a six-year, non-exclusive license agreement with AstraZeneca UK Limited to allow AstraZeneca to utilize the Company’s VelocImmuneÒ technology in its internal research programs to discover human monoclonal antibodies.  Under the terms of the agreement, AstraZeneca made a $20.0 million annual, non-refundable payment to the Company in each of 2010, 2009, 2008, and 2007.  Each annual payment was deferred and recognized as revenue ratably over approximately the ensuing twelve-month period.  In November 2010, as permitted by the agreement, MedImmune Limited (as successor by novation from AstraZeneca) gave written notice of voluntary termination of the agreement, effective in February 2011, thereby canceling its obligation to make either of the final two annual payments.  Regeneron remains entitled to receive mid-single digit royalties on any future sales of antibody products discovered by MedImmune/AstraZeneca using the VelocImmune® technology.  In connection with the AstraZeneca license agreement, for the years ended December 31, 2011, 2010, and 2009, the Company recognized $2.9 million, $20.0 million, and $20.0 million, respectively, of technology licensing revenue.
      XML 61 R23.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Employee Savings Plan
      		 12 Months Ended
      Dec. 31, 2011
      Employee Savings Plan [Abstract]  
      Employee Savings Plan
      16.  
      Employee Savings Plan

      In 1993, the Company adopted the provisions of the Regeneron Pharmaceuticals, Inc. 401(k) Savings Plan (the “Savings Plan”).  The terms of the Savings Plan provide for employees who have met defined service requirements to participate in the Savings Plan by electing to contribute to the Savings Plan a percentage of their compensation to be set aside to pay their future retirement benefits, as defined.  The Savings Plan, as amended and restated, provides for the Company to make discretionary contributions (“Contribution”), as defined.  The Company recognized $4.1 million, $3.2 million, and $2.6 million of Contribution expense in 2011, 2010, and 2009, respectively.  At December 31, 2011 and 2010, accrued Contribution expense totaled $3.6 million and $2.9 million, respectively.  During the first quarter of 2012 and 2011, the Company contributed 63,937 and 91,761 shares, respectively, of Common Stock to the Savings Plan in satisfaction of these obligations.
      XML 62 R19.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Commitments and Contingencies
      		 12 Months Ended
      Dec. 31, 2011
      Commitments and Contingencies [Abstract]  
      Commitments and Contingencies
      12.  
      Commitments and Contingencies

      a. Leases

      Descriptions of Lease Agreements

      The Company leases laboratory and office facilities in Tarrytown, New York, under a December 2006 lease agreement, as amended (the “Tarrytown Lease”).  The facilities leased by the Company under the Tarrytown Lease include (i) space in previously existing buildings, (ii) newly constructed space in two new buildings (“Buildings A and B”) that was completed in the third quarter of 2009 and, (iii) under a December 2009 amendment to the Tarrytown Lease, additional newly constructed space in a third new building (“Building C”) that was completed in the first quarter of 2011.  The Tarrytown Lease will expire in June 2024 and contains three renewal options to extend the term of the lease by five years each, escalations at 2.5% per annum, and early termination options for various portions of the space exclusive of the newly constructed space in Buildings A and B.   The Tarrytown Lease provides for monthly payments over its term and additional charges for utilities, taxes, and operating expenses.  Certain premises under the Tarrytown Lease are accounted for as operating leases.  However, for Buildings A, B, and C that the Company is leasing, the Company is deemed, in substance, to be the owner of the landlord’s buildings in accordance with the application of FASB authoritative guidance, and the landlord’s costs of constructing these new facilities are required to be capitalized on the Company’s books as a non-cash transaction, offset by a corresponding lease obligation on the Company’s balance sheet.

      In connection with the Tarrytown Lease, the Company issued a letter of credit in the amount of $3.4 million and collateralized the letter of credit with cash and marketable debt securities totaling $3.6 million at both December 31, 2011 and 2010.  Such collateral has been classified as restricted cash and marketable securities.

      In October 2008, the Company entered into a sublease with Sanofi U.S. for office space in Bridgewater, New Jersey.  The lease commenced in January 2009 and expired in July 2011.  In July 2011, the Company entered into an operating lease for office space in Liberty Corner, New Jersey, which expires in January 2017.

      The Company also leases certain equipment under operating and capital leases which expire at various times through 2014.

       
      Commitments under Operating Leases

      The estimated future minimum noncancelable lease commitments under operating leases were as follows:

      December 31,
      Facilities
      Equipment
                 Total
      2012
      $6,072
      $1,188
      $7,260
      2013
      7,304
      258
      7,562
      2014
      7,428
      35
      7,463
      2015
      7,583
      		 
      7,583
      2016
      7,738
      		 
      7,738
      Thereafter
      59,631
      ___
      59,631
       
      $95,756
      $1,481
      $97,237

      Rent expense under operating leases was:

      Year Ending December 31,
      Facilities
           Equipment
      Total
      2011
      $7,191
      $599
      $7,790
      2010
      7,301
      335
      7,636
      2009
      7,722
      395
      8,117

      In addition to its rent expense under operating leases, and payments under facility lease obligations (see below), for various facilities, the Company paid rental charges for utilities, real estate taxes, and operating expenses of $9.3 million, $10.3 million, and $8.4 million for the years ended December 31, 2011, 2010, and 2009, respectively.

      Commitments under Capital Leases

      In 2011 and 2010, the Company entered into capital leases in connection with acquisitions of new equipment.  The lease obligations are collateralized with marketable debt securities totaling $3.3 million and $3.5 at December 31, 2011 and 2010, respectively; such collateral has been classified as restricted cash and marketable securities at December 31, 2011 and 2010.

      The estimated future minimum noncancelable lease commitments under capital leases were as follows:

      December 31,
      Equipment
      2012
      $1,394
      2013
      1,254
      2014
      130
      Total minimum lease payments
      2,778
      Less: amount representing interest
      (272)
       
      $2,506

      At the end of the lease term, the Company is required to purchase the leased equipment for a nominal amount defined in the lease agreement.  At December 31, 2011 and 2010, capital lease obligations totaled $2.5 million and $2.8 million, respectively, and were included in other liabilities.

      Facility Lease Obligations

      As described above, in connection with the application of FASB authoritative guidance to the Company’s lease of office and laboratory facilities in Buildings A, B, and C, the Company capitalized the landlord’s costs of constructing the new facilities and recognized a corresponding facility lease obligation.  The Company also recognized, as additional facility lease obligation, reimbursements from the Company’s landlord for tenant improvement costs that the Company incurred since, under FASB authoritative guidance, such payments that the Company receives from its landlord are deemed to be a financing obligation.  Monthly lease payments on these facilities are allocated between the land element of the lease (which is accounted for as an operating lease) and the facility lease obligation, based on the estimated relative fair values of the land and buildings.

      As of December 31, 2010, the Company had capitalized the landlord’s costs of constructing Buildings A and B, which totaled $58.4 million, and of constructing Building C, which totaled $27.8 million.  Reimbursements from the Company’s landlord for Buildings A and B tenant improvement costs totaled $56.9 million and were received by the Company during 2010 and 2009.  Reimbursements for Building C tenant improvement costs totaled $14.2 million and were received by the Company during 2010.  With respect to Buildings A and B, monthly lease payments commenced in August 2009, the buildings were placed in service by the Company in September 2009, and the imputed interest rate applicable to the Company’s facility lease obligation is approximately 11%.  With respect to Building C, monthly lease payments commenced in January 2011, the building was placed in service by the Company in February 2011, and the imputed interest rate applicable to the Company’s facility lease obligation is approximately 9%.

      In 2011, the Company recognized $15.6 million of interest expense in connection with the Buildings A and B and the Building C facility lease obligations.  In 2010 and 2009, the Company recognized $9.1 million and $2.3 million, respectively, of interest expense in connection with the Buildings A and B facility lease obligation.  At December 31, 2011 and 2010, the Buildings A and B facility lease obligation balance was $113.0 million and $113.7 million, respectively, and the Building C facility lease obligation balance was $47.5 million and $46.4 million, respectively.

      The estimated future minimum noncancelable commitments under these facility lease obligations, as of December 31, 2011, were as follows:

      December 31,
      Buildings A and B
      Building C
      Total
      2012
      $12,847
      $2,825
      $15,672
      2013
      13,092
      4,370
      17,462
      2014
      13,343
      4,490
      17,833
      2015
      13,600
      4,614
      18,214
      2016
      13,864
      4,740
      18,604
      Thereafter
      113,040
      39,899
      152,939
       
      $179,786
      $60,938
      $240,724


      b. Research Collaboration and Licensing Agreements

      As part of the Company's research and development efforts, the Company enters into research collaboration and licensing agreements with related and unrelated companies, scientific collaborators, universities, and consultants.  These agreements contain varying terms and provisions which include fees and milestones to be paid by the Company, services to be provided, and ownership rights to certain proprietary technology developed under the agreements.  Some of the agreements contain provisions which require the Company to pay royalties, as defined, at rates that range from 0.25% to 16.5%, in the event the Company sells or licenses any proprietary products developed under the respective agreements.

      In December 2011, the Company and Genentech, Inc., a member of the Roche Group, entered into a Non-Exclusive License and Partial Settlement Agreement (the “Genentech Agreement”) relating to ophthalmic sales of EYLEAÒ in the United States.   Pursuant to the Genentech Agreement, the Company received a non-exclusive license to certain patents relating to VEGF receptor proteins, known as the Davis-Smyth patents, and other technology patents.  The Davis-Smyth patents are the subject of patent litigation between the Company and Genentech now pending in the United States District Court, Southern District of New York.  Patent litigation is continuing with respect to matters not covered by the Genentech Agreement (see Note 18).

      Under the terms of the Genentech Agreement, the Company agreed to make payments to Genentech based on U.S. sales of EYLEAÒ commencing upon FDA approval of EYLEAÒ in November 2011 through May 7, 2016.  The Company will be required to make a one-time, non-refundable $60 million payment upon cumulative U.S. sales of EYLEAÒ reaching $400 million.  In addition, the Company agreed to pay royalties of 4.75% on cumulative U.S. sales of EYLEAÒ between $400 million and $3 billion and 5.5% on any cumulative U.S sales of EYLEAÒ over $3 billion.  As the Company records net product sales of EYLEAÒ, the Company is recognizing expense in connection with the Genentech Agreement using a blended mid-single digit royalty rate that reflects both the $60 million payment and the royalties payable on cumulative sales and that is based upon the Company’s estimate of cumulative EYLEAÒ sales through May 7, 2016.

      The Company recognizes royalty expense based on net product sales of EYLEAÒ and ARCALYSTÒ under various licensing agreements, including, for EYLEAÒ, the Genentech Agreement described above.  For the years ended December 31, 2011, 2010, and 2009, royalties on net product sales totaled $3.2 million, $1.7 million, and $1.5 million, respectively, and are included in cost of goods sold.

       
      In July 2008, the Company and Cellectis S.A. (“Cellectis”) entered into an Amended and Restated Non-Exclusive License Agreement (the “Cellectis Agreement”).  The Cellectis Agreement resolved a dispute between the parties related to the interpretation of a license agreement entered into by the parties in December 2003 pursuant to which the Company licensed certain patents and patent applications from Cellectis.  Pursuant to the Cellectis Agreement, in July 2008, the Company made a non-refundable $12.5 million payment to Cellectis (the “Cellectis Payment”) and agreed to pay Cellectis a low single-digit royalty based on revenue received by the Company from any future licenses or sales of the Company’s VelociGene® or VelocImmune® products and services.  No royalties are payable to Cellectis with respect to the Company’s VelocImmune® license agreements with AstraZeneca and Astellas or the Company’s antibody collaboration with Sanofi.  Moreover, no royalties are payable to Cellectis on any revenue from commercial sales of antibodies from the Company’s VelocImmune® technology.

      The Company began amortizing the Cellectis Payment in the second quarter of 2008 in proportion to past and future anticipated revenues under the Company’s license agreements with AstraZeneca and Astellas and the Discovery and Preclinical Development Agreement under the Company’s antibody collaboration with Sanofi (as amended in November 2009).  In 2011, 2010, and 2009, the Company recognized $1.0 million, $0.9 million, and $2.3 million, respectively, of expense in connection with the Cellectis Payment.  At December 31, 2011 and 2010, the unamortized balance of the Cellectis Payment, which was included in other assets, was $5.7 million and $6.6 million, respectively.  The Company estimates that it will recognize expense of $1.0 million in each of 2012 and 2013, and $0.9 million in each of 2014, 2015 and 2016, in connection with the Cellectis Payment.
      XML 63 R15.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Property, Plant, and Equipment
      		 12 Months Ended
      Dec. 31, 2011
      Property, Plant, and Equipment [Abstract]  
      Property, Plant, and Equipment
      8.  
      Property, Plant, and Equipment

      Property, plant, and equipment as of December 31, 2011 and 2010 consist of the following:

       
      2011
      2010
      Land
         $2,117
         $2,117
      Building and improvements
      322,753
      242,035
      Leasehold improvements
      4,479
      4,063
      Construction-in-progress
      10,880
      70,356
      Laboratory and other equipment
      156,397
      137,951
      Furniture, computer and office equipment, and other
      29,468
      22,235
       
      526,094
      478,757
      Less, accumulated depreciation and amortization
      (158,139)
      (131,307)
       
      $367,955
      $347,450

      Depreciation and amortization expense on property, plant, and equipment amounted to $31.1 million, $19.7 million, and $14.2 million for the years ended December 31, 2011, 2010, and 2009, respectively.  Effective in the first quarter of 2010, the estimated useful lives of certain capitalized laboratory and other equipment, which is a component of property, plant, and equipment, were extended.  The effect of this change in estimate was to lower depreciation expense by $4.0 million and to lower the Company’s net loss per share by $0.05 for the year ended December 31, 2010.

      Included in property, plant, and equipment at December 31, 2011 and December 31 2010 was $3.6 million and $2.8 million, respectively, of leased equipment under capital leases, and related accumulated amortization was $0.5 million and $0.1 million at December 31, 2011 and December 31, 2010, respectively.

      Property, plant, and equipment at both December 31, 2011 and 2010 includes $86.2 million of costs incurred by the Company’s landlord to construct new laboratory and office facilities in Tarrytown, New York in connection with the Company’s December 2006 lease, as amended, of these facilities.  See Note 12a.

      The Company capitalized interest costs of $6.4 million in 2010.  The Company did not capitalize any interest costs in 2011.
      XML 64 R60.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Legal Matters (Details) (License Agreement With Genentech [Member], USD $)
      In Millions, unless otherwise specified
      		 12 Months Ended
      Dec. 31, 2011
      Percent
      License Agreement With Genentech [Member]
      		  
      Loss Contingencies [Line Items]  
      Amount of payment to be made upon reaching minimum sales target $ 60
      Cumulative sales range, minimum 400
      Royalty payment percentage of cumulative sales within cumulative sales range (in hundredths) 4.75%
      Cumulative sales range, maximum $ 3,000
      Royalty payment percentage of cumulative sales over range (in hundredths) 5.50%
      XML 65 R13.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Marketable Securities
      		 12 Months Ended
      Dec. 31, 2011
      Marketable Securities [Abstract]  
      Marketable Securities
      6.  
      Marketable Securities

      Marketable securities at December 31, 2011 and 2010 consisted of debt securities, as detailed below, and equity securities.  The aggregate fair value of the equity securities was $3.0 million and $3.6 million at December 31, 2011 and 2010, respectively, and the aggregate cost basis was $4.0 million at both December 31, 2011 and 2010.  The Company also held restricted marketable securities at both December 31, 2011 and December 31, 2010, which consisted of debt securities, as detailed below, that collateralize letters of credit and lease obligations.

      The following tables summarize the amortized cost basis of debt securities included in marketable securities, the aggregate fair value of those securities, and gross unrealized gains and losses on those securities at December 31, 2011 and 2010.  The Company classifies its debt securities, other than mortgage-backed securities, based on their contractual maturity dates.  Maturities of mortgage-backed securities have been estimated based primarily on repayment characteristics and experience of the senior tranches that the Company holds.

       
      Amortized
        Fair
      Unrealized
      		 
      At December 31, 2011
      Cost Basis
        Value
               Gains
           (Losses)
                   Net
      Unrestricted
      		         
      Maturities within one year
      		         
      U.S. government obligations
      $12,025
      $12,067
      $42
      		 
      $42
      U.S. government guaranteed corporate bonds
      15,263
      15,316
      53
      		 
      53
      U.S. government guaranteed collateralized mortgage obligations
      623
      622
      		 
      (1)
      (1)
      Municipal bonds
      15,314
      15,326
      13
      (1)
      12
       
      43,225
      43,331
      108
      (2)
      106
       
      Maturities after one year through five years
      		         
      U.S. government obligations
      272,433
      272,752
      400
      (81)
      319
      Mortgage-backed securities
      104
      28
      ___
      (76)
      (76)
       
      272,537
      272,780
      400
      (157)
      243
       
      Maturities after five years through ten years
      		         
      Mortgage-backed securities
      164
      87
      ___
      (77)
      (77)
       
      315,926
      316,198
      508
      (236)
      272
                 
      Restricted
      		         
      Maturities within one year
      		         
      U.S. government obligations
      3,347
      3,357
      10
      		 
      10
                 
      Maturities after one year through five years
      		         
      U.S. government obligations
      2,572
      2,583
      11
      ___
      11
       
      5,919
      5,940
      21
      ___
      21
                 
       
      $321,845
      $322,138
      $529
      $(236)
      $293

       
       
       


                 
       
      Amortized
        Fair
      Unrealized
      		 
      At December 31, 2010
      Cost Basis
        Value
               Gains
           (Losses)
                   Net
                 
      Unrestricted
      		         
      Maturities within one year
      		         
        U.S. government obligations
      $83,635
      $83,684
      $54
      $(5)
      $49
      U.S. government guaranteed corporate bonds
      48,173
      48,531
      358
      		 
      358
        U.S. government guaranteed
           collateralized mortgage obligations
      2,027
      2,131
      104
      		 
      104
      Municipal bonds
      1,597
      1,603
      6
      		 
      6
        Mortgage-backed securities
      875
      847
      ___
      (28)
      (28)
       
      136,307
      136,796
      522
      (33)
      489
       
      Maturities after one year through five years
      		         
        U.S. government obligations
      352,345
      350,683
      64
      (1,726)
      (1,662)
      U.S. government guaranteed corporate bonds
      15,522
      15,477
      		 
      (45)
      (45)
        Mortgage-backed securities
      110
      38
      ___
      (72)
      (72)
       
      367,977
      366,198
      64
      (1,843)
      (1,779)
       
      Maturities after five years through ten years
      		         
        Mortgage-backed securities
      284
      243
      ___
      (41)
      (41)
       
      504,568
      503,237
      586
      (1.917)
      (1,331)
                 
      Restricted
      		         
      Maturities within one year
      		         
        U.S. government obligations
      2,922
      2,921
      		 
      (1)
      (1)
                 
      Maturities after one year through five years
      		         
        U.S. government obligations
      4,135
      4,118
      ___
      (17)
      (17)
       
      7,057
      7,039
      ___
      (18)
      (18)
                 
       
      $511,625
      $510,276
      $586
      $(1,935)
      $(1,349)

       
       
       


                 
      At December 31, 2011 and 2010, marketable securities included an additional unrealized loss of $1.0 million and $0.4 million, respectively, related to one equity security in the Company’s marketable securities portfolio.

      The following table shows the fair value of the Company’s marketable securities that have unrealized losses and that are deemed to be only temporarily impaired, aggregated by investment category and length of time that the individual securities have been in a continuous unrealized loss position, at December 31, 2011 and 2010.  The debt securities listed at December 31, 2011, excluding mortgage-backed securities, mature at various dates through December 2014.  The mortgage-backed securities listed at December 31, 2011 mature at various dates through April 2018.

       
       
      Less than 12 Months
       
      12 Months or Greater
       
      Total
       
      At December 31, 2011
       
      Fair Value
      Unrealized Loss
       
      Fair Value
      Unrealized Loss
       
      Fair Value
      Unrealized Loss
      Unrestricted
      		           
      U.S. government obligations
      $103,529
      $(81)
      		   
      $103,529
      $(81)
      U.S. government guaranteed
        collateralized mortgage
        obligations
      623
      (1)
      		   
      623
      (1)
      Municipal bonds
      4,603
      (1)
      		   
      4,603
      (1)
      Equity security
      3,019
      (1,025)
      		   
      3,019
      (1,025)
      Mortgage-backed securities
      _____
      ____
      $116
      $(152)
      116
      (152)
       
      $111,774
      $(1,108)
      $116
      $(152)
      $111,890
      $(1,260)
                   
                   
      At December 31, 2010
      		           
      Unrestricted
      		           
      U.S. government obligations
      $340,444
      $(1,731)
      		   
      $340,444
      $(1,731)
      U.S. government guaranteed
        corporate bonds
      19,005
      (45)
      		   
      19,005
      (45)
      Equity security
      3,612
      (433)
      		   
      3,612
      (433)
      Mortgage-backed securities
      _____
      ____
      $1,128
      $(141)
      1,128
      (141)
       
      363,061
      (2,209)
      1,128
      (141)
      364,189
      (2,350)
                   
      Restricted
      		           
          U.S. government obligations
      6,154
      (18)
      ____
      ____
      6,154
      (18)
       
      6,154
      (18)
      ____
      ____
      6,154
      (18)
                   
       
      $369,215
      $(2,227)
      $1,128
      $(141)
      $370,343
      $(2,368)

      Realized gains and losses are included as a component of investment income.  For the years ended December 31, 2011, 2010, and 2009, total realized gains and losses on sales of marketable securities were not material.  In computing realized gains and losses, the Company computes the cost of its investments on a specific identification basis.  Such cost includes the direct costs to acquire the security, adjusted for the amortization of any discount or premium.

       
       
       


      The Company’s assets that are measured at fair value on a recurring basis, at December 31, 2011 and 2010, were as follows:

         
      Fair Value Measurements at Reporting Date Using
       
       
      Fair Value
      Quoted Prices in Active Markets for Identical Assets
      (Level 1)
      Significant Other Observable Inputs
      (Level 2)
      Significant Unobservable Inputs
      (Level 3)
      At December 31, 2011
      		       
      Unrestricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
      $284,819
      		 
      $284,819
      		 
      U.S. government guaranteed corporate bonds
      15,316
      		 
      15,316
      		 
      U.S. government guaranteed collateralized mortgage obligations
      622
      		 
      622
      		 
      Municipal bonds
      15,326
      		 
      15,326
      		 
      Mortgage-backed securities
      115
      		 
      115
      		 
      Equity security
      3,019
      $3,019
      _______
      		 
       
      319,217
      3,019
      316,198
      		 

               
      Restricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
          5,940
      _____
      5,940
      		 
               
       
      $325,157
      $3,019
      $322,138
      		 
               
      At December 31, 2010
      		       
      Unrestricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
      $434,367
      		 
      $434,367
      		 
      U.S. government guaranteed corporate bonds
      64,008
      		 
      64,008
      		 
      U.S. government guaranteed collateralized mortgage obligations
      2,131
      		 
      2,131
      		 
      Municipal bonds
      1,603
      		 
      1,603
      		 
      Mortgage-backed securities
      1,128
      		 
      1,128
      		 
      Equity security
      3,612
      $3,612
      _______
      		 
       
      506,849
      3,612
      503,237
      		 
               
      Restricted
      		       
      Available-for-sale marketable securities
      		       
      U.S. government obligations
          7,039
      _____
      7,039
      		 
               
       
      $513,888
      $3,612
      $510,276
      		 

      Marketable securities included in Level 2 were valued using a market approach utilizing prices and other relevant information, such as interest rates, yield curves, prepayment speeds, loss severities, credit risks, and default rates, generated by market transactions involving identical or comparable assets.  The Company considers market liquidity in determining the fair value for these securities.  During the year ended December 31, 2010, deterioration in the credit quality of a marketable security subjected the Company to the risk of not being able to recover the carrying value of these securities.  As a result, the Company recognized a $0.1 million impairment charge related to its Level 2 marketable securities in 2010, which the Company considered to be other-than-temporarily impaired.  The Company did not record any charges for other-than-temporary impairment of its Level 2 marketable securities in 2011 and 2009.

      The Company held one Level 3 marketable security, which had a fair value of $0 at December 31, 2011 and 2010.  This Level 3 security was valued using information provided by the Company’s investment advisors and other sources, including quoted bid prices which took into consideration the securities’ lack of liquidity.  In 2009, the Company recorded a charge of $0.1 million for other-than-temporary impairment of this Level 3 marketable security; therefore, as of December 31, 2009, the fair value of this security had been written down to zero.  There were no purchases, sales, or maturities of Level 3 marketable securities and no unrealized gains or losses related to Level 3 marketable securities for the years ended December 31, 2011 and 2010.  There were no transfers of marketable securities between Levels 1, 2, or 3 classifications during the years ended December 31, 2011 and 2010.
      XML 66 R14.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Inventory
      		 12 Months Ended
      Dec. 31, 2011
      Inventory [Abstract]  
      Inventory
      7.  
      Inventory

      Inventories as of December 31, 2011 and December 31, 2010 consist of the following:

       
      2011
      2010
                   Raw materials
      $1,608
      $592
                   Work in process
      10,806
      699
                   Finished goods
      1,142
      132
       
      $13,556
      $1,423

      At December 31, 2011, $3.5 million of inventories were included in prepaid expenses and other current assets and $10.1 million of inventories were included in other assets.  At December 31, 2010, inventories were included in prepaid expenses and other current assets.

      In 2011, cost of goods sold included inventory write-downs of $0.5 million.  In 2010, there were no inventory write-downs included in cost of goods sold.
      XML 67 R16.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Accounts Payable and Accrued Expenses
      		 12 Months Ended
      Dec. 31, 2011
      Accounts Payable and Accrued Expenses [Abstract]  
      Accounts Payable and Accrued Expenses
      9.  
      Accounts Payable and Accrued Expenses

      Accounts payable and accrued expenses as of December 31, 2011 and 2010 consist of the following:

       
      2011
      2010
      Accounts payable
      $27,736
      $15,589
      Accrued payroll and related costs
      42,835
      12,025
      Accrued clinical trial expense
      9,850
      9,727
      Accrued property, plant, and equipment costs
      1,070
      7,622
      Other accrued expenses and liabilities
      14,134
      6,441
      Payable to Bayer HealthCare
      _____
      2,254
       
      $95,625
      $53,658
      XML 68 R64.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Unaudited Quarterly Results (Details) (USD $)
      In Thousands, except Per Share data, unless otherwise specified
      		 3 Months Ended 12 Months Ended
      Dec. 31, 2011
      Sep. 30, 2011
      Jun. 30, 2011
      Mar. 31, 2011
      Dec. 31, 2010
      Sep. 30, 2010
      Jun. 30, 2010
      Mar. 31, 2010
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Unaudited Quarterly Results [Abstract]                      
      Revenues $ 122,977 $ 102,833 $ 107,810 $ 112,204 $ 133,675 $ 105,979 $ 115,886 $ 103,534 $ 445,824 $ 459,074 $ 379,268
      Net loss $ (53,443) $ (62,365) $ (62,505) $ (43,447) $ (14,597) $ (33,875) $ (25,474) $ (30,522) $ (221,760) $ (104,468) $ (67,830)
      Net loss per share, basic and diluted (in dollars per share) $ (0.58) $ (0.68) $ (0.69) $ (0.49) $ (0.17) $ (0.41) $ (0.31) $ (0.38) $ (2.45) $ (1.26) $ (0.85)
      XML 69 R63.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Statement of Cash Flows, Additional Disclosures (Details) (USD $)
      In Millions, unless otherwise specified
      		 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]      
      Facility lease obligation   $ 0.2 $ 31.7
      Capitalized and deferred interest   3.7  
      Capital lease obligations 0.7 2.9  
      Accrued interest income $ 0.7 $ 1.4 $ 0.6
      XML 70 R34.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Accounts Payable and Accrued Expenses (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Accounts Payable and Accrued Expenses [Abstract]  
      Accounts Payable and Accrued Expenses
      Accounts payable and accrued expenses as of December 31, 2011 and 2010 consist of the following:

       
      2011
      2010
      Accounts payable
      $27,736
      $15,589
      Accrued payroll and related costs
      42,835
      12,025
      Accrued clinical trial expense
      9,850
      9,727
      Accrued property, plant, and equipment costs
      1,070
      7,622
      Other accrued expenses and liabilities
      14,134
      6,441
      Payable to Bayer HealthCare
      _____
      2,254
       
      $95,625
      $53,658
      XML 71 R51.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Deferred Revenue (Details) (USD $)
      In Thousands, unless otherwise specified
      Dec. 31, 2011
      Dec. 31, 2010
      Current portion:    
      Deferred revenue, current $ 51,640 $ 54,723
      Long-term portion:    
      Deferred revenue, noncurrent 248,610 285,856
      Collaboration Agreement with Sanofi [Member]
      		    
      Current portion:    
      Deferred revenue, current 20,011 19,506
      Long-term portion:    
      Deferred revenue, noncurrent 86,017 97,081
      Collaboration Agreement with Bayer HealthCare LLC [Member]
      		    
      Current portion:    
      Deferred revenue, current 7,907 9,884
      Long-term portion:    
      Deferred revenue, noncurrent 34,456 37,067
      Technology License Agreements [Member]
      		    
      Current portion:    
      Deferred revenue, current 23,572 25,008
      Long-term portion:    
      Deferred revenue, noncurrent 128,137 151,708
      Other Deferred Revenue Agreements [Member]
      		    
      Current portion:    
      Deferred revenue, current $ 150 $ 325
      XML 72 R21.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Long-Term Incentive Plans
      		 12 Months Ended
      Dec. 31, 2011
      Long-Term Incentive Plans [Abstract]  
      Long-Term Incentive Plans
      14.  
      Long-Term Incentive Plans

      During 2000, the Company established the Regeneron Pharmaceuticals, Inc. 2000 Long-Term Incentive Plan which, as amended and restated (the “2000 Incentive Plan”), provides for the issuance of up to 41,307,016 shares of Common Stock in respect of awards.  Employees of the Company, including officers, and nonemployees, including consultants and nonemployee members of the Company’s board of directors, (collectively, “Participants”) may receive awards as determined by a committee of independent directors (“Committee”).  The awards that may be made under the 2000 Incentive Plan include: (a) Incentive Stock Options (“ISOs”) and Nonqualified Stock Options, (b) shares of Restricted Stock, (c) shares of Phantom Stock, (d) Stock Bonuses, and (e) Other Awards.

      Stock Option awards grant Participants the right to purchase shares of Common Stock at prices determined by the Committee; however, in the case of an ISO, the option exercise price will not be less than the fair market value of a share of Common Stock on the date the Option is granted.  Options vest over a period of time determined by the Committee, generally on a pro rata basis over a three to five year period.  The Committee also determines the expiration date of each Option; however, no ISO is exercisable more than ten years after the date of grant.  The maximum term of options that have been awarded under the 2000 Incentive Plan is ten years.

      Restricted Stock awards grant Participants shares of restricted Common Stock or allow Participants to purchase such shares at a price determined by the Committee.  Such shares are nontransferable for a period determined by the Committee (“vesting period”).  Should employment terminate, as defined by the 2000 Incentive Plan, the ownership of the Restricted Stock, which has not vested, will be transferred to the Company, except under defined circumstances with Committee approval, in consideration of amounts, if any, paid by the Participant to acquire such shares.  In addition, if the Company requires a return of the Restricted Shares, it also has the right to require a return of all dividends paid on such shares.

      Phantom Stock awards provide the Participant the right to receive, within 30 days of the date on which the share vests, an amount, in cash and/or shares of the Company’s Common Stock as determined by the Committee, equal to the sum of the fair market value of a share of Common Stock on the date such share of Phantom Stock vests and the aggregate amount of cash dividends paid with respect to a share of Common Stock during the period from the grant date of the share of Phantom Stock to the date on which the share vests.  Stock Bonus awards are bonuses payable in shares of Common Stock which are granted at the discretion of the Committee.

      Other Awards are other forms of awards which are valued based on the Company’s Common Stock.  Subject to the provisions of the 2000 Incentive Plan, the terms and provisions of such Other Awards are determined solely on the authority of the Committee.

      The 2000 Incentive Plan contains provisions that allow for the Committee to provide for the immediate vesting of awards upon a change in control of the Company, as defined in the plan.

      As of December 31, 2011, there were 10,244,318 shares available for future grants under the 2000 Incentive Plan.

       
      a.
      Stock Options

      Transactions involving stock option awards during 2011 under the 2000 Incentive Plan is summarized in the table below.

       
       
       
       
       
      Stock Options:
       
       
       
       
      Number of Shares
       
       
       
      Weighted-Average
      Exercise Price
      Weighted-Average Remaining Contractual Term (in years)
       
       
       
      Intrinsic Value (in thousands)
      Outstanding at December 31, 2010
      23,362,248
      $19.93
      		   
      2011:   Granted
      4,286,640
      $51.96
      		   
                   Forfeited
      (247,898)
      $28.11
      		   
                   Expired
      (551,456)
      $13.31
      		   
                   Exercised
       (4,523,173)
      $18.73
      		   
                   Outstanding at December 31, 2011
      22,326,361
      $26.40
      6.90
      $663,376
               
      Vested and expected to vest at December 31, 2011
      21,755,141
      $26.04
      6.84
      $653,990
               
      Exercisable at December 31, 2011
      11,963,345
      $18.27
      5.27
      $451,478

      The Company satisfies stock option exercises with newly issued shares of the Company’s Common Stock.  The total intrinsic value of stock options exercised during 2011, 2010, and 2009 was $49.2 million, $21.4 million, and $13.2 million,    respectively.  The intrinsic value represents the amount by which the market price of the underlying stock exceeds the exercise price of an option.

       
      The Company grants stock options with exercise prices that are equal to or greater than the average market price of the Company’s Common Stock on the date of grant (“Market Price”).  The table below summarizes the weighted-average exercise prices and weighted-average grant-date fair values of options issued during the years ended December 31, 2011, 2010, and 2009.  The fair value of each option granted under the 2000 Incentive Plan during 2011, 2010, and 2009 was estimated on the date of grant using the Black-Scholes option-pricing model.

       
       
      Number of Options Granted
      Weighted-Average Exercise Price
      Weighted-Average Fair Value
      2011:
      		     
         Exercise price equal to Market Price
      4,286,640
      $51.96
      $23.82
             
      2010:
      		     
         Exercise price equal to Market Price
      4,319,856
      $29.43
      $13.36
             
      2009:
      		     
         Exercise price equal to Market Price
      3,490,560
      $20.69
      $10.89
             
      For the years ended December 31, 2011, 2010, and 2009, the Company recognized $39.2 million, $29.4 million, and $27.4 million, respectively, of non-cash stock-based compensation expense related to non-performance based stock option awards.  As of December 31, 2011, there was $93.6 million of stock-based compensation cost related to outstanding non-performance based stock options, net of estimated forfeitures, which had not yet been recognized.  The Company expects to recognize this compensation cost over a weighted-average period of 1.9 years.

      In addition, there were 2,195,429 performance-based options which were outstanding and unvested as of December 31, 2011 of which, subject to the optionee satisfying certain service conditions, 203,429 options that were issued in 2005 would vest upon achieving certain defined sales targets for the Company’s products and 1,992,000 options that were issued in 2011, 2010, and 2009 would vest upon achieving certain development milestones for the Company’s product candidates.  In light of the Company’s receipt of marketing approval for EYLEAÒ for the treatment of wet AMD in November 2011, and the status of the Company’s development programs at December 31, 2011, the Company estimates that all of the remaining performance-based options issued in 2005, 2009, and 2010 will vest and approximately 50% of the performance-based options issued in 2011 will vest.

      For the years ended December 31, 2011 and 2010, the Company recognized $11.7 million and $8.1 million, respectively, of non-cash stock-based compensation expense related to these performance options.  As of December 31, 2011 there was $17.4 million of stock-based compensation cost which had not yet been recognized related to the performance–based options that the Company currently estimates will vest.  The Company expects to recognize this compensation cost over a weighted-average period of 2.5 years.  In addition, potential compensation cost of $10.2 million related to the performance options issued in 2011, whose performance conditions (based on current facts and circumstances) are not currently considered by the Company to be probable of attainment, will begin to be recognized only if and when the Company estimates that it is probable that these options will vest.  The Company’s estimates of the number of performance-based options that will vest will be revised, if necessary, in subsequent periods.  Changes in these estimates may materially affect the amount of stock-based compensation recognized in future periods related to performance-based options.

      Fair value Assumptions:

      The following table summarizes the weighted average values of the assumptions used in computing the fair value of option grants during 2011, 2010, and 2009.

       
       
      2011
      2010
      2009
      Expected volatility
      48%
      47%
      54%
      Expected lives from grant date
      6.1 years
      5.6 years
        5.9 years
      Expected dividend yield
      0%
      0%
      0%
      Risk-free interest rate
      1.31%
      2.11%
      2.87%

      Expected volatility has been estimated based on actual movements in the Company’s stock price over the most recent historical periods equivalent to the options’ expected lives.  Expected lives are principally based on the Company’s historical exercise experience with previously issued employee and board of directors’ option grants.  The expected dividend yield is zero as the Company has never paid dividends and does not currently anticipate paying any in the foreseeable future.  The risk-free interest rates are based on quoted U.S. Treasury rates for securities with maturities approximating the options’ expected lives.

       
      b.
      Restricted Stock

      A summary of the Company’s activity related to Restricted Stock awards for the year ended December 31, 2011 is summarized below:

       
       
       
      Restricted Stock:
       
       
      Number of Shares
      		 
      Weighted-Average
      Grant Date Fair Value
      Outstanding at December 31, 2010
      845,000
      		 
      $25.37
      2011:   Granted
      16,500
      		 
      $58.59
                   Released
      (110,001)
      		 
      $30.63
                   Outstanding at December 31, 2011
      751,499
      		 
      $25.33


      The Company recognized non-cash stock-based employee compensation expense from Restricted Stock awards of $5.7 million, $2.4 million, and $2.2 million in 2011, 2010, and 2009, respectively.  As of December 31, 2011, there were 751,499 unvested shares of Restricted Stock outstanding and $9.8 million of stock-based compensation cost related to these unvested shares which had not yet been recognized.  The Company expects to recognize this compensation cost over a weighted-average period of 1.4 years.
      XML 73 R26.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Net Loss Per Share Data
      		 12 Months Ended
      Dec. 31, 2011
      Net Loss Per Share Data [Abstract]  
      Net Loss Per Share Data
      19.  
      Net Loss Per Share Data

      The Company’s basic net loss per share amounts have been computed by dividing net loss by the weighted average number of Common and Class A shares outstanding.  Net loss per share is presented on a combined basis, inclusive of Common Stock and Class A Stock outstanding, as each class of stock has equivalent economic rights.  In 2011, 2010, and 2009, the Company reported net losses; therefore, no common stock equivalents were included in the computation of diluted net loss per share since such inclusion would have been antidilutive.  The calculations of basic and diluted net loss per share are as follows:

       
      December 31,
       
      2011
      2010
      2009
             
         Net loss (Numerator)
      $(221,760)
      $(104,468)
      $(67,830)
             
         Weighted-average shares, in thousands (Denominator)
       
      90,610
       
      82,926
       
      79,782
             
      Basic and diluted net loss per share
      $(2.45)
      $(1.26)
      $(0.85)

      Shares issuable upon the exercise of options and warrants, vesting of restricted stock awards, and conversion of convertible senior notes, which have been excluded from the diluted per share amounts because their effect would have been antidilutive, include the following:

         
      December 31,
      		 
       
      2011
      2010
      2009
      Options:
      		     
         Weighted average number, in thousands
      20,942
      21,428
      20,040
         Weighted average exercise price
      $21.21
      $18.80
      $17.66
             
      Restricted Stock:
      		     
         Weighted average number, in thousands
      846
      526
      500
             
      Convertible Senior Notes:
      		     
          Weighted average number, in thousands
      939
      		   
             
      Warrants:
      		     
          Weighted average number, in thousands
      939
      		   
      XML 74 R49.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Property, Plant, and Equipment (Details) (USD $)
      		 12 Months Ended
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross $ 526,094,000 $ 478,757,000  
      Less, accumulated depreciation and amortization (158,139,000) (131,307,000)  
      Property, plant and equipment, net 367,955,000 347,450,000  
      Depreciation and amortization expense 31,100,000 19,700,000 14,200,000
      Capitalized interest costs   6,400,000  
      Change in Accounting Estimate [Line Items]      
      Change in accounting estimate, decrease in depreciation expense   4,000,000  
      Change in accounting estimate, decrease in net loss per share (in dollars per share)   $ 0.05  
      Land [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 2,117,000 2,117,000  
      Building and Improvements [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 322,753,000 242,035,000  
      Leasehold Improvements [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 4,479,000 4,063,000  
      Construction-in-Progress [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 10,880,000 70,356,000  
      Laboratory and Other Equipment [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 156,397,000 137,951,000  
      Furniture, Computer and Office Equipment, and Other [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 29,468,000 22,235,000  
      Leased Equipment Under Capital Leases [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Property, plant and equipment, gross 3,600,000 2,800,000  
      Less, accumulated depreciation and amortization (500,000) (100,000)  
      New Laboratory and Office Facilities [Member]
      		      
      Property, Plant and Equipment [Line Items]      
      Costs incurred by the landlord to construct new laboratory and office facilities $ 86,200,000 $ 86,200,000  
      XML 75 R41.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Unaudited Quarterly Results (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Unaudited Quarterly Results [Abstract]  
      Summarized Quarterly Financial Data
      Summarized quarterly financial data for the years ended December 31, 2011 and 2010 are set forth in the following tables.

       
      First Quarter
      Ended
      March 31, 2011
      Second Quarter Ended
      June 30, 2011
      Third Quarter Ended
      September 30, 2011
      Fourth Quarter
      Ended
      December 31, 2011
       
      (Unaudited)
      Revenues
       $112,204
      $107,810
      $102,833
      $122,977
      Net loss
       (43,447)
         (62,505)
         (62,365)
         (53,443)
      Net loss per share, basic and diluted:
       
          $(0.49)
       
         $(0.69)
       
         $(0.68)
       
        $(0.58)


       
      First Quarter
      Ended
      March 31, 2010
      Second Quarter Ended
      June 30, 2010
      Third Quarter Ended
      September 30, 2010
      Fourth Quarter
      Ended
      December 31, 2010
       
      (Unaudited)
      Revenues
       $103,534
      $115,886
      $105,979
      $133,675
      Net loss
       (30,522)
         (25,474)
         (33,875)
         (14,597)
      Net loss per share, basic and diluted:
       
          $(0.38)
       
         $(0.31)
       
         $(0.41)
       
        $(0.17)
      XML 76 R5.htm IDEA: XBRL DOCUMENT v2.4.0.6
      STATEMENTS OF STOCKHOLDERS' EQUITY (USD $)
      In Thousands, unless otherwise specified
      Total
      Class A Stock [Member]
      Common Stock [Member]
      Additional Paid-in Capital [Member]
      Accumulated Deficit [Member]
      Accumulated Other Comprehensive Income (Loss) [Member]
      Comprehensive Loss [Member]
      Balance at Dec. 31, 2008 $ 421,514 $ 2 $ 78 $ 1,294,813 $ (873,265) $ (114)  
      Balance (in shares) at Dec. 31, 2008   2,249 77,642        
      Increase (decrease) in stockholders' equity [Roll Forward]              
      Issuance of Common Stock in connection with exercise of stock options, net of shares tendered 9,270   1 9,269      
      Issuance of Common Stock in connection with exercise of stock options, net of shares tendered (in shares)     1,134        
      Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution 1,391     1,391      
      Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution (in shares)     81        
      Conversion of Class A Stock to Common Stock 0            
      Conversion of Class A Stock to Common Stock (in shares)   (4) 4        
      Stock-based compensation charges 31,259     31,259      
      Net loss (67,830)       (67,830)   (67,830)
      Change in net unrealized gain (loss) on marketable securities, net of tax effect 1,158         1,158 1,158
      Balance at Dec. 31, 2009 396,762 2 79 1,336,732 (941,095) 1,044 (66,672)
      Balance (in shares) at Dec. 31, 2009   2,245 78,861        
      Increase (decrease) in stockholders' equity [Roll Forward]              
      Issuance of Common Stock in a public offering, net of issuance costs 174,828   6 174,822      
      Issuance of Common Stock in a public offering, net of issuance costs (in shares)     6,325        
      Issuance of Common Stock in connection with exercise of stock options, net of shares tendered 21,464   2 21,462      
      Issuance of Common Stock in connection with exercise of stock options, net of shares tendered (in shares)     1,533        
      Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution 2,867     2,867      
      Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution (in shares)     111        
      Issuance of restricted Common Stock under Long-Term Incentive Plan 0            
      Issuance of restricted Common Stock under Long-Term Incentive Plan (in shares)     345        
      Conversion of Class A Stock to Common Stock 0            
      Conversion of Class A Stock to Common Stock (in shares)   (63) 63        
      Stock-based compensation charges 39,897     39,897      
      Net loss (104,468)       (104,468)   (104,468)
      Change in net unrealized gain (loss) on marketable securities, net of tax effect (3,535)         (3,535) (3,535)
      Balance at Dec. 31, 2010 527,815 2 87 1,575,780 (1,045,563) (2,491) (108,003)
      Balance (in shares) at Dec. 31, 2010   2,182 87,238        
      Increase (decrease) in stockholders' equity [Roll Forward]              
      Issuance of Common Stock in connection with exercise of stock options, net of shares tendered 21,175   4 21,171      
      Issuance of Common Stock in connection with exercise of stock options, net of shares tendered (in shares)     3,324        
      Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution 6,979     6,979      
      Issuance of Common Stock in connection with Company 401(k) Savings Plan contribution (in shares)     92        
      Issuance of restricted Common Stock under Long-Term Incentive Plan 0            
      Issuance of restricted Common Stock under Long-Term Incentive Plan (in shares)     16        
      Restricted Common Stock tendered upon vesting in connection with employee tax obligations (2,638)     (2,638)      
      Restricted Common Stock tendered upon vesting in connection with employee tax obligations (in shares)     (51)        
      Conversion of Class A Stock to Common Stock 0            
      Conversion of Class A Stock to Common Stock (in shares)   (73) 73        
      Stock-based compensation charges 56,609     56,609      
      Equity component of convertible senior notes, net of issuance costs       120,623      
      Purchase of convertible note hedges (117,500)     (117,500)      
      Issuance of warrants in connection with issuance of convertible senior notes 93,800     93,800      
      Net loss (221,760)       (221,760)   (221,760)
      Change in net unrealized gain (loss) on marketable securities, net of tax effect 629         629 629
      Balance at Dec. 31, 2011 $ 485,732 $ 2 $ 91 $ 1,754,824 $ (1,267,323) $ (1,862) $ (221,131)
      Balance (in shares) at Dec. 31, 2011   2,109 90,692        
      XML 77 R10.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Collaboration and Contract Research Agreements
      		 12 Months Ended
      Dec. 31, 2011
      Collaboration and Contract Research Agreements [Abstract]  
      Collaboration and Contract Research Agreements
      3.  
      Collaboration and Contract Research Agreements

      The Company has entered into various agreements related to its activities to develop and commercialize product candidates and utilize its technology platforms.  Significant agreements of this kind are described below.

       
       
      a.   Sanofi

      As described in Note 13, Sanofi has purchased a total of 15,816,953 shares of the Company’s Common Stock, principally in connection with the companies’ ZALTRAP® and antibody collaborations described below.  Total Company-incurred expenses associated with these Sanofi collaborations, which include reimbursable and non-reimbursable amounts and an allocable portion of general and administrative costs, were $318.2 million in 2011, $282.4 million in 2010, and $209.4 million in 2009.

      ZALTRAP® ( aflibercept)

      In September 2003, the Company entered into a collaboration agreement (the “ZALTRAP® Agreement”) with Aventis Pharmaceuticals Inc. (predecessor to Sanofi U.S.), to jointly develop and commercialize ZALTRAP®.  In connection with this agreement, Sanofi made a non-refundable up-front payment of $80.0 million and purchased 2,799,552 newly issued unregistered shares of the Company’s Common Stock for $45.0 million.

      In January 2005, the Company and Sanofi amended the ZALTRAP® Agreement to exclude intraocular delivery of aflibercept to the eye (“Intraocular Delivery”) from joint development under the agreement, and product rights to aflibercept in Intraocular Delivery reverted to Regeneron.  In connection with this amendment, Sanofi made a $25.0 million non-refundable payment to Regeneron (the “Intraocular Termination Payment”).

      In December 2005, the Company and Sanofi amended the ZALTRAP® Agreement to expand the territory in which the companies are collaborating on the development of ZALTRAP® to include Japan.  In connection with this amendment, Sanofi agreed to make a $25.0 million non-refundable up-front payment to the Company, which was received in January 2006.  Under the ZALTRAP® Agreement, as amended, the Company and Sanofi will share co-promotion rights and profits on sales, if any, of ZALTRAP® outside of Japan, for disease indications included in the companies’ collaboration.  The Company is entitled to a royalty of approximately 35% on annual sales of ZALTRAP® in Japan, subject to certain potential adjustments.  The Company may also receive up to $400 million in substantive milestone payments upon receipt of specified marketing approvals, including up to $360 million in milestone payments related to the receipt of marketing approvals for up to eight ZALTRAP® oncology and other indications in the United States or the European Union and up to $40 million related to the receipt of marketing approvals for up to five ZALTRAP® oncology indications in Japan.

      Under the ZALTRAP® Agreement, as amended, agreed upon worldwide development expenses incurred by both companies during the term of the agreement will be funded by Sanofi.  If the collaboration becomes profitable, Regeneron will be obligated to reimburse Sanofi for 50% of these development expenses, or half of $763.4 million as of December 31, 2011, in accordance with a formula based on the amount of development expenses and Regeneron’s share of the collaboration profits and Japan royalties, or at a faster rate at Regeneron’s option.  Regeneron has the option to conduct additional pre-Phase III studies at its own expense.  In connection with the January 2005 amendment to the ZALTRAP® Agreement, the Intraocular Termination Payment of $25.0 million will also be subject to 50% reimbursement by Regeneron to Sanofi if the collaboration becomes profitable.  In addition, if the first commercial sale of an aflibercept product in Intraocular Delivery predates the first commercial sale of a ZALTRAP® product under the collaboration by two years, Regeneron will begin reimbursing Sanofi for up to $7.5 million of ZALTRAP® development expenses in accordance with a formula until the first commercial ZALTRAP® sale under the collaboration occurs.

      Sanofi has the right to terminate the agreement without cause with at least twelve months advance notice.  Upon termination of the agreement for any reason, Regeneron’s obligation to reimburse Sanofi, for 50% of ZALTRAP® development expenses will terminate, and the Company will retain all rights to ZALTRAP®.

      In accordance with the Company’s revenue recognition policy described in Note 2, the up-front payments received in September 2003 and January 2006, of $80.0 million and $25.0 million, respectively, and reimbursement of Regeneron-incurred development expenses, are being recognized as collaboration revenue over the related performance period.  In addition, in 2011, the Company and Sanofi began equally sharing ZALTRAP® pre-launch commercialization expenses under the ZALTRAP® Agreement.  The Company’s share of these expenses was $9.3 million in 2011, which reduced collaboration revenue in connection with the ZALTRAP® Agreement.

      The Company recognized $17.5 million, $26.4 million, and $36.5 million of collaboration revenue in 2011, 2010, and 2009, respectively, in connection with the ZALTRAP® Agreement, as amended.  In connection with the ZALTRAP® Agreement, (i) at December 31, 2011, there was a net payable of $3.7 million to Sanofi, (ii) at December 31, 2010, amounts receivable from Sanofi were $3.9 million, and (iii) deferred revenue at December 31, 2011 and 2010 was $22.9 million and $32.6 million, respectively.

      Antibodies

      In November 2007, the Company entered into a global, strategic collaboration (the “Antibody Collaboration”) with Sanofi to discover, develop, and commercialize fully human monoclonal antibodies.  In connection with the collaboration, in December 2007, Sanofi purchased 12 million newly issued, unregistered shares of the Company’s Common Stock for $312.0 million (see Note 13).

      The Antibody Collaboration is governed by a Discovery and Preclinical Development Agreement (the “Discovery Agreement”) and a License and Collaboration Agreement (the “License Agreement”).  In connection with the execution of the Discovery Agreement in 2007, the Company received a non-refundable up-front payment of $85.0 million from Sanofi.  In addition, under the Discovery Agreement, Sanofi is funding the Company’s research to identify and validate potential drug discovery targets and develop fully human monoclonal antibodies against these targets.  In November 2009, the Company and Sanofi amended these collaboration agreements to expand and extend the Antibody Collaboration.  Pursuant to the Discovery Agreement, as amended, Sanofi agreed to fund up to $160 million per year of the Company’s research activities in 2010 through 2017, subject to a one-time option for Sanofi to adjust the maximum reimbursement amount down to $120 million per year commencing in 2014 if over the prior two years certain specified criteria were not satisfied.  In 2010, as the Company scaled up its capacity to conduct antibody discovery activities, Sanofi funded $137.7 million of the Company’s preclinical research under the amended Discovery Agreement.  The balance between that amount and $160 million, or $22.3 million, has been added to the funding otherwise available to the Company in 2011-2012 under the amended Discovery Agreement.  The amended Discovery Agreement will expire on December 31, 2017; however, Sanofi has an option to extend the agreement for up to an additional three years for further antibody development and preclinical activities.

      For each drug candidate identified under the Discovery Agreement, Sanofi has the option to license rights to the candidate under the License Agreement.  If it elects to do so, Sanofi will co-develop the drug candidate with the Company through product approval.  Under certain defined circumstances, upon exercising its option to license rights to particular candidates, Sanofi must make a $10 million substantive milestone payment to the Company.  If Sanofi does not exercise its option to license rights to a particular drug candidate under the License Agreement, the Company retains the exclusive right to develop and commercialize such drug candidate, and Sanofi will receive a royalty on sales, if any.  The Company and Sanofi are currently co-developing seven therapeutic antibodies under the License Agreement.

      Under the License Agreement, agreed upon worldwide development expenses incurred by both companies during the term of the agreement are funded by Sanofi, except that following receipt of the first positive Phase 3 trial results for a co-developed drug candidate, subsequent Phase 3 trial-related costs for that drug candidate (“Shared Phase 3 Trial Costs”) are shared 80% by Sanofi and 20% by Regeneron.  If the Antibody Collaboration becomes profitable, Regeneron will be obligated to reimburse Sanofi for 50% of development expenses that were fully funded by Sanofi (or half of $582.3 million as of December 31, 2011) and 30% of Shared Phase 3 Trial Costs, in accordance with a defined formula based on the amounts of these expenses and the Company’s share of collaboration profits from commercialization of collaboration products.  However, the Company is not required to apply more than 10% of its share of the profits from the antibody collaboration in any calendar quarter to reimburse Sanofi for these development costs.

      Sanofi will lead commercialization activities for products developed under the License Agreement, subject to the Company’s right to co-promote such products.  The parties will equally share profits and losses from sales within the United States.  The parties will share profits outside the United States on a sliding scale based on sales starting at 65% (Sanofi)/35% (Regeneron) and ending at 55% (Sanofi)/45% (Regeneron), and losses outside the United States at 55% (Sanofi)/45% (Regeneron).  In addition to profit sharing, the Company is entitled to receive up to $250 million in sales milestone payments, with milestone payments commencing only if and after aggregate annual sales outside the United States exceed $1.0 billion on a rolling 12-month basis.

      Regeneron is obligated to use commercially reasonable efforts to supply clinical requirements of each drug candidate under the Antibody Collaboration until commercial supplies of that drug candidate are being manufactured.  In connection with the November 2009 amendment of the collaboration’s Discovery Agreement, Sanofi is funding up to $30 million of agreed-upon costs incurred by the Company to expand its manufacturing capacity at the Company’s Rensselaer, New York facilities, of which $28.2 million has been received or is receivable at December 31, 2011.

      With respect to each antibody product which enters development under the License Agreement, Sanofi or the Company may, by giving twelve months notice, opt-out of further development and/or commercialization of the product, in which event the other party retains exclusive rights to continue the development and/or commercialization of the product.  The Company may also opt-out of the further development of an antibody product if it gives notice to Sanofi within thirty days of the date that Sanofi enters joint development of such antibody product under the License Agreement.  Each of the Discovery Agreement and the License Agreement contains other termination provisions, including for material breach by the other party.  Prior to December 31, 2017, Sanofi has the right to terminate the amended Discovery Agreement without cause with at least three months advance written notice; however, except under defined circumstances, Sanofi would be obligated to immediately pay to the Company the full amount of unpaid research funding during the remaining term of the research agreement through December 31, 2017.  Upon termination of the collaboration in its entirety, the Company’s obligation to reimburse Sanofi for development costs out of any future profits from collaboration products will terminate.  Upon expiration of the amended Discovery Agreement, Sanofi has an option to license the Company’s VelocImmuneÒ technology for agreed upon consideration.

      In connection with the Antibody Collaboration, in August 2008, the Company entered into a separate agreement with Sanofi to use Regeneron's proprietary VelociGeneÒ technology platform to supply Sanofi with genetically modified mammalian models of gene function and disease (the “VelociGene® Agreement”).  The VelociGene® Agreement provides for minimum annual order quantities for the term of the agreement, which extends through December 2012, for which the Company expects to receive payments totaling a minimum of $21.5 million.

      In accordance with the Company’s revenue recognition policy described in Note 2, the (i) $85.0 million up-front payment received in December 2007, (ii) reimbursement of Regeneron-incurred expenses under the Discovery and License Agreements, (iii) $21.5 million of aggregate minimum payments under the VelociGene® Agreement, and (iv) reimbursement of agreed-upon costs to expand the Company’s manufacturing capacity are being recognized as collaboration revenue over the related performance period.  In connection with the amendments to expand and extend the Company’s antibody collaboration with Sanofi, during the fourth quarter of 2009, the Company extended its estimated performance period related to the $85.0 million up-front payment received from Sanofi under the Discovery Agreement and the $21.5 million of aggregate minimum payments under the VelociGene® Agreement.  The effect of this change in estimate resulted in the recognition of $5.3 million less in collaboration revenue in both 2011 and 2010, compared to 2009.

      In connection with the Antibody Collaboration, the Company recognized $309.1 million, $284.9 million, and $210.7 million of collaboration revenue in 2011, 2010, and 2009, respectively.  In addition, at December 31, 2011 and 2010, amounts receivable from Sanofi totaled $78.5 million and $75.7 million and deferred revenue was $83.1 million and $84.0 million, respectively.



      b.  
      Bayer HealthCare LLC

      In October 2006, the Company entered into a license and collaboration agreement with Bayer HealthCare for the global development and commercialization outside the United States of EYLEAÒ.  Under the terms of the agreement, Bayer HealthCare made a non-refundable up-front payment to the Company of $75.0 million.  In August 2007, the Company received a $20.0 million milestone payment from Bayer HealthCare following dosing of the first patient in a Phase 3 study of EYLEAÒ in the neovascular form of wet AMD.  In July 2009, the Company received a $20.0 million substantive milestone payment from Bayer HealthCare following dosing of the first patient in a Phase 3 study of EYLEAÒ in central retinal vein occlusion (“CRVO”).  In the fourth quarter of 2010, the Company earned two $10.0 million substantive milestone payments (for a total of $20.0 million) from Bayer HealthCare for achieving positive 52-week results in the Phase 3 study of EYLEAÒ in wet AMD and positive 6-month results in the Phase 3 study of EYLEAÒ in CRVO.  One of these $10.0 million payments was received in December 2010 and the other $10.0 million payment was received in January 2011.  The Company is eligible to receive up to $50 million in future substantive milestone payments related to marketing approvals of EYLEAÒ in major market countries outside the United States.  The Company is also eligible to receive up to $135 million in sales milestone payments when and if total annual sales of EYLEAÒ outside the United States achieve certain specified levels starting at $200 million.

      The Company will share equally with Bayer HealthCare in any future profits arising from the commercialization of EYLEAÒ outside the United States.  If EYLEAÒ is granted marketing authorization in a major market country outside the United States and the collaboration becomes profitable, the Company will be obligated to reimburse Bayer HealthCare out of its share of the collaboration profits for 50% of the agreed upon development expenses that Bayer HealthCare has incurred (or half of $370.9 million as of December 31, 2011) in accordance with a formula based on the amount of development expenses that Bayer HealthCare has incurred and the Company’s share of the collaboration profits, or at a faster rate at the Company’s option.  Within the United States, the Company is responsible for commercialization of EYLEAÒ and retains exclusive rights to any profits from such commercialization in the United States.

      Starting in 2009, all agreed upon EYLEAÒ development expenses incurred by the Company and Bayer HealthCare, under a global development plan, are being shared equally.  The Company is also obligated to use commercially reasonable efforts to supply clinical and commercial product requirements.

      Bayer HealthCare has the right to terminate the Bayer Agreement without cause with at least six months or twelve months advance notice depending on defined circumstances at the time of termination.  In the event of termination of the agreement for any reason, the Company retains all rights to EYLEAÒ.

      The $75.0 million up-front licensing payment and the $20.0 million milestone payment received in August 2007 from Bayer HealthCare are being recognized as collaboration revenue over the related estimated performance period in accordance with the Company’s revenue recognition policy as described in Note 2.    In periods when the Company recognizes EYLEAÒ development expenses that the Company incurs under the collaboration, the Company also recognizes, as collaboration revenue, the portion of those EYLEAÒ development expenses that is reimbursable from Bayer HealthCare.  In periods when Bayer HealthCare incurs agreed upon EYLEAÒ development expenses that benefit the collaboration and Regeneron, the Company also recognizes, as additional research and development expense, the portion of Bayer HealthCare’s EYLEAÒ development expenses that the Company is obligated to reimburse.

      The Company recognized $43.1 million, $75.4 million, and $67.3 million of collaboration revenue from Bayer HealthCare in 2011, 2010, and 2009, respectively.  In both 2010 and 2009, collaboration revenue from Bayer HealthCare included $20.0 million in milestone payments, as described above, which, for the purpose of revenue recognition, were considered substantive.  In addition, in 2011, 2010, and 2009, the Company recognized as additional research and development expense $47.8 million, $48.9 million, and $37.7 million, respectively, of EYLEAÒ development expenses that the Company was obligated to reimburse to Bayer HealthCare.

      In connection with cost-sharing of EYLEAÒ expenses under the collaboration, $4.5 million was receivable from Bayer HealthCare at December 31, 2011 and $2.3 million was payable to Bayer HealthCare at December 31, 2010.  In addition, at December 31, 2011 and 2010, deferred revenue from the Company’s collaboration with Bayer HealthCare was $42.4 million and $47.0 million, respectively.

       
      c.  
      National Institute of Health

       
      In September 2006, the Company was awarded a grant from the National Institutes of Health (“NIH”) as part of the NIH’s Knockout Mouse Project.  As amended, the NIH grant provided a minimum of $25.3 million in funding over a five-year period, including $1.5 million in funding to optimize certain existing technology, subject to compliance with its terms and annual funding approvals, for the Company’s use of its VelociGene® technology to generate a collection of targeting vectors and targeted mouse embryonic stem cells which can be used to produce knockout mice.  The Company records revenue in connection with the NIH grant using a proportional performance model as it incurs expenses related to the grant, subject to the grant’s terms and annual funding approvals.  In 2011, 2010, and 2009, the Company recognized contract research revenue of $3.6 million, $4.6 million, and $5.5 million, respectively, from the NIH Grant.  As of the end of 2011, no further revenue will be recognized by the Company in connection with this NIH Grant.
      XML 78 R58.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Employee Savings Plan (Details) (USD $)
      In Millions, except Share data in Thousands, unless otherwise specified
      		 3 Months Ended 12 Months Ended
      Mar. 31, 2012
      Mar. 31, 2011
      Dec. 31, 2011
      Dec. 31, 2010
      Dec. 31, 2009
      Employee Savings Plan [Abstract]          
      Employer contribution expense to 401(k) Savings Plan     $ 4.1 $ 3.2 $ 2.6
      Accrued contribution expense to 401(k) Savings Plan     $ 3.6 $ 2.9  
      Common Stock contributed to the Savings Plan (in shares, thousands) 64 92      
      XML 79 R27.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Statement of Cash Flows
      		 12 Months Ended
      Dec. 31, 2011
      Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]  
      Statement of Cash Flows
      20.  
      Statement of Cash Flows

      Supplemental disclosure of noncash investing and financing activities:

      Included in accounts payable and accrued expenses at December 31, 2011, 2010, and 2009 were $6.2 million, $10.7 million, and $9.8 million of accrued capital expenditures, respectively.

      Pursuant to the application of FASB authoritative guidance to the Company’s lease of office and laboratory facilities in Tarrytown, New York (see Note 12a), the Company recognized a facility lease obligation of $0.2 million and $31.7 million during 2010 and 2009, respectively, in connection with capitalizing, on the Company’s books, the landlord’s costs of constructing new facilities that the Company has leased.  The Company did not recognize any such facility lease obligations during 2011.

      Included in facility lease obligations and property, plant, and equipment at December 31, 2010 was $3.7 million of capitalized and deferred interest for the year ended December 31, 2010, as the related facilities being leased by the Company were under construction and lease payments on these facilities did not commence until January 2011.  For the years ended December 31, 2011 and 2009, the Company did not capitalize any interest.

      The Company incurred capital lease obligations of $0.7 and $2.9 million during 2011 and 2010 in connection with acquisitions of new equipment.

      Included in marketable securities at December 31, 2011, 2010, and 2009 were $0.7 million, $1.4 million, and $0.6 million of accrued interest income, respectively.
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M```$.0$``%!+`0(>`Q0````(`.T[54!T?JX^[(<``"Z="0`5`!@```````$` M``"D@=.Z`P!R96=N+3(P,3$Q,C,Q7W!R92YX;6Q55`4``YV.0T]U>`L``00E M#@``!#D!``!02P$"'@,4````"`#M.U5`V8^*97,@``#C>@$`$0`8```````! M````I($.0P0``L``00E#@`` ;!#D!``!02P4&``````8`!@`:`@``S&,$```` ` end XML 82 R38.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Long-Term Incentive Plans (Tables)
      		 12 Months Ended
      Dec. 31, 2011
      Long-Term Incentive Plans [Abstract]  
      Transactions Involving Stock Option Awards
      Transactions involving stock option awards during 2011 under the 2000 Incentive Plan is summarized in the table below.

       
       
       
       
       
      Stock Options:
       
       
       
       
      Number of Shares
       
       
       
      Weighted-Average
      Exercise Price
      Weighted-Average Remaining Contractual Term (in years)
       
       
       
      Intrinsic Value (in thousands)
      Outstanding at December 31, 2010
      23,362,248
      $19.93
      		   
      2011:   Granted
      4,286,640
      $51.96
      		   
                   Forfeited
      (247,898)
      $28.11
      		   
                   Expired
      (551,456)
      $13.31
      		   
                   Exercised
       (4,523,173)
      $18.73
      		   
                   Outstanding at December 31, 2011
      22,326,361
      $26.40
      6.90
      $663,376
               
      Vested and expected to vest at December 31, 2011
      21,755,141
      $26.04
      6.84
      $653,990
               
      Exercisable at December 31, 2011
      11,963,345
      $18.27
      5.27
      $451,478
      Weighted-Average Exercise Prices and Weighted-Average Grant-Date Fair Values of Options Issued
      The fair value of each option granted under the 2000 Incentive Plan during 2011, 2010, and 2009 was estimated on the date of grant using the Black-Scholes option-pricing model.

       
       
      Number of Options Granted
      Weighted-Average Exercise Price
      Weighted-Average Fair Value
      2011:
      		     
         Exercise price equal to Market Price
      4,286,640
      $51.96
      $23.82
             
      2010:
      		     
         Exercise price equal to Market Price
      4,319,856
      $29.43
      $13.36
             
      2009:
      		     
         Exercise price equal to Market Price
      3,490,560
      $20.69
      $10.89
      Weighted-Average Values of Assumptions Used in Computing Fair Value of Option Grants
      The following table summarizes the weighted average values of the assumptions used in computing the fair value of option grants during 2011, 2010, and 2009.

       
       
      2011
      2010
      2009
      Expected volatility
      48%
      47%
      54%
      Expected lives from grant date
      6.1 years
      5.6 years
        5.9 years
      Expected dividend yield
      0%
      0%
      0%
      Risk-free interest rate
      1.31%
      2.11%
      2.87%
      Activity Related to Restricted Stock Awards
      A summary of the Company's activity related to Restricted Stock awards for the year ended December 31, 2011 is summarized below:

       
       
       
      Restricted Stock:
       
       
      Number of Shares
      		 
      Weighted-Average
      Grant Date Fair Value
      Outstanding at December 31, 2010
      845,000
      		 
      $25.37
      2011:   Granted
      16,500
      		 
      $58.59
                   Released
      (110,001)
      		 
      $30.63
                   Outstanding at December 31, 2011
      751,499
      		 
      $25.33

      XML 83 R20.htm IDEA: XBRL DOCUMENT v2.4.0.6
      Stockholders Equity
      		 12 Months Ended
      Dec. 31, 2011
      Stockholders Equity [Abstract]  
      Stockholders Equity
      13.  
      Stockholders’ Equity

      The Company's Restated Certificate of Incorporation provides for the issuance of up to 40 million shares of Class A Stock, par value $0.001 per share, and 160 million shares of Common Stock, par value $0.001 per share.  Shares of Class A Stock are convertible, at any time, at the option of the holder into shares of Common Stock on a share-for-share basis.   Holders of Class A Stock have rights and privileges identical to Common Stockholders except that each share of Class A is entitled to ten votes per share, while each share of Common Stock is entitled to one vote per share.  Class A Stock may only be transferred to specified Permitted Transferees, as defined.  Under the Company’s Restated Certificate of Incorporation, the Company’s board of directors is authorized to issue up to 30 million shares of preferred stock, in series, with rights, privileges, and qualifications of each series determined by the board of directors.

      In September 2003, Sanofi purchased 2,799,552 newly issued, unregistered shares of the Company’s Common Stock for $45.0 million.  See Note 3.

      In December 2007, Sanofi purchased 12 million newly issued, unregistered shares of the Company’s Common Stock for an aggregate cash price of $312.0 million.  As a condition to the closing of this transaction, Sanofi entered into an investor agreement with the Company, which was amended in November 2009.  Under the amended investor agreement, Sanofi has three demand rights to require the Company to use all reasonable efforts to conduct a registered underwritten public offering with respect to shares of the Company’s Common Stock beneficially owned by Sanofi immediately after the closing of the transaction.  Until the later of the fifth anniversaries of the expiration or earlier termination of the License and Collaboration Agreement, as amended in 2009, under the Company’s antibody collaboration with Sanofi (see Note 3) and the Company’s collaboration agreement with Sanofi for the development and commercialization of ZALTRAP® (see Note 3), Sanofi will be bound by certain “standstill” provisions.  These provisions include an agreement not to acquire more than a specified percentage of the outstanding shares of the Company’s Class A Stock and Common Stock.  The percentage increased from 25% to 30% as of December 20, 2011.  Under the amended investor agreement, Sanofi has also agreed not to dispose of any shares of the Company’s Common Stock that were beneficially owned by Sanofi immediately after the closing of the transaction until December 20, 2017, subject to certain limited exceptions.  Following December 20, 2017, Sanofi will be permitted to sell shares of the Company’s Common Stock (i) in a registered underwritten public offering undertaken pursuant to the demand registration rights granted to Sanofi and described above, subject to the underwriter's broad distribution of securities sold, (ii) pursuant to Rule 144 under the Securities Act and transactions exempt from registration under the Securities Act, subject to a volume limitation of one million shares of the Company’s Common Stock every three months and a prohibition on selling to beneficial owners, or persons that would become beneficial owners as a result of such sale, of 5% or more of the outstanding shares of the Company’s Common Stock, and (iii) into an issuer tender offer, or a tender offer by a third party that is recommended or not opposed by the Company’s board of directors.  Sanofi has agreed to vote, and cause its affiliates to vote, all shares of the Company’s voting securities they are entitled to vote, at Sanofi's election, either as recommended by the Company’s board of directors or proportionally with the votes cast by the Company’s other shareholders, except with respect to certain change of control transactions, liquidation or dissolution, stock issuances equal to or exceeding 10% of the then outstanding shares or voting rights of the Company’s Class A Stock and Common Stock, and new equity compensation plans or amendments if not materially consistent with the Company’s historical equity compensation practices.  The rights and restrictions under the investor agreement are subject to termination upon the occurrence of certain events.

      In October 2010, the Company completed an underwritten public offering of 6,325,000 shares of Common Stock and received net proceeds of $174.8 million.  Sanofi purchased 1,017,401 shares of Common Stock in this offering.

      In October 2011, the Company completed a private placement of $400.0 million aggregate principal amount of Notes, which are convertible into shares of the Company’s Common Stock.   In accordance with accounting guidance for debt with conversion and other options, the Company accounted for the liability and equity components of the Notes separately.   The equity component of the Notes was $120.6 million, net of issuance costs.  In connection with the offering of the Notes, the Company entered into convertible note hedge and warrant transactions.  The Company paid $117.5 million for the convertible note hedge, which was recorded as a reduction to additional paid-in capital.  The warrant transactions have an initial strike price of approximately $103.41 per share, and may be settled in cash or shares of the Company’s Common Stock, at the Company’s option.  Proceeds received from the warrant transactions totaled $93.8 million and were recorded as additional paid-in capital.  The warrants expire at various dates during 2017.  See Note 11.