Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands	Sep. 30, 2011	Dec. 31, 2010
Accounts payable and accrued expenses [Abstract]
Accounts payable	$ 17,309	$ 15,589
Accrued payroll and related costs	37,616	12,025
Accrued clinical trial expense	10,018	9,727
Accrued property, plant, and equipment costs	2,333	7,622
Other accrued expenses and liabilities	8,208	6,441
Payable to Bayer HealthCare	3,406	2,254
Accounts payable and accrued expenses	$ 78,890	$ 53,658