EX-12.1

Exhibit 12.1

Regeneron Pharmaceuticals, Inc.
Computation of Ratio of Earnings to Combined Fixed Charges
(Dollars in thousands)


															Three months
															ended
	Years ended December 31,														March 31,
	2002			2003			2004		2005			2006			2007
Earnings:
Income (loss) from continuing operations before income (loss) from equity investee	$	(124,350	)	$	(107,395	)	$	41,565	$	(95,456	)	$	(103,150	)	$	(29,917	)
Fixed charges		13,685			14,108			14,060		13,687			13,643			3,425
Amortization of capitalized interest		—			33			78		78			73			6
Interest capitalized		(222	)		(276	)		—		—			—			—


Adjusted earnings	$	(110,887	)	$	(93,530	)	$	55,703	$	(81,691	)	$	(89,434	)	$	(26,486	)


Fixed charges:
Interest expense	$	11,859		$	11,932		$	12,175	$	12,046		$	12,043		$	3,011
Interest capitalized		222			276			—		—			—			—
Assumed interest component of rental charges		1,604			1,900			1,885		1,641			1,600			414

Total fixed charges	$	13,685		$	14,108		$	14,060	$	13,687		$	13,643		$	3,425


Ratio of earnings to fixed charges		(A	)		(A	)		3.96		(A	)		(A	)		(A	)


(A)		Due to the registrant’s losses for the years ended December 31, 2002, 2003, 2005, and 2006, and for the three months ended March 31, 2007, the ratio coverage was less than 1:1. To achieve a coverage ratio of 1:1, the registrant must generate additional earnings of the amounts shown in the table below.