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Stockholders' Equity (Details 1)
12 Months Ended
Dec. 31, 2018
$ / shares
shares
Summary of outstanding warrants to purchase common stock  
Shares 1,116,368
August 2016 Prefunded Warrants [Member]  
Summary of outstanding warrants to purchase common stock  
Issue Date Aug. 16, 2016 [1]
Exercise Price | $ / shares $ 10 [1]
Shares 360,000 [1]
Expiration Date Feb. 16, 2022 [1]
August 2016 Purchase Warrants [Member]  
Summary of outstanding warrants to purchase common stock  
Issue Date Aug. 17, 2016
Exercise Price | $ / shares $ 11.20
Shares 431,368
Expiration Date Feb. 17, 2022
August 2017 Purchase Warrants [Member]  
Summary of outstanding warrants to purchase common stock  
Issue Date Aug. 08, 2017
Exercise Price | $ / shares $ 20.00
Shares 325,000
Expiration Date Aug. 08, 2020
[1] Under the terms of the prefunded warrants, the warrant holder prepaid $9.90 of the original $10.00 warrant per share exercise price at the time of issuance of the warrant. The remaining $0.10 exercise price is required to be paid in full prior to the issuance of any common stock under the terms of the prefunded warrant agreement.