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Stockholders' Equity (Details) - $ / shares
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Summary of all stock option plans        
Weighted Average Exercise Price, Options outstanding and exercisable, Ending Balance   $ 0.67 $ 1.24  
Warrants [Member]        
Summary of all stock option plans        
Number of Shares/Warrants, Options outstanding, Beginning Balance 7,913,676 464,073 3,335,073  
Warrants, Issued (Prefunded)   4,313,676  
Warrants, Issued (Purchase) 3,250,001 3,600,000    
Warrants, Expired/forfeited (384,073) (2,591,000)  
Number of Shares, Options exercised (80,000) (280,000)  
Number of Shares/Warrants, Options outstanding, Ending Balance 11,163,677 7,913,676 464,073 3,335,073
Number of Shares/Warrants, Options outstanding, Ending Balance and exercisable 7,913,676      
Weighted Average Exercise Price, Options outstanding, Beginning Balance $ 0.62 $ 3.02 $ 4.45  
Weighted Average Exercise Price, Issued (Prefunded)   0.01  
Weighted Average Exercise Price, Issued (Purchase) 2.00 1.12    
Weighted Average Exercise Price, Options cancelled or expired 3.13 5.06  
Weighted Average Exercise Price, Options exercised 2.00 1.30  
Weighted Average Exercise Price, Options outstanding, Ending Balance 1.02 $ 0.62 $ 3.02 $ 4.45
Weighted Average Exercise Price, Options outstanding and exercisable, Ending Balance $ 0.62      
Weighted Average Remaining Contractual Life, Outstanding 3 years 8 months 5 days 5 years 1 month 17 days 2 months 8 days 11 months 4 days
Weighted Average Remaining Contractual Life, Outstanding and exercisable 4 years 1 month 16 days