Exhibit 31.2  

Certification of Chief Financial Officer pursuant to Exchange

Act Rules 13a-14 and 15d-14, as adopted pursuant to Section 302 of

Sarbanes-Oxley Act of 2002

I, Louis J. Arcudi, III, certify that:

1. I have reviewed this Amendment No. 1 to Annual Report on Form 10-K of Idera Pharmaceuticals, Inc.; and

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

/s/ Louis J. Arcudi, III

Louis J. Arcudi, III

Chief Financial Officer

Dated: March 16, 2017