-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, U6Qy8CsGBAZuBTe6htAq5rrYvdJDmMsIcFcapdtnQZBL5gEN6bdHqERnT/N3D9R7 uNtVV0++9wcsVWDpGIymxw== 0000950116-98-000338.txt : 19980218 0000950116-98-000338.hdr.sgml : 19980218 ACCESSION NUMBER: 0000950116-98-000338 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 19980213 SROS: NONE GROUP MEMBERS: HAROLD R. WERNER GROUP MEMBERS: HEALTHCARE PARTNERS II, L.P. GROUP MEMBERS: HEALTHCARE PARTNERS III, L.P. GROUP MEMBERS: HEALTHCARE PARTNERS IV, L.P. GROUP MEMBERS: HEALTHCARE VENTURES II LP GROUP MEMBERS: HEALTHCARE VENTURES III, L.P. GROUP MEMBERS: HEALTHCARE VENTURES IV, L.P. GROUP MEMBERS: JAMES H. CAVANAUGH, PH.D. GROUP MEMBERS: JOHN W. LITTLECHILD GROUP MEMBERS: MARK LESCHLY GROUP MEMBERS: WILLIAM CROUSE SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: VIRUS RESEARCH INSTITUTE INC CENTRAL INDEX KEY: 0000902010 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 223098869 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: SEC FILE NUMBER: 005-49497 FILM NUMBER: 98539178 BUSINESS ADDRESS: STREET 1: 61 MOULTON ST CITY: CAMBRIDGE STATE: MA ZIP: 02139 BUSINESS PHONE: 6178646232 MAIL ADDRESS: STREET 1: 61 MOULTON ST CITY: CAMBRIDGE STATE: MA ZIP: 02138 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: HEALTHCARE VENTURES II LP CENTRAL INDEX KEY: 0000859649 STANDARD INDUSTRIAL CLASSIFICATION: UNKNOWN SIC - 0000 [0000] IRS NUMBER: 223015728 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 08837 BUSINESS PHONE: 9089064613 MAIL ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 08837 SC 13G/A 1 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13D-1 (b) AND (c) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b) (Amendment No. 1 )* Virus Research Institute, Inc. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock, $.001 par value - -------------------------------------------------------------------------------- (Title of Class of Securities) 927920108 ------------------------------------------ (CUSIP Number) * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). (Continued on following page(s)) Page 1 of 20 Pages ________________________________________________________________________________ CUSIP No. 927920108 13G Page 2 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | HealthCare Ventures II, L.P. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | Delaware ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 1,324,975 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 1,324,975 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 1,324,975 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 14.8% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | PN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 3 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | HealthCare Partners II, L.P. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | Delaware ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 1,324,975 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 1,324,975 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 1,324,975 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 14.8% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | PN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 4 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | HealthCare Ventures III, L.P. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | Delaware ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 1,174,575 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 1,174,575 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 1,174,575 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 13.1% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | PN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 5 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | HealthCare Partners III, L.P. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | Delaware ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 1,174,575 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 1,174,575 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 1,174,575 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 13.1% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | PN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 6 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | HealthCare Ventures IV, L.P. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | Delaware ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 344,928 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 344,928 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 344,928 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 3.9% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | PN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 7 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | HealthCare Partners IV, L.P. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | Delaware ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 344,928 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 344,928 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 344,928 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 3.9% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | PN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 8 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | James H. Cavanaugh, Ph.D. ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | United States ________|_______________________________________________________________________ | | | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 2,844,478 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 2,844,478 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 2,844,478 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 31.7% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | IN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 9 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | Harold R. Werner ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | United States ________|_______________________________________________________________________ | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 2,844,478 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 2,844,478 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 2,844,478 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 31.7% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | IN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 10 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | William Crouse ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | United States ________|_______________________________________________________________________ | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY | | 2,844,478 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 2,844,478 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 2,844,478 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 31.7% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | IN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 11 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | John W. Littlechild ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | United States ________|_______________________________________________________________________ | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY 2,844,478 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 2,844,478 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 2,844,478 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 31.7% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | IN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 12 of 20 Pages ________________________________________________________________________________ 1 | NAME OF REPORTING PERSON | S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON | | Mark Leschly ________|_______________________________________________________________________ 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] | (b) [ ] ________|_______________________________________________________________________ 3 | SEC USE ONLY ________|_______________________________________________________________________ 4 | CITIZENSHIP OR PLACE OF ORGANIZATION | United States ________|_______________________________________________________________________ | 5 | SOLE VOTING POWER | | |_____|__________________________________________________________ NUMBER OF | | SHARES | 6 | SHARED VOTING POWER BENEFICIALLY 1,519,503 OWNED BY |_____|__________________________________________________________ EACH | | REPORTING | 7 | SOLE DISPOSITIVE POWER PERSON WITH | | |_____|__________________________________________________________ | | | 8 | SHARED DISPOSITIVE POWER | | 1,519,503 _______________|_____|__________________________________________________________ 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 1,519,503 _______|________________________________________________________________________ 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES* [ ] _______|________________________________________________________________________ 11 | PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 16.9% _______|________________________________________________________________________ 12 | TYPE OF REPORTING PERSON* | IN _______|________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT! ________________________________________________________________________________ CUSIP No. 927920108 13G Page 13 of 20 Pages ________________________________________________________________________________ Item 1. (a) Name of Issuer: Virus Research Institute, Inc. (b) Address of Issuer's Principal Executive Offices: 61 Moulton Street Cambridge, Massachusetts 02138 Item 2. (a) Name of Person Filing: HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II, L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV III"), HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV, L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly(1). See attached Exhibit A which is a copy of their agreement in writing to file this statement on behalf of each of them.(2) (b) Address of Principal Business Office or, if none, Residence: The business address for HCV II, HCP II, HCV III, HCP III, HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street, Princeton, New Jersey 08542. The business address for Messrs. Littlechild and Leschly is One Kendall Square, Building 300, Cambridge, Massachusetts 02139. (c) Citizenship: HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are limited partnerships organized under the laws of the State of Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are each United States citizens. - -------- (1) Mr. Leschly became a general partner of each of HCP III and HCP IV effective January 1, 1998. (2) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general partners of HCP II, which is the general partner of HCV II, and Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are general partners of each of HCP III and HCP IV, which is the general partner of each of HCV III and HCV IV, respectively, the record holder of Issuer's securities. ________________________________________________________________________________ CUSIP No. 927920108 13G Page 14 of 20 Pages ________________________________________________________________________________ (d) Title of Class of Securities: Common Stock, par value $.001 ("Shares"). (e) CUSIP Number: 927920108 Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), check whether the person filing is a: Inapplicable. Item 4. Ownership. (a) Amount Beneficially Owned: As of December 31, 1997: HCV II and HCP II beneficially owned 1,324,975 Shares of Issuer's Common Stock; HCV III and HCP III beneficially owned 1,174,575 Shares of Issuer's Securities, consisting of 1,131,595 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 42,980 Shares of Issuer's Common Stock; HCV IV and HCP IV beneficially owned 344,928 Shares of Issuer's Securities, consisting of 332,306 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 12,622 Shares of Issuer's Common Stock; Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse beneficially owned 2,844,478 Shares of Issuer's Securities, consisting of 2,788,876 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 55,602 Shares of Issuer's Common Stock; and Mr. Leschly beneficially owned 1,519,503 Shares of Issuer's Securities, consisting of 1,463,901 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 55,602 Shares of Issuer's Common Stock. (b) Percent of Class: As of December 31, 1997: the 1,324,975 Shares of Issuer's Securities beneficially owned by HCV II and HCP II constitute 14.8% of Issuer's Shares outstanding; the 1,174,575 Shares of Issuer's Securities beneficially owned by HCV III and HCP III constitute 13.1% of the Issuer's Shares outstanding; the 344,928 Shares of Issuer's Securities beneficially owned by HCV IV and HCP IV consisted 3.9% of Issuer's Shares outstanding; the 2,844,478 Shares of Issuer's Securities beneficially owned by Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse constitute 31.7% of Issuer's Shares outstanding; and the 1,519,503 Shares of Issuer's Securities beneficially owned by Mr. Leschly constitute 16.9% of Issuer's Shares outstanding. ________________________________________________________________________________ CUSIP No. 927920108 13G Page 15 of 20 Pages ________________________________________________________________________________ (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: Inapplicable (ii) shared power to vote or to direct the vote: HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild, and Crouse share the power to vote or direct the vote of those shares owned by HCV II. HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those shares owned by HCV III. HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those shares owned by HCV IV. (iii) sole power to dispose or to direct the disposition of: Inapplicable (iv) shared power to dispose of or to direct the disposition of: HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to dispose of or direct the disposition of those shares owned by HCV II. HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to dispose of or direct the disposition of those shares owned by HCV III. HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to dispose of or direct the disposition of those shares owned by HCV IV. Item 5. Ownership of Five Percent or less of a Class: Inapplicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person: Inapplicable. ________________________________________________________________________________ CUSIP No. 927920108 13G Page 16 of 20 Pages ________________________________________________________________________________ Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: Inapplicable. Item 8. Identification and Classification of Members of the Group: Inapplicable. Item 9. Notice of Dissolution of Group: Inapplicable. Item 10. Certification: Inapplicable. ________________________________________________________________________________ CUSIP No. 927920108 13G Page 17 of 20 Pages ________________________________________________________________________________ SIGNATURES After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: February 10, 1998 HealthCare Ventures II, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P. By: /s/ Jeffrey Steinberg ------------------------------- A General Partner Dated: February 10, 1998 HealthCare Partners II, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------- A General Partner Dated: February 10, 1998 HealthCare Ventures III, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P. By: /s/ Jeffrey Steinberg ------------------------------- A General Partner Dated: February 10, 1998 HealthCare Partners III, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------- A General Partner Dated: February 10, 1998 HealthCare Ventures IV, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P. By: /s/ Jeffrey Steinberg ------------------------------- A General Partner Dated: February 10, 1998 HealthCare Partners IV, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------- A General Partner Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Princeton, New Jersey ------------------------------ James H. Cavanaugh, Ph.D. Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Princeton, New Jersey ------------------------------ Harold R. Werner ________________________________________________________________________________ CUSIP No. 927920108 13G Page 18 of 20 Pages ________________________________________________________________________________ Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Cambridge, Massachusetts ------------------------------- John W. Littlechild Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Princeton, New Jersey ------------------------------- William Crouse Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Cambridge, Massachusetts ------------------------------- Mark Leschly ________________________________________________________________________________ CUSIP No. 927920108 13G Page 19 of 20 Pages ________________________________________________________________________________ EXHIBIT A AGREEMENT JOINT FILING OF SCHEDULE 13G The undersigned hereby agree to jointly prepare and file with regulatory authorities a Schedule 13G and any future amendments thereto reporting each of the undersigned's ownership of securities of Virus Research Institute, Inc. and hereby affirm that such Schedule 13G is being filed on behalf of each of the undersigned. Dated: February 10, 1998 HealthCare Ventures II, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P. By: /s/ Jeffrey Steinberg ------------------------------ A General Partner Dated: February 10, 1998 HealthCare Partners II, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------ A General Partner Dated: February 10, 1998 HealthCare Ventures III, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P. By: /s/ Jeffrey Steinberg ------------------------------ A General Partner Dated: February 10, 1998 HealthCare Partners III, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------ A General Partner Dated: February 10, 1998 HealthCare Ventures IV, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P. By: /s/ Jeffrey Steinberg ------------------------------ A General Partner Dated: February 10, 1998 HealthCare Partners IV, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------ A General Partner Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Princeton, New Jersey ------------------------------ James H. Cavanaugh, Ph.D. Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Princeton, New Jersey ------------------------------- Harold R. Werner ________________________________________________________________________________ CUSIP No. 927920108 13G Page 20 of 20 Pages ________________________________________________________________________________ Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Cambridge, Massachusetts ------------------------------- John W. Littlechild Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Princeton, New Jersey ------------------------------- William Crouse Dated: February 10, 1998 By: /s/ Jeffrey Steinberg Cambridge, Massachusetts ------------------------------- John W. Littlechild -----END PRIVACY-ENHANCED MESSAGE-----