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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 8CrzUVYk3JLpFgkZyIXpsg==

<SEC-DOCUMENT>0001246360-05-001782.txt : 20051006
<SEC-HEADER>0001246360-05-001782.hdr.sgml : 20051006
<ACCEPTANCE-DATETIME>20051006171310
ACCESSION NUMBER:		0001246360-05-001782
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050930
FILED AS OF DATE:		20051006
DATE AS OF CHANGE:		20051006

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDICIS PHARMACEUTICAL CORP
		CENTRAL INDEX KEY:			0000859368
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521574808
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		8125 NORTH HAYDEN ROAD
		CITY:			SCOTTSDALE
		STATE:			AZ
		ZIP:			85258
		BUSINESS PHONE:		2125992000

	MAIL ADDRESS:	
		STREET 1:		8125 NORTH HAYDEN ROAD
		CITY:			SCOTTSDALE
		STATE:			AZ
		ZIP:			85258

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KNIGHT PETER S
		CENTRAL INDEX KEY:			0001189792

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14471
		FILM NUMBER:		051127740

	BUSINESS ADDRESS:	
		STREET 1:		1737 H. STREET NW
		STREET 2:		2ND FLOOR
		CITY:			WASHINGTON
		STATE:			DC
		ZIP:			20006

	MAIL ADDRESS:	
		STREET 1:		9640 MEDICAL CENTER DR
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-09-30</periodOfReport>

    <notSubjectToSection16>false</notSubjectToSection16>

    <issuer>
        <issuerCik>0000859368</issuerCik>
        <issuerName>MEDICIS PHARMACEUTICAL CORP</issuerName>
        <issuerTradingSymbol>MRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001189792</rptOwnerCik>
            <rptOwnerName>KNIGHT PETER S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>8125 N. HAYDEN ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SCOTTSDALE</rptOwnerCity>
            <rptOwnerState>AZ</rptOwnerState>
            <rptOwnerZipCode>85258</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Non-Employee Director Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>32.56</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-09-30</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>15000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2006-09-30</value>
            </exerciseDate>
            <expirationDate>
                <value>2015-09-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <ownerSignature>
        <signatureName>Peter Knight</signatureName>
        <signatureDate>2005-10-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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