SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 12b-25

                         Commission File Number 0-23268

                           NOTIFICATION OF LATE FILING

|X| Form 10-K |_| Form 11-K |_| Form 20-F | | Form 10-Q |_| Form N-SAR

For Period Ended: December 31, 2006

|_| Transition Report on Form 10-K |_| Transition Report on Form 10-Q
|_| Transition Report on Form 20-F |_| Transition Report on Form N-SAR

For the Transition Period Ended:________________________________________________

Nothing in this form shall be construed to imply that the Commission has
verified any information contained herein.

If the notification relates to a portion of the filing checked above, identify
the item(s) to which the notification relates:__________________________________

                                     PART I
                             REGISTRANT INFORMATION

Full name of registrant                     Protein Polymer Technologies, Inc.
Former name if applicable:
Address of principal executive office       10655 Sorrento Valley Road
City, state and zip code                    San Diego, California 92121




                                     PART II
                             RULE 12b-25 (b) AND (c)

      If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25 (b), the
following should be completed. (Check box if appropriate.)

            (a)The reasons described in reasonable detail in Part III of this
            form could not be eliminated without unreasonable effort or expense;

(X)         (b)The subject annual report, semi-annual report, transition report
            on Form 10-K, 20-F, 11-K or Form 10-Q, or portion thereof will be
            filed on or before the 15th calendar day following the prescribed
            due date; or the subject quarterly report or transition report on
            Form 10-Q, or portion thereof will be filed on or before the fifth
            calendar day following the prescribed due date; and

            (c)The accountant's statement or other exhibit required by Rule
            12b-25(c) has been attached if applicable.

                                    PART III
                                    NARRATIVE

      State below in reasonable detail the reasons why Form 10-K, 11-K, 20-F,
10-Q, N-SAR or the transition report portion thereof could not be filed within
the prescribed time period.

The registrant is in the process of preparing and reviewing the financial
information of the Company on a consolidated basis. The process of compiling and
disseminating the information required to be included in the Form 10-KSB for the
relevant fiscal year, as well as the completion of the required review of the
Company's financial information on a consolidated basis, could not be completed
without incurring undue hardship and expense. The registrant undertakes the
responsibility to file such annual report no later than fifteen days after its
original date.

                                     PART IV
                                OTHER INFORMATION

(1) Name and telephone number of person to contact in regard to this
notification

    William N. Plamondon               (858)                558-6064
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           (Name)                   (Area Code)        (Telephone Number)

(2) Have all other periodic reports required under Section 13 or 15(d) of the
Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of
1940 during the preceding 12 months or for such shorter period that the
registrant was required to file such report(s) been filed? If the answer is no,
identify report(s).

                                 |X| Yes |_| No

(3) Is it anticipated that any significant change in results of operations from
the corresponding period for the last fiscal year will be reflected by the
earnings statements to be included in the subject report or portion thereof?

                                 |X| Yes |_| No

If so: attach an explanation of the anticipated change, both narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.

      For the year ended December 31, 2005, the registrant had revenues of
$867,433 and a net loss of $6,581,440. For the year ended December 31, 2006, the
registrant currently estimates that it had revenues and a net loss of
approximately $570,000 and $6,900,000, respectively. Results for the year ended
December 31, 2006 remain subject to further adjustment and actual results may
differ significantly from the foregoing estimates.

On or about March 13, 2007, we received a letter from Surgica Corporation's
counsel alleging that we had breached the License Agreement and the Supply and
Services Agreement which we entered into with Surgica on December 19, 2005, and,
based thereon, Surgica was terminating these Agreements. In connection therewith
Surgica's counsel demanded that we reassign the 501(k) Clearances, as defined in
the License Agreement, back to Surgica. We do not believe that we have breached
these Agreements. Accordingly, we do not believe that we are obligated to
reassign the 501(k) Clearances back to Surgica and are so notifying Surgica.
However, in the event that Surgica should ultimately prevail in its position, we
would incur an additional loss ranging from $750,000 to approximately
$1,300,000. No amount of loss arising from Surgica's assertion was included the
estimated net loss set forth in the preceding paragraph.




                        Protein Polymer Technology, Inc.
                        --------------------------------
                   Name of Registrant as Specified in Charter

Has caused this notification to be signed on its behalf by the undersigned
thereunto duly authorized.

Date: March 30, 2007

By: /s/ William N. Plamondon
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William N. Plamondon, CEO