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Note 9 - Patents (Tables)
6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedule of Finite-Lived Intangible Assets [Table Text Block]
   
2018
   
2017
 
   
Cost
   
Accumulated Amortization
   
Net
   
Cost
   
Accumulated Amortization
   
Net
 
Patents-foundation intellectual property
  $
1,377,863
    $
(817,235
)   $
560,628
    $
1,377,863
    $
(787,821
)   $
590,042
 
Epidural-APAD acquired patents
   
2,639,646
     
(879,882
)    
1,759,764
     
2,639,647
     
(439,941
)    
2,199,706
 
Total
  $
4,017,509
    $
(1,697,117
)   $
2,320,392
    $
4,017,510
    $
(1,227,762
)   $
2,789,748