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Liability Related to Sale of Future Royalties (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended 96 Months Ended
Jan. 31, 2019
USD ($)
May 31, 2000
Jun. 30, 2021
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2022
USD ($)
Liability Related to Sale of Future Royalties                
Non-cash royalty revenue related to the sale of future royalties       $ 12,836 $ 39,155 $ 68,529    
Kadcyla                
Liability Related to Sale of Future Royalties                
Percentage of royalty payments if applicable threshold is met             85.00%  
OMERS | Kadcyla                
Liability Related to Sale of Future Royalties                
Non-cash royalty revenue related to the sale of future royalties       7,700 7,700      
Net proceeds from sale of residual rights to receive royalty payments     $ 16,400          
IRH | Kadcyla                
Liability Related to Sale of Future Royalties                
Percentage of royalty payments             100.00%  
Proceeds from sale of future royalties             $ 200,000 $ 194,135
Percentage of royalty payments if applicable threshold is met             15.00%  
Transaction costs for royalty agreements             $ 5,900  
Change in liability related to sale of future royalties                
Liability related to sale of future royalties, net - beginning balance       41,044        
Proceeds from sale of future royalties, net             200,000  
KADCYLA royalty payments received and paid       (13,101)       (276,958)
Non-cash interest expense recognized       4,165       114,931
Liability related to sale of future royalties, net - ending balance       $ 32,108 41,044     $ 32,108
Current effective interest rate       10.5        
IRH | Kadcyla | Maximum                
Liability Related to Sale of Future Royalties                
Royalties threshold             260,000  
IRH | Kadcyla | Minimum                
Liability Related to Sale of Future Royalties                
Royalties threshold             $ 235,000  
OMERS | Kadcyla                
Liability Related to Sale of Future Royalties                
Percentage of royalty payments 100.00%              
Non-cash royalty revenue related to the sale of future royalties $ 65,200              
Contingent broker fees 1,500              
Net proceeds from sale of residual rights to receive royalty payments $ 65,200              
Roche                
Liability Related to Sale of Future Royalties                
Period in arrears to receive royalty reports and payments related to sales of kadcyla   3 months   3 months        
Roche | Kadcyla                
Liability Related to Sale of Future Royalties                
Non-cash royalty revenue related to the sale of future royalties       $ 29,300 $ 46,800 $ 68,500