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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities:    
Net loss $ (24,145) $ (34,051)
Adjustments to reconcile net loss to net cash used for operating activities:    
Non-cash royalty revenue related to sale of future royalties (2,364) (15,545)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes 1,249 4,644
Depreciation and amortization 473 551
Stock and deferred share unit compensation 4,407 3,823
Change in operating assets and liabilities:    
Accounts receivable 3,277 (58)
Unbilled receivable (1,298) (5,394)
Prepaid and other current assets (1,485) (7,520)
Operating lease right-of-use assets 504 424
Other assets 39 3,661
Accounts payable (2,308) 3,802
Accrued compensation (2,061) (1,571)
Other accrued liabilities 5,023 3,487
Deferred revenue (21,957) (72)
Operating lease liability (756) (802)
Net cash used for operating activities (41,402) (44,621)
Cash flows from investing activities:    
Purchases of property and equipment (307) (893)
Net cash used for investing activities (307) (893)
Cash flows from financing activities:    
Proceeds from issuance of common stock under stock plans 620 1,286
Proceeds from common stock issuance, net of $70 of transaction costs   33,492
Net cash provided by financing activities 620 34,778
Net change in cash and cash equivalents (41,089) (10,736)
Cash and cash equivalents, beginning of period 478,750 293,856
Cash and cash equivalents, end of period $ 437,661 $ 283,120