CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
CONSOLIDATED BALANCE SHEETS
Sale of future royalties, current portion and deferred financing costs	$ 199	$ 198
Sale of future royalties, noncurrent portion and deferred financing costs	$ 323	$ 381
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, authorized shares	5,000,000	5,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, authorized shares	300,000,000	300,000,000
Common stock, issued shares	220,536,000	220,361,000
Common stock, outstanding shares	220,536,000	220,361,000