Agreements - AmgenOxford BioTherapeutics (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Oct. 31, 2013
Collaborative Agreements disclosures
Revenue from contract with customer	$ 69,856	$ 132,299	$ 82,271
Amgen
Collaborative Agreements disclosures
Revenue from contract with customer	1,000
Upfront payment | Amgen
Collaborative Agreements disclosures
Revenue from contract with customer	1,000
License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer	$ 22,650	$ 63,742	$ 34,788
License and milestone fees | Amgen
Collaborative Agreements disclosures
Potential milestone payment				$ 34,000