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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended 60 Months Ended
Mar. 31, 2019
Jan. 31, 2019
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2015
Dec. 31, 2019
Liability Related to Sale of Future Royalties              
Non-cash royalty revenue related to the sale of future royalties     $ 47,415 $ 32,154 $ 28,142    
Kadcyla              
Liability Related to Sale of Future Royalties              
Percentage of royalty payments if applicable threshold is met           85.00%  
IRH | Kadcyla              
Liability Related to Sale of Future Royalties              
Percentage of royalty payments           100.00%  
Percentage of royalty payments if applicable threshold is met           15.00%  
Proceeds from sale of future royalties - net     200,000     $ 200,000 $ 194,135
Transaction costs for royalty agreements           5,900  
Change in liability related to sale of future royalties              
Liability related to sale of future royalties, net - beginning balance   $ 148,225 148,225        
Proceeds from sale of future royalties - net     200,000     200,000 194,135
Royalty payments received and paid     (41,548)       (145,172)
Non-cash interest expense recognized     16,864       74,578
Liability related to sale of future royalties, net - ending balance     $ 123,541 $ 148,225     $ 123,541
Effective annual interest rate     9.70%        
Current effective interest rate     15.5        
IRH | Kadcyla | Maximum              
Liability Related to Sale of Future Royalties              
Royalties threshold           260,000  
IRH | Kadcyla | Minimum              
Liability Related to Sale of Future Royalties              
Royalties threshold           $ 235,000  
OMERS | Kadcyla              
Liability Related to Sale of Future Royalties              
Percentage of royalty payments 100.00%            
Non-cash royalty revenue related to the sale of future royalties   $ 65,200          
Contingent broker fees $ 1,500            
Net proceeds from sale of residual rights to receive royalty payments $ 65,200   $ 0