June 17, 2009

VIA EDGAR AND

FEDERAL EXPRESS

Securities and Exchange Commission

Divison of Corporation Finance

100 F Street, N.E.

Washington, DC  20549

Attention:  Jeffrey Krutzik

Re: PLX Technology, Inc.

Amendment No. 1 to the Registration Statement on Form S-3

Initially Filed June 2, 2009

File No. 333-159668

Dear Mr. Krutzik:

On behalf of PLX Technology, Inc. (the “Company”), we submit this letter in response to oral comments from the staff (the “Staff”) of the Securities and Exchange Commission received by telephone on June 5, 2009 relating to the Company’s Registration Statement on Form S-3 (File No. 333-159668) (the “Registration Statement”).

On behalf of the Company and pursuant to Rule 472, we are concurrently filing via EDGAR Amendment No. 1 to the Registration Statement (“Amendment No. 1”).   Per our telephone conversation with Mr. Krutzik on June 5, 2009, the Company has filed Exhibit 5.1 with Amendment No. 1 in response to the Staff’s comment.  For the convenience of the Staff, we are providing copies of this letter and marked copies of Amendment No. 1 to Mr. Mr. Krutzik by overnight delivery.  The Company confirms that no additional material changes were made in Amendment No. 1 for reasons other than in response to a specific Staff comment.

Please direct your questions or comments to Stephen J. Schrader of this office (415-576-3028) or me (650-251-5926). In addition, we would request that you provide a facsimile of any additional comments you may have to Mr. Schrader at 415-576-3099 and me at 650-856-9299. Thank you for your assistance.

Very truly yours,

/s/ Jenny C. Yeh

cc:  Stephen J. Schrader Esq.

       Arthur O. Whipple