Sorrento Therapeutics, Inc.
4955 Directors Place

San Diego, California 92121

May 8, 2018

VIA EDGAR

Securities and Exchange Commission
100 F Street, NE
Washington, D.C. 20549-0406

Re:	Sorrento Therapeutics, Inc.
	Registration Statement on Form S-3, Filed March 22, 2018, as amended
	File No. 333-223857

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Sorrento Therapeutics, Inc. (the “Company”) hereby requests that the effectiveness of the Registration Statement on Form S-3 (Registration No. 333-223857) of the Company (the “Registration Statement”), filed with the Securities and Exchange Commission (the “Commission”) on March 22, 2018, as amended, be accelerated so that such Registration Statement shall become effective at 4:30 p.m. (Eastern Time) on May 10, 2018, or as soon as possible thereafter. There are no underwriters for this proposed offering, which is an offering of the Company’s common stock by selling stockholders.

The Company hereby confirms that it is aware of its responsibilities under the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended, as they relate to the proposed offering of the securities specified in the Registration Statement.

It would be appreciated if, promptly after the Registration Statement has become effective, you would so inform our outside counsel, Jeffrey T. Hartlin of Paul Hastings LLP, by telephone at (650) 320-1804 or by email at jeffhartlin@paulhastings.com. The Company hereby authorizes Mr. Hartlin to orally modify or withdraw this request for acceleration.

		Sincerely, SORRENTO THERAPEUTICS, INC.
		By:	/s/ Henry Ji, Ph.D.
			Henry Ji, Ph.D.
			President and Chief Executive Officer
cc:	Jeffrey T. Hartlin, Paul Hastings LLP