Loan and Security Agreement and Convertible Notes - Future Minimum Payments under the Loan and Security Agreement (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 21, 2017	Dec. 31, 2016
Debt Disclosure [Abstract]
Amount due in 2018	$ 2,366
Amount due in 2019	2,500
Amount due in 2020	2,500
Amount due in 2021	2,500
Amount due in 2022	2,500
Amount due in 2023	50,134
Total future minimum payments	62,500
Unpaid interest	(12,500)
Unamortized debt discount	(44,705)	$ (44,800)
Capitalized debt issuance costs	(84)
Total minimum payment	5,211		$ 47,107
Current portion	0		$ (209)
Long-term debt	$ 5,211

Debt instrument unamortized interest on debt.

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Long term debt maturities repayments of principal amount.

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Amount, after accumulated amortization, of debt discount (premium).

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Amount, after accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.

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Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations.

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Amount after unamortized (discount) premium and debt issuance costs of long-term debt classified as noncurrent and excluding amounts to be repaid within one year or the normal operating cycle, if longer. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations.

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