Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Treasury Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated deficit [Member]	Noncontrolling Interest [Member]
Balance at Dec. 31, 2014	$ 108,713	$ 4		$ 176,227		$ (67,518)
Balance, shares at Dec. 31, 2014		36,184,912
Issuance of common stock with exercise of warrants	0			0
Issuance of common stock with exercise of warrants, shares		3,563
Issuance of common stock with exercise of options	1,699			1,699
Issuance of common stock with exercise of options, shares		276,712
Issuance of common stock upon achievement of milestone, shares		1,306,272
Issuance of common stock upon achievement of milestone	0			0
Stock-based compensation	6,972			6,972
Change in unrealized gain on marketable securities	73,579				$ 73,579
Foreign currency translation adjustment	0
Sale of noncontrolling interest	49						$ 49
Net income (loss)	(50,074)					(45,811)	(4,263)
Balance at Dec. 31, 2015	140,938	$ 4		184,898	73,579	(113,329)	(4,214)
Balance, shares at Dec. 31, 2015		37,771,459
Issuance of common stock with exercise of options	527	$ 0		524
Issuance of common stock with exercise of options, shares		204,668
Issuance of common stock for private placement and investments, net	108,301	$ 3		108,298
Issuance of common stock for private placement and investments, shares		27,598,235
Issuance of common stock upon acquisition	19,061	$ 1		5,368			13,693
Issuance of common stock upon acquisition, shares		754,911
Cancellation of stock issuance	(50,807)	$ (2)	$ (49,464)	(1,341)
Cancellation of stock issuance, shares		15,446,417	(7,568,182)
Stock-based compensation	4,741			4,741
Change in unrealized gain on marketable securities	(73,579)				(73,579)
Foreign currency translation adjustment	(118)				(118)
Hercules warrant	1,377			1,377
Net income (loss)	(63,937)					(60,923)	(3,014)
Balance at Dec. 31, 2016	$ 86,502	$ 6	$ (49,464)	303,865	(118)	(174,252)	6,465
Balance, shares at Dec. 31, 2016	50,882,856	50,882,856	7,568,182
Scilex acquisition adjustments	$ (2,027)			(627)			(1,400)
Issuance of common stock for public placement and investments, net	57,928	$ 3		57,925
Issuance of common stock for public placement and investments, net, shares		30,468,700
Beneficial conversion feature recorded on convertible notes	32,062			32,062
Warrants issued in connection with convertible notes	12,669			12,669
Issuance of common stock upon acquisition	3,055	$ 0		3,055
Issuance of common stock upon acquisition, shares		1,552,011
Stock-based compensation	4,952			4,952
Change in unrealized gain on marketable securities	0
Foreign currency translation adjustment	360				360
Net income (loss)	11,109					9,132	1,977
Balance at Dec. 31, 2017	$ 206,610	$ 9	$ (49,464)	$ 413,901	$ 242	$ (165,120)	$ 7,042
Balance, shares at Dec. 31, 2017	82,903,567	82,903,567	7,568,182