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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 QtcArGSQzX3netDaCCi5fQjKo7f6oWlGeOoIbmR7QJR2hJUnmFyZBf4MTx1vJ8x9
 qKzdvfg3EmPleSvfac38EQ==

<SEC-DOCUMENT>0001021890-05-000216.txt : 20051202
<SEC-HEADER>0001021890-05-000216.hdr.sgml : 20051202
<ACCEPTANCE-DATETIME>20051202162310
ACCESSION NUMBER:		0001021890-05-000216
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051128
FILED AS OF DATE:		20051202
DATE AS OF CHANGE:		20051202

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ONODY STEPHEN K
		CENTRAL INDEX KEY:			0001252897

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30489
		FILM NUMBER:		051241134

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		3035461300

	MAIL ADDRESS:	
		STREET 1:		C/O FAEGRE & BENSON LLP
		STREET 2:		1900 FIFTEENTH STREET
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIFELINE THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0000849146
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				841097796
		STATE OF INCORPORATION:			CO
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		6400 SOUTH FIDDLER
		STREET 2:		SUITE 1750
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80111
		BUSINESS PHONE:		720-488-1711

	MAIL ADDRESS:	
		STREET 1:		6400 SOUTH FIDDLER
		STREET 2:		SUITE 1750
		CITY:			ENGLEWOOD
		STATE:			CO
		ZIP:			80111

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	YAAK RIVER RESOURCES INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANDRAPLEX CORP
		DATE OF NAME CHANGE:	19920406
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2005-11-28</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000849146</issuerCik>
        <issuerName>LIFELINE THERAPEUTICS, INC.</issuerName>
        <issuerTradingSymbol>LFLT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001252897</rptOwnerCik>
            <rptOwnerName>ONODY STEPHEN K</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>6400 S. FIDDLER'S GREEN CIR., STE 1970</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ENGLEWOOD</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.47</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-11-28</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1000000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">1/3 of the stock option shall vest upon the weighted average trading price of the Company's common stock for 90 days reaching each of $8.00, $14.00, and $18.00.  Notwithstanding the foregoing, to the extent not previously vested, 1/3 of the stock option shall vest on the 11/28/06, and the remaining 2/3 shall vest quarterly in eight equal installments, beginning ninety days after 11/28/06 and ending on 11/28/08.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Stephen K. Onody</signatureName>
        <signatureDate>2005-12-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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