-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 IA3q4baArjm8L8rAADGzHjwvwK6PD6yLe07FLObp5o/lAeiXgOPgVcg2iJIBtb+I
 svwPSMNNOsyXotT09Kda9g==

<SEC-DOCUMENT>0000899140-04-000546.txt : 20040421
<SEC-HEADER>0000899140-04-000546.hdr.sgml : 20040421
<ACCEPTANCE-DATETIME>20040421133449
ACCESSION NUMBER:		0000899140-04-000546
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040419
FILED AS OF DATE:		20040421

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LEFF JONATHAN S
		CENTRAL INDEX KEY:			0001215242

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-18311
		FILM NUMBER:		04744956

	BUSINESS ADDRESS:	
		STREET 1:		WARBURG PINCUS & CO
		STREET 2:		466 LEXINGTON AVE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		2128780600

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NEUROGEN CORP
		CENTRAL INDEX KEY:			0000849043
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				222845714
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		35 NORTHEAST INDUSTRIAL RD
		CITY:			BRANFORD
		STATE:			CT
		ZIP:			06405
		BUSINESS PHONE:		2034888201

	MAIL ADDRESS:	
		STREET 1:		35 NORTHEAST INDUSTRIAL RD
		CITY:			BRANFORD
		STATE:			CT
		ZIP:			06405
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>leff_neurogen4-042104ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-04-19</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000849043</issuerCik>
        <issuerName>NEUROGEN CORP</issuerName>
        <issuerTradingSymbol>NRGN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001215242</rptOwnerCik>
            <rptOwnerName>LEFF JONATHAN S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O WARBURG PINCUS LLC</rptOwnerStreet1>
            <rptOwnerStreet2>466 LEXINGTON AVE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy common stock)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>9.35</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2004-04-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>20000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-04-19</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>20000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>20000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Pursuant to the Neurogen Corporation 2000 Non-Employee Directors Stock Option Program, as amended, the options vest over a three-year period in thirty-six equal monthly installments on the last day of each month, beginning the last day of the month in which the options were granted.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jonathan S. Leff</signatureName>
        <signatureDate>2004-04-21</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----