May 2, 2005

Securities and Exchange Commission 

Judiciary Plaza 

450 Fifth Street, NW 

Washington, DC 20549 

Attention: Filings – Rule 497(j) 

Re: Dreyfus Stock Index Fund, Inc. 

Post-Effective Amendment No. 21 to Registration Statement on Form N1-A 

REGISTRATION NO: 811-5719 

Dear Sir or Madam:

Pursuant to Rule 497(j) under the Securities Act of 1933, this is to certify that the form of Prospectus and Statement of Additional Information that would have been filed under paragraph (b) or (c) of this section does not differ from that contained in the most recent amendment, Post-Effective Amendment No. 21 to the Registration Statement, electronically filed with the Securities and Exchange Commission on April 25, 2005.

Very truly yours, 

/s/ Matthew J. Tronzano 

Matthew J. Tronzano 

Paralegal 

497(j)letter