DREYFUS LIFE AND ANNUITY INDEX FUND, INC.
                                200 PARK AVENUE
                              NEW YORK, NY  10166



Securities and Exchange Commission
Judiciary Plaza
450 Fifth Street, NW
Washington, DC  20549


     24f-2 Notice - DREYFUS LIFE AND ANNUITY INDEX FUND, INC.
     Registration Statement No. 33-27172 - CIK #0000846800

Gentlemen:

    On September 25, 1989, the Registration Statement of Dreyfus Life and
Annuity Index Fund, Inc. was declared effective by the SEC.  The Registration
Statement represented the Fund's election to register an indefinite number of
shares and this Notice, filed pursuant to Rule 24f-2, is for the fiscal year
ended December 31, 1993.

    The following information is furnished:

    (a) Shares registered under Securities Act
        of 1933 other than pursuant to Rule 24f(2)
        which remained unsold on January 1, 1993:                   None

    (b) Shares registered during fiscal year
        other than pursuant to Section 24(f)

    Post-Effective Amendment No. 6 effective 8/27/93               462,655
                                                                  ---------

    Total of (a) and (b)                                           462,655
                                                                  =========


                                                  SHARES        DOLLAR AMOUNT

    (c) Total number of shares sold during
        fiscal year ended 12/31/93 subject
        to registration under Rule 24f-2:       2,578,684     $40,165,929

    (d) Less shares redeemed during
        fiscal year ended 12/31/93:             3,516,794      53,943,720
                                               -----------   -------------

    Net Sales During Year [(c) - (d)]:         (  938,110)   ($13,777,791)
                                               ===========   =============
    Less shares registered other
    than pursuant to Section 24(f)
         [(a) + (b)]                              462,655       7,328,455
                                               -----------    ------------

    Unsold balance of registered shares        (1,400,765)   ($21,106,246)
                                               ===========   =============
                                       -2-


                               CALCULATION OF FEE

    Since the shares redeemed exceed the shares sold, no registration fee is
required.  An opinion of counsel is enclosed.


SFN/ems                                            Very truly yours,

cc:  Mr. J. deMichaelis, SEC
     Mr. K. Brennan, C&L                           Steven F. Newman
     Mr. S. Rosenberg, BONY                        Secretary