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Exhibit 32.1

URANIUM RESOURCES, INC.
405 State Highway 121 Bypass, Building A, Suite 110, Lewisville, TX 75067
972.219.3330 Phone 972.219.3311 Fax

March 12, 2012

Securities and Exchange Commission
450 5th Street, N.W.
Washington, D.C. 20549

CERTIFICATION OF CHIEF EXECUTIVE OFFICER
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

        I, Donald C. Ewigleben, President and Chief Executive Officer of Uranium Resources, Inc. (the "Company"), certify, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

(1)

The Annual Report on Form 10-K of the Company for the period ended December 31, 2011 which this certification accompanies fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and



(2)

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

/s/ DONALD C. EWIGLEBEN
Donald C. Ewigleben
President, Chief Executive Officer and Chief Operating Officer
March 12, 2012

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Exhibit 32.1

URANIUM RESOURCES, INC. 405 State Highway 121 Bypass, Building A, Suite 110, Lewisville, TX 75067 972.219.3330 Phone 972.219.3311 Fax
CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002