Exhibit 21

Athene Annuity and Life Company

Subsidiaries

As of 12/31/20

•AAIA RML 3526 Massey Ford, LLC

•AAIA RML, LLC

•Centralife Annuities Service, Inc.

•Athene Annuity & Life Assurance Company of New York

•Athene Life Insurance Company of New York

•Structured Annuity Reinsurance Company

•Athene Re USA IV, Inc.