Cover - USD ($)	3 Months Ended	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2023	Apr. 12, 2024	Jun. 30, 2023
Cover [Abstract]
Document Type		10-K
Amendment Flag		false
Document Annual Report		true
Document Transition Report		false
Document Period End Date		Dec. 31, 2023
Document Fiscal Period Focus		FY
Document Fiscal Year Focus		2023
Current Fiscal Year End Date		--12-31
Entity File Number		0-22182
Entity Registrant Name		MOSAIC IMMUNOENGINEERING, INC.
Entity Central Index Key		0000836564
Entity Tax Identification Number		84-1070278
Entity Incorporation, State or Country Code		DE
Entity Address, Address Line One		9114 Adams Avenue, #202
Entity Address, City or Town		Huntington Beach
Entity Address, State or Province		CA
Entity Address, Postal Zip Code		92646
City Area Code		657
Local Phone Number		208-0890
Title of 12(b) Security		Common Stock, $0.00001 par value
Entity Well-known Seasoned Issuer		No
Entity Voluntary Filers		No
Entity Current Reporting Status		Yes
Entity Interactive Data Current		Yes
Entity Filer Category		Non-accelerated Filer
Entity Small Business		true
Entity Emerging Growth Company		false
Entity Shell Company		false
Entity Public Float				$ 816,893
Entity Common Stock, Shares Outstanding			7,242,137
ICFR Auditor Attestation Flag		false
Document Financial Statement Error Correction [Flag]		false
Rule 10b5-1 Arrangement Adopted [Flag]	false
Non-Rule 10b5-1 Arrangement Adopted [Flag]	false
Rule 10b5-1 Arrangement Terminated [Flag]	false
Non-Rule 10b5-1 Arrangement Terminated [Flag]	false
Auditor Firm ID		170
Auditor Name		KMJ Corbin & Company LLP
Auditor Location		Irvine, California