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Stockholders' Equity and Share-Based Compensation (Details - Share Based Compensation) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Share-based compensation expense $ 97,997 $ 420,779 $ 237,002 $ 695,022
Research and Development Expense [Member]        
Share-based compensation expense 29,894 184,476 101,544 225,012
General and Administrative Expense [Member]        
Share-based compensation expense $ 68,103 $ 236,303 $ 135,458 $ 470,010