Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Cash flows from operating activities:
Net loss	$ (16,801)	$ (18,735)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	878	1,077
Depreciation and amortization	742	557
Non-cash interest expense	61	71
Other		11
Change in fair value of contingent consideration liability	(300)	900
Changes in assets and liabilities:
Accounts receivable	9,786	(1,136)
Other current assets	968	(447)
Other assets	286	146
Accounts payable	1,618	124
Accrued expenses	(4,888)	(991)
Other current liabilities	217	18
Other liabilities	(174)	(114)
Net cash used in operating activities	(7,607)	(18,519)
Cash flows from investing activities:
Acquisition of AZEDRA manufacturing assets		(8,000)
Purchases of property and equipment	(3,553)	(491)
Net cash used in investing activities	(3,553)	(8,491)
Cash flows from financing activities:
Repayment of debt	(1,682)	(1,037)
Proceeds from exercise of stock options	162
Net cash used in financing activities	(1,520)	(1,037)
Effect of currency rate changes on cash, cash equivalents and restricted cash	(201)	(46)
Net decrease in cash, cash equivalents, and restricted cash	(12,881)	(28,093)
Cash, cash equivalents, and restricted cash at beginning of period	45,065	139,220
Cash, cash equivalents, and restricted cash at end of period	32,184	111,127
Supplemental disclosure of cash flow information
Cash paid for interest	939	1,077
Cash, cash equivalents and restricted cash information
Cash and cash equivalents at beginning of period	42,049	137,686
Restricted cash included in long-term assets at the beginning of period	3,016	1,534
Cash, cash equivalents, and restricted cash at beginning of period	45,065	139,220
Cash and cash equivalents at end of period	29,531	109,587
Restricted cash included in long-term assets at the end of period	2,653	1,540
Cash, cash equivalents, and restricted cash at end of period	$ 32,184	$ 111,127