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Note 1 - Summary of Significant Accounting Policies (Tables)
3 Months Ended
Mar. 31, 2020
Notes Tables  
Disaggregation of Revenue [Table Text Block]
   
Three months ended March 31,
 
   
2020
   
2019
 
Product sales
  $
1,359
    $
-
 
Royalty income
   
4,789
     
4,161
 
License and other revenue
   
100
     
120
 
Total revenue
 
$
6,248
   
$
4,281
 
Property, Plant and Equipment [Table Text Block]
   
March 31,
   
December 31,
 
   
2020
   
2019
 
Machinery and equipment
  $
6,809
    $
5,204
 
Leasehold improvements
   
3,621
     
3,204
 
Computer equipment
   
710
     
691
 
Furniture and fixtures
   
908
     
908
 
Construction in progress
   
6,884
     
5,475
 
Property and equipment, gross
   
18,932
     
15,482
 
Less - accumulated depreciation
   
(4,259
)    
(3,794
)
Property and equipment, net
 
$
14,673
   
$
11,688