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Note 1 - Summary of Significant Accounting Policies (Tables)
9 Months Ended
Sep. 30, 2019
Notes Tables  
Disaggregation of Revenue [Table Text Block]
   
Three months ended September 30,
   
Nine months ended September 30,
 
   
2019
   
2018
   
2019
   
2018
 
Product sales
  $
570
    $
-
    $
840
    $
-
 
Royalty income
   
4,912
     
5,169
     
12,666
     
11,757
 
License and other revenue
   
131
     
148
     
6,354
     
627
 
Total revenue
 
$
5,613
   
$
5,317
   
$
19,860
   
$
12,384
 
Property, Plant and Equipment [Table Text Block]
   
September 30,
   
December 31,
 
   
2019
   
2018
 
Machinery and equipment
  $
4,030
    $
2,992
 
Leasehold improvements
   
3,052
     
1,734
 
Computer equipment
   
655
     
721
 
Furniture and fixtures
   
908
     
878
 
Construction in progress
   
4,079
     
317
 
Property and equipment, gross
   
12,724
     
6,642
 
Less - accumulated depreciation
   
(3,470
)    
(2,698
)
Property and equipment, net
 
$
9,254
   
$
3,944