Note 8 - Commitments and Contingencies - Licensing, Service and Supply Agreements (Details)	Dec. 31, 2018 USD ($)
Amgen Fremont, Inc. Formerly Abgenix [Member]
Commitments, paid from inception	$ 1,350
Future Commitments	5,750	[1]
Former Member of PSMA LLC [Member]
Commitments, paid from inception	466
Future Commitments	52,188	[1]
Selexis Commercial License Agreement [Member]
Commitments, paid from inception	125
Future Commitments	1,799	[1]
University of Zurich and Paul Scherrer Institute [Member]
Commitments, paid from inception	565
Future Commitments	1,125	[1]
University of Western Ontario [Member]
Commitments, paid from inception	39
Future Commitments	145	[1]
Johns Hopkins University Technology [Member]
Commitments, paid from inception	250
Future Commitments	$ 2,685	[1]

[1] Amounts based on known contractual obligations as specified in the respective license agreements, which are dependent on the achievement or occurrence of future milestones or events and exclude amounts for royalties which are dependent on future sales and are unknown.