Note 4 - Fair Value Measurements - Quantitative Information for Fair Value Measurement of Level 3 (Details) $ in Thousands	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)
Fair value	$ 11,000	$ 16,800
AZEDRA Commercialization [Member]
Fair value	$ 7,050	$ 5,500
Measurement input	2,019	2,018
AZEDRA Commercialization [Member] | Measurement Input, Probability of Success [Member]
Measurement input	0.9	0.72
AZEDRA Commercialization [Member] | Measurement Input, Discount Rate [Member]
Measurement input	0.1	0.1
MIP-1095 Commercialization [Member]
Fair value	$ 450	$ 400
Measurement input	2,026	2,025
MIP-1095 Commercialization [Member] | Measurement Input, Probability of Success [Member]
Measurement input	0.18	0.16
MIP-1095 Commercialization [Member] | Measurement Input, Discount Rate [Member]
Measurement input	0.1	0.1
MIP - 1404 Commercialization [Member]
Fair value		$ 4,500
Measurement input		2,020
MIP - 1404 Commercialization [Member] | Measurement Input, Probability of Success [Member]
Measurement input		0.59
MIP - 1404 Commercialization [Member] | Measurement Input, Discount Rate [Member]
Measurement input		0.1
Net sales targets [Member]
Fair value	$ 3,500	$ 6,400
Measurement input	0.1
Net sales targets [Member] | Measurement Input, Probability of Success [Member] | Minimum [Member]
Measurement input	0.18	0.16
Net sales targets [Member] | Measurement Input, Probability of Success [Member] | Maximum [Member]
Measurement input	0.9	0.72
Net sales targets [Member] | Measurement Input, Discount Rate [Member]
Measurement input		0.1