Note 13 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

	2018			2017			2016
Current taxes:
United States	$	(2	)	$	3		$	11
Foreign		-			-			-
State		(82	)		(16	)		22
Total current taxes	$	(84	)	$	(13	)	$	33
Deferred taxes:
United States	$	(1,188	)	$	(8,777	)	$	-
Foreign		-			-			-
State		(360	)		(2,882	)		1,811
Total deferred taxes	$	(1,548	)	$	(11,659	)	$	1,811
(Benefit from) provision for income taxes	$	(1,632	)	$	(11,672	)	$	1,844

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	2018			2017
Deferred tax assets:
Depreciation	$	-		$	100
Research & Experimental and Orphan Drug tax credit carry-forwards		35,435			33,496
NYS investment tax credit carry-forwards		1,282			1,284
Net operation loss carry-forwards		188,588			177,313
Capitalized research and development expenditures		1,066			3,066
Stock compensation		5,236			5,666
Other items		819			1,279
Total gross deferred tax assets		232,426			222,204
Less valuation allowance		(232,174	)		(217,382	)
Deferred tax assets		252			4,822
Deferred tax liabilities:
Indefinite-lived intangibles		(136	)		(6,397	)
Depreciation and amortization		(144	)		-
Deferred tax liabilities		(280	)		(6,397	)
Net deferred tax liability	$	(28	)	$	(1,575	)

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	2018			2017			2016
U.S. Federal statutory rate		21.0	%		34.0	%		34.0	%
State income taxes, net of Federal benefit		0.9	%		1.5	%		10.8	%
Foreign rate differential		0.0	%		(0.6	%)		2.6	%
Research and experimental and Orphan Drug tax credit		2.3	%		6.4	%		(50.6	%)
Effect of federal and state tax rate changes		0.3	%		(6.1	%)		(43.0	%)
Tax Reform Impact		0.0	%		13.9	%		0.0	%
Change in fair value of contingent consideration liability		1.8	%		(1.4	%)		(12.4	%)
Stock option shortfalls		(2.2	%)		(3.1	%)		22.3	%
Other		(0.5	%)		(0.1	%)		0.1	%
Change in valuation allowance		(21.2	%)		(25.9	%)		50.9	%
Effective tax rate		2.4	%		18.6	%		14.7	%

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

	2018			2017
Beginning uncertain tax benefits	$	1,951		$	2,661
Prior year - increases (decreases)		-			(710	)
Current year - increases (decreases)		-			-
Settlements		-			-
Expired statuses		(7	)		-
Ending uncertain tax benefits	$	1,944		$	1,951