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Note 7 - Accrued Expenses (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
   
2018
   
2017
 
Accrued payroll and related costs
  $
2,871
    $
2,400
 
Accrued contract manufacturing costs
   
2,516
     
666
 
Accrued clinical trial costs
   
2,318
     
2,570
 
Accrued consulting and service fee expenses
   
1,229
     
1,860
 
Accrued legal and professional fees
   
1,191
     
1,022
 
Other
   
408
     
1,037
 
Accrued expenses
 
$
10,533
   
$
9,555