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Note 3 - Goodwill and Acquired Intangible Assets (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Intangible Assets and Goodwill [Table Text Block]
   
 
 
 
 
 
 
 
 
Other
 
   
 
 
 
 
 
 
 
 
Intangible
 
   
Goodwill
   
IPR&D
   
Assets
 
Balance at January 1, 2017
  $
13,074
    $
28,700
    $
1,881
 
Amortization expense
   
-
     
-
     
(212
)
Balance at December 31, 2017
   
13,074
     
28,700
     
1,669
 
Reclassification
   
-
     
(4,900
)    
4,900
 
Amortization expense
   
-
     
-
     
(503
)
Impairment
   
-
     
(23,200
)    
-
 
Balance at December 31, 2018
 
$
13,074
   
$
600
   
$
6,066
 
Components of Finite Lived Intangible Assets [Table Text Block]
   
Gross Amount
   
Accumulated
Amortization
   
Net Carrying
Value
 
Intangible assets - AZEDRA product rights
  $
4,900
    $
291
    $
4,609
 
Intangible assets - EXINI technology
   
2,120
     
663
     
1,457
 
Total
 
$
7,020
   
$
954
   
$
6,066