-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001266375-06-000054.txt : 20060418
<SEC-HEADER>0001266375-06-000054.hdr.sgml : 20060418
<ACCEPTANCE-DATETIME>20060418171705
ACCESSION NUMBER:		0001266375-06-000054
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060417
FILED AS OF DATE:		20060418
DATE AS OF CHANGE:		20060418

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PROGENICS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000835887
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133379479
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		777 OLD SAW MILL RIVER ROAD
		CITY:			TARRYTOWN
		STATE:			NY
		ZIP:			10591
		BUSINESS PHONE:		9147892800

	MAIL ADDRESS:	
		STREET 1:		777 OLD SAW MILL RIVER ROAD
		CITY:			TARRYTOWN
		STATE:			NY
		ZIP:			10591

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MADDON PAUL J
		CENTRAL INDEX KEY:			0001250313

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23143
		FILM NUMBER:		06765411

	MAIL ADDRESS:	
		STREET 1:		777 OLD SAW MILL RIVER RD
		CITY:			TARRYTOWN
		STATE:			NY
		ZIP:			10591
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2006-04-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000835887</issuerCik>
        <issuerName>PROGENICS PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>PGNX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
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            <rptOwnerName>MADDON PAUL J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>777 OLD SAW MILL RIVER ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>TARRYTOWN</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10591</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer/CSO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
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            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
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            <transactionCoding>
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                <transactionCode>M</transactionCode>
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            <transactionAmounts>
                <transactionShares>
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                </transactionShares>
                <transactionPricePerShare>
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            <securityTitle>
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                    <footnoteId id="F1"/>
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                <transactionPricePerShare>
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                <transactionPricePerShare>
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                <sharesOwnedFollowingTransaction>
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        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
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            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
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            <transactionAmounts>
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        </nonDerivativeTransaction>
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    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Non-Qualified Stock Option (right to buy)</value>
                <footnoteId id="F2"/>
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            <conversionOrExercisePrice>
                <value>5.33</value>
            </conversionOrExercisePrice>
            <transactionDate>
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            </transactionDate>
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            <transactionAmounts>
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                </transactionShares>
                <transactionPricePerShare>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>1997-12-15</value>
            </exerciseDate>
            <expirationDate>
                <value>2007-12-16</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
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                </underlyingSecurityTitle>
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                </underlyingSecurityShares>
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                </sharesOwnedFollowingTransaction>
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                <transactionAcquiredDisposedCode>
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                    <value>D</value>
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            </expirationDate>
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                <underlyingSecurityTitle>
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                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2500</value>
                </underlyingSecurityShares>
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                    <value>52274</value>
                </sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
                    <value>D</value>
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                <value>Non-Qualified Stock Option (right to buy)</value>
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                <value>5.33</value>
            </conversionOrExercisePrice>
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                <value>2006-04-17</value>
            </transactionDate>
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                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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                <transactionShares>
                    <value>2500</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
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                <value>2007-12-16</value>
            </expirationDate>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                    <value>2500</value>
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                    <value>49774</value>
                </sharesOwnedFollowingTransaction>
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    <footnotes>
        <footnote id="F1">Sale under a 10b5-1 Plan, which was established in accordance with the policies and procedures of the Issuer, approved by its Board of Directors</footnote>
        <footnote id="F2">The Reporting Person is exercising options under this grant in pre-established increments under and in accordance with provisions of a previously established Plan of Sale under Rule 10b5-1, which was established in accordance with the policies and procedures of the Issuer, approved by its Board of Directors.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Paul J. Maddon</signatureName>
        <signatureDate>2006-04-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----