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Fair Value Measurements, Quantitative Information (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Summary of activities in financial instruments with significant Level 3 inputs [Roll Forward]      
Balance at beginning of period $ 18,800 $ 17,200 $ 17,200
Fair value change included in net loss 200 300  
Balance at end of period 19,000 17,500 18,800
Changes in unrealized gains or losses for the period included in earnings (or changes in net assets) for liabilities held at the end of the reporting period 200 300  
Fair Value Measurements, Quantitative Information      
Contingent consideration liability 19,000   18,800
Increase in contingent consideration liability 200 $ 300  
Fair Value $ 19,000   $ 18,800
Azedra commercialization [Member]      
Fair Value Measurements, Quantitative Information      
Period of milestone expected achievement 2018   2018
Fair Value $ 2,600   $ 2,500
Valuation technique Probability adjusted discounted cash flow model   Probability adjusted discounted cash flow model
Discount Rate 10.00%   10.00%
Probability of success 40.00%   40.00%
MIP - 1404 commercialization [Member]      
Fair Value Measurements, Quantitative Information      
Period of milestone expected achievement 2019   2019
Fair Value $ 4,300   $ 4,200
Valuation technique Probability adjusted discounted cash flow model   Probability adjusted discounted cash flow model
Discount Rate 10.00%   10.00%
Probability of success 59.00%   59.00%
MIP-1095 commercialization [Member]      
Fair Value Measurements, Quantitative Information      
Period of milestone expected achievement 2023   2023
Fair Value $ 500   $ 500
Valuation technique Probability adjusted discounted cash flow model   Probability adjusted discounted cash flow model
Discount Rate 10.00%   10.00%
Probability of success 19.00%   19.00%
Net sales targets [Member]      
Fair Value Measurements, Quantitative Information      
Fair Value $ 11,600   $ 11,600
Valuation technique Monte-Carlo simulation   Monte-Carlo simulation
Net sales targets [Member] | Minimum [Member]      
Fair Value Measurements, Quantitative Information      
Period of milestone expected achievement 2019   2019
Discount Rate 4.00%   3.50%
Probability of success 19.00%   19.00%
Net sales targets [Member] | Maximum [Member]      
Fair Value Measurements, Quantitative Information      
Period of milestone expected achievement 2024   2025
Discount Rate 11.50%   12.00%
Probability of success 59.00%   59.00%
Net sales targets [Member] | Weighted average [Member]      
Fair Value Measurements, Quantitative Information      
Probability of success 37.40%   37.40%