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Fair Value Measurements, Part 2 (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Azedra commercialization [Member]    
Fair Value Measurements, Quantitative Information    
Period of milestone expected achievement 2018 2018
Fair Value $ 2,500 $ 2,300
Valuation technique Probability adjusted discounted cash flow model Probability adjusted discounted cash flow model
Discount Rate 10.00% 10.00%
Probability of success 40.00% 40.00%
MIP-1095 commercialization [Member]    
Fair Value Measurements, Quantitative Information    
Period of milestone expected achievement 2023 2023
Fair Value $ 500 $ 400
Valuation technique Probability adjusted discounted cash flow model Probability adjusted discounted cash flow model
Discount Rate 10.00% 10.00%
Probability of success 19.00% 19.00%
Net sales targets [Member]    
Fair Value Measurements, Quantitative Information    
Fair Value $ 11,600 $ 10,700
Valuation technique Monte-Carlo simulation Monte-Carlo simulation
Contingent Consideration Liability [Member]    
Summary of activities in financial instruments with significant Level 3 inputs [Roll Forward]    
Balance at beginning of period $ 17,200 $ 15,700
Fair value change to contingent consideration included in net income (loss) 1,600 1,500
Balance at end of period 18,800 17,200
Changes in unrealized gains or losses for the period included in earnings (or changes in net assets) for assets or liabilities held at the end of the reporting period $ 1,600 $ 1,500
1404 commercialization [Member]    
Fair Value Measurements, Quantitative Information    
Period of milestone expected achievement 2019 2019
Fair Value $ 4,200 $ 3,800
Valuation technique Probability adjusted discounted cash flow model Probability adjusted discounted cash flow model
Discount Rate 10.00% 10.00%
Probability of success 59.00% 59.00%
Minimum [Member] | Net sales targets [Member]    
Fair Value Measurements, Quantitative Information    
Period of milestone expected achievement 2019 2019
Discount Rate 3.50% 3.50%
Probability of success 19.00% 19.00%
Maximum [Member] | Net sales targets [Member]    
Fair Value Measurements, Quantitative Information    
Period of milestone expected achievement 2025 2026
Discount Rate 12.00% 12.00%
Probability of success 59.00% 59.00%
Weighted average [Member] | Net sales targets [Member]    
Fair Value Measurements, Quantitative Information    
Probability of success 37.40% 37.40%