Summary of Significant Accounting Policies (Details) - USD ($) $ in Thousands	3 Months Ended				12 Months Ended
	Dec. 31, 2015	Sep. 30, 2014	Mar. 31, 2014	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Accounts Receivable [Abstract]
Allowance for Doubtful Accounts Receivable, Current	$ 10				$ 10	$ 10
Auction Rate Securities [Abstract]
Auction rate securities							$ 2,208
Decrease in temporary impairment of auction rate securities						192
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Contingent consideration liability	18,800				18,800	17,200	15,700
Change in contingent consideration liability					1,600	1,500	(200)
Intangible impairment charge					0	2,676	919
Other current assets	5,639				5,639	2,515
Restricted cash	1,692				1,692	157
Other Asset Impairment Charges				$ 347
Deferred Lease Liability and Incentive [Abstract]
Deferred lease incentive - current	115				115	115
Deferred lease liability	402				402	336
Deferred lease incentive - noncurrent	$ 460				$ 460	$ 575
Income Taxes [Abstract]
Percentage of income tax benefit realization (in hundredths)	50.00%				50.00%
Computer Equipment [Member]
Estimated useful lives of fixed assets [Abstract]
Estimated useful life					3 years
Furniture and Fixtures [Member]
Estimated useful lives of fixed assets [Abstract]
Estimated useful life					5 years
Leasehold Improvements [Member]
Estimated useful lives of fixed assets [Abstract]
Useful life description					Earlier of life of improvement or lease
Minimum [Member] | Machinery and Equipment [Member]
Estimated useful lives of fixed assets [Abstract]
Estimated useful life					5 years
Minimum [Member] | Leasehold Improvements [Member]
Estimated useful lives of fixed assets [Abstract]
Estimated useful life					6 years 4 months 24 days	6 years 4 months 24 days
Maximum [Member] | Machinery and Equipment [Member]
Estimated useful lives of fixed assets [Abstract]
Estimated useful life					7 years
Maximum [Member] | Leasehold Improvements [Member]
Estimated useful lives of fixed assets [Abstract]
Estimated useful life					10 years 9 months 18 days	10 years 9 months 18 days
Valeant Agreement [Member]
Revenue Recognition [Abstract]
Milestone Revenue Recognized		$ 40,000
Fuji Agreement [Member]
Revenue Recognition [Abstract]
Milestone Revenue Recognized			$ 1,000
MedImmune Agreement [Member]
Revenue Recognition [Abstract]
Upfront license fee, received							$ 5,000
CytoDyn Agreement [Member]
Revenue Recognition [Abstract]
Upfront license fee, received								$ 3,500
Milestone Revenue Recognized	$ 1,500
Money Market Funds [Member]
Cash and Cash Equivalents [Line Items]
Cash equivalents	62,855				$ 62,855	$ 112,808
Commercial Bank [Member]
Cash and Cash Equivalents [Line Items]
Cash equivalents	$ 11,248				$ 11,248	$ 6,494
MIP-1095 commercialization [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Beginning of significant cash inflows - year						2024	2021
Indefinite lived intangible assets - Discount Rate						13.50%	20.00%
Contingent Consideration Liability [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Period of milestone achievement - Minimum					2019
Period of milestone achievement - Maximum					2025
Discount rate - milestone-based					10.00%
Discount Rate - net sales targets					3.50%