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Restructuring (Tables)
 12 Months Ended
Dec. 31, 2015
Restructuring [Abstract]  
Activity in restructuring accrual
Activity in the restructuring accrual, which is included in accounts payable and accrued expenses in our Consolidated Balance Sheets, and in research and development and general and administrative expenses in the Consolidated Statements of Operations, is specified below.

  
Severance and Related Benefits
  
Other Exit Costs
  
Contract Termination Costs
  
Total Restructuring Accrual
 
Balance at December 31, 2012
 
$
813
  
$
-
  
$
-
  
$
813
 
 Additions, net
  
1,492
   
15
   
1,359
   
2,866
 
Payments
  
(2,305
)
  
(15
)
  
(1,359
)
  
(3,679
)
Balance at December 31, 2013
  
-
   
-
   
-
   
-
 
Additions, net
  
359
   
-
   
-
   
359
 
Payments
  
(359
)
  
-
   
-
   
(359
)
Balance at December 31, 2014 and 2015
 
$
-
  
$
-
  
$
-
  
$
-