Progenics Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown, New York 10591 Fax: (914) 789-2817  (914) 789-2800   www.progenics.com

December 3, 2013

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, NE

Washington, D.C. 20549

Attention:  Mr. Jeffrey P. Riedler

Re:	Progenics Pharmaceuticals, Inc.
	Form 10-K for the fiscal year ended December 31, 2012
	Filed March 15, 2013
	Form 10-Q for the Quarterly Period Ended June 30, 2013 Filed August 9, 2013 File No. 000-23143

Dear Mr. Riedler:

We have received your November 19^th letter to Mr. Baker conveying additional comments of the SEC Staff on the above-referenced filings in response to our October 18^th response letter.  In order to complete the collection and compilation of relevant information, and to prepare responses to the Staff's comments with necessary and appropriate input from Company officers, employees and advisors, Progenics hereby respectfully requests the Staff to grant an extension of an additional ten business days to provide its response.  This extension will permit the Company to respond fully and properly to all of the matters raised in your letter.

Please contact me at (914) 789-2805 or dmartin@progenics.com if you have any questions or require additional information.

Sincerely,

/s/ David E. Martin

David E. Martin

General Counsel

cc: Mr. Baker Bryan J. Pitko, Esq. Austin Stephenson, Esq.