Income Taxes (Details) (USD $)	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Income Taxes [Abstract]
Income tax benefit	$ 0	$ 0	$ 95,000
Deferred tax assets and liabilities [Abstract]
Depreciation and amortization	6,497,000	6,865,000
R&E tax credit carry-forwards	11,843,000	11,966,000
NYS investment tax credit carry-forwards	1,084,000	1,088,000
AMT credit carry-forwards	211,000	211,000
Net operating loss carry-forwards	112,966,000	85,110,000
Capitalized research and development expenditures	30,884,000	43,113,000
Stock compensation	14,436,000	13,789,000
Deferred tax assets, net	2,069,000	0
Other items	2,193,000	3,600,000
Deferred tax assets, gross	180,114,000	165,742,000
Valuation allowance	(178,045,000)	(165,742,000)
Deferred Tax Assets, Net of Valuation Allowance	2,069,000
Deferred tax liability - current	2,069,000	0
Net deferred tax asset (liability)	0	0
Reconciliation of income taxes computed at the Federal statutory income tax rate to the actual effective income tax [Abstract]
U.S. Federal statutory rate (in hundredths)	(35.00%)	35.00%	(34.00%)
State income taxes, net of Federal benefit (in hundredths)	(5.40%)	8.00%	(5.10%)
Research and experimental tax credit (in hundredths)	0.00%	(4.10%)	(1.70%)
Change in valuation allowance (in hundredths)	34.70%	(22.60%)	38.20%
Effect of federal tax rate bracket change on valuation allowance (in hundredths)	0.00%	(34.80%)	0.00%
Equity compensation (in hundredths)	4.20%	17.00%	2.30%
Investment tax credit (in hundredths)	0.00%	(0.10%)	0.10%
Other (in hundredths)	1.50%	1.60%	0.10%
Income tax provision (benefit) (in hundredths)	0.00%	0.00%	(0.10%)
Net operating loss carryforwards	298,000,000
Net operating loss carry-forwards not reflected in deferred tax assets	18,200,000
Valuation allowance related to net operating loss carryforwards attributable to excess tax deductions for equity compensation	11,400,000
Unrecognized tax benefits	0	0	0
Tax credit carryforwards of R&E expired	125,000
Deferred Tax Assets, Net, Current	17,000
Deferred Tax Assets, Net, Noncurrent	$ 2,052,000	$ 0