CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenues:
Royalty income	$ 4,963	$ 3,046	$ 1,826
Collaboration revenue	8,525	76,764	1,413
Research grants	488	4,810	4,573
Other revenues	72	176	140
Total revenues	14,048	84,796	7,952
Expenses:
Research and development	31,840	53,183	50,640
License fees - research and development	1,170	578	1,270
Royalty expense	499	405	241
General and administrative	14,706	18,248	22,832
Depreciation and amortization	1,324	2,066	2,853
Total expenses	49,539	74,480	77,836
Operating (loss) income	(35,491)	10,316	(69,884)
Other income:
Interest income	60	65	64
Total other income	60	65	64
Net (loss) income before income taxes	(35,431)	10,381	(69,820)
Income tax benefit	0	0	95
Net (loss) income	$ (35,431)	$ 10,381	$ (69,725)
Net (loss) income per share - basic	$ (1.02)	$ 0.31	$ (2.14)
Weighted-average shares - basic	34,754	33,375	32,590
Net (loss) income per share - diluted	$ (1.02)	$ 0.31	$ (2.14)
Weighted-average shares - diluted	34,754	33,494	32,590