CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Revenues:
Royalty income	$ 1,619	$ 527	$ 3,453	$ 527
Collaboration revenue	94	72,460	385	73,543
Research grants	88	1,401	174	2,665
Other revenues	19	19	34	60
Total revenues	1,820	74,407	4,046	76,795
Expenses:
Research and development	7,957	13,302	18,866	32,481
License fees - research and development	110	88	150	452
Royalty expense	162	70	347	127
General and administrative	4,025	4,952	7,746	10,149
Depreciation and amortization	300	525	772	1,061
Total expenses	12,554	18,937	27,881	44,270
Operating (loss) income	(10,734)	55,470	(23,835)	32,525
Other income:
Interest income	14	16	29	34
Total other income	14	16	29	34
Net (loss) income	$ (10,720)	$ 55,486	$ (23,806)	$ 32,559
Net (loss) income per share - basic	$ (0.32)	$ 1.66	$ (0.70)	$ 0.97
Weighted-average shares - basic	33,798	33,510	33,779	33,397
Net (loss) income per share - diluted	$ (0.32)	$ 1.64	$ (0.70)	$ 0.97
Weighted-average shares - diluted	33,798	33,787	33,779	33,567