0000835887-12-000029.txt : 20120508 0000835887-12-000029.hdr.sgml : 20120508 20120508171847 ACCESSION NUMBER: 0000835887-12-000029 CONFORMED SUBMISSION TYPE: 10-Q PUBLIC DOCUMENT COUNT: 12 CONFORMED PERIOD OF REPORT: 20120331 FILED AS OF DATE: 20120508 DATE AS OF CHANGE: 20120508 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PROGENICS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000835887 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 133379479 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-Q SEC ACT: 1934 Act SEC FILE NUMBER: 000-23143 FILM NUMBER: 12822526 BUSINESS ADDRESS: STREET 1: 777 OLD SAW MILL RIVER ROAD CITY: TARRYTOWN STATE: NY ZIP: 10591 BUSINESS PHONE: 9147892800 MAIL ADDRESS: STREET 1: 777 OLD SAW MILL RIVER ROAD CITY: TARRYTOWN STATE: NY ZIP: 10591 10-Q 1 form10_q03312012.htm PROGENICS FORM 10-Q 03/31/2012 form10_q03312012.htm



UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
____________

                FORM 10-Q                
 
(Mark One)
 
x
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
 
For the quarterly period ended March 31, 2012
 
Or
¨
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
 
For the transition period from ___________ to ___________


Commission File No. 000-23143
____________

PROGENICS PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)

Delaware
13-3379479
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer Identification Number)
____________
 
777 Old Saw Mill River Road
Tarrytown, NY 10591
(Address of principal executive offices, including zip code)

Registrant’s telephone number, including area code: (914) 789-2800
 

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No o

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes x No o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act:

Large accelerated filer  ¨                                                                                               Accelerated filer   x
Non-accelerated filer    ¨  (Do not check if a smaller reporting company)            Smaller reporting company   ¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes o  No x
 
As of May 1, 2012, a total of 33,861,903 shares of common stock, par value $.0013 per share, were outstanding.

 
 

 



PROGENICS PHARMACEUTICALS, INC.
 
 
   
Page No.
Part I
FINANCIAL INFORMATION
 
Item 1.
 
 
3
 
4
 
5
 
6
 
7
 
8
Item 2.
14
Item 3.
23
Item 4.
23
     
PART II
OTHER INFORMATION
 
Item 1A.
23
Item 6.
24
 
25

 

 

 

 
2




PART I — FINANCIAL INFORMATION
 
 
PROGENICS PHARMACEUTICALS, INC.
CONSOLIDATED BALANCE SHEETS
 
(amounts in thousands, except for par value and share amounts)

 
March 31,
2012
 
December 31,
2011
   
(Unaudited)
         
Assets
             
Current assets:
             
Cash and cash equivalents
$
56,099
   
$
70,105
 
Accounts receivable
 
2,403
     
1,516
 
Other current assets
 
960
     
919
 
Total current assets
 
59,462
     
72,540
 
Auction rate securities
 
3,240
     
3,332
 
Fixed assets, at cost, net of accumulated depreciation and amortization
 
4,004
     
4,038
 
Other assets
 
200
     
200
 
Total assets
$
66,906
   
$
80,110
 
               
Liabilities and Stockholders’ Equity
             
Current liabilities:
             
Accounts payable and accrued expenses
$
4,099
   
$
6,331
 
Deferred revenue - current
 
204
     
204
 
Other current liabilities
 
115
     
115
 
Total current liabilities
 
4,418
     
6,650
 
Deferred revenue – long term
 
111
     
162
 
Other liabilities
 
963
     
1,497
 
Total liabilities
 
5,492
     
8,309
 
Commitments and contingencies (Note 8)
             
Stockholders’ equity:
             
Preferred stock, $.001 par value; 20,000,000 shares authorized; issued and outstanding – none
 
-
     
-
 
Common stock, $.0013 par value; 80,000,000 shares authorized; issued – 34,061,834 in 2012 and 34,046,409 in 2011
 
44
     
44
 
Additional paid-in capital
 
466,131
     
463,440
 
Accumulated deficit
 
(401,760
)
   
(388,674
)
Accumulated other comprehensive loss
 
(260
)
   
(268
)
Treasury stock, at cost (200,000 shares in 2012 and 2011)
 
(2,741
)
   
(2,741
)
Total stockholders’ equity
 
61,414
     
71,801
 
Total liabilities and stockholders’ equity
$
66,906
   
$
80,110
 



The accompanying notes are an integral part of these consolidated financial statements.

 
3


PROGENICS PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS
 
(amounts in thousands, except net loss per share)
(Unaudited)

 
For the Three Months Ended
 
March 31,
 
2012
 
2011
Revenues:
             
Royalty income
$
1,834
   
$
-
 
Collaboration revenue
 
291
     
1,083
 
Research grants
 
86
     
1,264
 
Other revenues
 
15
     
41
 
Total revenues
 
2,226
     
2,388
 
               
Expenses:
             
Research and development
 
10,909
     
19,179
 
License fees – research and development
 
40
     
364
 
Royalty expense
 
185
     
57
 
General and administrative
 
3,721
     
5,197
 
Depreciation and amortization
 
472
     
536
 
Total expenses
 
15,327
     
25,333
 
               
Operating loss
 
(13,101
)
   
(22,945
)
               
Other income:
             
Interest income
 
15
     
18
 
Total other income
 
15
     
18
 
               
Net loss
$
(13,086
)
 
$
(22,927
)
               
Net loss per share – basic and diluted
$
(0.39
)
 
$
(0.69
)
Weighted-average shares – basic and diluted
 
33,761
     
33,273
 



The accompanying notes are an integral part of these consolidated financial statements.

 
4



PROGENICS PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(amounts in thousands)
(Unaudited)

 
For the Three Months Ended
 
March 31,
 
2012
 
2011
               
Net loss
$
(13,086
)
 
$
(22,927
)
Other comprehensive income:
             
Net change in unrealized loss on auction rate securities
 
8
     
-
 
Total other comprehensive income
 
8
     
-
 
Comprehensive loss
 $
(13,078
 
 $
(22,927


The accompanying notes are an integral part of these consolidated financial statements.


 
5



PROGENICS PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
FOR THE THREE MONTHS ENDED MARCH 31, 2012 AND 2011
 
(amounts in thousands)
(Unaudited)
 
   
Common Stock
   
Additional
         
Accumulated
Other
   
Treasury Stock
       
   
Shares
   
Amount
   
Paid-In
Capital
   
Accumulated
Deficit
   
Comprehensive
Income (Loss)
   
Shares
   
Amount
   
Total
 
Balance at December 31,  2011
    34,046     $ 44     $ 463,440     $ (388,674 )   $ (268 )     (200 )   $ (2,741 )   $ 71,801  
Net loss
    -       -       -       (13,086 )     -       -       -       (13,086 )
Other comprehensive income
    -       -       -       -       8       -       -       8  
Compensation expenses for share-based payment arrangements
    -       -       2,609       -       -       -       -       2,609  
Exercise of stock options
    16       -       82       -       -       -       -       82  
Balance at March 31, 2012
    34,062     $ 44     $ 466,131     $ (401,760 )   $ (260 )     (200 )   $ (2,741 )   $ 61,414  

   
Common Stock
   
Additional
         
Accumulated
Other
   
Treasury Stock
       
   
Shares
   
Amount
   
Paid-In
Capital
   
Accumulated
Deficit
   
Comprehensive
Income (Loss)
   
Shares
   
Amount
   
Total
 
Balance at December 31,  2010
    33,326     $ 43     $ 453,353     $ (399,055 )   $ (292 )     (200 )   $ (2,741 )   $ 51,308  
Net loss
    -       -       -       (22,927 )     -       -       -       (22,927 )
Compensation expenses for share-based payment arrangements
    -       -       1,495       -       -       -       -       1,495  
Issuance of restricted stock, net of forfeitures
    (10 )     -       -       -       -       -       -       -  
Sale of common stock under employee stock purchase plans and exercise of stock options
    283       1       1,271       -       -       -       -       1,272  
Balance at March 31, 2011
    33,599     $ 44     $ 456,119     $ (421,982 )   $ (292 )     (200 )   $ (2,741 )   $ 31,148  

The accompanying notes are an integral part of these consolidated financial statements.

 
6




PROGENICS PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF CASH FLOWS
 
(amounts in thousands)
(Unaudited)

 
For the Three Months Ended
 
March 31,
 
2012
 
2011
Cash flows from operating activities:
         
Net loss
$
(13,086
)
 
$
(22,927
)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
             
Depreciation and amortization
 
472
     
536
 
Gains on sales of fixed assets
 
(93
)
   
-
 
Expenses for share-based compensation awards
 
2,609
     
1,495
 
Changes in assets and liabilities:
             
(Increase) decrease in accounts receivable
 
(887
)
   
1,559
 
Decrease (increase) in other current assets
 
8
     
(467
)
Decrease in other assets
 
-
     
1,050
 
Decrease in accounts payable and accrued expenses
 
(2,232
)
   
(1,848
)
Increase in other current liabilities
 
-
     
2
 
(Decrease) increase in deferred revenue – long term
 
(51
)
   
60,000
 
(Decrease) increase in other liabilities
 
(534
)
   
93
 
Net cash (used in) provided by operating activities
 
(13,794
)
   
39,493
 
Cash flows from investing activities:
             
Capital expenditures
 
(518
)
   
(29
)
Proceeds from sales of fixed assets
 
124
     
-
 
Proceeds from redemption of auction rate securities
 
100
     
-
 
Net cash used in investing activities
 
(294
)
   
(29
)
Cash flows from financing activities:
             
Proceeds from the exercise of stock options and sale of common stock under employee stock purchase plans
 
82
     
1,272
 
Net cash provided by financing activities
 
82
     
1,272
 
Net (decrease) increase in cash and cash equivalents
 
(14,006
)
   
40,736
 
Cash and cash equivalents at beginning of period
 
70,105
     
47,918
 
Cash and cash equivalents at end of period
$
56,099
   
$
88,654
 


The accompanying notes are an integral part of these consolidated financial statements.

 
7

PROGENICS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – (unaudited)
(amounts in thousands, except per share amounts or as otherwise noted)



Progenics Pharmaceuticals, Inc. (“Progenics,” “we” or “us”) is dedicated to the development of innovative medicines to treat disease. In 2011, we licensed our first commercial product, Relistor® (methylnaltrexone bromide) subcutaneous injection, to Salix Pharmaceuticals, Inc., a leading gastrointestinal disease specialty company. Salix is marketing Relistor directly through its specialty sales force in the U.S. and sublicensing the drug to regional companies elsewhere except Japan, where we have previously licensed to Ono Pharmaceutical Co., Ltd. the subcutaneous formulation of the drug. In addition to the FDA-approved indication for advanced illness patients, the U.S. Prescription Drug User Fee Act (PDUFA) action date for Salix’s pending supplemental New Drug Application (sNDA) for subcutaneous Relistor in non-cancer pain patients is now July 27, 2012. We and Salix also announced in December 2011 successful top-line data from the ongoing phase 3 trial of oral methylnaltrexone in non-cancer pain patients. Our current principal sources of revenue from operations are upfront, commercialization milestone, royalty and revenue-sharing payments from Salix’s Relistor operations.

Progenics also has proprietary research and development programs for drug candidates focused on oncology. Our principal product candidate is PSMA ADC, a fully human monoclonal antibody-drug conjugate (ADC) directed against prostate specific membrane antigen (PSMA), a protein found at high levels on the surface of prostate cancer cells and also on the neovasculature of a number of other types of solid tumors. We expect that the ongoing phase 1 trial of PSMA ADC will be completed in 2012 and if the results are successful we plan to commence a phase 2 trial of PSMA ADC in advanced prostate cancer.

We are also conducting preclinical development work on novel multiplex phosphoinositide 3-kinase (PI3K) inhibitors that may be effective in blocking signaling pathways that are critical in the growth of aggressive cancers. We are seeking to in-license or acquire opportunities in the oncology field and supportive, diagnostic and/or other areas complementary to these ongoing and prospective initiatives. As we have expanded our focus on oncology, we have terminated certain research efforts not within the Company’s oncology focus, and are working to out-license others, such as our PRO 140 and C.difficile programs.

Progenics commenced principal operations in 1988, became publicly traded in 1997 and throughout has been engaged primarily in research and development efforts, establishing corporate collaborations and related activities. All of our operations are conducted at our facilities in Tarrytown, New York.

Relistor (methylnaltrexone bromide) subcutaneous injection is a first-in-class therapy for opioid-induced constipation (OIC) which we developed over the course of the last decade and since 2008 has been approved for sale in the United States and over 50 other countries worldwide, including countries in the European Union, Canada and Australia. Marketing applications are pending elsewhere throughout the world. Under our License Agreement, Salix is responsible for further developing and commercializing subcutaneous Relistor, including completing clinical development necessary to support regulatory marketing approvals for potential new indications and formulations of the drug. We have received under this Agreement a $60.0 million upfront cash payment and $0.2 million in respect of Salix ex-U.S. sublicensee revenue, and are eligible to receive (i) up to $40.0 million upon U.S. marketing approval for subcutaneous Relistor in non-cancer pain patients, (ii) up to $50.0 million upon U.S. marketing approval of an oral formulation of Relistor, (iii) up to $200.0 million of commercialization milestone payments upon achievement of specified U.S. sales targets, (iv) royalties ranging from 15 to 19 percent of net sales by Salix and its affiliates, and (v) 60% of any upfront, milestone, reimbursement or other revenue (net of costs of goods sold, as defined, and territory-specific research and development expense reimbursement) Salix receives from sublicensees outside the U.S. In the event that either marketing approval is subject to a Black Box Warning or Risk Evaluation and Mitigation Strategy (REMS), payment of a substantial portion of the milestone amount would be deferred, and subject, to achievement of the first commercialization milestone (payable upon annual U.S. sales first exceeding $100.0 million).

Funding and Financial Matters. At March 31, 2012, we held $56.1 million in cash and cash equivalents, a $14.0 million decrease from $70.1 million at December 31, 2011, and we expect that this amount will be sufficient to fund operations as currently anticipated beyond one year. We may require additional funding in the future. If we do not realize sufficient royalty or other revenue or are unable to enter into favorable collaboration, license, asset sale, capital raising or other financing transactions, we will have to reduce, delay or eliminate spending on some current operations, and/or reduce salary and other overhead expenses, to extend our remaining operations.

 

 
8

PROGENICS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – continued (unaudited)
(amounts in thousands, except per share amounts or as otherwise noted)



In April 2008, our Board of Directors approved a share repurchase program to acquire up to $15.0 million of our outstanding common shares, under which we have $12.3 million remaining available. Purchases may be discontinued at any time. We did not repurchase any common shares during the three months ended March 31, 2012.

Our interim Consolidated Financial Statements included in this report have been prepared in accordance with applicable presentation requirements, and accordingly do not include all information and disclosures necessary for a presentation of our financial position, results of operations and cash flows in conformity with accounting principles generally accepted in the United States of America (“GAAP”). In the opinion of management, these financial statements reflect all adjustments, consisting primarily of normal recurring accruals necessary for a fair statement of results for the periods presented. The results of operations for interim periods are not necessarily indicative of the results for the full year. Our interim financial statements should be read in conjunction with the financial statements and notes thereto contained in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011. The year-end consolidated balance sheet data in these financial statements were derived from audited financial statements, but do not include all disclosures required by GAAP.

2.  Revenue Recognition

We recognize revenue from all sources based on the provisions of the SEC’s Staff Accounting Bulletin (SAB) No. 104 (SAB 104) and ASC 605 Revenue Recognition. Under ASC 605, the delivered items are separate units of accounting, provided (i) the delivered items have value to a collaborator on a stand-alone basis, and (ii) if the arrangement includes a general right of return relative to the delivered item, delivery or performance of the undelivered items is considered probable and substantially in our control. In April 2010, the FASB issued a separate update to ASC 605 which provides guidance on the criteria that should be met when determining whether the milestone method of revenue recognition is appropriate. This method is effective on a prospective basis for milestones achieved after January 1, 2011.

There have been no changes to our revenue recognition accounting policies as of and for the three months ended March 31, 2012 which policies are disclosed in Note 2 to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2011.

License Agreement with Salix – February 2011

Under our license agreement, Salix is responsible for further developing and commercializing subcutaneous Relistor worldwide other than Japan, including completing clinical development necessary to support regulatory marketing approvals for potential new indications and formulations. We have granted Salix an exclusive license of relevant know-how, patent rights and technology, assigned relevant third-party contracts and we are responsible for serving on joint committees provided for in the License Agreement. We expect to perform joint committee services through 2013. We recognized $0.1 million and $0 million during the three months ended March 31, 2012 and 2011, respectively, and $59.6 million for the year ended December 31, 2011, all from the $60.0 million upfront payment. At March 31, 2012, the $0.3 million remaining deferred revenue, which pertains to joint committee services, will be recognized in collaboration revenue as such activities are performed in the future.

3.  Net Loss Per Share

Our basic net loss per share amounts have been computed by dividing net loss by the weighted-average number of common shares outstanding during the period. As of March 31, 2012 and 2011, our 79 and 331 shares, respectively, of unvested restricted stock outstanding have non-forfeitable rights to dividends. The allocation of 2012 and 2011 net losses to these participating securities pursuant to the two-class method is not material to both basic and diluted earnings per share. For the three months ended March 31, 2012 and 2011, we reported net losses and, therefore, potential common stock were not included in the computation of diluted net loss per share since such inclusion would have been anti-dilutive. The calculations of net loss per share, basic and diluted, are as follows:

 
9

PROGENICS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – continued (unaudited)
(amounts in thousands, except per share amounts or as otherwise noted)
 


   
Net Loss
(Numerator)
   
Weighted Average
Common Shares
(Denominator)
   
Per Share
Amount
 
Three months ended March 31, 2012
                 
Basic and diluted
  $ (13,086 )     33,761     $ (0.39 )
Three months ended March 31, 2011
                       
Basic and diluted
  $ (22,927 )     33,273     $ (0.69 )

For the three months ended March 31, 2012 and 2011, anti-dilutive common shares excluded from diluted per share amounts consist of the following:

   
Three Months Ended March 31,
 
   
2012
   
2011
 
   
Weighted
Average
Number
   
Weighted
Average
Exercise Price
   
Weighted
Average
Number
   
Weighted
Average
Exercise Price
 
Options
    5,785     $ 12.46       5,146     $ 14.10  
Restricted stock
    96               29          
Total
    5,881               5,175          

4.  Fair Value Measurements

Our auction rate securities are recorded at fair value in the accompanying Consolidated Balance Sheets in accordance with ASC 320 Investments – Debt and Equity Securities. The change in the fair value of these investments is recorded as a component of other comprehensive loss (see Note 2. Summary of Significant Accounting Policies - Fair Value Measurements in the notes to consolidated financial statements included in our 2011 Annual Report on Form 10-K).

The following tables present our money market funds and auction rate securities measured at fair value on a recurring basis as of March 31, 2012 and December 31, 2011, classified by valuation hierarchy:

         
Fair Value Measurements at March 31, 2012
 
Investment Type
 
Balance at
March 31, 2012
   
Quoted Prices
in Active
Markets for
Identical Assets
 (Level 1)
   
Significant
Other
Observable
Inputs
 (Level 2)
   
Significant
Unobservable
Inputs
 (Level 3)
 
                         
Money market funds
  $ 50,182     $ 50,182     $ -     $ -  
Auction rate securities
    3,240       -       -       3,240  
Total
  $ 53,422     $ 50,182     $ -     $ 3,240  
 
         
Fair Value Measurements at December 31, 2011
 
Investment Type
 
Balance at
December 31, 2011
   
Quoted Prices
in Active
Markets for
Identical Assets
 (Level 1)
   
Significant
Other
Observable
Inputs
 (Level 2)
   
Significant
Unobservable
Inputs
 (Level 3)
 
                         
Money market funds
  $ 64,068     $ 64,068     $ -     $ -  
Auction rate securities
    3,332       -       -       3,332  
Total
  $ 67,400     $ 64,068     $ -     $ 3,332  

At March 31, 2012 we hold $3,240 in auction rate securities which are classified as Level 3. The fair value of these securities includes $2,300 of U.S. government subsidized securities collateralized by student loan obligations, with maturities greater than 10 years, and $940 of investment company perpetual preferred stock, without a stated maturity. We will not realize cash in respect of the principal amount of these securities until the issuer calls or restructures the security, the security reaches any scheduled maturity and is paid, or a buyer outside the auction process emerges. As of March 31, 2012, we have received all scheduled interest payments on these securities, which, in the event of auction failure, are reset according to contractual terms in the governing instruments.

 
10

PROGENICS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – continued (unaudited)
(amounts in thousands, except per share amounts or as otherwise noted)
 

 
The valuation of auction rate securities we hold is based on Level 3 unobservable inputs which consist of our internal analysis of (i) timing of expected future successful auctions or issuer calls of the securities, (ii) collateralization of underlying assets of the security and (iii) credit quality of the security. We use a discounted cash flow model to estimate the value of these auction rate securities and the unobservable inputs consist of a redemption period ranging from four to 17 years (weighted-average: 6.6 years) and discount rates ranging from 0.25% to 2.39% (weighted-average: 1.1%). Significant increases (decreases) in the redemption period or discount rates would result in a significantly lower (higher) fair value measurement. In re-evaluating the valuation of these securities as of March 31, 2012, the temporary impairment amount, the duration of which is greater than 12 months, decreased $8 from $268 at December 31, 2011, to $260, which is reflected as part of accumulated other comprehensive loss on our accompanying Consolidated Balance Sheets and based on such re-evaluation, we believe that we have the ability to hold these securities until recovery of fair value. Due to the uncertainty related to the liquidity in the auction rate security market and therefore when individual positions may be liquidated, we have classified these auction rate securities as long-term assets on our accompanying Consolidated Balance Sheets. We continue to monitor markets for our investments and consider the impact, if any, of market conditions on the fair market value of our investments. We do not believe the carrying values of our investments are other than temporarily impaired and therefore expect the positions will eventually be liquidated without significant loss.

For those of our financial instruments with significant Level 3 inputs (all of which are auction rate securities), the following table summarizes the activities for the three months ended March 31, 2012 and 2011:

   
Fair Value Measurements Using Significant
Unobservable Inputs
(Level 3)
For the Three Months Ended March 31
 
Description
 
2012
   
2011
 
             
Balance at beginning of period
  $ 3,332     $ 3,608  
Transfers into Level 3
    -       -  
Transfers out of Level 3
    -       -  
Total gains (losses)
               
Included in net loss
    -       -  
Included in other comprehensive loss
    8       -  
Settlements at par
    (100 )     -  
Balance at end of period
  $ 3,240     $ 3,608  
    Changes in unrealized gains or losses for the period included in earnings (or changes in net assets) for assets held at the end of the reporting period
  $ -     $ -  

5.  Accounts Receivable

   
March 31,
2012
   
December 31,
2011
 
Royalties
  $ 1,835     $ 1,279  
Collaborators
    480       77  
Research grants
    74       100  
Other
    14       60  
Total
  $ 2,403     $ 1,516  

The increase in accounts receivable as of March 31, 2012 as compared to December 31, 2011, is primarily due to higher Relistor sales during the first quarter of 2012. In addition, during the first quarter we collected substantially all of our December 31, 2011 accounts receivable balances.

 
11

PROGENICS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – continued (unaudited)
(amounts in thousands, except per share amounts or as otherwise noted)
 


6.  Accounts Payable and Accrued Expenses

   
March 31,
2012
   
December 31,
2011
 
Accrued consulting and clinical trial costs
  $ 1,750     $ 1,637  
Accrued payroll and related costs
    1,130       3,149  
Restructuring accrual
    130       731  
Legal and professional fees
    594       371  
Accounts payable
    309       309  
Other
    186       134  
Total
  $ 4,099     $ 6,331  

Accounts payable and accrued expenses decreased as of March 31, 2012, compared to year end, primarily due to the payment of 2011 accrued bonuses in the first quarter of 2012.

7. Restructuring

In the third and fourth quarters of 2011, we reduced headcount resulting in a restructuring accrual of $1.3 million of severance and related benefits, which are being paid during the period from October 2011 through August 2012. We incurred other exit and contract termination costs, including expenses related to a lease amendment and consolidation of employees within reduced facility space.

Activity in the restructuring accrual, which is included in accounts payable and accrued expenses in our Consolidated Balance Sheets and research and development and general and administrative expenses in the Consolidated Statements of Operations, is specified below.

   
Severance
and Related
Benefits
   
Other Exit
Costs
   
Contract
Termination
Costs
   
Total
Restructuring
Accrual
 
Balance at December 31, 2011
  $ 571     $ 6     $ 154     $ 731  
Additions, net
    -       122       3       125  
Payments
    (456 )     (123 )     (147 )     (726 )
Balance at March 31, 2012
  $ 115     $ 5     $ 10     $ 130  

8.  Commitments and Contingencies

In the ordinary course of our business, we enter into agreements with third parties, such as business partners, clinical sites and suppliers, that include indemnification provisions which in our judgment are normal and customary for companies in our industry sector. We generally agree to indemnify, hold harmless and reimburse the indemnified parties for losses suffered or incurred by them with respect to our products or product candidates, use of such products or other actions taken or omitted by us. The maximum potential amount of future payments we could be required to make under these indemnification provisions is not limited. We have not incurred material costs to defend lawsuits or settle claims related to these provisions. As a result, the estimated fair value of liabilities relating to indemnification provisions is minimal. We have no liabilities recorded for these provisions as of March 31, 2012.

On March 14, 2012, Progenics and Vice Chairman Paul Maddon entered into an agreement for his retirement from full-time employment. In connection with this agreement, Progenics incurred $2.1 million in salary and related benefits expenses and $1.6 million non-cash equity vesting expenses, and of these amounts together $0.2 million and $3.5 million were expensed in the fourth quarter of 2011 and first quarter of 2012, respectively. Progenics paid $2.0 million cash in respect of these expenses during the first quarter of 2012.

 
12

PROGENICS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS – continued (unaudited)
(amounts in thousands, except per share amounts or as otherwise noted)
 


9.  Recently Adopted Accounting Standards

In June 2011, the FASB issued ASU No. 2011-05, which requires that comprehensive income and the related components be presented in a single continuous statement or in two separate but consecutive statements. The ASU is effective for fiscal years, and interim periods within those years, beginning after December 15, 2011, except for the deferral of the effective date related to the presentation of reclassification of items out of accumulated other comprehensive income under ASU No. 2011-12, which was issued in January 2012. We adopted this new standard and applied it retrospectively on January 1, 2012 and it had no material impact on our consolidated financial statements.

In May 2011, the FASB issued ASU No. 2011-04, which is the result of joint efforts by the FASB and International Accounting Standards Board to develop a single, converged fair value framework. The converged guidance specifies how to measure fair value and what disclosures to provide about fair value measurements. The ASU is effective for interim and annual periods beginning after December 15, 2011. We adopted this new standard on January 1, 2012 and it had no material impact on our consolidated financial statements.

 
13


Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

Note Regarding Forward-Looking Statements

This document and other public statements we make may contain statements that do not relate strictly to historical fact, any of which may be forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. When we use the words “anticipates,” “plans,” “expects” and similar expressions, we are identifying forward-looking statements. Forward-looking statements involve known and unknown risks and uncertainties which may cause our actual results, performance or achievements to be materially different from those expressed or implied by forward-looking statements. While it is impossible to identify or predict all such matters, these differences may result from, among other things, the inherent uncertainty of the timing and success of, and expense associated with, research, development, regulatory approval and commercialization of our products and product candidates, including the risks that clinical trials will not commence or proceed as planned; products appearing promising in early trials will not demonstrate efficacy or safety in larger-scale trials; clinical trial data on our products and product candidates will be unfavorable; our products will not receive marketing approval from regulators or, if approved, do not gain sufficient market acceptance to justify development and commercialization costs; competing products currently on the market or in development might reduce the commercial potential of our products; we, our collaborators or others might identify side effects after the product is on the market; or efficacy or safety concerns regarding marketed products, whether or not originating from subsequent testing or other activities by us, governmental regulators, other entities or organizations or otherwise, and whether or not scientifically justified, may lead to product recalls, withdrawals of marketing approval, reformulation of the product, additional pre-clinical testing or clinical trials, changes in labeling of the product, the need for additional marketing applications, declining sales or other adverse events.

We are also subject to risks and uncertainties associated with the actions of our corporate, academic and other collaborators and government regulatory agencies, including risks from market forces and trends; potential product liability; intellectual property, litigation, environmental and other risks; the risk that we may not be able to enter into favorable collaboration or other relationships or that existing or future relationships may not proceed as planned; the risk that current and pending patent protection for our products may be invalid, unenforceable or challenged, or fail to provide adequate market exclusivity, or that our rights to in-licensed intellectual property may be terminated for our failure to satisfy performance milestones; the risk of difficulties in, and regulatory compliance relating to, manufacturing products; and the uncertainty of our future profitability.

Risks and uncertainties also include general economic conditions, including interest and currency exchange-rate fluctuations and the availability of capital; changes in generally accepted accounting principles; the impact of legislation and regulatory compliance; the highly regulated nature of our business, including government cost-containment initiatives and restrictions on third-party payments for our products; trade buying patterns; the competitive climate of our industry; and other factors set forth in this document and other reports filed with the U.S. Securities and Exchange Commission (SEC). In particular, we cannot assure you that Relistor® will be commercially successful or be approved in the future in other formulations, indications or jurisdictions, or that any of our other programs will result in a commercial product.

We do not have a policy of updating or revising forward-looking statements and we assume no obligation to update any statements as a result of new information or future events or developments. It should not be assumed that our silence over time means that actual events are bearing out as expressed or implied in forward-looking statements.

Overview

General. Progenics Pharmaceuticals is dedicated to the development of innovative medicines to treat disease. Our focus is on the treatment of cancer.

Our first commercial drug is Relistor®, for the treatment of opioid induced constipation (OIC) in patients with advanced illnesses, such as cancer. OIC is the constipation that often arises when patients take opioids for pain relief. Relistor is the only prescription medicine approved in the United States to treat this form of constipation. Relistor subcutaneous injection is now approved in the U.S. and over 50 other countries around the world. In the U.S. Relistor is marketed by our commercial partner Salix Pharmaceuticals, a leading specialty pharmaceutical company focusing on gastrointestinal diseases; it is sold outside the U.S. by sublicensees of Salix. Our partner Ono Pharmaceutical is currently developing subcutaneous Relistor for Japan. Our current principal sources of revenue from operations are upfront, commercialization milestone, royalty and revenue-sharing payments from Salix’s Relistor operations.

 
14



Together with Salix we have applied to the U.S. Food and Drug Administration to expand the population that can be treated with subcutaneous Relistor to include patients taking opioids for non-cancer pain, and who suffer from OIC as a result. This population includes patients taking opioids for conditions such as back pain or joint pain. The action date on this marketing application under the U.S. Prescription Drug User Fee Act (PDUFA) is now July 27, 2012. We also announced in December 2011, results from a phase 3 clinical test of an oral form of Relistor, in which the efficacy of oral methylnaltrexone was comparable to that reported in clinical studies of subcutaneous methylnaltrexone in subjects with chronic, non-cancer pain, and the overall observed safety profile in patients treated was comparable to placebo.

Our lead oncology product candidate is PSMA ADC, a fully human monoclonal antibody-drug conjugate (ADC) directed against prostate specific membrane antigen (PSMA), a protein found at high levels on the surface of prostate cancer cells and also on the neovasculature of a number of other types of solid tumors. We are conducting a phase 1 clinical trial of PSMA ADC for the treatment of prostate cancer which we expect will be completed in 2012, and if the results are successful we plan then to commence a phase 2 trial of PSMA ADC in advanced prostate cancer. As a part of our work in oncology, we are also conducting preclinical development of novel multiplex phosphoinositide 3-kinase (PI3K) inhibitors. We believe these compounds may be effective in blocking signaling pathways that are critical in the growth of aggressive cancers, particularly RAS-mutated tumors. With our focus on the development of medicines to treat cancer, we are seeking opportunities to expand our oncology pipeline through in-licensing and acquisitions. We have discontinued most of our work on programs outside of this focus and are working to out-license them.

Our sources of revenues for the three months ended March 31, 2012 and 2011 have been payments under our collaboration agreements, including royalties, and funds from NIH research grants for expenses incurred in respect of programs we are seeking to out-license. Salix, Progenics and former collaborator Wyeth have transitioned U.S., European and other marketing authorizations and are transitioning additional commercialization outside of the U.S. and Japan. Salix has secured distribution and marketing partners for Relistor in Europe and has granted a license to Link Medical Products Pty Limited for distribution in Australia, New Zealand, South Africa and certain other markets in Asia. Royalty income is based on net sales reported by Salix. Salix is continuing its efforts to secure additional distribution partners and/or sublicensees. To date, our product sales have consisted solely of limited revenues from the sale of research reagents and we expect that those sales will not significantly increase over current levels in the near future.

A majority of our expenditures to date have been for research and development activities. In light of our strategic focus on oncology, our research and development project categories are Oncology, Relistor and Other, a change from Cancer, Relistor, HIV and Other in prior years. During the three months ended March 31, 2012, expenses for Oncology, primarily related to PSMA ADC, were $8.4 million compared to $4.2 million in 2011. Expenses for Relistor and Other research programs were $0.8 million and $1.9 million, respectively, during the three months ended March 31, 2012 compared to $13.0 million and $2.4 million, respectively, for the same period in 2011. We expect to incur significant development expenses for our PSMA ADC product candidate as this clinical trial progresses, while expenses related to Relistor will depend on the amount of research and development work we perform upon requests by Salix or Ono.

At March 31, 2012, we held $56.1 million in cash and cash equivalents, a decrease of $14.0 million from $70.1 million at December 31, 2011. We expect that this amount will be sufficient to fund operations as currently anticipated beyond one year. We may require additional funding in the future, and if we are unable to conclude favorable collaboration, license, asset sale, capital raising or other financing transactions, we will have to reduce, delay or eliminate spending on some current operations, and/or reduce salary and other overhead expenses, to extend our remaining operations. We expect to incur operating losses during the near term. At March 31, 2012, cash, cash equivalents and auction rate securities decreased $14.1 million to $59.3 million from $73.4 million at December 31, 2011.
 
Relistor. Relistor has been approved by regulatory authorities in the U.S., countries in the European Union, Canada and Australia since 2008 for treatment of OIC in advanced-illness patients receiving palliative care when laxative therapy has not been sufficient. Marketing applications are pending elsewhere throughout the world.

Under our 2011 License Agreement, Salix is responsible for further developing and commercializing subcutaneous Relistor, including completing clinical development necessary to support regulatory marketing approvals for potential new indications and formulations of the drug. In 2011, we received under this Agreement a $60.0 million upfront cash payment and $0.2 million in respect of Salix ex-U.S. sublicensee revenue and are eligible to receive (i) up to $40.0 million upon U.S. marketing approval for subcutaneous Relistor in non-cancer pain patients, (ii) up to $50.0 million upon U.S. marketing approval of an oral formulation of Relistor, (iii) up to $200.0 million of commercialization milestone payments upon achievement of specified U.S. sales targets, (iv) royalties ranging from 15 to 19 percent of net sales by Salix and its affiliates, and (v) 60% of any upfront, milestone, reimbursement or other revenue (net of costs of goods sold, as defined, and territory-specific research and development expense reimbursement) Salix receives from sublicensees outside the U.S. In the event that either marketing approval is subject to a Black Box Warning or Risk Evaluation and Mitigation Strategy (REMS), payment of a substantial portion of the milestone amount would be deferred, and subject, to achievement of the first commercialization milestone (payable upon annual U.S. sales first exceeding $100.0 million).

 
15



Salix, Progenics, and Progenics’ former collaborator Wyeth have transitioned U.S., European and other marketing authorizations and are transitioning additional commercialization outside the U.S. and Japan. Salix has secured distribution and marketing partners for Relistor in the European territory and has licensed Link Medical Products Pty Limited for distribution in Australia, New Zealand, South Africa and certain other markets in Asia. Salix is continuing efforts to secure additional distribution partners and/or sublicensees. Royalty income is based on net sales reported by Salix. Under the Transition Agreement, Wyeth paid us $10.0 million in six quarterly installments through January 2011. Wyeth also provided financial resources for the development of a multi-dose pen for subcutaneous Relistor for which we recognized $1.1 million during the three months ended March 31, 2011.

Together with Salix we have applied to the FDA to expand the population that can be treated with subcutaneous Relistor to include patients taking opioids for non-cancer pain, and who suffer from OIC as a result. This population includes patients taking opioids for conditions such as back pain or joint pain. We have also received U.S., E.U. and Canadian approvals to market Relistor in pre-filled syringes, which are designed to ease preparation and administration for patients and caregivers, and Salix introduced that product in the first quarter of 2012. Ono may request us to perform activities related to its development and commercialization responsibilities beyond our participation in joint committees and specified technology transfer related tasks which will be at its expense, and reimbursable at the time we perform these services.

Royalty and milestone payments will depend on success in development and commercialization of Relistor, which is dependent on many factors, such as the actions of Salix and Ono and any other business partner(s) with which we may collaborate, decisions by the FDA and other regulatory bodies, the outcome of clinical and other testing of Relistor, and our own efforts. Many of these matters are outside our control. In particular, we cannot guarantee that Salix will be successful in furthering the development and commercialization of the Relistor franchise.

Oncology. We recently announced a summary of current interim results from an ongoing phase 1 clinical trial of a fully human monoclonal ADC directed against PSMA for the treatment of prostate cancer and presented data from preclinical studies of novel multiplex phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer.

Results of Operations (amounts in thousands unless otherwise noted)

During the three months ended March 31, 2012 and 2011, our net losses from operations were $13,086 and $22,927, respectively.  Revenues and interest income for the three months ended March 31, 2012 were $2,226 and $15, respectively, compared to $2,388 and $18 for the same period in 2011. Expenses during the three months ended March 31, 2012 and 2011, were $15,327 and $25,333, respectively.

Revenues:

Our sources of revenue during the three months ended March 31, 2012 and 2011 included our License Agreement with Salix, Transition Agreement with Wyeth, our License Agreement with Ono, our research grants from the NIH and, to a small extent, our sale of research reagents.

   
Three Months Ended March 31,
       
Sources of Revenue
 
2012
   
2011
   
Percent
Change
 
                   
Royalty income
  $ 1,834     $ -       100%  
Collaboration revenue
    291       1,083       (73%)  
Research grants
    86       1,264       (93%)  
Other revenues
    15       41       (63%)  
Total
  $ 2,226     $ 2,388       (7%)  


 
16



Royalty income. During the three months ended March 31, 2012 we recognized $1,834 of royalty income based on net sales of Relistor reported by Salix or its sublicensees. No royalties were payable to us during the first quarter of 2011.

   
Relistor Net Sales Reported by Collaborators
 
   
Three Months Ended March 31,
 
   
2012
   
2011
 
U.S.
  $ 11,300     $ 1,800  
Ex-U.S.
    1,000       1,500  
   Global
  $ 12,300     $ 3,300  

Collaboration revenue:

Salix Collaboration. During the three months ended March 31, 2012, we recognized $289 of revenue from Salix, which includes $51 from the $60,000 upfront cash payment under the License Agreement and $238 as reimbursement of our expenses, in accordance with the License Agreement. As of March 31, 2012, $204 and $111 are recorded in deferred revenue – current and long-term, respectively. During the three months ended March 31, 2011, we recognized $1,058 of revenue from Wyeth, our collaborator before Salix, as reimbursement of our expenses under the 2009 Transition Agreement. We received no such reimbursement in 2012.

Ono Collaboration. During the three months ended March 31, 2012 and 2011, we recognized $2 and $25, respectively, of reimbursement revenue for activities requested by Ono under the 2008 Ono Agreement.

Research grants. During the three months ended March 31, 2012 and 2011, we recognized $86 and $1,264, respectively, as revenue from federal government grants by the NIH to partially offset costs related to our research and development programs. The decrease in grant revenue resulted from lower reimbursable expenses in 2012 than in 2011. We expect a further decline in the NIH reimbursable expenses for programs we are working to out-license.

Other revenues, primarily from orders for research reagents, decreased to $15 for the three months ended March 31, 2012, from $41 for the same period in 2011.

Expenses:

Research and Development Expenses include scientific labor, clinical trial costs, supplies, product manufacturing costs, consulting, license fees, royalty payments and other operating expenses. Research and development expenses decreased to $11,134 for the three months ended March 31, 2012 from $19,600 for the same period of 2011, as follows:

   
Three Months Ended March 31,
   
   
      2012
 
    2011
 
Percent
Change
             
Salaries and benefits
 
$      5,763
 
$      4,855
 
19%

Salaries and benefits increased due to expenses of $1,804 incurred in the first quarter of 2012 in connection with Vice Chairman Paul Maddon’s retirement agreement, which were partially offset by a decrease due to a decline in average headcount to 79 from 120 for the three months ended March 31, 2012 and 2011, respectively, in the research and development departments.

   
Three Months Ended March 31,
   
   
      2012
 
   2011
 
Percent
Change
             
Share-based compensation
 
$      2,288
 
$      1,001
 
129%

Share-based compensation increased for the three months ended March 31, 2012 compared to the same period in 2011, primarily due to the acceleration of options and restricted stock expenses of $1,638 resulting from Dr. Maddon’s retirement agreement, partially offset by lower restricted stock expenses and lower employee stock purchase plan expenses, due to the termination of the Company’s employee stock purchase plans in 2011.

 
17



   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Clinical trial costs
 
$         590
 
$      6,754
 
(91%)

Clinical trial costs decreased primarily due to lower expenses for Relistor ($6,563), from decreased clinical trial expense activities related to the oral methylnaltrexone phase 3 study, and Other ($37), partially offset by increased expenses in Oncology ($436), primarily related to PSMA ADC, all for the three months ended March 31, 2012 compared to the same period in 2011.

   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Laboratory and manufacturing supplies
 
$         196
 
$         871
 
(77%)

Laboratory and manufacturing supplies decreased due to lower expenses in (i) Oncology ($311), resulting from a decline in manufacturing supplies for PSMA ADC, (ii) Other ($301), and (iii) Relistor ($63), all for the three months ended March 31, 2012 compared to the same period in 2011.

   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Contract manufacturing and subcontractors
 
$         844
 
$      2,930
 
(71%)

Contract manufacturing and subcontractors decreased due to lower expenses for Relistor ($1,894), resulting from a decrease in purchases of subcutaneous Relistor related products, and Other ($312), partially offset by an increase in Oncology ($120), all for the three months ended March 31, 2012 compared to the same period in 2011. These expenses are related to the conduct of clinical trials, including manufacture by third parties of drug materials, testing, analysis, formulation and toxicology services, and vary as the timing and level of such services are required.

   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Consultants
 
$         110
 
$         847
 
(87%)

Consultants expense decreased due to lower expenses for Relistor ($767), primarily related to the sNDA submission for subcutaneous Relistor in non-cancer pain patients, partially offset by higher expenses for Oncology ($17) and Other programs ($13), all for the three months ended March 31, 2012 compared to the same period in 2011. These expenses are related to the monitoring of clinical trials as well as the analysis of data from completed clinical trials and vary as the timing and level of such services are required.

   
Three Months Ended March 31,
   
   
          2012
 
2011
 
Percent
Change
             
License fees
 
$           40
 
$         364
 
(89%)

License fees decreased due to lower expenses for Relistor ($174) and Other ($151), all for the three months ended March 31, 2012 compared to the same period in 2011.

 
18



   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Royalty expense
 
$         185
 
$           57
 
225%

We recognized $185 and $57, respectively, of royalty expenses during the three months ended March 31, 2012 and 2011, due to increased net sales of Relistor in 2012.

   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Other operating expenses
 
$      1,118
 
$      1,921
 
(42%)

Other operating expenses decreased for the three months ended March 31, 2012 compared to the same period in 2011, primarily due to decreases in rent ($737), travel ($41) and other operating expenses ($182), partially offset by increases in facilities ($135) and insurance ($22).

General and Administrative Expenses decreased to $3,721 for the three months ended March 31, 2012 from $5,197 for the same period of 2011, as follows:

   
Three Months Ended March 31,
   
   
          2012
 
2011
 
Percent
Change
             
Salaries and benefits
 
$      1,799
 
$      2,157
 
(17%)

Salaries and benefits decreased for the three months ended March 31, 2012 compared to the same period in 2011, due to a decline in average headcount to 28 from 36, in the general and administrative departments.

   
Three Months Ended March 31,
   
   
            2012
 
2011
 
Percent
Change
             
Share-based compensation
 
$         321
 
$         494
 
(35%)

Share-based compensation decreased due to lower restricted stock expenses and lower employee stock purchase plan expenses, due to the termination of the Company’s employee stock purchase plans in 2011, partially offset by higher stock option expenses, all for the three months ended March 31, 2012 compared to the same period in 2011.

   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Consulting and professional fees
 
$        628
 
$      1,370
 
(54%)

Consulting and professional fees decreased due to lower patent ($335), consulting ($315), audit ($56) and other fees ($70), partially offset by legal fees of $34 incurred in connection with Dr. Maddon’s retirement, all for the three months ended March 31, 2012 compared to the same period in 2011.

   
Three Months Ended March 31,
   
   
            2012
 
2011
 
Percent
Change
             
Other operating expenses
 
$         973
 
$      1,176
 
(17%)

Other operating expenses decreased due to lower expenses for rent ($244), investor relations ($16) and other operating expenses ($81), partially offset by an increase in recruiting ($138), all for the three months ended March 31, 2012 compared to the same period in 2011.

 
19



   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Depreciation and amortization
 
$        472
 
$         536
 
(12%)

Depreciation and amortization expense decreased to $472 for the three months ended March 31, 2012 from $536 for the three months ended March 31, 2011, primarily due to lower machinery and equipment fixed assets balances.

Other income:

   
Three Months Ended March 31,
   
   
           2012
 
2011
 
Percent
Change
             
Interest income
 
$          15
 
$           18
 
(17%)

Interest income decreased to $15 for the three months ended March 31, 2012 from $18 for the three months ended March 31, 2011, due to lower average balance of cash equivalents in 2012 than in 2011.

Income Taxes:

For the three months ended March 31, 2012 and 2011, our pre-tax losses were $13,086 and $22,927, respectively. As a result of the $60,000 Salix upfront cash payment received in 2011, we had taxable income in 2011, which has been offset fully with net operating loss carry-forwards.

Net Loss:

Our net loss was $13,086 for the three months ended March 31, 2012 compared to $22,927 for the same period of 2011.

Liquidity and Capital Resources

We have to date funded operations principally through payments received from private placements of equity securities, public offerings of common stock, collaborations, grants and contracts, royalties, interest on investments, and proceeds from the exercise of outstanding options and warrants.

Under the Salix License Agreement, we received in 2011 a $60,000 upfront cash payment and $225 in respect of Salix ex-U.S. sublicensee revenue and are eligible to receive development and commercialization milestone payments plus royalties on net sales and 60% of any upfront, milestone, reimbursement or other revenue (net of costs of goods sold, as defined, and territory-specific research and development expense reimbursement) Salix receives from ex-U.S. sublicensees.

Our expenses and reimbursement revenue related to Relistor have declined substantially since Salix assumed direct responsibility for expenses under third-party contracts we have assigned to it. Under the Salix License Agreement, we are reimbursed for Salix approved full-time equivalents (FTE) and third-party development expenses incurred and paid by us after February 3, 2011.

At March 31, 2012, we held $56,099 in cash and cash equivalents, a decrease of $14,006 from $70,105 at December 31, 2011. We expect that this amount will be sufficient to fund operations as currently anticipated beyond one year. In addition, at March 31, 2012, our investment in auction rate securities classified as long-term assets on the Consolidated Balance Sheets amounted to $3,240.

We may require additional funding in the future, and if we are unable to enter into favorable collaboration, license, asset sale, capital raising or other financing transactions, we will have to reduce, delay or eliminate spending on some current operations, and/or reduce salary and other overhead expenses, to extend our remaining operations.

Our cash flow from operating activities was negative for the three months ended March 31, 2012, due primarily to the excess of expenditures on our research and development programs and general and administrative costs over cash received from collaborators and government grants to fund such programs, as described below. Our cash flow from operating activities was positive for the three months ended March 31, 2011, due to the receipt in 2011 of a $60,000 Salix upfront payment from Salix, partially offset by expenditures on our research and development programs and general and administrative costs.

 
20



Sources of Cash

Operating Activities. During the three months ended March 31, 2012 we received $1,349 under our collaborations, consisting of (i) $58 in reimbursement payments under the Salix License Agreement, (ii) $1,278 in royalties from Salix and (iii) $13 under the License Agreement with Ono. During the three months ended March 31, 2011, we received $62,716 under our collaborations, consisting of (i) $60,000 Salix upfront cash payment and (ii) $2,716 under the Transition Agreement with Wyeth.

We have partially funded research programs through awards from the NIH. For the three months ended March 31, 2012 and 2011, we received $112 and $1,189, respectively, of revenue from all of our NIH awards. We expect a further decline in the NIH reimbursable expenses for programs we are working to out-license.

Changes in Accounts receivable and Accounts payable for the three months ended March 31, 2012 and 2011 resulted from the timing of receipts from Salix, the NIH, Wyeth and Ono, and payments made to trade vendors in the normal course of business.

Other than amounts to be received from Salix and Ono, we have no committed external sources of capital. Other than revenues from Relistor, we expect no significant product revenues for a number of years, as it will take at least that much time, if ever, to bring our product candidates to the commercial marketing stage.

Investing Activities. Of $56,099 in cash and cash equivalents at March 31, 2012, $50,590 is guaranteed by the U.S. Treasury or Federal Deposit Insurance Corporation’s guarantee program. Our auction rate securities of $3,240 include $2,300 of securities collateralized by student loan obligations subsidized by the U.S. government, $100 of which was redeemed at par during the first quarter of 2012. These investments, while rated investment grade by the Standard & Poor’s and Moody’s rating agencies and predominantly having scheduled maturities greater than ten years, are heavily concentrated in the U.S. financial sector. During the first quarter of 2012, proceeds from sales of fixed assets were $124.

Financing Activities. During the three months ended March 31, 2012 and 2011, we received cash of $82 and $1,272, respectively, from the exercise of stock options and, in 2011, from the sale of our common stock under our employee stock purchase plan. The amount of cash we receive from these sources fluctuates commensurate with headcount levels and changes in the price of our common stock on the grant date for options exercised, and on the sale date for shares sold under the employee stock purchase plan.

Unless we obtain regulatory approval from the FDA for additional product candidates and/or enter into agreements with corporate collaborators with respect to our additional technologies, we will be required to fund our operations in the future through sales of common stock or other securities, royalty or other financing agreements and/or grants and government contracts. Adequate additional funding may not be available to us on acceptable terms or at all. Our inability to raise additional capital on terms reasonably acceptable to us may seriously jeopardize the future success of our business.

Uses of Cash

Operating Activities. The majority of our cash has been used to advance our research and development programs. Our expenses for research and development for the three months ended March 31, 2012 and 2011 were $11,134 and $19,600, respectively. Included in the 2012 period is $2,022 of cash disbursements incurred in connection with Vice Chairman Paul Maddon’s first quarter retirement agreement. For various reasons, including the early stage of certain of our programs, the timing and results of our clinical trials, our dependence in certain instances on third parties, many of which are outside of our control, we cannot estimate the total remaining costs to be incurred and timing to complete all our research and development programs.

We may require additional funding to continue our research and product development programs, conduct pre-clinical studies and clinical trials, fund operating expenses, pursue regulatory approvals for our product candidates, file and prosecute patent applications and enforce or defend patent claims, if any, and fund product in-licensing and any possible acquisitions.

Investing Activities. During the three months ended March 31, 2012 and 2011, we have spent $518 and $29, respectively, on capital expenditures.

 
21



Contractual Obligations

Our funding requirements, both for the next 12 months and beyond, will include required payments under operating leases and fixed and contingent payments under our licensing and collaboration agreements. The following table summarizes our contractual obligations as of March 31, 2012 for future payments under these agreements:

         
Payments due by March 31,
 
   
Total
   
2013
      2014-2015       2016-2017    
Thereafter
 
   
(in millions)
 
Operating leases
  $ 22.4     $ 2.5     $ 4.8     $ 5.0     $ 10.1  
License and collaboration agreements:
                                       
Fixed payments
    2.2       0.3       0.4       0.6       0.9  
Contingent payments (1)
    84.7       2.3       2.4       -       80.0  
Total
  $ 109.3     $ 5.1     $ 7.6     $ 5.6     $ 91.0  
_______________
 
(1)  
Based on assumed achievement of milestones covered under each agreement, the timing and payment of which is highly uncertain.

We periodically assess the scientific progress and merits of each of our programs to determine if continued research and development is commercially and economically viable. Certain of our programs have been terminated due to the lack of scientific progress and prospects for ultimate commercialization. Because of the uncertainties associated with research and development in these programs, the duration and completion costs of our research and development projects are difficult to estimate and are subject to considerable variation. Our inability to complete research and development projects in a timely manner or failure to enter into collaborative agreements could significantly increase capital requirements and adversely affect our liquidity.

Our cash requirements may vary materially from those now planned because of results of research and development and product testing, changes in existing relationships or new relationships with licensees, licensors or other collaborators, changes in the focus and direction of our research and development programs, competitive and technological advances, the cost of filing, prosecuting, defending and enforcing patent claims, the regulatory approval process, manufacturing and marketing and other costs associated with the commercialization of products following receipt of regulatory approvals and other factors.

The above discussion contains forward-looking statements based on our current operating plan and the assumptions on which it relies. There could be deviations from that plan that would consume our assets earlier than planned.

Off-Balance Sheet Arrangements and Guarantees

We have no obligations under off-balance sheet arrangements and do not guarantee the obligations of any other unconsolidated entity.

Critical Accounting Policies

We prepare our financial statements in conformity with accounting principles generally accepted in the United States of America. Our significant accounting policies are disclosed in Note 2 to our consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2011. The selection and application of these accounting principles and methods requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses, as well as certain financial statement disclosures. On an ongoing basis, we evaluate our estimates. We base our estimates on historical experience and on various other assumptions that are believed to be reasonable under the circumstances. The results of our evaluation form the basis for making judgments about the carrying values of assets and liabilities that are not otherwise readily apparent. While we believe that the estimates and assumptions we use in preparing the financial statements are appropriate, these estimates and assumptions are subject to a number of factors and uncertainties regarding their ultimate outcome and, therefore, actual results could differ from these estimates.

There have been no other changes to our critical accounting policies and estimates as of and for the three months ended March 31, 2012, which are disclosed in Management’s Discussion and Analysis of Financial Condition and Results of Operations included in our 2011 Annual Report on Form 10-K.

 
22



Item 3.  Quantitative and Qualitative Disclosures about Market Risk (amounts in thousands unless otherwise noted)
 
Our primary investment objective is to preserve principal. Our money market funds and auction rate securities have interest rates that were variable and totaled $53,422 at March 31, 2012. As a result, we do not believe that these investment balances have a material exposure to interest-rate risk.

At March 31, 2012, we continue to hold approximately $3,240 (6.1% of assets measured at fair value) of auction rate securities, in respect of which we have received all scheduled interest payments. The principal amount of these remaining auction rate securities will not be accessible until the issuer calls or restructures the underlying security, the underlying security matures and is paid or a buyer outside the auction process emerges.

We continue to monitor the market for auction rate securities and consider the impact, if any, of market conditions on the fair market value of our investments. We believe that the failed auctions experienced to date are not a result of the deterioration of the underlying credit quality of these securities, although valuation of them is subject to uncertainties that are difficult to predict, such as changes to credit ratings of the securities and/or the underlying assets supporting them, default rates applicable to the underlying assets, underlying collateral value, discount rates, counterparty risk, ongoing strength and quality of market credit and liquidity, and general economic and market conditions. We do not believe the carrying values of these auction rate securities are other than temporarily impaired and therefore expect the positions will eventually be liquidated without significant loss.

The valuation of the auction rate securities we hold is based on an internal analysis of timing of expected future successful auctions, collateralization of underlying assets of the security and credit quality of the security. We re-evaluated the valuation of these securities as of March 31, 2012 and the temporary impairment amount decreased $8 from $268 at December 31, 2011 to $260. A 100 basis point increase to our internal analysis would result in a $35 increase in the temporary impairment of these securities as of the three months ended March 31, 2012.

Item 4.  Controls and Procedures

We maintain disclosure controls and procedures, as such term is defined under Rules 13a-15(e) and 15d-15(e) promulgated under the U.S. Securities Exchange Act of 1934, that are designed to ensure that information required to be disclosed in our Exchange Act reports is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our Chief Executive Officer (CEO) and Chief Financial Officer (CFO), as appropriate, to allow timely decisions regarding required disclosures. In designing and evaluating the disclosure controls and procedures, management recognized that any controls and procedures, no matter how well designed and operated, can only provide reasonable assurance of achieving the desired control objectives, and in reaching a reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures. We have a Disclosure Committee consisting of certain members of our senior management which monitors and implements our policy of disclosing material information concerning the Company in accordance with applicable law.

The Disclosure Committee, under the supervision and with the participation of our senior management, including our CEO and CFO, carried out an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the period covered by this report. Based upon their evaluation and subject to the foregoing, the CEO and CFO concluded that our disclosure controls and procedures, as designed and implemented, were effective at the reasonable assurance level.

There have been no changes in our internal control over financial reporting that occurred during our last fiscal quarter that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

PART II — OTHER INFORMATION

Item 1A. Risk Factors

 
Our business and operations entail a variety of serious risks and uncertainties, including those described in Item 1A of our Form 10-K for the year ended December 31, 2011 and our other public reports.
 

 
23


Item 6. Exhibits

(a)           Exhibits

Exhibit
 Number
Description
   
   
10‡
Retirement Agreement, dated as of March 14, 2012, between the Registrant and Paul J. Maddon.
 
12.1
Statement re computation of ratio of earnings (loss) to combined fixed charges and preferred stock dividends.
   
31.1
Certification of Mark R. Baker, Chief Executive Officer of the Registrant, pursuant to Rule 13a-14(a) and Rule 15d-14(a) under the Securities Exchange Act of 1934, as amended.
   
31.2
Certification of Robert A. McKinney, Chief Financial Officer, Senior Vice President, Finance and Operations of the Registrant, pursuant to Rule 13a-14(a) and Rule 15d-14(a) under the Securities Exchange Act of 1934, as amended.
   
32
Certification of the Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
   
101
Interactive Data File
   
101.INS
XBRL Instance Document
   
101.SCH
XBRL Taxonomy Extension Schema
   
101.CAL
XBRL Taxonomy Extension Calculation Linkbase
   
101.LAB
XBRL Taxonomy Extension Label Linkbase
   
101.PRE
XBRL Taxonomy Extension Presentation Linkbase
   
101.DEF
XBRL Taxonomy Extension Definition Document
   
Management contract or compensatory plan or arrangement.
   

 
24




Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 
PROGENICS PHARMACEUTICALS, INC.
Date: May 8, 2012
By:
/s/ Robert A. McKinney
   
Robert A. McKinney
(Chief Financial Officer
Senior Vice President, Finance & Operations and Principal Financial and Accounting Officer)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
25


EX-10 2 ex1003312012.htm PROGENICS EXHIBIT 10 03/31/2012 ex1003312012.htm

 
Exhibit 10
 
RETIREMENT AGREEMENT
 
RETIREMENT AGREEMENT (“Agreement”), dated as of March 14, 2012, by and between Progenics Pharmaceuticals, Inc. (the “Corporation”) and Paul J. Maddon (“Maddon”) (each a “Party,” and together, the “Parties”).
 
WHEREAS, Maddon is a long-service and highly valued employee of the Corporation and has served as a member of the Corporation’s Board of Directors (the “Board”) since the Corporation’s inception;
 
WHEREAS, Maddon has elected to retire as an employee of the Corporation;
 
WHEREAS, the Corporation desires to recognize Maddon’s significant contributions by providing the Retirement Benefits set forth below and desires to continue to benefit from Maddon’s experience and professional expertise through his continued services as a member of the Board;
 
NOW, THEREFORE, in consideration of the covenants and conditions set forth herein and other good and valuable consideration, the receipt and sufficiency of which the Parties hereby acknowledge, the Parties, intending to be legally bound, hereby agree as follows:
 
   1.   Resignation as Chief Science Officer.  As of the date hereof (the “Effective Date”), Maddon shall resign as the Corporation’s Chief Science Officer.  For the avoidance of doubt, Maddon’s resignation as the Corporation’s Chief Science Office is voluntary and shall not constitute “Good Reason” within the meaning of Section 8.3 of the employment agreement between Maddon and the Corporation dated as of December 31, 2007, as amended on March 31, 2011 (the “Employment Agreement”).
 
   2.   Continued Employment through June 13, 2012.  During the period beginning on the Effective Date and continuing through June 13, 2012 (the “Retirement Date”), Maddon will (a) continue to be employed on a full-time basis by the Corporation, (b) continue to receive his base salary at the rate in effect as of the Effective Date, (c) continue to be eligible for the pension and welfare benefits at the same level and on the same terms in effect as of the Effective Date, (d) remain a member of the Board and (e) remain a Vice Chairman of the Board.  For the avoidance of doubt, the Retirement Date shall be the last day of Maddon’s employment with the Corporation.
 
   3.   Continuing Service after June 13, 2012.  From and after the Retirement Date, Maddon will continue to serve as a member of the Board and be a Vice Chairman of the Board subject to his re-election to the Board and the Corporation’s charter, by-laws and other applicable requirements, without restriction or liability except as specifically provided in Section 4(c) this Agreement.  As a non-employee director, Maddon will receive standard non-employee director compensation, including the Corporation’s standard equity award grants, subject to the terms of the Corporation’s non-employee director compensation policy as in effect from time to time.  Maddon agrees that, after the Retirement Date while he is a member of the Board, he will make himself reasonably available to participate in executive meetings as reasonably requested by the Corporation’s Chief Executive Officer.
 


 
 

 


 
 
   4.   Retirement Benefits.  In connection with Maddon’s retirement and the ending of his employment relationship with the Corporation on the Retirement Date, the Corporation shall pay and provide to Maddon, and Maddon shall only be entitled to, the following payments and benefits, subject to his compliance with Section 6:
 
(a) payment of an amount equal to $1,789,333 in cash (less applicable withholdings), which shall be paid to Maddon within five (5) calendar days following the Release Effective Date as defined in Appendix A (the “Payment Date”);
 
(b) any equity awards that are unvested as of the Retirement Date that were granted before March 31, 2011 will become fully vested with respect to options and nonforfeitable with respect to restricted stock, effective immediately upon the Release Effective Date, and the exercise period with respect to Maddon’s options shall extend until the date the option expires as set forth in each respective option award.
 
(c) any equity awards that are unvested as of the Retirement Date that were granted on or after March 31, 2011 will continue to vest in accordance with their terms so long as Maddon continues to serve on the Board; provided, and notwithstanding anything to the contrary in any policies, equity award documents or otherwise, in the event Maddon ceases to serve on the Board for any reason other than Maddon’s resignation from the Board, any unvested portion of any options granted to Maddon shall become fully vested and restricted stock grants shall become nonforfeitable effective upon the last day of Maddon’s Board service and the exercise period with respect to Maddon’s options shall extend until the date the option expires as set forth in each respective option award;
 
(d) Maddon shall receive an annual incentive bonus for the Corporation’s 2011 fiscal year in the amount of $150,000 on the Payment Date (and, for the avoidance of doubt, Maddon shall not be eligible to receive any bonus for the Corporation’s 2012 fiscal year);
 
(e) Within five (5) calendar days following the Retirement Date, Maddon shall be entitled to receive any salary, expense reimbursements or other amounts from the Corporation then due but unpaid as of the Retirement Date, which in the case of the salary shall be prorated to the date of termination, and in the case of other accrued but unpaid vacation, expense reimbursement or other benefits shall each be provided pursuant to the applicable Corporation policy; provided that, notwithstanding anything to the contrary in the Company’s policy, Maddon’s final accrued vacation shall be calculated based on his carryover of up to a maximum of four weeks of unused vacation, as substantiated by Maddon and approved by the Corporation’s Chief Financial Officer;
 
(f) for the period beginning on the Retirement Date and ending on the second anniversary of the Retirement Date, Maddon shall be entitled to continue to receive the Welfare Benefits (as defined in the Employment Agreement) which Maddon actually received as of the Effective Date; provided, that at the Corporation’s sole discretion, the Corporation may pay Maddon the Welfare Cash Equivalent (as defined in the Employment Agreement) of the Welfare Benefits;
 

 
 
2

 


 
(g) the Corporation shall provide Maddon with access to appropriate office space in the Innovation Center that is not materially less favorable than the office space provided to other senior executives and continued secretarial and administrative support through December 31, 2012.  Maddon (1) shall be permitted to retain the cell phone and home computer provided to him in connection with his employment and will remain on the company’s cell phone plan until December 31, 2012, provided that Maddon shall be responsible for transferring his cell phone number to a personal account effective January 1, 2013, and (2) will have access to the Company’s email system until December 31, 2012, provided that on or before such date, Maddon will transfer his personal files and other electronic information to a non-Company email account; notwithstanding the foregoing, if, prior to December 31, 2012, the Board determines that Maddon has engaged in activity that constitutes “Cause” as defined in Section 8.1.3 of the Employment Agreement, then the Corporation’s obligations pursuant to this Section 4(g) shall cease as of the date of such determination;
 
(h) the Corporation shall reimburse Maddon up to $7,500 for the legal fees he has incurred in connection with the negotiation and execution of this Agreement, subject to Maddon’s submission of appropriate expense documentation in accordance with the Corporation’s reimbursement policies in effect as of the Effective Date; and
 
(i) except as set forth in this Agreement, Maddon agrees that he shall not be entitled to any other remuneration under the Employment Agreement or otherwise.
 
    5.   Nondisparagement.  Maddon agrees, and the Corporation agrees that its Board members and senior executives with a title of senior vice president or higher shall not make any statement, orally or in writing, which disparages or criticizes the reputation of Maddon, on the one hand, or the Corporation, any of its Board members or executive officers on the other hand, except, in either case, as required by law or an order of a court or governmental agency with jurisdiction.
 
   6.   Mutual Release Required.  The Corporation shall not be required to make or provide, and Maddon shall not be entitled to receive, the payments and benefits stated in Section 4 (other than the payments and benefits in Section 4(e)) unless (1) Maddon executes and delivers to the Corporation the mutual release agreement set forth in Appendix A (“Mutual Release”) and (2) the Release Effective Date for such Mutual Release occurs on or prior to the fifty-fifth (55th) calendar day following the Retirement Date.  If Maddon does not execute the Release or the Mutual Release Effective Date does not occur on or prior to the fifty-fifth (55th) day following the Retirement Date, then the Corporation shall not be required to make any of the payments or provide any of the benefits set forth in Section 4 (other than the payments and benefits in Section 4(e)).  As a material condition of this Agreement, of the Mutual Release and of Maddon’s obligations to the Corporation, the Company shall execute and deliver to Maddon the Mutual Release no later than five (5) calendar days after Maddon’s execution of the Mutual Release.
 
   7.   Continuing Employment Agreement Obligations.  The Parties will continue to be bound by the terms of Employment Agreement Section 9.1 (“Non-Disclosure of Confidential Information”), Section 9.3 (regarding employee non-solicitation), Section 10 (“Proprietary Information”), Section 12 (“Indemnification and Insurance”), and Section 17 (“Adverse Public Statements and Disclosures”), in each case, in accordance with the terms set forth in the Employment Agreement, provided, that Employment Agreement Section 12 shall only apply to Maddon in his capacity as a senior executive through the Retirement Date, and after the Retirement Date and for so long as Maddon continues to serve on the Board, Maddon will be provided with the same indemnification provisions and directors and officers insurance as that which is provided to other directors.
 

 
 
3

 


 
 
   8.   No Setoff.  For the avoidance of doubt, Maddon is not required to seek other employment or to attempt in any way to reduce any amounts payable to him by the Corporation pursuant to this Agreement.  Furthermore, the amount of any payment or benefit provided for in this Agreement shall not be reduced by any compensation earned by Maddon or benefit provided to him as the result of employment by another employer or otherwise.  In addition, the amounts payable hereunder shall not be subject to setoff, counterclaim, recoupment, defense or any other right which the Corporation may have against Maddon or others, except upon obtaining by the Corporation of a final nonappealable judgment against Maddon.
 
   9.   Entire Agreement.  This Agreement contains the entire agreement between the Parties with respect to the subject matter hereof and supersedes all prior agreements, written or oral, with respect thereto, provided, that Employment Agreement Section 9.1 (“Non-Disclosure of Confidential Information”), Section 9.3 (regarding employee non-solicitation), Section 10 (“Proprietary Information”), Section 12 (“Indemnification and Insurance”) to the extent set forth above in Section 7 above, Section 13 (“Remedies”), Section 14 (“Transfer and Assignment”), Section 15, (“Modifications”), Section 16 (“Notices”), Section 17 (“Adverse Public Statements and Disclosures”), Section 18 (“Waiver and Breach”), Section 19 (“Governing Law and Jury Trial”), Section 20 (“Severability”) and Section 22 (“Section 409A of the Internal Revenue Code”) are expressly incorporated herein, and shall be deemed to refer to this Agreement, mutatis mutandis and the Indemnification Agreement entered into between the Corporation and Maddon dated January 1, 2007 (the “Indemnification Agreement”) shall remain in full force and effect.  Except with respect to Employment Agreement provisions incorporated herein by express reference, which several provisions shall continue in full force and effect, the Employment Agreement shall terminate upon the Effective Date.  Maddon’s equity grants shall be governed by applicable stock plans and agreements; provided no options or restricted stock shall be subject to any limitations under any stock plan or otherwise in the post-employment period during which such options shall vest and be exercised or restricted stock may be outstanding, except as provided herein.  No modification, amendment or waiver of all or any part of this Agreement will be valid unless made in writing and signed by the Parties.
 
[Signatures on next page]

 
 
4

 

IN WITNESS WHEREOF, the Parties hereto, intending to be legally bound hereby, have executed this Agreement as of the day and year first above mentioned.
 
 
MADDON
 
____________________________________
Paul J. Maddon
 
THE CORPORATION
 
By:_________________________________
 
For Progenics Pharmaceuticals, Inc.

 
 
5

 
APPENDIX A



MUTUAL RELEASE
 
MUTUAL RELEASE (this “Mutual Release”) is entered into by  Paul J. Maddon (“Maddon”) in favor of Progenics Pharmaceuticals, Inc. (the “Corporation”), its subsidiaries, affiliates, officers, directors, executives, members, attorneys and agents and their predecessors, successors and assigns, individually and in their official capacities (together, the “Corporation Released Parties”) and in favor of Maddon and his heirs, executors, and administrators, (together the “Maddon Released Parties”).
 
WHEREAS, Maddon and the Corporation are seeking benefits under the Retirement Agreement between the Parties, dated March 14, 2012 (the “Retirement Agreement”), that are conditioned on the effectiveness of this Mutual Release.
 
NOW, THEREFORE, in consideration of the covenants and agreements hereinafter set forth, the parties agree as follows:
 
   1.   Mutual Release
 
(a) Maddon knowingly and voluntarily waives, terminates, cancels, releases and discharges forever the Corporation Released Parties from any and all actions, causes of action, claims, allegations, rights, obligations, liabilities, or charges (collectively, “Claims”) that he (or his heirs, executors, administrators, successors and assigns) has or may have, whether known or unknown, by reason of any matter, cause or thing occurring at any time before and including the date of this Mutual Release arising under or in connection with Maddon’s employment or termination of employment with the Corporation and its affiliates (together, as constituted from time to time, the “Group”), including, without limitation:  claims for compensation or bonuses, whether or not paid under any compensation plan or arrangement; breach of contract; tort; wrongful, abusive, unfair, constructive, or unlawful discharge or dismissal; impairment of economic opportunity; defamation; age and national origin discrimination; sexual harassment; back pay; front pay; benefits; attorneys’ fees; whistleblower claims; emotional distress; intentional infliction of emotional distress; assault; battery, pain and suffering; punitive or exemplary damages; violations of the Equal Pay Act, Title VII of the Civil Rights Act of 1964, the Civil Rights Act of 1991, the Age Discrimination in Employment Act of 1967 (“ADEA”), the Americans with Disabilities Act of 1991, the Employee Retirement Income Security Act, the Worker Adjustment Retraining and Notification Act, the Family Medical Leave Act, including all amendments to any of the aforementioned acts; and violations of any other federal, state, or municipal fair employment statutes or laws, including, without limitation, violations of any other law, rule, regulation, or ordinance pertaining to employment, wages, compensation, hours worked, or any other matters related in any way to Maddon’s employment with the Group or the termination of that employment.  In addition, in consideration of the provisions of this Mutual Release, Maddon further agrees to waive any and all rights under the laws of any jurisdiction in the United States, or any other country, that limit a general Mutual Release to those claims that are known or suspected to exist in Maddon’s favor as of the Release Effective Date (as defined below).
 
 
 
 
 


 
 

 

 
 
(b) The Corporation, on behalf of each of the Corporation Released Parties, knowingly and voluntarily waives, terminates, cancels, releases and discharges forever the Maddon Released Parties from any and all actions, causes of action, claims, allegations, rights, obligations, liabilities, or charges (collectively, “Claims”) that any Corporation Released Parties has or may have, whether known or unknown, by reason of any matter, cause or thing occurring at any time before and including the date of this Mutual Release arising under or in connection with Maddon’s employment or termination of employment with the Group including, without limitation, claims for any matters related in any way to Maddon’s employment with the Group or the termination of that employment; provided, however, that the foregoing release shall not apply to any claims of fraud (including any fraud or falsification related to financial statements or scientific results) or other conduct that satisfies the elements of a criminal offense (the “Excepted Claims”).  The Compensation Committee of the Board has no knowledge or reason to believe that any Corporation Released Party has any Excepted Claim against Maddon.  In addition, in consideration of the provisions of this Mutual Release, the Corporation further agrees to waive any and all rights under the laws of any jurisdiction in the United States, or any other country, that limit a general release to those claims that are known or suspected to exist in any Corporation Released Party’s favor as of the Release Effective Date.
 
   2.   Surviving Claims.  Notwithstanding anything herein to the contrary, this Mutual Release shall not:
 
                         2.1  
release any Claims arising after the date of this Mutual Release;
 
                         2.2  
limit or prohibit in any way Maddon’s (or his beneficiaries’ or legal representatives’) or the Corporation’s ability to bring an action to enforce the terms of this Mutual Release;
 
                         2.3  
release any claim for continuation of benefits under the law known as COBRA or for employee benefits under plans covered by the Employee Retirement Income Security Act of 1974, as amended, to the extent that such claims may not lawfully be waived or for any payments or benefits under any plans of the Group that have vested according to the terms of those plans;
 
                         2.4  
waive any rights under the stock plan(s) or related agreements governing Maddon’s equity awards;
 
                         2.5  
release any claims for payment or benefits under the Retirement Agreement; or
 
                         2.6  
release any claims under the Indemnification Agreement (as defined in the Retirement Agreement) or for indemnification in accordance with applicable laws and the corporate governance documents of the Corporation or any other member of the Group, including any right to contribution, in accordance with their terms as in effect from time to time or pursuant to any applicable directors and officers insurance policy including, without limitation, with respect to any liability incurred by Maddon as an officer or director of the Corporation or any member of the Group or any right Maddon may have to obtain contribution as permitted by law in the event of entry of judgment.
 
   3.   Additional Representations.  The Parties further represent and warrant that he/it has not filed any civil action, suit, arbitration, administrative charge, or legal proceeding against any Released Party nor has he/it assigned, pledged, or hypothecated as of the Release Effective Date his claim to any person and no other person has an interest in the claims that he is releasing.
 

 

 
2

 


 
 
   4.   Acknowledgements by Maddon.  Maddon acknowledges and agrees that he has read this Mutual Release in its entirety and that this Mutual Release is a general release of all known and unknown claims, including, without limitation, to rights and claims arising under ADEA.  Maddon further acknowledges and agrees that:
 
                         4.1  
this Mutual Release does not release, waive or discharge any rights or claims that may arise for actions or omissions after the date of this Mutual Release;
 
                         4.2  
Maddon is entering into this Mutual Release and releasing, waiving and discharging rights or claims only in exchange for consideration which he is not already entitled to receive;
 
                         4.3  
Maddon has been advised, and is being advised by the Corporation, to consult with an attorney before executing this Mutual Release; Maddon acknowledges that he has consulted with counsel of his choice concerning the terms and conditions of this Mutual Release;
 
                         4.4  
Maddon has been advised, and is being advised by this Mutual Release, that he has forty-five (45) calendar days within which to consider the Mutual Release; and
 
                         4.5  
Maddon is aware that this Mutual Release shall become null and void if he revokes his agreement to this Mutual Release within seven (7) calendar days following the date of execution of this Mutual Release.  Maddon may revoke this Mutual Release at any time during such seven-day period by delivering (or causing to be delivered) to each of the notice parties set forth in the Employment Agreement written notice of his revocation of this Mutual Release no later than 5:00 p.m. eastern time on the seventh (7th) full calendar day following the date of execution of this Mutual Release (the “Revocation Period”).  If Maddon revokes during the Revocation Period and the Corporation has signed this Mutual Release, the Corporation’s signature shall become void ab initio and of no force or effect.  This Mutual Release shall become effective on the next business day after the Revocation Period, provided it is signed by Maddon and the Corporation and it is not revoked by Maddon during the Revocation Period (the “Release Effective Date”).  Maddon agrees and acknowledges that a letter of revocation that is not received during the Revocation Period will be invalid and will not revoke this Mutual Release.
 

 

 
3

 


 
 
   5.   Additional Agreements.  Maddon agrees that should any person or entity file or cause to be filed any civil action, suit, arbitration, or other legal proceeding seeking equitable or monetary relief concerning any claim released by Maddon herein, Maddon shall not seek or accept any personal relief from or as the result of such civil action, suit, arbitration, or other legal proceeding.  If a Corporation Released Party whom Maddon has released pursuant to Section 1(a) commences a Claim against Maddon and the release therein is deemed ineffective with respect to that Corporation Released Party because the Corporation was not empowered to release Claims on that person’s or entity’s behalf, then the release Maddon provided pursuant to Section 1(a) will not be effective solely with respect to the Corporation Released Party commencing such Claim.  For the avoidance of doubt, (i) Maddon’s release in favor of the Corporation, its subsidiaries and the Corporation Released Parties other than the Corporation Released Party commencing such Claim shall at all times remain in full force and effect, (ii) nothing herein shall be construed to affect the validity or enforceability of Sections 1 (a) or (b) and (iii) under no circumstances shall Maddon's release in favor of the Corporation and its subsidiaries ever be impacted by an action brought by another Corporation Released Party.
 
   6.   Governing Law.  To the extent not subject to federal law, this Mutual Release will be governed by and construed in accordance with the law of the State of New York applicable to contracts made and to be performed entirely within that state.
 
   7.   Captions; Section Headings.  Captions and section headings used herein are for convenience only and are not a part of this Mutual Release and shall not be used in construing it.
 
   8.   Counterparts; Facsimile Signatures.  This Mutual Release may be executed in any number of counterparts, each of which when so executed and delivered shall be deemed an original instrument without the production of any other counterpart.  Any signature on this Mutual Release delivered by either party by facsimile transmission shall be deemed to be an original signature thereto.
 
[Signatures on next page]

 

 
4

 


IN WITNESS WHEREOF, Maddon has executed this Mutual Release on _______________, 2012.
 
MADDON



_____________________________________
Paul J. Maddon


Accepted and Agreed:

THE CORPORATION



By:           _______________________________
For Progenics Pharmaceuticals, Inc.

 
 
 
 
 
5
 
 
EX-12.1 3 ex12_103312012.htm PROGENICS EXHIBIT 12.1 03/31/2012 ex12_103312012.htm


Exhibit 12.1
 
Progenics Pharmaceuticals, Inc.
Ratio of Earnings (Loss) to Combined Fixed Charges and Preferred Stock Dividends
(in thousands)
 
   
Three Months
Ended
March 31,
   
Years Ended December 31,
 
   
2012
   
2011
   
2010
   
2009
   
2008
   
2007
 
Determination of earnings (loss):
                                   
Income (loss) from operations
  $ (13,086 )   $ 10,381     $ (69,820 )   $ (30,612 )   $ (44,672 )   $ (43,688 )
Add:
                                               
Fixed charges
    17       695       709       555       594       483  
                                                 
Earnings (loss), as adjusted
  $ (13,069 )   $ 11,076     $ (69,111 )   $ (30,057 )   $ (44,078 )   $ (43,205 )
                                                 
Fixed charges:
                                               
                                                 
Estimate of interest within rental expense
    17       695       709       555       594       483  
                                                 
Fixed charges
  $ 17     $ 695     $ 709     $ 555     $ 594     $ 483  
                                                 
Preferred stock dividends
  $ -     $ -     $ -     $ -     $ -     $ -  
                                                 
                                                 
Ratio of earnings (loss) to fixed charges and preferred stock dividends
    *       16       *       *       *       *  
Coverage deficiency amount for total fixed charges and preferred stock dividends (1)
  $ 13,086     $ -     $ 69,820     $ 30,612     $ 44,672     $ 43,688  
________________
(1)
For the years ended 2007 through 2010 and for the three months ended March 31, 2012, the Company’s coverage ratio is less than one-to-one and it must generate additional earnings of these specified amounts to achieve a coverage ratio of 1:1.


EX-31.1 4 ex31_103312012.htm PROGENICS EXHIBIT 31.1 03/31/2012 ex31_103312012.htm

Exhibit 31.1

CERTIFICATION
PURSUANT TO RULE 13a-14(a) AND RULE 15d-14(a) UNDER THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED

I, Mark R. Baker, certify that:

1.
I have reviewed this quarterly report on Form 10-Q of Progenics Pharmaceuticals, Inc.;

2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.
The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 
a)
designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant is made known to us by others within the registrant, particularly during the period in which this report is being prepared;

 
b)
designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 
c)
evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 
d)
disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.
The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s independent registered public accounting firm and the audit committee of the registrant’s board of directors (or persons performing the equivalent function):

 
a)
all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

 
b)
any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 
/s/ Mark R. Baker
Date: May 8, 2012
Mark R. Baker
Chief Executive Officer (Principal Executive Officer)



EX-31.2 5 ex31_203312012.htm PROGENICS EXHIBIT 31.2 03/31/2012 ex31_203312012.htm

Exhibit 31.2

CERTIFICATION
PURSUANT TO RULE 13a-14(a) AND RULE 15d-14(a) UNDER THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED

I, Robert A. McKinney, certify that:

1.
I have reviewed this quarterly report on Form 10-Q of Progenics Pharmaceuticals, Inc.;

2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.
The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 
a)
designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant is made known to us by others within the registrant, particularly during the period in which this report is being prepared;

 
b)
designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 
c)
evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 
d)
disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.
The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s independent registered public accounting firm and the audit committee of the registrant’s board of directors (or persons performing the equivalent function):

 
a)
all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

 
b)
any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 
/s/ Robert A. McKinney
Date: May 8, 2012
Robert A. McKinney
Chief Financial Officer
Senior Vice President, Finance & Operations (Principal Financial Officer)



EX-32 6 ex3203312012.htm PROGENICS EXHIBIT 32 03/31/2012 ex3203312012.htm

Exhibit 32
 
CERTIFICATION PURSUANT
 
TO 18 U.S.C. SECTION 1350,
 
AS ADOPTED PURSUANT TO
 
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
 
Each of the undersigned hereby certifies, in his capacity as an officer of Progenics Pharmaceuticals, Inc. (the “Company”), for the purposes of 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to his knowledge:
 
(1)
The Quarterly Report of the Company on Form 10-Q for the period ended March 31, 2012 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
 
(2)
The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
Date: May 8, 2012
 
/s/ Mark R. Baker
 
Mark R. Baker
Chief Executive Officer (Principal Executive Officer)
 
   
   
 
 
/s/ Robert A. McKinney
 
Robert A. McKinney
Chief Financial Officer
(Principal Finance and Accounting Officer)

 
A signed original of this written statement required by Section 906, or other document authenticating, acknowledging, or otherwise adopting the signature that appears in typed form within the electronic version of this written statement required by Section 906, has been provided to Progenics Pharmaceuticals, Inc. and will be retained by Progenics Pharmaceuticals, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.
 







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("Progenics," "we" or "us") is dedicated to the development of innovative medicines to treat disease. In 2011, we licensed our first commercial product, <font style="DISPLAY: inline; FONT-WEIGHT: bold">Relistor</font><font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top; FONT-WEIGHT: bold">&#65533;</font> (methylnaltrexone bromide) subcutaneous injection, to Salix Pharmaceuticals, Inc., a leading gastrointestinal disease specialty company. Salix is marketing Relistor directly through its specialty sales force in the U.S. and sublicensing the drug to regional companies elsewhere except Japan, where we have previously licensed to Ono Pharmaceutical Co., Ltd. the subcutaneous formulation of the drug. In addition to the FDA-approved indication for advanced illness patients, the&#160;U.S. Prescription Drug User Fee Act (PDUFA) action date&#160;for Salix's pending supplemental New Drug Application (sNDA) for subcutaneous Relistor in non-cancer pain patients is now July 27, 2012. We and Salix also announced in December 2011 successful top-line data from the ongoing phase 3 trial of oral methylnaltrexone in non-cancer pain patients. Our current principal sources of revenue from operations are upfront, commercialization milestone, royalty and revenue-sharing payments from Salix's Relistor operations.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Progenics also has proprietary research and development programs for drug candidates focused on oncology. Our principal product candidate is <font style="DISPLAY: inline; FONT-WEIGHT: bold">PSMA ADC</font>, a fully human monoclonal antibody-drug conjugate (ADC) directed against prostate specific membrane antigen (PSMA), a protein found at high levels on the surface of prostate cancer cells and also on the neovasculature of a number of other types of solid tumors. We expect that the ongoing phase 1 trial of PSMA ADC will be completed in 2012 and if the results are successful we plan to commence a phase 2 trial of PSMA ADC in advanced prostate cancer.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">We are also conducting preclinical development work on novel multiplex phosphoinositide 3-kinase (<font style="DISPLAY: inline; FONT-WEIGHT: bold">PI3K</font>) inhibitors that may be effective in blocking signaling pathways that are critical in the growth of aggressive cancers. We are seeking to in-license or acquire opportunities in the oncology field and supportive, diagnostic and/or other areas complementary to these ongoing and prospective initiatives. As we have expanded our focus on oncology, we have terminated certain research efforts not within the Company's oncology focus, and are working to out-license others, such as our PRO 140 and <font style="FONT-STYLE: italic; DISPLAY: inline">C.difficile</font> programs.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">Progenics commenced principal operations in 1988, became publicly traded in 1997 and throughout has been engaged primarily in research and development efforts, establishing corporate collaborations and related activities. All of our operations are conducted at our facilities in Tarrytown, New York.</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline; FONT-WEIGHT: bold">Relistor</font> (methylnaltrexone bromide) subcutaneous injection is a first-in-class therapy for opioid-induced constipation (OIC) which we developed over the course of the last decade and since 2008 has been approved for sale in the United States and over 50 other countries worldwide, including countries in the European Union, Canada and Australia. Marketing applications are pending elsewhere throughout the world. Under our License Agreement, Salix is responsible for further developing and commercializing subcutaneous Relistor, including completing clinical development necessary to support regulatory marketing approvals for potential new indications and formulations of the drug. We have received under this Agreement a $60.0 million upfront cash payment and $0.2 million in respect of Salix ex-U.S. sublicensee revenue, and are eligible to receive (i) up to $40.0 million upon U.S. marketing approval for subcutaneous Relistor in non-cancer pain patients, (ii) up to $50.0 million upon U.S. marketing approval of an oral formulation of Relistor, (iii) up to $200.0 million of commercialization milestone payments upon achievement of specified U.S. sales targets, (iv) royalties ranging from 15 to 19 percent of net sales by Salix and its affiliates, and (v) 60% of any upfront, milestone, reimbursement or other revenue (net of costs of goods sold, as defined, and territory-specific research and development expense reimbursement) Salix receives from sublicensees outside the U.S. In the event that either marketing approval is subject to a Black Box Warning or Risk Evaluation and Mitigation Strategy (REMS), payment of a substantial portion of the milestone amount would be deferred, and subject, to achievement of the first commercialization milestone (payable upon annual U.S. sales first exceeding $100.0 million).</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-WEIGHT: bold">Funding and Financial Matters</font>. At March 31, 2012, we held $56.1 million in cash and cash equivalents, a $14.0 million decrease from $70.1 million at December 31, 2011, and we expect that this amount will be sufficient to fund operations as currently anticipated beyond one year. We may require additional funding in the future. If we do not realize sufficient royalty or other revenue or are unable to enter into favorable collaboration, license, asset sale, capital raising or other financing transactions, we will have to reduce, delay or eliminate spending on some current operations, and/or reduce salary and other overhead expenses, to extend our remaining operations.</font><br /></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">In April 2008, our Board of Directors approved a share repurchase program to acquire up to $15.0 million of our outstanding common shares, under which we have $12.3 million remaining available. Purchases may be discontinued at any time. 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The results of operations for interim periods are not necessarily indicative of the results for the full year. Our interim financial statements should be read in conjunction with the financial statements and notes thereto contained in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011. The year-end consolidated balance sheet data in these financial statements were derived from audited financial statements, but do not include all disclosures required by GAAP.</font></div> <div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">8.&#160;&#160;Commitments and Contingencies</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">In the ordinary course of our business, we enter into agreements with third parties, such as business partners, clinical sites and suppliers, that include indemnification provisions which in our judgment are normal and customary for companies in our industry sector. 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DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">The increase in accounts receivable as of March 31, 2012 as compared to December 31, 2011, is primarily due to higher Relistor sales during the first quarter of 2012. In addition, during the first quarter we collected substantially all of our December 31, 2011 accounts receivable balances.</font></div><br /> 33861903 No 82000 1272000 -13078000 -22927000 8000 0 -13086000 -22927000 0.0013 0.0013 86000 1264000 4418000 6650000 115000 115000 <div style="TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">2.&#160;&#160;Revenue Recognition</font></div><div style="TEXT-INDENT: 0pt; DISPLAY: block"><br /></div><div style="TEXT-INDENT: 36pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">We recognize revenue from all sources based on the provisions of the SEC's Staff Accounting Bulletin (SAB) No. 104 (SAB 104) and ASC 605 Revenue Recognition. 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Net Loss Per Share
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Net Loss Per Share
3.  Net Loss Per Share

Our basic net loss per share amounts have been computed by dividing net loss by the weighted-average number of common shares outstanding during the period. As of March 31, 2012 and 2011, our 79 and 331 shares, respectively, of unvested restricted stock outstanding have non-forfeitable rights to dividends. The allocation of 2012 and 2011 net losses to these participating securities pursuant to the two-class method is not material to both basic and diluted earnings per share. For the three months ended March 31, 2012 and 2011, we reported net losses and, therefore, potential common stock were not included in the computation of diluted net loss per share since such inclusion would have been anti-dilutive. The calculations of net loss per share, basic and diluted, are as follows:


   
Net Loss
(Numerator)
  
Weighted Average
Common Shares
(Denominator)
  
Per Share
Amount
 
Three months ended March 31, 2012
         
Basic and diluted
 $(13,086)  33,761  $(0.39)
Three months ended March 31, 2011
            
Basic and diluted
 $(22,927)  33,273  $(0.69)

For the three months ended March 31, 2012 and 2011, anti-dilutive common shares excluded from diluted per share amounts consist of the following:

   
Three Months Ended March 31,
 
   
2012
  
2011
 
   
Weighted
Average
Number
  
Weighted
Average
Exercise Price
  
Weighted
Average
Number
  
Weighted
Average
Exercise Price
 
Options
  5,785  $12.46   5,146  $14.10 
Restricted stock
  96       29     
Total
  5,881       5,175     
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Revenue Recognition
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Revenue Recognition
2.  Revenue Recognition

We recognize revenue from all sources based on the provisions of the SEC's Staff Accounting Bulletin (SAB) No. 104 (SAB 104) and ASC 605 Revenue Recognition. Under ASC 605, the delivered items are separate units of accounting, provided (i) the delivered items have value to a collaborator on a stand-alone basis, and (ii) if the arrangement includes a general right of return relative to the delivered item, delivery or performance of the undelivered items is considered probable and substantially in our control. In April 2010, the FASB issued a separate update to ASC 605 which provides guidance on the criteria that should be met when determining whether the milestone method of revenue recognition is appropriate. This method is effective on a prospective basis for milestones achieved after January 1, 2011.

There have been no changes to our revenue recognition accounting policies as of and for the three months ended March 31, 2012 which policies are disclosed in Note 2 to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2011.

License Agreement with Salix - February 2011

Under our license agreement, Salix is responsible for further developing and commercializing subcutaneous Relistor worldwide other than Japan, including completing clinical development necessary to support regulatory marketing approvals for potential new indications and formulations. We have granted Salix an exclusive license of relevant know-how, patent rights and technology, assigned relevant third-party contracts and we are responsible for serving on joint committees provided for in the License Agreement. We expect to perform joint committee services through 2013. We recognized $0.1 million and $0 million during the three months ended March 31, 2012 and 2011, respectively, and $59.6 million for the year ended December 31, 2011, all from the $60.0 million upfront payment. At March 31, 2012, the $0.3 million remaining deferred revenue, which pertains to joint committee services, will be recognized in collaboration revenue as such activities are performed in the future.
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CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) (USD $)
Mar. 31, 2012
Dec. 31, 2011
Stockholders' equity:    
Preferred stock, par value $ 0.001 $ 0.001
Preferred stock, authorized 20,000,000 20,000,000
Preferred stock, issued 0 0
Preferred stock, outstanding 0 0
Common stock, par value $ 0.0013 $ 0.0013
Common stock, authorized 80,000,000 80,000,000
Common stock, issued 34,061,834 34,046,409
Common stock, outstanding 33,861,834 33,846,409
Treasury stock, shares 200,000 200,000
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CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2012
Mar. 31, 2011
Cash flows from operating activities:    
Net loss $ (13,086) $ (22,927)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:    
Depreciation and amortization 472 536
Gains on sales of fixed assets (93) 0
Expenses for share-based compensation awards 2,609 1,495
Changes in assets and liabilities:    
(Increase) decrease in accounts receivable (887) 1,559
Decrease (increase) in other current assets 8 (467)
Decrease in other assets 0 1,050
Decrease in accounts payable and accrued expenses (2,232) (1,848)
Increase in other current liabilities 0 2
(Decrease) increase in deferred revenue - long term (51) 60,000
(Decrease) increase in other liabilities (534) 93
Net cash (used in) provided by operating activities (13,794) 39,493
Cash flows from investing activities:    
Capital expenditures (518) (29)
Proceeds from sales of fixed assets 124 0
Proceeds from redemption of auction rate securities 100 0
Net cash used in investing activities (294) (29)
Cash flows from financing activities:    
Proceeds from the exercise of stock options and sale of common stock under the employee stock purchase plan 82 1,272
Net cash provided by financing activities 82 1,272
Net (decrease) increase in cash and cash equivalents (14,006) 40,736
Cash and cash equivalents at beginning of period 70,105 47,918
Cash and cash equivalents at end of period $ 56,099 $ 88,654
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Interim Financial Statements
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Interim Financial Statements

Progenics Pharmaceuticals, Inc. ("Progenics," "we" or "us") is dedicated to the development of innovative medicines to treat disease. In 2011, we licensed our first commercial product, Relistor (methylnaltrexone bromide) subcutaneous injection, to Salix Pharmaceuticals, Inc., a leading gastrointestinal disease specialty company. Salix is marketing Relistor directly through its specialty sales force in the U.S. and sublicensing the drug to regional companies elsewhere except Japan, where we have previously licensed to Ono Pharmaceutical Co., Ltd. the subcutaneous formulation of the drug. In addition to the FDA-approved indication for advanced illness patients, the U.S. Prescription Drug User Fee Act (PDUFA) action date for Salix's pending supplemental New Drug Application (sNDA) for subcutaneous Relistor in non-cancer pain patients is now July 27, 2012. We and Salix also announced in December 2011 successful top-line data from the ongoing phase 3 trial of oral methylnaltrexone in non-cancer pain patients. Our current principal sources of revenue from operations are upfront, commercialization milestone, royalty and revenue-sharing payments from Salix's Relistor operations.

Progenics also has proprietary research and development programs for drug candidates focused on oncology. Our principal product candidate is PSMA ADC, a fully human monoclonal antibody-drug conjugate (ADC) directed against prostate specific membrane antigen (PSMA), a protein found at high levels on the surface of prostate cancer cells and also on the neovasculature of a number of other types of solid tumors. We expect that the ongoing phase 1 trial of PSMA ADC will be completed in 2012 and if the results are successful we plan to commence a phase 2 trial of PSMA ADC in advanced prostate cancer.

We are also conducting preclinical development work on novel multiplex phosphoinositide 3-kinase (PI3K) inhibitors that may be effective in blocking signaling pathways that are critical in the growth of aggressive cancers. We are seeking to in-license or acquire opportunities in the oncology field and supportive, diagnostic and/or other areas complementary to these ongoing and prospective initiatives. As we have expanded our focus on oncology, we have terminated certain research efforts not within the Company's oncology focus, and are working to out-license others, such as our PRO 140 and C.difficile programs.

Progenics commenced principal operations in 1988, became publicly traded in 1997 and throughout has been engaged primarily in research and development efforts, establishing corporate collaborations and related activities. All of our operations are conducted at our facilities in Tarrytown, New York.

Relistor (methylnaltrexone bromide) subcutaneous injection is a first-in-class therapy for opioid-induced constipation (OIC) which we developed over the course of the last decade and since 2008 has been approved for sale in the United States and over 50 other countries worldwide, including countries in the European Union, Canada and Australia. Marketing applications are pending elsewhere throughout the world. Under our License Agreement, Salix is responsible for further developing and commercializing subcutaneous Relistor, including completing clinical development necessary to support regulatory marketing approvals for potential new indications and formulations of the drug. We have received under this Agreement a $60.0 million upfront cash payment and $0.2 million in respect of Salix ex-U.S. sublicensee revenue, and are eligible to receive (i) up to $40.0 million upon U.S. marketing approval for subcutaneous Relistor in non-cancer pain patients, (ii) up to $50.0 million upon U.S. marketing approval of an oral formulation of Relistor, (iii) up to $200.0 million of commercialization milestone payments upon achievement of specified U.S. sales targets, (iv) royalties ranging from 15 to 19 percent of net sales by Salix and its affiliates, and (v) 60% of any upfront, milestone, reimbursement or other revenue (net of costs of goods sold, as defined, and territory-specific research and development expense reimbursement) Salix receives from sublicensees outside the U.S. In the event that either marketing approval is subject to a Black Box Warning or Risk Evaluation and Mitigation Strategy (REMS), payment of a substantial portion of the milestone amount would be deferred, and subject, to achievement of the first commercialization milestone (payable upon annual U.S. sales first exceeding $100.0 million).

Funding and Financial Matters. At March 31, 2012, we held $56.1 million in cash and cash equivalents, a $14.0 million decrease from $70.1 million at December 31, 2011, and we expect that this amount will be sufficient to fund operations as currently anticipated beyond one year. We may require additional funding in the future. If we do not realize sufficient royalty or other revenue or are unable to enter into favorable collaboration, license, asset sale, capital raising or other financing transactions, we will have to reduce, delay or eliminate spending on some current operations, and/or reduce salary and other overhead expenses, to extend our remaining operations.

In April 2008, our Board of Directors approved a share repurchase program to acquire up to $15.0 million of our outstanding common shares, under which we have $12.3 million remaining available. Purchases may be discontinued at any time. We did not repurchase any common shares during the three months ended March 31, 2012.

Our interim Consolidated Financial Statements included in this report have been prepared in accordance with applicable presentation requirements, and accordingly do not include all information and disclosures necessary for a presentation of our financial position, results of operations and cash flows in conformity with accounting principles generally accepted in the United States of America ("GAAP"). In the opinion of management, these financial statements reflect all adjustments, consisting primarily of normal recurring accruals necessary for a fair statement of results for the periods presented. The results of operations for interim periods are not necessarily indicative of the results for the full year. Our interim financial statements should be read in conjunction with the financial statements and notes thereto contained in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011. The year-end consolidated balance sheet data in these financial statements were derived from audited financial statements, but do not include all disclosures required by GAAP.
XML 21 R3.htm IDEA: XBRL DOCUMENT v2.4.0.6
STATEMENTS OF OPERATIONS (Unaudited) (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended
Mar. 31, 2012
Mar. 31, 2011
Revenues:    
Royalty income $ 1,834 $ 0
Collaboration revenue 291 1,083
Research grants 86 1,264
Other revenues 15 41
Total revenues 2,226 2,388
Expenses:    
Research and development 10,909 19,179
License fees - research and development 40 364
Royalty expense 185 57
General and administrative 3,721 5,197
Depreciation and amortization 472 536
Total expenses 15,327 25,333
Operating loss (13,101) (22,945)
Other income:    
Interest income 15 18
Total other income 15 18
Net loss $ (13,086) $ (22,927)
Net loss per share - basic and diluted $ (0.39) $ (0.69)
Weighted-average shares - basic and diluted 33,761 33,273
XML 22 R17.htm IDEA: XBRL DOCUMENT v2.4.0.6
Entity Information (USD $)
3 Months Ended
Mar. 31, 2012
Dec. 31, 2011
Entity [Text Block] PROGENICS PHARMACEUTICALS INC  
Entity Registrant Name PROGENICS PHARMACEUTICALS INC  
Entity Central Index Key 0000835887  
Current Fiscal Year End Date --12-31  
Entity Well-known Seasoned Issuer No  
Entity Voluntary Filers No  
Entity Current Reporting Status No  
Entity Filer Category Accelerated Filer  
Entity Public Float   $ 144,724,374
Entity Common Stock, Shares Outstanding 33,861,903  
Document Fiscal Year Focus 2012  
Document Fiscal Period Focus Q1  
XML 23 R1.htm IDEA: XBRL DOCUMENT v2.4.0.6
CONSOLIDATED BALANCE SHEETS (Unaudited) (USD $)
In Thousands, unless otherwise specified
Mar. 31, 2012
Dec. 31, 2011
Mar. 31, 2011
Current assets:      
Cash and cash equivalents $ 56,099 $ 70,105 $ 88,654
Accounts receivable 2,403 1,516  
Other current assets 960 919  
Total current assets 59,462 72,540  
Auction rate securities 3,240 3,332  
Fixed assets, at cost, net of accumulated depreciation and amortization 4,004 4,038  
Other assets 200 200  
Total assets 66,906 80,110  
Current liabilities:      
Accounts payable and accrued expenses 4,099 6,331  
Deferred revenue - current 204 204  
Other current liabilities 115 115  
Total current liabilities 4,418 6,650  
Deferred revenue - long term 111 162  
Other liabilities 963 1,497  
Total liabilities 5,492 8,309  
Commitments and contingencies (Note 8)        
Stockholders' equity:      
Common stock 44 44  
Additional paid-in capital 466,131 463,440  
Accumulated deficit (401,760) (388,674)  
Accumulated other comprehensive loss (260) (268)  
Treasury stock (2,741) (2,741)  
Total stockholders' equity 61,414 71,801 31,148
Total liabilities and stockholders' equity $ 66,906 $ 80,110  
XML 24 R4.htm IDEA: XBRL DOCUMENT v2.4.0.6
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Unaudited) (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2012
Mar. 31, 2011
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS [Abstract]    
Net loss $ (13,086) $ (22,927)
Other comprehensive income:    
Net change in unrealized loss on auction rate securities 8 0
Total other comprehensive income 8 0
Comprehensive loss $ (13,078) $ (22,927)
XML 25 R12.htm IDEA: XBRL DOCUMENT v2.4.0.6
Accounts Payable and Accrued Expenses
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Accounts Payable and Accrued Expenses
6.  Accounts Payable and Accrued Expenses

   
March 31,
2012
  
December 31,
2011
 
Accrued consulting and clinical trial costs
 $1,750  $1,637 
Accrued payroll and related costs
  1,130   3,149 
Restructuring accrual
  130   731 
Legal and professional fees
  594   371 
Accounts payable
  309   309 
Other
  186   134 
Total
 $4,099  $6,331 

Accounts payable and accrued expenses decreased as of March 31, 2012, compared to year end, primarily due to the payment of 2011 accrued bonuses in the first quarter of 2012.
XML 26 R11.htm IDEA: XBRL DOCUMENT v2.4.0.6
Accounts Receivable
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Accounts Receivable
5.  Accounts Receivable

   
March 31,
2012
  
December 31,
2011
 
Royalties
 $1,835  $1,279 
Collaborators
  480   77 
Research grants
  74   100 
Other
  14   60 
Total
 $2,403  $1,516 

The increase in accounts receivable as of March 31, 2012 as compared to December 31, 2011, is primarily due to higher Relistor sales during the first quarter of 2012. In addition, during the first quarter we collected substantially all of our December 31, 2011 accounts receivable balances.

XML 27 R15.htm IDEA: XBRL DOCUMENT v2.4.0.6
Recently Adopted Accounting Standards
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Recently Adopted Accounting Standards
9.  Recently Adopted Accounting Standards

In June 2011, the FASB issued ASU No. 2011-05, which requires that comprehensive income and the related components be presented in a single continuous statement or in two separate but consecutive statements. The ASU is effective for fiscal years, and interim periods within those years, beginning after December 15, 2011, except for the deferral of the effective date related to the presentation of reclassification of items out of accumulated other comprehensive income under ASU No. 2011-12, which was issued in January 2012. We adopted this new standard and applied it retrospectively on January 1, 2012 and it had no material impact on our consolidated financial statements.

In May 2011, the FASB issued ASU No. 2011-04, which is the result of joint efforts by the FASB and International Accounting Standards Board to develop a single, converged fair value framework. The converged guidance specifies how to measure fair value and what disclosures to provide about fair value measurements. The ASU is effective for interim and annual periods beginning after December 15, 2011. We adopted this new standard on January 1, 2012 and it had no material impact on our consolidated financial statements.

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Restructuring
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Restructuring
7. Restructuring

In the third and fourth quarters of 2011, we reduced headcount resulting in a restructuring accrual of $1.3 million of severance and related benefits, which are being paid during the period from October 2011 through August 2012. We incurred other exit and contract termination costs, including expenses related to a lease amendment and consolidation of employees within reduced facility space.

Activity in the restructuring accrual, which is included in accounts payable and accrued expenses in our Consolidated Balance Sheets and research and development and general and administrative expenses in the Consolidated Statements of Operations, is specified below.

   
Severance
and Related
Benefits
  
Other Exit
Costs
  
Contract
Termination
Costs
  
Total
Restructuring
Accrual
 
Balance at December 31, 2011
 $571  $6  $154  $731 
Additions, net
  -   122   3   125 
Payments
  (456 )  (123 )  (147 )  (726 )
Balance at March 31, 2012
 $115  $5  $10  $130 

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Commitments and Contingencies
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Commitments and Contingencies
8.  Commitments and Contingencies

In the ordinary course of our business, we enter into agreements with third parties, such as business partners, clinical sites and suppliers, that include indemnification provisions which in our judgment are normal and customary for companies in our industry sector. We generally agree to indemnify, hold harmless and reimburse the indemnified parties for losses suffered or incurred by them with respect to our products or product candidates, use of such products or other actions taken or omitted by us. The maximum potential amount of future payments we could be required to make under these indemnification provisions is not limited. We have not incurred material costs to defend lawsuits or settle claims related to these provisions. As a result, the estimated fair value of liabilities relating to indemnification provisions is minimal. We have no liabilities recorded for these provisions as of March 31, 2012.

On March 14, 2012, Progenics and Vice Chairman Paul Maddon entered into an agreement for his retirement from full-time employment. In connection with this agreement, Progenics incurred $2.1 million in salary and related benefits expenses and $1.6 million non-cash equity vesting expenses, and of these amounts together $0.2 million and $3.5 million were expensed in the fourth quarter of 2011 and first quarter of 2012, respectively. Progenics paid $2.0 million cash in respect of these expenses during the first quarter of 2012.

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Document Information
3 Months Ended
Mar. 31, 2012
Document Type 10-Q
Amendment Flag false
Document Period End Date Mar. 31, 2012
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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) (USD $)
In Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Treasury Stock
Balance, beginning at Dec. 31, 2010 $ 51,308 $ 43 $ 453,353 $ (399,055) $ (292) $ (2,741)
Balance, beginning (in shares) at Dec. 31, 2010   33,326       (200)
Net loss (22,927)     (22,927)    
Compensation expenses for share-based payment arrangements 1,495   1,495      
Issuance of restricted stock, net of forfeitures (in shares)   (10)        
Sale of common stock under employee stock purchase plans and exercise of stock options (in shares)   283        
Sale of common stock under employee stock purchase plans and exercise of stock options 1,272 1 1,271      
Balance, ending at Mar. 31, 2011 31,148 44 456,119 (421,982) (292) (2,741)
Balance, ending (in shares) at Mar. 31, 2011   33,599       (200)
Balance, beginning at Dec. 31, 2011 71,801 44 463,440 (388,674) (268) (2,741)
Balance, beginning (in shares) at Dec. 31, 2011   34,046       (200)
Net loss (13,086)     (13,086)    
Other comprehensive income 8       8  
Compensation expenses for share-based payment arrangements 2,609   2,609      
Sale of common stock under employee stock purchase plans and exercise of stock options (in shares)   16        
Sale of common stock under employee stock purchase plans and exercise of stock options 82   82      
Balance, ending at Mar. 31, 2012 $ 61,414 $ 44 $ 466,131 $ (401,760) $ (260) $ (2,741)
Balance, ending (in shares) at Mar. 31, 2012   34,062       (200)
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Fair Value Measurements
3 Months Ended
Mar. 31, 2012
Notes to Financial Statements [Abstract]  
Fair Value Measurements
4.  Fair Value Measurements

Our auction rate securities are recorded at fair value in the accompanying Consolidated Balance Sheets in accordance with ASC 320 Investments - Debt and Equity Securities. The change in the fair value of these investments is recorded as a component of other comprehensive loss (see Note 2. Summary of Significant Accounting Policies - Fair Value Measurements in the notes to consolidated financial statements included in our 2011 Annual Report on Form 10-K).

The following tables present our money market funds and auction rate securities measured at fair value on a recurring basis as of March 31, 2012 and December 31, 2011, classified by valuation hierarchy:

      
Fair Value Measurements at March 31, 2012
 
Investment Type
 
Balance at
March 31, 2012
  
Quoted Prices
in Active
Markets for
Identical Assets
 (Level 1)
  
Significant
Other
Observable
Inputs
 (Level 2)
  
Significant
Unobservable
Inputs
 (Level 3)
 
              
Money market funds
 $50,182  $50,182  $-  $- 
Auction rate securities
  3,240   -   -   3,240 
Total
 $53,422  $50,182  $-  $3,240 

      
Fair Value Measurements at December 31, 2011
 
Investment Type
 
Balance at
December 31, 2011
  
Quoted Prices
in Active
Markets for
Identical Assets
 (Level 1)
  
Significant
Other
Observable
Inputs
 (Level 2)
  
Significant
Unobservable
Inputs
 (Level 3)
 
              
Money market funds
 $64,068  $64,068  $-  $- 
Auction rate securities
  3,332   -   -   3,332 
Total
 $67,400  $64,068  $-  $3,332 

At March 31, 2012 we hold $3,240 in auction rate securities which are classified as Level 3. The fair value of these securities includes $2,300 of U.S. government subsidized securities collateralized by student loan obligations, with maturities greater than 10 years, and $940 of investment company perpetual preferred stock, without a stated maturity. We will not realize cash in respect of the principal amount of these securities until the issuer calls or restructures the security, the security reaches any scheduled maturity and is paid, or a buyer outside the auction process emerges. As of March 31, 2012, we have received all scheduled interest payments on these securities, which, in the event of auction failure, are reset according to contractual terms in the governing instruments.
 
The valuation of auction rate securities we hold is based on Level 3 unobservable inputs which consist of our internal analysis of (i) timing of expected future successful auctions or issuer calls of the securities, (ii) collateralization of underlying assets of the security and (iii) credit quality of the security. We use a discounted cash flow model to estimate the value of these auction rate securities and the unobservable inputs consist of a redemption period ranging from four to 17 years (weighted-average: 6.6 years) and discount rates ranging from 0.25% to 2.39% (weighted-average: 1.1%). Significant increases (decreases) in the redemption period or discount rates would result in a significantly lower (higher) fair value measurement. In re-evaluating the valuation of these securities as of March 31, 2012, the temporary impairment amount, the duration of which is greater than 12 months, decreased $8 from $268 at December 31, 2011, to $260, which is reflected as part of accumulated other comprehensive loss on our accompanying Consolidated Balance Sheets and based on such re-evaluation, we believe that we have the ability to hold these securities until recovery of fair value. Due to the uncertainty related to the liquidity in the auction rate security market and therefore when individual positions may be liquidated, we have classified these auction rate securities as long-term assets on our accompanying Consolidated Balance Sheets. We continue to monitor markets for our investments and consider the impact, if any, of market conditions on the fair market value of our investments. We do not believe the carrying values of our investments are other than temporarily impaired and therefore expect the positions will eventually be liquidated without significant loss.

For those of our financial instruments with significant Level 3 inputs (all of which are auction rate securities), the following table summarizes the activities for the three months ended March 31, 2012 and 2011:

   
Fair Value Measurements Using Significant
Unobservable Inputs
(Level 3)
For the Three Months Ended March 31
 
Description
 
2012
  
2011
 
        
Balance at beginning of period
 $3,332  $3,608 
Transfers into Level 3
  -   - 
Transfers out of Level 3
  -   - 
Total gains (losses)
        
Included in net loss
  -   - 
Included in other comprehensive loss
  8   - 
Settlements at par
  (100 )  - 
Balance at end of period
 $3,240  $3,608 
    Changes in unrealized gains or losses for the period included in earnings (or changes in net assets) for assets held at the end of the reporting period
 $-  $- 
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