STATEMENTS OF OPERATIONS (Unaudited) (USD $) In Thousands, except Per Share data	3 Months Ended		9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010	Sep. 30, 2011	Sep. 30, 2010
Revenues:
Collaboration revenue	$ 2,855	$ 82	$ 76,398	$ 1,175
Royalty income	1,240	620	1,767	1,826
Research grants	1,681	1,234	4,346	2,667
Other revenues	28	31	88	127
Total revenues	5,804	1,967	82,599	5,795
Expenses:
Research and development	12,406	12,967	44,887	35,518
License fees - research and development	114	110	566	1,217
General and administrative	4,064	5,414	14,213	17,568
Royalty expense	147	62	274	182
Depreciation and amortization	520	532	1,581	2,283
Total expenses	17,251	19,085	61,521	56,768
Operating income (loss)	(11,447)	(17,118)	21,078	(50,973)
Other income:
Interest income	15	17	49	48
Total other income	15	17	49	48
Net income (loss)	$ (11,432)	$ (17,101)	$ 21,127	$ (50,925)
Net income (loss) per share - basic	$ (0.34)	$ (0.52)	$ 0.63	$ (1.57)
Weighted-average shares - basic	33,710	32,814	33,501	32,444
Net income (loss) per share - diluted	$ (0.34)	$ (0.52)	$ 0.63	$ (1.57)
Weighted-average shares - diluted	33,710	32,814	33,664	32,444