Note 17 - Subsequent Events (Details Textual) - USD ($)				12 Months Ended
	May 14, 2020	Apr. 29, 2020	Apr. 20, 2020	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2019	Dec. 31, 2018
Class of Warrant or Right, Exercised During Period (in shares)						121,000	2,608,844
Subsequent Event [Member]
Proceeds from Paycheck Protection Program Under CARES Act			$ 2,175,320
Repayments of Borrowings Under Paycheck Protection Program Under CARES Act		$ 2,175,320
Subsequent Event [Member] | WAVI Holding AG and Taurus4757 GmbH Warrants [Member]
Stock Issued During Period, Shares, Warrant Exercises (in shares)	2,747,970
Class of Warrant or Right, Exercised During Period (in shares)	3,871,405
Subsequent Event [Member] | Casdin Capital LLC [Member]
Share Repurchase Agreement, Amount of Shares to be Issued	$ 20,000,000
Share Repurchase Agreement, Shares Issued, Price Per Share (in dollars per share)	$ 10.50
Share Repurchase Agreement, Shares to be Issued (in shares)	1,904,762
Forecast [Member]
Deferred Social Security Payments, Percentage to be Paid				50.00%	50.00%