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Note 3 - Acquisition of Astero Bio Corporation (Details Textual) - USD ($)
3 Months Ended 6 Months Ended
Apr. 01, 2019
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2018
Goodwill, Ending Balance   $ 9,524,000   $ 9,524,000  
Business Combination, Acquisition Related Costs   39,000 247,000  
Astero [Member]            
Payments to Acquire Businesses, Gross $ 12,521,000          
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High 8,500,000          
Business Combination, Contingent Consideration, Liability, Total 1,900,000          
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net Tangible Assets 324,000          
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Indefinite-Lived Intangible Assets 4,600,000          
Goodwill, Ending Balance $ 9,500,000 9,524,000   9,524,000    
Business Combination, Acquisition Related Costs   39,000   247,000 103,000  
Business Combination, Pro Forma Information, Revenue of Acquiree since Acquisition Date, Actual   374,000   374,000    
Business Combination, Pro Forma Information, Earnings or Loss of Acquiree since Acquisition Date, Actual   $ (542,000)   (542,000)    
Business Combination, Pro Forma Information, Amortization Expense       104,000 208,000  
Business Combination, Pro Forma Information, Share-based Compensation Expense       108,000 216,000  
Business Combination, Pro Forma Information, Employee Related Expense       $ 47,000 $ 94,000