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Note 7 - Net Loss Per Common Share (Tables)
3 Months Ended
Mar. 31, 2018
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Month Period Ended
March 31,
 
   
2018
   
2017
 
Basic and diluted weighted average common stock shares outstanding
   
14,098,610
     
12,964,639
 
Potentially dilutive securities excluded from loss per share computations:
               
Common stock options
   
3,326,841
     
3,387,581
 
Common stock purchase warrants
   
6,676,849
     
7,603,141
 
Restricted stock unvested
   
337,981
     
282,350